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Impact Analysis of Microscopic Defect Types on the Macroscopic Crack Propagation in Sintered Silver Nanoparticles 被引量:1
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作者 Zhongqing Zhang Bo Wan +4 位作者 Guicui Fu Yutai Su Zhaoxi Wu Xiangfen Wang Xu Long 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期441-458,共18页
Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,t... Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs. 展开更多
关键词 Sintered silver nanoparticles defect types microscopic defect evolution macroscopic crack propagation molecular dynamics simulation cohesive zone model
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Plume-lithosphere interaction in the Comei Large Igneous Province: Evidence from two types of mafic dykes in Gyangze, south Tibet, China 被引量:1
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作者 Ya-ying Wang Ling-sen Zeng +6 位作者 Li-e Gao Li-long Yan Ling-hao Zhao Jia-hao Gao Ying-long Di Guang-xu Li Yi-hong Tian 《China Geology》 CAS CSCD 2024年第1期80-90,共11页
Two suites of mafic dykes,T1193-A and T1194-A,outcrop in Gyangze area,southeast Tibet.They are in the area of Comei LIP and have indistinguishable field occurrences with two other dykes in Gyangze,T0902 dyke with 137.... Two suites of mafic dykes,T1193-A and T1194-A,outcrop in Gyangze area,southeast Tibet.They are in the area of Comei LIP and have indistinguishable field occurrences with two other dykes in Gyangze,T0902 dyke with 137.7±1.3 Ma zircon age and T0907 dyke with 142±1.4 Ma zircon age reported by Wang YY et al.(2016),indicating coeval formation time.Taking all the four diabase dykes into consideration,two different types,OIB-type and weak enriched-type,can be summarized.The“OIB-type”samples,including T1193-A and T0907 dykes,show OIB-like geochemical features and have initial Sr-Nd isotopic values similar with most mafic products in Comei Large Igneous Provinces(LIP),suggesting that they represent melts directly generated from the Kerguelen mantle plume.The“weak enriched-type”samples,including T1194-A and T0902 dykes,have REEs and trace element patterns showing withinplate affinity but have obvious Nb-Ta-Ti negative anomalies.They show uniform lowerεNd(t)values(−6‒−2)and higher 87Sr/86Sr(t)values(0.706‒0.709)independent of their MgO variation,indicating one enriched mantle source.Considering their closely spatial and temporal relationship with the widespread Comei LIP magmatic products in Tethyan Himalaya,these“weak enriched-type”samples are consistent with mixing of melts from mantle plume and the above ancient Tethyan Himalaya subcontinental lithospheric mantle(SCLM)in different proportions.These weak enriched mafic rocks in Comei LIP form one special rock group and most likely suggest large scale hot mantle plume-continental lithosphere interaction.This process may lead to strong modification of the Tethyan Himalaya lithosphere in the Early Cretaceous. 展开更多
关键词 OIB type diabase Comei Large Igneous Province Weakly enriched diabase Plume-lithosphere interaction Nb-Ta-Ti negative anomaly Kerguelen plume Geological survey engineering Tibet Plateau
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PLFA Analysis of Soil Microbial Community Structure in Different Forest Types
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作者 Jiayi Zhang Songzhe Li +2 位作者 Xiangping Fu Shunbao Lu Yanjie Zhang 《American Journal of Plant Sciences》 CAS 2024年第10期930-939,共10页
Soil soluble organic matter is an important component in the study of carbon and nitrogen cycling in terrestrial ecosystems. Soil microorganisms, as soil decomposers, participate in soil biogeochemical processes and p... Soil soluble organic matter is an important component in the study of carbon and nitrogen cycling in terrestrial ecosystems. Soil microorganisms, as soil decomposers, participate in soil biogeochemical processes and play an important role in maintaining the balance of soil ecosystems. As a typical subtropical regional unit, Queensland, Australia, is a relatively concentrated distribution area of forests in Australia. It is very sensitive to climate change and plays an important role in Australian climate and even global climate change. Its unique natural environment and ecosystem occupy a special position in the world. However, the knowledge of available carbon and nitrogen pool and microbial activity in forest soil is still very limited. Pinus elliottii, Araucaria cunninghamii and Agathis australis are the three most important forest types in southern Queensland, Australia. In our research, the function and structural diversity of soil microbial communities of these three forest types were studied using biochemical and molecular biological methods, and the effective carbon and nitrogen pools of soil of different forest types and related microbial processes were discussed, which has important theoretical guiding significance for further research on the structure and function of soil ecosystem. The number of PLFAs in the soil of P. elliottii was 45, the number of PLFAs in the soil of Araucaria cunninghamii and Agathis australis was 39 and 35, respectively. The number and content of PLFAs monomer in P. elliottii were higher than those in the other two kinds of forest soil. 展开更多
关键词 Forest type SOIL Microbial Community PLFA
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Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients
