一种MAKLINK图多节点链路建模的路径规划研究

针对传统MAKLINK图规划路径线路改变时,其最优化路径易与环境约束条件冲突的问题,提出了在MAKLINK图中各链路上增加节点数目的方法,以提高系统建模的适应性和鲁棒性。设计的多节点链路通过dijkstra算法得到更为理想的次优化路径,由蚁群算法进行迭代计算获得最优化路径,实现了在保证路径适应度的前提下,提高优化路径对环境约束条件的适应性。实验结果表明,与基本MAKLINK图路径规划算法相比,多节点链路的建模路径规划算法可有效提高次优路径的建模精度,最优路径的适应度值较单节点链路减小了1.43%,具有一定的建模优势。

Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal cancer.Nevertheless,LCE is not suitable for general population screening given its side effects.Linked color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal color.AIM To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions.METHODS In this prospective study,we enrolled 543 patients who underwent white light imaging(WLI),LCI and LCE successively.We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions.Clinicopathological features and color analysis of lesions were assessed.RESULTS In total,43 patients(45 neoplastic lesions)were analyzed.Among them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with LCE.The sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,P<0.001].The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI.However,the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer.CONCLUSION LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions,and LCI represents a promising screening strategy for general populations.

Evaluation of Linear Precoding Schemes for Cooperative Multi-Cell MU MIMO in Future Mobile Communication Systems

In Mobile Communication Systems, inter-cell interference becomes one of the challenges that degrade the system’s performance, especially in the region with massive mobile users. The linear precoding schemes were proposed to mitigate interferences between the base stations (inter-cell). These schemes are categorized into linear and non-linear;this study focused on linear precoding schemes, which are grounded into three types, namely Zero Forcing (ZF), Block Diagonalization (BD), and Signal Leakage Noise Ratio (SLNR). The study included the Cooperative Multi-cell Multi Input Multi Output (MIMO) System, whereby each Base Station serves more than one mobile station and all Base Stations on the system are assisted by each other by shared the Channel State Information (CSI). Based on the Multi-Cell Multiuser MIMO system, each Base Station on the cell is intended to maximize the data transmission rate by its mobile users by increasing the Signal Interference to Noise Ratio after the interference has been mitigated due to the usefully of linear precoding schemes on the transmitter. Moreover, these schemes used different approaches to mitigate interference. This study mainly concentrates on evaluating the performance of these schemes through the channel distribution models such as Ray-leigh and Rician included in the presence of noise errors. The results show that the SLNR scheme outperforms ZF and BD schemes overall scenario. This implied that when the value of SNR increased the performance of SLNR increased by 21.4% and 45.7% for ZF and BD respectively.

New Approach of Multi-Cell Stacked Cell Inverter for Solar Photovoltaic System

In this paper, a new inverter topology dedicated to isolated or grid-connected PV systems is proposed. This inverter is based on the structures of a stacked multi-cell converter (SMC) and an H-bridge. This new topology has allowed the voltage stresses of the converter to be distributed among several switching cells. Secondly, divide the input voltage into several fractions to reduce the number of power semiconductors to be switched. In this contribution, the general topology of this micro-inverter has been described and the simulation tests developed to validate its operation have been presented. Finally, we discussed the simulation results, the efficiency of this topology and the feasibility of its use in a grid-connected photovoltaic production system.

多音干扰下Nakagami-m信道传输Link16数据链的性能分析

Link16数据链的应用综合广泛,由于运用了跳扩频和编码技术使其具有强大的抗干扰能力。为了探究Link16数据链在衰落信道下的响应,在加性高斯白噪信道的基础之上,研究了Link16数据链经过Nakagami-m衰落信道的系统性能。着重推导了Link16数据链单脉冲结构在多音干扰下经过Nakagami-m衰落信道的误码率(bit error rate,BER)表达式,并给出了双脉冲结构BER公式。仿真实验结果验证了Link16数据链单脉冲结构在多音干扰下经过Nakagami-m衰落信道的BER公式的准确性,分析了多径参数对Link16数据链抗干扰性能的影响,得出增加衰落参数m和可分辨路径可以提升Link16数据链的系统性能,且当信干比一定、被干扰频点个数在25个及以上时系统BER达到10-1。

Chemotactic signaling and beyond: link between interleukin-16 and axonal degeneration in multiple sclerosis

