Interplay between microglia and environmental risk factors in Alzheimer's disease

Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.

Effects of inorganic nutrients and environmental factors on the removal of n-propylbenzene and isopropylbenzene in seawater by cryptophytes Rhinomonas reticulata S6A

To effectively remove n-propylbenzene(n-PBZ)and isopropylbenzene(i-PBZ)leaked into seawater using Rhinomonas reticulata S6A(a newly isolated marine microalga),the effects of three inorganic nutrients and four environmental factors on their degradation were determined after 7 d of inoculation.Results show that NaNO_(3) at 300 mg/L caused a higher removal efficiency of both n-PBZ and i-PBZ(44.79%and 39.26%),while for NaH_(2) PO_(4)·H_(2) O,greater removal rates of two PBZs(47.30%and 42.23%)were achieved at 30 and 20 mg/L,respectively.NaHCO_(3) supplementation(500-750 mg/L)resulted in a large reduction(43.67%-45.04%)in i-PBZ concentration.The change in seawater pH(from 6 to 9)did not affect the elimination of n-PBZ and i-PBZ.The most suitable salinity and temperature were 30 and 25-30℃,respectively,leading to the PBZs removal of~40%.Light intensity exhibited significant influence on elimination of PBZs,and the maximum removal efficiencies of 56.07%(n-PBZ)and 55.00%(i-PBZ)were recorded under 200 and 600μmol/(m^(2)·s),respectively.In addition,the microalga could still remove PBZs when it failed to grow well due to darkness,strong light,low temperature,or low salinity,which might mean that good growth of alga is not always a necessary condition for PBZs removal.Therefore,attention should be paid to the suitability of nutrient levels and environmental conditions(excluding pH)in seawater when using microalgae for bioremediating PBZs-contaminated seawater.

Variation Characteristics of Root Traits of Different Alfalfa Cultivars under Saline-Alkaline Stress and their Relationship with Soil Environmental Factors

Soil salinization is the main factor that threatens the growth and development of plants and limits the increase of yield.It is of great significance to study the key soil environmental factors affecting plant root traits to reveal the adaptation strategies of plants to saline-alkaline-stressed soil environments.In this study,the root biomass,root morphological parameters and root mineral nutrient content of two alfalfa cultivars with different sensitivities to alkaline stress were analyzed with black soil as the control group and the mixed saline-alkaline soil with a ratio of 7:3 between black soil and saline-alkaline soil as the saline-alkaline treatment group.At the same time,the correlation analysis of soil salinity indexes,soil nutrient indexes and the activities of key enzymes involved in soil carbon,nitrogen and phosphorus cycles was carried out.The results showed that compared with the control group,the pH,EC,and urease(URE)of the soil surrounding the roots of two alfalfa cultivars were significantly increased,while soil total nitrogen(TN),total phosphorus(TP),organic carbon(SOC),andα-glucosidase activity(AGC)were significantly decreased under saline-alkaline stress.There was no significant difference in root biomass and root morphological parameters of saline-alkaline tolerant cultivar GN under saline-alkaline stress.The number of root tips(RT),root surface area(RS)and root volume(RV)of AG were reduced by 61.16%,44.54%,and 45.31%,respectively,compared with control group.The ratios of K^(+)/Na^(+),Ca^(2+)/Na^(+)and Mg^(2+)/Na^(+)of GN were significantly higher than those of AG(p<0.05).The root fresh weight(RFW)and dry weight(RDW),root length(RL),RV and RT of alfalfa were positively regulated by soil SOC and TN,but negatively regulated by soil pH,EC,and URE(p<0.01).Root Ca^(2+)/Na+ratio was significantly positively correlated with soil TN,TP and SOC(p<0.01).The absorption of Mg and Ca ions in roots is significantly negatively regulated by soilβ-glucosidase activity(BGC)and acid phosphatase activity(APC)(p<0.05).This study improved knowledge of the relationship between root traits and soil environmental factors and offered a theoretical framework for elucidating how plant roots adapt to saline-alkaline stressed soil environments.