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作者 Drasko M Gostiljac Srdjan S Popovic +4 位作者 Vesna Dimitrijevic-Sreckovic Sasa M Ilic Jelena A Jevtovic Dragan M Nikolic Ivan A Soldatovic 《World Journal of Diabetes》 SCIE 2024年第4期664-674,共11页
BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food ... BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(STB)to achieve better effects on postprandial glucose and insulin levels in patients with T2DM.AIM To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM patients.METHODS This trial included 97 patients with T2DM.A parallel group of 16 healthy subjects was also investigated.All participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive days.Postprandial blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of bread.RESULTS Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed STB.No relevant differences were found among the healthy subjects.Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread.CONCLUSION STB have better effects than rye bread on postprandial glucoregulation in T2DM patients.Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread.Therefore,STB can be recommended for nutrition in T2DM patients. 展开更多
关键词 Special types of bread Postprandial glucoregulation INSULIN NUTRITION type 2 diabetes mellitus
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Disparities in tree mortality among plant functional types(PFTs)in a temperate forest:Insights into size-dependent and PFT-specific patterns
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作者 Man Hu Hang Shi +6 位作者 Rui He Bingbin Wen Haikun Liu Kerong Zhang Xiao Shu Haishan Dang Quanfa Zhang 《Forest Ecosystems》 SCIE CSCD 2024年第4期480-490,共11页
Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains incomplete.This s... Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains incomplete.This study analysed size-dependent tree mortality in a temperate forest,encompassing 46 tree species and 32,565 individuals across different PFTs(i.e.,evergreen conifer vs.deciduous broadleaf species,shade-tolerant vs.shade-intolerant species).By employing all-subset regression procedures and logistic generalized linear mixed-effects models,we identified distinct mortality patterns influenced by biotic and abiotic factors.Our results showed a stable mortality patte rn in eve rgreen conifer species,contrasted by a declining pattern in deciduous broadleaf and shadetolerant,as well as shade-intolerant species,across size classes.The contribution to tree mortality of evergreen conifer species shifted from abiotic to biotic factors with increasing size,while the mortality of deciduous broadleaf species was mainly influenced by biotic factors,such as initial diameter at breast height(DBH)and conspecific negative density.For shade-tolerant species,the mortality of small individuals was mainly determined by initial DBH and conspecific negative density dependence,whereas the mortality of large individuals was subjected to the combined effect of biotic(competition from neighbours)and abiotic factors(i.e.,convexity and pH).As for shade-intolerant species,competition from neighbours was found to be the main driver of tree mortality throughout their growth stages.Thus,these insights enhance our understanding of forest dynamics by revealing the size-dependent and PFT-specific tree mortality patterns,which may inform strategies for maintaining forest diversity and resilience in temperate forest ecosystems. 展开更多
关键词 Size-dependent tree mortality Plant functional type Neighbourhood competition Topography variables Soil properties
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Identification of reservoir types in deep carbonates based on mixedkernel machine learning using geophysical logging data
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作者 Jin-Xiong Shi Xiang-Yuan Zhao +3 位作者 Lian-Bo Zeng Yun-Zhao Zhang Zheng-Ping Zhu Shao-Qun Dong 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1632-1648,共17页
Identification of reservoir types in deep carbonates has always been a great challenge due to complex logging responses caused by the heterogeneous scale and distribution of storage spaces.Traditional cross-plot analy... Identification of reservoir types in deep carbonates has always been a great challenge due to complex logging responses caused by the heterogeneous scale and distribution of storage spaces.Traditional cross-plot analysis and empirical formula methods for identifying reservoir types using geophysical logging data have high uncertainty and low efficiency,which cannot accurately reflect the nonlinear relationship between reservoir types and logging data.Recently,the kernel Fisher discriminant analysis(KFD),a kernel-based machine learning technique,attracts attention in many fields because of its strong nonlinear processing ability.However,the overall performance of KFD model may be limited as a single kernel function cannot simultaneously extrapolate and interpolate well,especially for highly complex data cases.To address this issue,in this study,a mixed kernel Fisher discriminant analysis(MKFD)model was established and applied to identify reservoir types of the deep Sinian carbonates in central Sichuan Basin,China.The MKFD model was trained and tested with 453 datasets from 7 coring wells,utilizing GR,CAL,DEN,AC,CNL and RT logs as input variables.The particle swarm optimization(PSO)was adopted for hyper-parameter optimization of MKFD model.To evaluate the model performance,prediction results of MKFD were compared with those of basic-kernel based KFD,RF and SVM models.Subsequently,the built MKFD model was applied in a blind well test,and a variable importance analysis was conducted.The comparison and blind test results demonstrated that MKFD outperformed traditional KFD,RF and SVM in the identification of reservoir types,which provided higher accuracy and stronger generalization.The MKFD can therefore be a reliable method for identifying reservoir types of deep carbonates. 展开更多