Multiple sclerosis（MS）is a progressive inflammatory,and chronic demyelinating,neurodegenerative disease of central nervous system（CNS）.Autoimmune responses to myelin and other CNS antigens mediated by cluster of differentiation 4（CD4＋）T cells are critical for initiation and progression of disease.Migration of autoimmune T cells from the peripheral lymph organs into CNS parenchyma leads to inflammation,demyelination and damage of axonal cytoskeleton, which manifest in decreased impulse conduction velocity of motor and sensory nerves. Myelin and axonal pathology causes motor, sensory and autonomic nerve dysfunction, including optic nerve damage leading to double or distorted vision; paresis and paralysis of extremities, painful sensations, and bladder sphincter dysfunction, manifested as bladder incontinence. Gray matter pa- thology in cortical and subcortical regions, including cerebellum and hippocampus underlies cognitive and behavioral dysfunction consisting of memory deficits, depression, and ataxic gait and tremor.

In Vitro Evaluation of Cytotoxicity and Oxidative Stress Induced by Multiwalled Carbon Nanotubes in Murine RAW 264.7 Macrophages and Human A549 Lung Cells

Objective To investigate in vitro cytotoxicity and oxidative stress response induced by multiwalled carbon nanotubes （MWCNTs）. Methods Cultured macrophages （murine RAW264.7 cells） and alveolar epithelium cells type II （human A549 lung cells） were exposed to the blank control, DNA salt control, and the MWCNTs suspensions at 2.5, 10, 25, and 100 ug/mL for 24 h. Each treatment was evaluated by cell viability, cytotoxicity and oxidative stress. Results Overall, both cell lines had similar patterns in response to the cytotoxicity and oxidative stress of MWCNTs. DNA salt treatment showed no change compared to the blank control. In both cell lines, significant changes at the doses of 25 and 100 ug/mL treatments were found in cell viabilities, cytotoxicity, and oxidative stress indexes. The reactive oxygen species （ROS） generation was also found to be significantly higher at the dose of 10 ug/mL treatment, whereas no change was seen in most of the indexes. The ROS generation in both cell lines went up in minutes, reached the climax within an hour and faded down after several hours. Conclusion Exposure to MWCNTs resulted in a dose-dependent cytotoxicity in cultured RAW264.7 cells and A549 cells, that was closely correlated to the increased oxidative stress.

Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters

It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials.

Integrated Manufacturing Cell Formation Technology Orienting Multi-product Type and Variant Volume Production

What is pursued by multi-product type and variant volume（MPTVV） production is rapid response and quick switching,so that structure of transferring line in manufacturing system is no longer unalterable.Cell formation（CF） algorithm is the key technology of cellular manufacturing system（CMS）.Currently,CF methods are mainly extended on the idea of group technology（GT） that covers a lot on analysis of resource capability matching and its algorithm.Various constraints are considered,but seldom utilized comprehensively.Aimed to the problem of manufacturing cell（MC） formation under MPTVV production mode,integrated formation technologies for typical MC as group type of cell（GC）,flow type of cell（FC） and inherited cell（IC） are presented based on technical analysis of CF.Oriented to practical production constraints like delivery time,product batch,equipment ability,key machine,key part and machine sharing,etc,an integrated formation model is constructed and internal interrelations of these constraints are analyzed synthetically.Ulteriorly,formation goals of types of MCs and their formation procedures under joint effect of formation constraints and rules are spread.In case study,three highly balanced GC are formed first;then FC formation are implemented based on the same data which indicate good balancing effect of cell load and flow-style production for key tasks;When task is adjusted,a new scheme is constructed on the result of FC configuration by using IC formation method,and more optimal performance of flow-style production is manifested.The proposed comparative study of different type of cells strongly explains the validation of integrated MC formation in support of rapid manufacturing resource transformation under MPTVV production mode.

O-linked N-acetylglucosamine transferase(OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma

The aim of this present study was to explore the expression and clinical significance of O-linked N-acetylglucosamine（O-GlcNAc） transferase（OGT） and enzymatic O-linked glycosylation（O-GlcNAcation） through the addition of O-linked-β-N-acetylglucosamine in esophageal squamous cell carcinoma.OGT expression and O-GlcNAcation in 40 samples from patients with esophageal squamous cell carcinoma was detected by immunohistochemical staining with anti-OGT antib ody and O-GlcNAc-specific antibody RL 2,respectively.The relationship between pathological and clinical factors of patients was analyzed.We found that the expression of OGT was higher in esophageal squamous cell carcinoma samples compared to the normal tissues.RL 2 antibody level was positively correlated with OGT expression,and the metastasis of lymph node,which means the level of O-GlcNAcation was high and related to the metastasis of lymph node in esophageal squamous cell carcinoma.In conclusion,OGT activation is the main reason for promoting the level of O-GlcNAcation in esophageal squamous cell carcinoma.O-GlcNAcylation may play an important role in esophageal squamous cell carcinoma.