Analysis of the Factors That Cause Environmental Degradation of Lake Santa Maria Tasi Tolu Dili Timor-Leste

This research aims to understand more closely the damage to the lake environment and the factors that cause pollution in Lake Santa Maria are the first factor of increasing urbanization, the use of the land around the lake as a place to live, the absence of maximum control from the local government this case, the Dili municipal authority. Types of solid waste consist of iron from car accidents, motorcycles, used building materials, plastic, used drink bottles and clothes, mosquito nets, food scraps from household waste, as well as old fishing nets from residents. In addition, household waste such as bath and bath, dishwashing, detergents, and waste from tempeh and tofu factories, including burnt oil from cars and motorcycles, are thrown into the lake. Municipal waste management is based on environmental standards to determine the quality of waste management in Dili Municipality. It is possible to identify the composition of waste and waste, as well as predict its environmental impact. Human (Anthropic) factors Domestic Liquid Waste, Domestic Solid Waste: Composed of organic and inorganic waste. Synthetic Waste, Disposal of Used Oil, Disposal of Domestic Animal Waste, Shallow Drains and Septic Tanks, Mountain Garbage, Garbage Thrown by Visitors, Natural Factors, Climate change, Prolonged drought, Low rainfall, El Niño and La Niña factors, Wind speed, Heat (high daily temperature pressure), Greater water evaporation, Dry wind. The occurrence of contamination necessarily implies an ecological imbalance. The impact introduced by residual compounds and waste that may be associated with the toxicity.

Impacts of Environmental Factors on the Structure Characteristics of Avian Community in Shanghai Woodlots in Spring

From March to May, 2004, we selected 8 typical parks or green lands in Shanghai downtown as the study sites to conduct a ornithological research. During this study, total 55 species of birds were recorded, which included 31 resident and 24 migratory species. With statistics methodology, we analyzed the avian communities with 10 major environmental factors covering the park area, water percentage, vegetation species, canopy cover, shrub cover, grass cover, hill number, location condition, human quantity, path width, the study results indicated that: (1) the following 7 environmental factors were important to impact the structures of the avian community, they were park area, vegetation species, shrub coverage, grass coverage, hill number, location condition of the parks and path width; (2) the avian community of theses urban parks tended to deteriorate in the bird number and diversity; the man-made lake which was currently promoted in the park designing and planning process would not be good to attract the birds.

Effects of Environmental Factors on NH_4^+ Release in Sediment from Chaohu Lake

[Objective] The aim of the research was to reveal the influence mechanism of sediment-water exchange of nutrients in Chaohu Lake. [Method] The effects of environmental factors (overlying water, temperature, pH and dissolved oxygen concentration) on NH_4^+ release in sediment from Chaohu Lake were studied under controlled laboratory conditions. [Results] With the rising of temperature and the decrease of NH_4^+ concentration in overlying water, NH_4^+ released from sediment increased significantly. pH had a great effect on NH_4^+ release with a complicated mechanism. The largest release amount of NH_4^+ under anaerobic condition was about 6 times as much as that under aerobic condition. [Conclusion] This research would provide theoretical support for environmental management of Chaohu Lake in the project of leading water from the Yangtze River to Chaohu Lake.

Grey Relational Analysis between Chlorophyll a and Environmental Factors in ShaHu Lake

[Objective] The aim was to explore effects of environmental factors on the content of Chlorophyll a in ShaHu Lake.[Method] Based on the data in Shahu Lake from November in 2007 to September in 2008,the relationship between chlorophyll a and environmental factors like water temperature,pH,secchi-depth （SD）,total nitrogen,total phosphorus and potassium permanganate index was studied by grey relational analysis method.[Result] The main environmental factors affecting the content of Chlorophyll a in ShaHu Lake were in order of water temperature potassium permanganate index 〉total nitrogen 〉pH〉 total phosphorus 〉SD.[Conclusion] The research provides reference for the control of eutrophication and the reasonable development and utilization of Shahu Lake.

