The Huize large-sized Pb-Zn deposit in Yunnan Province, China, is characterized by favorable metallogenic background and particular geological settings. This suggested that the ore-forming mechanism is relatively uniq...The Huize large-sized Pb-Zn deposit in Yunnan Province, China, is characterized by favorable metallogenic background and particular geological settings. This suggested that the ore-forming mechanism is relatively unique. On the basis of geological features such as the contents of mineralization elements, the REE concentrations of gangue calcites, the REE concentrations of calcite veins in the NE-trending tectonic zone and the Pb, Sr, C, H and O isotopic compositions of different minerals, this paper presents that the ore-forming materials and ore-forming fluids of the deposit were derived from various types of strata or rocks. This is a very significant conclusion for us to further discuss the mineralization mechanism of the deposit at depth and establish an available genetic model.展开更多
The mechanical properties of multi-lead rubber bearings （MLRBs） were investigated by experiment and finite element analysis. First, the vertical stiffness, horizontal stiffness and yielded shear force were tested fo...The mechanical properties of multi-lead rubber bearings （MLRBs） were investigated by experiment and finite element analysis. First, the vertical stiffness, horizontal stiffness and yielded shear force were tested for four MLRB specimens and two specimens of the single-lead rubber bearings （ SLRBs）. Then, the MLRBs were modeled by the explicit finite element analysis software ANSYS/ LS-DYNA, in order to evaluate the horizontal force-displacement hysteretic curves under static vertical and dynamical horizontal loadings. The disagreement between the tested and theoretical values was less than 11.4%, and MLRBs and SLRBs were similar in vertical stiffness, pre-yield stiffness and yield stiffness.展开更多
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a...Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.展开更多
The three dimensional lead rubber dish spring bearing (3DB) is proposed in this paper. The 3DB is composed of lead rubber bearing (LRB) and dish spring bearing (DSB) with damper in series. The 3DB put forward in t...The three dimensional lead rubber dish spring bearing (3DB) is proposed in this paper. The 3DB is composed of lead rubber bearing (LRB) and dish spring bearing (DSB) with damper in series. The 3DB put forward in this paper is effective in the resolution of difficulties in strong vertical capacity and vertical damping of three dimensional isolation bearings. It effectively suppresses rocking motions as well. The analytical model and motion equations of multi dimensional seismic responses of 3D base isolated frame structures are established. Taking a five storey frame structure as an example, an extensive simulation analysis is carried out. The results show that the 3D base isolated structure with the proposed 3DB is effective in 3D isolation; it can reduce seismic responses by 50 % compared to a non isolated structure. Therefore, the 3D isolation problem in building can be solved easily and effectively with the 3DB proposed in this paper.展开更多
文摘The Huize large-sized Pb-Zn deposit in Yunnan Province, China, is characterized by favorable metallogenic background and particular geological settings. This suggested that the ore-forming mechanism is relatively unique. On the basis of geological features such as the contents of mineralization elements, the REE concentrations of gangue calcites, the REE concentrations of calcite veins in the NE-trending tectonic zone and the Pb, Sr, C, H and O isotopic compositions of different minerals, this paper presents that the ore-forming materials and ore-forming fluids of the deposit were derived from various types of strata or rocks. This is a very significant conclusion for us to further discuss the mineralization mechanism of the deposit at depth and establish an available genetic model.
文摘The mechanical properties of multi-lead rubber bearings （MLRBs） were investigated by experiment and finite element analysis. First, the vertical stiffness, horizontal stiffness and yielded shear force were tested for four MLRB specimens and two specimens of the single-lead rubber bearings （ SLRBs）. Then, the MLRBs were modeled by the explicit finite element analysis software ANSYS/ LS-DYNA, in order to evaluate the horizontal force-displacement hysteretic curves under static vertical and dynamical horizontal loadings. The disagreement between the tested and theoretical values was less than 11.4%, and MLRBs and SLRBs were similar in vertical stiffness, pre-yield stiffness and yield stiffness.
基金Poly U(G-YBGQ G-SB81+3 种基金 G-YZ95)the Research Grant Council of Hong Kong(15101014)ITSP-Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/012/16GD)Shenzhen Basic Research Program(JCYJ20160331141459373)
文摘Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.
文摘The three dimensional lead rubber dish spring bearing (3DB) is proposed in this paper. The 3DB is composed of lead rubber bearing (LRB) and dish spring bearing (DSB) with damper in series. The 3DB put forward in this paper is effective in the resolution of difficulties in strong vertical capacity and vertical damping of three dimensional isolation bearings. It effectively suppresses rocking motions as well. The analytical model and motion equations of multi dimensional seismic responses of 3D base isolated frame structures are established. Taking a five storey frame structure as an example, an extensive simulation analysis is carried out. The results show that the 3D base isolated structure with the proposed 3DB is effective in 3D isolation; it can reduce seismic responses by 50 % compared to a non isolated structure. Therefore, the 3D isolation problem in building can be solved easily and effectively with the 3DB proposed in this paper.