An early report: a modified porphyrin-linked metronidazole targeting intracellular Porphyromonas gingivalis in cultured oral epithelial cells

Porphyromonas gingivalis （P. gingivalis） has a strong association with the pathogenesis of periodontal disease. Recurrence of periodontal disease following therapy is attributed to numerous factors, and of growing interest is the potential problem of intracellular bacteria that are able to persist and multiply within the host cell, thereby facilitating relapse of infection. The effect of antibiotic therapy in controlling P. gingivalis is questionable. Accordingly, while metronidazole is very effective against anaerobic extracellular P. gingivalis by disrupting the DNA of anaerobic microbial cells, this antibiotic does not effectively penetrate into mammalian cells to inhibit intracellular bacteria. Therefore in the present study, a modified porphyrin-linked metronidazole adducts, developed in our laboratory, was used to kill intracellular P. gingivalis. A series of experiments were performed, including cytotoxicity assays and cellular uptake of adducts by flow cytometry coupled with live cell imaging analysis, P. gingivalis invasion and elimination assays, and the analysis of colocalization of P. gingivalis and porphyrin-linked metronidazole by confocal laser scanning microscopy. Findings indicated that P. gingivalis and porphyrin-linked metronidazole were colocalized in the cytoplasm, and this compound was able to kill P. gingivalis intracellular with a sufficient culture time. This is a novel antimicrobial approach in the elimination of P. gingivalis from the oral cavity.

Handover initiation performance of a new multi-cell cellular configuration with a developed base-station multi-beam antenna

A new multi-cell cellular configuration networks is provided for analysis of handover initiation probability, which is based on multi-beam base-station antenna splitting in the elevation-radiating plane. The sum of the received signal power in the mobile station, including both desired and interference signal power, has been introduced into the handover initiation algorithm. Along with the idea, we present three models of handover initiation algorithm with the shadowing process of Gaussian distribution. The formulation of handover initiation probability of those algorithms is also analyzed. The validity of the presented models has been checked through the comparison with simulation results. The results present the performance characteristics of handover initiation vary with cluster number and base-station antenna elevation angle.

Link between dysregulated hypoxia signaling and aberrant methylation in clear cell renal cell carcinoma？

Dysregulated pseudo-hypoxia （through its effects on cell survival, angiogenesis, metabolism, invasion） and epigenetic dysregulation [through widespread suppression of tumor suppressor genes involved in cell cycle, apoptosis, adhesion, immune evasion, etc. （1）] are considered to be the two central driving pathogenic features in the progression of clear cell Renal Cell Carcinoma （ccRCC） （2,3）.

Intensification of Power Quality Using PMSG and Cascaded Multi Cell Trans-Z-Source Inverter

This script depicts the power quality intensification of Wind Energy Transfer System (WETS) using Permanent Magnet Synchronous Generator (PMSG) and Cascaded Multi Cell Trans-Z-Source Inverter (CMCTZSI). The PMSG knocks the induction generator and earlier generators, because of their stimulating performances without taking the frame power. The Trans-Z-Source Inverter with one transformer and one capacitor is connected newly. To increase the boosting ratio gratuity a cascaded impression is proposed with adopting multi-winding transformer which provides an option for this manuscript to use coupled inductor as an alternative of multi-winding transformer and remains the matching voltage gain as cascaded multi cell trans-Z- source inverter. Accordingly the parallel capacitances are also balancing the voltage gain. The parallel correlation of the method is essentially to trim down the voltage stresses and to improve the input current gain of the inverter. By using MALAB Simulation, harmonics can be reduced up to 1.32% and also DC side can be boosted up our required level 200 - 1000 V achievable. The new hardware setup results demonstrate to facilitate the multi cell Trans Z-source inverter. This can be generated high-voltage gain [50 V - 1000 V] and also be credible. Moreover, the level of currents, voltages and Harmonics on the machinery is low.

Aircraft Landing Gear Control with Multi-Objective Optimization Using Generalized Cell Mapping

This paper presents a numerical algorithm tuning aircraft landing gear control system with three objectives,including reducing relative vibration, reducing hydraulic strut force and controlling energy consumption. Sliding mode control is applied to the vibration control of a simplified landing gear model with uncertainty. A two-stage generalized cell mapping algorithm is applied to search the Pareto set with gradient-free scheme. Drop test simulations over uneven runway show that the vibration and force interaction can be considerably reduced, and the Pareto optimum form a tight range in time domain.