关键词 Reservoir type identification Geophysical logging data Kernel Fisher discriminantanalysis Mixedkernel function Deep carbonates
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The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products
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作者 Yue SUN Huiling YANG +5 位作者 Hui XIAO Liang FENG Wei CHENG Libo ZHOU Weixi SHU Jingzhe SUN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第2期310-324,共15页
The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud typ... The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds. 展开更多
关键词 CloudSat and CALIPSO cloud type cloud phase temporal and spatial distribution interannual variation
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Differential Expression of Genes Related to Fruit Development and Capsaicinoids Synthesis in Habanero Pepper Plants Grown in Contrasting Soil Types
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作者 Eduardo Burgos-Valencia Federico García-Laynes +4 位作者 Ileana Echevarría-Machado Fatima Medina-Lara Miriam Monforte-González JoséNarváez-Zapata Manuel Martínez-Estévez 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第2期151-183,共33页
Habanero pepper(Capsicum chinense Jacq.)is a crop of economic relevance in the Peninsula of Yucatan.Its fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world,which gives the... Habanero pepper(Capsicum chinense Jacq.)is a crop of economic relevance in the Peninsula of Yucatan.Its fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world,which gives them industrial importance.Soil is an important factor that affects pepper development,nutritional quality,and capsaicinoid content.However,the effect of soil type on fruit development and capsaicinoid metabolism has been little understood.This work aimed to compare the effect of soils with contrasting characteristics,black soil(BS)and red soil(RS),on the expression of genes related to the development of fruits,and capsaicinoid synthesis using a transcriptomic analysis of the habanero pepper fruits.Plants growing in RS had bigger fruits and higher expression of genes related to floral development,fruit abscission,and softening which suggests that RS stimulates fruit development from early stages until maturation stages.Fruits from plants growing in BS had enrichment in metabolic pathways related to growth,sugars,and photosynthesis.Besides,these fruits had higher capsaicinoid accumulation at 25 days post-anthesis,and higher expression of genes related to the branched-chain amino acids metabolism(ketol-acid reductisomerase KARI),pentose phosphate pathway and production of NADPH(glucose-6-phosphate-1-dehydrogenase G6PDH),and proteasome and vesicular traffic in cells(26S proteasome regulatory subunit T4 RPT4),which suggest that BS is better in the early stimulation of pathways related to the nutritional quality and capsaicinoid metabolism in the fruits. 展开更多
关键词 Capsicum chinense jacq soil types plant growth environmental conditions fruit quality capsaicinoid metabolism TRANSCRIPTOME
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Effect of Types and Orders of Electromagnetic Field Finite Element Meshes on Power Communication Harmonic Parameters Calculation Results of Tubular Hydrogenerators
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作者 Fan Zhennan Chen Jie +1 位作者 Zhou Zhiting Yang Yong 《China Communications》 SCIE CSCD 2024年第10期288-300,共13页
In generator design field,waveform total harmonic distortion(THD)and telephone harmonic factor(THF)are parameters commonly used to measure the impact of generator no-load voltage harmonics on the power communication q... In generator design field,waveform total harmonic distortion(THD)and telephone harmonic factor(THF)are parameters commonly used to measure the impact of generator no-load voltage harmonics on the power communication quality.Tubular hydrogenerators are considered the optimal generator for exploiting low-head,high-flow hydro resources,and they have seen increasingly widespread application in China's power systems recent years.However,owing to the compact and constrained internal space of such generators,their internal magnetic-field harmonics are pronounced.Therefore,accurate calculation of their THD and THF is crucial during the analysis and design stages to ensure the quality of power communication.Especially in the electromagnetic field finite element modeling analysis of such generators,the type and order of the finite element meshes may have a significant impact on the THD and THF calculation results,which warrants in-depth research.To address this,this study takes a real 34 MW large tubular hydrogenerator as an example,and establishes its electromagnetic field finite element model under no-load conditions.Two types of meshes,five mesh densities,and two mesh orders are analyzed to reveal the effect of electromagnetic field finite element mesh types and orders on the calculation results of THD and THF for such generators. 展开更多