Research on the Relationship between Three Isomers of Microcystins and Environmental Factors

[Objective] The relationship between three isomers of microcystins and environmental factors were studied in the fields.[Method] Three isomers of microcystins （MC-LR,RR and YR） from water of five sampling spots in a northern reservoir were observed for one year with High Performance Liquid Chromatography analytical method in order to study the relationship between three isomers and environmental factors.[Result] The three isomers of microcystins showed positive correlation with chlorophyll a;LR and YR isomers all had significant linear positive correlations with the water temperature,but the RR isomer showed no significant correlation with the water temperature;LR and YR isomers had relatively significantly correlativities with the contents of total nitrogen,nitrate nitrogen and organic nitrogen,while the RR isomer only showed a significant negative correlation with the content of nitrate nitrogen;LR and RR isomers both showed significant positive correlations with the contents of total phosphorus and organic phosphorus,while the phosphorus hardly affected the YR isomer and showed no evident correlation.[Conclusion] The relationship between three isomers of microcystins and environmental factors such as chlorophyll a,water temperature,nitrogen,phosphorus were studied and investigated the reasons,which might offered a reference for controlling the growth of blue algae in water and toxin synthesis.

Relationship between Phytoplankton Distribution and Environmental Factors in the Chukchi Sea

Based on the samples collected from the Chukchi Sea during the FCNARE cruise from July to August in 1999 with the ＂Xuelong＂, the research vessel of SOA, China, the relationship between the distribution characterization of phytoplankton and environmental factors was analyzed with Primer 5.2 software. The result showed that the assemblages of phytoplankton in Chukchi Sea can be divided into three ecological groups： Arctic-boreal group, distributed mostly in northeastern ice-edge where the depth is more than 2 000 m and affected directly by Arctic Ocean; Boreal group, distributed in shelf-break ice in the center water where the depth is less 100 m; Eurythermal group, mainly distributed in the south which exchanged with North Pacific water through Bering Strait. The species diversity, cell density and distribution variability of phytoplankton among stations were great different. The range of phytoplankton density among stations was 1.6 × 10^3- 90 680.2 × 10^4 cells/m^3, and the ranges of diversity index and evenness index among stations were 0.07 - 0.87 and 0.33 - 3.82, respectively. Principal components analysis （PCA） showed that temperature and salinity had made important roles in the distribution of phytoplankton in the Chukchi Sea. Furthermore, the different influences of the variant water regimes, and the extremely dynamic physical nature of the drifting pack ice （e.g. packing, breaking up and melting ） introduce short-term variability into the water conditions that no doubt affect the phytoplankton distrubition.

Effects of Environmental Factors on Tomato Growth

[Objective] This study was conducted to evaluate the effects of environmental factors on the biological characteristics of tomatoes.[Method] The growth traits such as plant height,stem diameter,leaf shape index of tomato plants grown under different environmental conditions（temperature,light and soil moisture content）were measured and compared.[Result] The effect of light on tomatoes was higher than that of soil moisture in high-temperature environment（30 ℃ or higher）;while the speed of tomato plant growth and fruit development were improved by low light.The synthesis of chlorophyll was influenced by soil moisture and light,and greater impact of soil water content on the synthesis of chlorophyll was observed.Among the three treatments,the chlorophyll content of all the three tomato cultivars was in a descending order as follows：control〉 shading treatment〉 drought treatment.[Conclusion] This study will provide references for the control of temperature,light and soil water in tomato cultivation.