Performance Analysis of Cell Loss Probability Based on ATM Self-healing Multi-section-backup VP Scheme

Based on ATM Multi section backup VP self healing scheme, analysis of cell loss probability under finite buffer is made by use of queue system method. Optimal buffer size can be fixed on.

Multi-objective Optimal Design of Vibration Absorber with Simple Cell Mapping Algorithm

In this paper, we investigate a multi-objective optimal design of a tuned vibration absorber for a two degrees-of-freedom linear system, in which we take white Gaussian noise as the excitation. We use the simple cell mapping method to obtain solutions to the multi-objective optimization problem. We optimize tuned vibration absorbers in two different configurations. As our objective, we take various features of the response of the power spectrum density function. Our results show that the primary mass vibration with the optimally designed absorber has a lower peak power spectrum value. In addition, the two natural frequencies of the optimized system are further apart than in the non-optimized system, which implies that the absorber has a wider effective region in the frequency domain. © 2017, Tianjin University and Springer-Verlag GmbH Germany.

Low-Temperature Growing Anatase TiO2/SnO2 Multi-dimensional Heterojunctions at MXene Conductive Network for High-Efficient Perovskite Solar Cells

A multi-dimensional conductive heterojunction structure,composited by TiO2,SnO2,and Ti3C2TX MXene,is facilely designed and applied as electron transport layer in efficient and stable planar perovskite solar cells.Based on an oxygen vacancy scramble effect,the zero-dimensional anatase TiO2 quantum dots,surrounding on two-dimensional conductive Ti3C2TX sheets,are in situ rooted on three-dimensional SnO2 nanoparticles,constructing nanoscale TiO2/SnO2 heterojunctions.The fabrication is implemented in a controlled lowtemperature anneal method in air and then in N2 atmospheres.With the optimal MXene content,the optical property,the crystallinity of perovskite layer,and internal interfaces are all facilitated,contributing more amount of carrier with effective and rapid transferring in device.The champion power conversion efficiency of resultant perovskite solar cells achieves 19.14%,yet that of counterpart is just 16.83%.In addition,it can also maintain almost 85%of its initial performance for more than 45 days in 30–40%humidity air;comparatively,the counterpart declines to just below 75%of its initial performance.

Iron Status of Multiple Transfused Sickle Cell Anaemia Patients Attending a Sickle Cell Clinic in Benin City, Nigeria

This study was aimed at evaluating the iron status of multiple blood transfused sickle cell anaemia (SCA) patients in Benin City, Nigeria. A total of 86 subjects participated in the study, comprising of 30 multiple transfused SCA subjects, 30 of rarely transfused SCA subjects and 26 of age and sex matched healthy control subjects. Serum ferritin was determined by enzyme linked immuno sorbent assay technique. Serum iron and Total iron binding capacity was determined by spectrophometric method. The mean serum ferritin concentration was elevated in the sickle cell anaemia patients whose multiple transfusions (MT) are more than those who were rarely transfused (RT) as compared with the control groups (p < 0.001). There was a positive correlation between the serum ferritin and the number of units of blood transfused (r = 0.719, p = 0.000). This study revealed that a high level of serum ferritin, percentage transferrin saturation and a reduction in total iron binding capacity were observed in sickle cell anaemia patients who received ≥3 units of packed cells in one year.

Seropositivity rates of water channel protein 4 antibodies compared between a cell-based immunofluorescence assay and an enzyme-linked immunosorbent assay in neuromyelitis optica patients

A total of 66 samples （from 27 cases with neuromyelitis optica, 26 cases with multiple sclerosis, aa 13 cases with optic neuritis） were tested for aquaporin-4 antibody by a cell-based immunofluorescence assay and an enzyme-linked immunosorbent assay. The sensitivities and specificities of the two assays were similar. We further analyzed an additional 68 patients and 93 healthy controls using the enzyme-linked immunosorbent assay. A Kappa test showed good consistency between the two methods in terms of detection of anti-aquaporin-4 antibody in the se of neuromyelitis optica patients. No significant correlations were identified with onset age or disea duration, suggesting that aquaporin-4 antibody is a good marker for neuromyelitis optica. The enzyme-linked immunosorbent assay can be used for quantifying aquaporin-4 antibody concentrations and may be useful to dynamically monitor changes in the levels of aquaporin-4 antibody during disease duration.