Correlation Between the Animal Community Structure and Environmental Factors in Dongbei Cave and Shuijiang Cave of Guizhou Province

Mollusks, arthropods and chordates which were visible to the naked eye were observed and collected in Dongbei and Shuijiang caves of Libo county five times between February and July from 2002 to 2005. Four hundred and forty samples from Dongbei Cave were classified into three phyla, five classes, 10 orders, 20 families and 39 species or groups of species. Four hundred and ninety-eight samples from Shuijiang Cave were classified into three phyla, six classes, 11 orders, 20 families and 25 species or groups of species. Six animal communities were identified in the light belt of the two caves according to their species types and numbers of individuals in the light belt of two cave. The communities which have the highest values of species richness community diversity, maximum diversity, evenness, dominance and community similarity are respectively： B （4. 1059）, H （2.4716）, B （3.3322）, E （0.9042）, C （0.3442） and A - C （0. 5251）. The community diversity and correlation of environmental factors were also studied. The temperature, humidity, content of CO2 and N2, content of organic matter and some inorganic salts in soil were analyzed by Pearson correlation. The results showed that the content of organic matter in soil is positively related to species number, species richness and maximum community diversity, with correlations of 0. 885, 0.909, 0. 868 respectively （two-tailed significance test, P ≤ 0. 05）, and significantly positively related to diversity, with the coefficient of 0.611, （two-tailed significance test, P ≤ 0. 1）. This suggests that the content of organic matter in soil is one of the important elements influencing the community variation of cave animals. Outside the cave, temperature and humidity are important factors impacting on community diver- sity. As the temperature in all seasons in the cave is stable and the humidity is always high （above 90% ）, the temperature and humidity have weak correlation to community diversity in caves.

Analysis on the Influencing Factors of Residents' WTP for Environmental Protection in Tourist Destination——A Case Study of Yellow River Stone Forest in Jingtai of Gusu Province

On the basis of questionnaire survey,by adopting Contingent Valuation Method,residents' WTP for the protection of Yellow River Hoodoo National Geopark in Longwan Village,Jingtai County of Gansu Province was investigated.The result showed that tourism development had greatly influenced local society,economy and culture.Residents in this area had a strong awareness of all the factors above mentioned and showed a positive attitude.Local residents would definitely like to provide a certain degree of labor or money to promote the development of tourism,which was different from the residents' attitude of developed countries.To some extent,it reflected the characteristics of tourism development in developing countries.However,the result of this paper that demographic among residents had little effect on WTP also differed from previous researches.The improvement of living standard and residents' consciousness of environmental protection were the main reasons affecting residents' WTP.Besides,the amount of payment was also in remarkable correlation with the improvement of living standard and the destruction degree of local ecological environment.

Effect of Multi-parameter Environmental Factors on Cucumber Leaf Surface Wetness

In this study, artificial leaf resistance was used to simulate leaf wetness. Specific to the solar greenhouse environment in Tianjin, microclimate monitoring equipment was installed for the collection of temperature group and humidity group data, as well as solar radiation and leaf wetness in the greenhouse. In order to reduce the complexity of multivariate factor prediction and ensure the richness of selected data types, correlation analysis was made to the 2 groups of data, screening 5 000 groups of data, including the humidity group data RH, RH_(20), RH_(40), temperature group data T, T_(20), T_(40), and solar radiation W. The data were then analyzed by principal component analysis, screening out 4 groups of principal components to show the leaf wetness index.

Key Environmental Factors Monitoring System of Low-power Greenhouse Based on WSN Technology

A low-power environmental monitoring system based on WSN technology is proposed to effectively monitor the environmental status and ensure the healthy growth of greenhouse crops in the greenhouse. The system performs dynamic mon- itoring on the environmental data of temperature, humidity, illumination, soil tempera- ture and humidity of the greenhouse, and it reduces the energy consumption by us- ing solar energy and lithium battery as the power supply mode and dynamic power management algorithm combined with improved routing protocol. Stable and reliable, the system could effectively monitor the key environmental factors in the green- house, making it of certain promotion value.

Responding of zooplankton to environmental factor changes in the Changjiang River estuarine regions in spring-summer from 2016 to 2020

The estuarine areas are under frequent influence from freshwater intrusion and ocean currents,in which zooplankton species are diversified and variable as they are sensitive to physio-chemical variations in water.Therefore,understanding the relationships between zooplankton and environmental factors help us know the water quality.To achieve co-existence with species in similar ecological group or habit,they could inevitably alter themselves to fit the ecology and adjust the function according to the competitive exclusion in ecological theory.However,information of the co-existence of dominant species in the Changjiang(Yangtze)River estuary(CRE)and adjacent waters remains scarce.We explored the relationships between dominant zooplankton and environmental factors in the study region in spring-summer from 2016 to 2020,involving particularly the composition of dominant species,ecological groups,their relationships with environmental factors,and co-existence of important species,using the non-multidimensional scale analysis(nMDS)method and redundancy analysis.Results show that Labidocera euchaeta and Tortanus vermiculus were dominant species in the study scope.The turnover rate of dominant zooplankton was greater(>50%)in spring while the species number was higher in summer.The dominant species were estuarine,offshore,and eurytopic based on the adaptation to salinity.In spring,the ecological groups were dominated by estuarine species,while in summer by estuarine and offshore species.In addition,the nMDS showed that the dominant species in the same ecological group were more dispersed and not prominently clustered;the dominant species were staggered among different ecological groups.The temperature,salinity,pH,dissolved oxygen,and chlorophyll a were the main environmental factors on the distribution of the dominant species in spring,while in summer were dissolved oxygen,temperature,salinity,and pH.The domination of medusae of Nemopsis bachei and Pleurobrachia globosa in zooplankton community in spring,and the continuous decrease in abundance of L.euchaeta reflected the effects of local climate change.The temperature and salinity changes in different years and the subsequent response of zooplankton reflected the influence of freshwater intrusion and/or ocean currents.Zooplankton in similar ecological habits exhibited the competitive exclusion in terms of co-existence.

Ecological environmental quality evaluation and driving factor analysis of the Lijiang River Basin,based on Google Earth Engine

For regional ecological management,it is important to evaluate the quality of ecosystems and analyze the underlying causes of ecological changes.Using the Google Earth Engine(GEE)platform,the remote sensing ecological index(RSEI)was calculated for the Lijiang River Basin in Guangxi Zhuang Autonomous Region for 1991,2001,2011,and 2021.Spatial autocorrelation analysis was employed to investigate spatiotemporal variations in the ecological environmental quality of the Lijiang River Basin.Furthermore,geographic detectors were used to quantitatively analyze influencing factors and their interaction effects on ecological environmental quality.The results verified that:1)From 1991 to 2021,the ecological environmental quality of the Lijiang River Basin demonstrated significant improvement.The area with good and excellent ecological environmental quality in proportion increased by 19.69%(3406.57 km^(2)),while the area with fair and poor ecological environmental quality in proportion decreased by 10.76%(1860.36 km^(2)).2)Spatially,the ecological environmental quality of the Lijiang River Basin exhibited a pattern of low quality in the central region and high quality in the periphery.Specifically,poor ecological environmental quality characterized the Guilin urban area,Pingle County,and Lingchuan County.3)From 1991 to 2021,a significant positive spatial correlation was observed in ecological environmental quality of the Lijiang River Basin.Areas with high-high agglomeration were predominantly forests and grasslands,indicating good ecological environmental quality,whereas areas with low-low agglomeration were dominated by cultivated land and construction land,indicating poor ecological environmental quality.4)Annual average precipitation and temperature exerted the most significant influence on the ecological environmental quality of the basin,and their interactions with other factors had the great influence.This study aimed to enhance understanding of the evolution of the ecological environment in the Lijiang River Basin of Guangxi Zhuang Autonomous Region and provide scientific guidance for decision-making and management related to ecology in the region.

Environmental risk factors for inflammatory bowel diseases: Evidence based literature review

AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research.

Distribution of meiofaunal abundance in relation to environmental factors in Beibu Gulf,South China Sea

This study aims to explore the distribution of meiofaunal abundance in relation to environmental factors in the Beibu Gulf, a natural semi-enclosed part of the South China Sea, surrounded by China and Vietnam. Meiofauna and ten benthic environmental factors were determined at 27 sampling stations in the Beibu Gulf in four surveys during 2006 2007. The results show a clear geographical trend in meiofaunal abundance, water depth, salinity and clay content. The meiofaunal abundance and the clay content decreased, whereas the water depth and the salinity increased from the north to the south of the Gulf. The percentage of meiofaunal abundance in the 0 2 cm layer increased, whereas in the 2-5 cm and 5 10 cm layers it decreased from the north to the south of the Gulf. Correlation analysis show significant negative correlations between meiofaunal abundance and water depth, benthic temperature, salinity and pH, but significant positive correlations between meiofaunal abundance and dissolved oxygen, chlorophyll a and clay content.

Plankton community composition in the Three Gorges Reservoir Region revealed by PCR-DGGE and its relationships with environmental factors

To explore the relationships between community composition and the environment in a reservoir ecosystem, plankton communities from the Three Gorges Reservoir Region were studied by PCR-denaturing gradient gel electrophoresis fingerprinting. Bacterial and eukaryotic operational taxonomic units （OTUs）, generated by DGGE analysis of the PCR-amplified 16S and 18S rRNA genes, were used as surrogates for the dominant ＂biodiversity units＂. OTU composition among the sites was heterogeneous; 46.7% of the total bacterial OTUs （45） and 64.1% of the eukaryotic OTUs （39） were identified in less than half of the sampling sites. Unweighted pair group method with arithmetic averages （UPGMA） clustering of the OTUs suggested that the plankton communities in the Xiangxi Rive sites were not always significantly different from those from the Yangtze River sites, despite clear differences in their environmental characterizations. Canonical correspondence analysis （CCA） was applied to further investigate the relationships between OTU composition and the environmental factors. The first two CCA ordination axes suggested that the bacterial community composition was primarily correlated with the variables of NO3^--N, dissolved oxygen （DO）, and SiO3^2--Si, whereas, the eukaryotic community was mainly correlated with the concentrations of DO, PO4^3--P, and SiO3^2--Si.

Prototype observation and influencing factors of environmental vibrationinduced by flood discharge

Due to a wide range of field vibration problems caused by flood discharge at the Xiangjiaba Hydropower Station, vibration characteristics and influencing factors were investigated based on prototype observation. The results indicate that field vibrations caused by flood discharge have distinctive characteristics of constancy, low frequency, small amplitude, and randomness with impact, which significantly differ from the common high-frequency vibration characteristics. Field vibrations have a main frequency of about 0.5-3.0 Hz and the characteristics of long propagation distance and large-scale impact. The vibration of a stilling basin slab runs mainly in the vertical direction. The vibration response of the guide wall perpendicular to the flow is significantly stronger than it is in other directions and decreases linearly downstream along the guide wall. The vibration response of the underground turbine floor is mainly caused by the load of unit operation. Urban environmental vibration has particular distribution characteristics and change patterns, and is greatly affected by discharge, scheduling modes, and geological conditions. Along with the increase of the height of residential buildings, vibration responses show a significant amplification effect. The horizontal and vertical vibrations of the 7th floor are, respectively, about 6 times and 1.5 times stronger than the corresponding vibrations of the 1st floor. The vibration of a large-scale chemical plant presents the combined action of flood discharge and working machines. Meanwhile, it is very difficult to reduce the low-frequency environmental vibrations. Optimization of the discharge scheduling mode is one of the effective measures of reducing the flow impact loads at present. Choosing reasonable dam sites is crucial.