关键词 calculation results electromagnetic field finite element meshes power communication harmonic parameters tubular hydrogenerator types and orders
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Influences of Skin and Base Types on the Soothing Assessment of Cosmetic Products
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作者 Yu Hui Yu Xiaoyi +5 位作者 Chen Jing Yan Yongtao Li Xiaomin Gao Yecheng Ou Jinglin Zhang Yunying 《China Detergent & Cosmetics》 CAS 2024年第2期49-55,共7页
In order to assess the responses of different skin types stimulated by tape stripping,after which two kinds of brand cosmetics of cream and hydrogel,were separately applied to evaluate the individual soothing effect o... In order to assess the responses of different skin types stimulated by tape stripping,after which two kinds of brand cosmetics of cream and hydrogel,were separately applied to evaluate the individual soothing effect of the product on different skin types.A total of 30 volunteers aged 18~65 years were recruited,which were divided into four groups(oily,dry,normal and combined)according to the self-oiling ability of facial and T zones.Four 3 cm×3 cm of skins on inner forearm of each volunteer were chosen and randomly marked as blank,negative control,soothing cream and soothing gel.The blank area was kept untreated,and the remaining areas were tape-stripped by 10 times(Transparent universal 1527C-1,3M China Co.,Ltd.,)to disrupt the skin corneum and induce erythema.Images,erythema index(EI)and transcutaneous water loss rate(TEWL)of the marked skin areas before and 5 min after tape-stripping were taken to assess the distinct responses of different skin type to the taping treatment;Ten minutes after tape-stripping,The soothing products were applied to the test area,the skin images,EI and TEWL at 20 min and 50 min(corresponding to 30 min and 60 min after tape-stripping,respectively)were measured after cosmetics application to compare and evaluate the soothing effects of cream and hydrogel on different skin types.Results showed that different skin displayed diverse reactions to the tape-stripping,and the oily skin was more sensitive with longer duration of erythema than other skin types.After the application of soothing products,both cream and hydrogel could relieve skin erythema,while the soothing effects are dependent both on skin types and the cosmetic base materials:Hydrogel has a better efficacy in alleviating erythema and TEWL of dry skin,while the cream was more effective on normal,oily and combined skin types.The results suggest that the modelling method for soothing evaluation should consider the skin types of the volunteers,and the cosmetics of different base materials might have the target skin types. 展开更多
关键词 soothing efficacy assessment skin types base materials
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Soil Organic Carbon Stock Variation under Different Soil Types and Land Uses in the Sub-Humid Noun Plain, Western Cameroon
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作者 Frank Abigail Sobze Kenfack Georges Kogge Kome +2 位作者 Achille Bienvenue Ibrahim Viviane Pauline Mandah Dieudonne Bitondo 《Open Journal of Soil Science》 2024年第4期191-209,共19页
This study was conducted to assess the current stock of soil organic carbon under different agricultural land uses, soil types and soil depths in the Noun plain in western Cameroon. Three sites were selected for the s... This study was conducted to assess the current stock of soil organic carbon under different agricultural land uses, soil types and soil depths in the Noun plain in western Cameroon. Three sites were selected for the study, namely Mangoum, Makeka and Fossang, representative of the three dominant soil types of the noun plain (Andosols, Acrisols and Ferralsols). Three land uses were selected per site including natural vegetation, agroforest and crop field. Soil was sampled at three depths;0 - 20 cm, 20 - 40 cm, and 40 - 60 cm. Analysis of variance showed that soil type did not significantly influence carbon storage, but rather land uses and soil depth. SOCS decreased significantly with depth in all the sites, with an average stock of 66.3 ± 15.8 tC/ha at 0 - 20 cm, compared to an average stock of 33.3 ± 7.4 tC/ha at 40 - 60 cm. SOCS was significantly highest in the natural formation with 57.2 ± 19.7 tC/ha, and lowest in cultivated fields, at 37.7 ± 10.6 tC/ha. Andosols, with their high content of coarse fragments, stored less organic carbon than Ferralsols and Acrisols. 展开更多
关键词 Carbon Stocks Soil type Soil Depth Agricultural Land Use Noun Plain
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Principles for Designing New Types of Housing for a Strong and Resilient Local Economy in the Republic of Congo
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作者 Alain Symphorien Ndongo Destin Gemetone Etou Christian Tathy 《Open Journal of Civil Engineering》 2024年第1期82-95,共14页
The Congolese population is organised into households, which are thus headed by a chief who ensures the social well-being, development and integration into working life of the individuals in his charge. This study exa... The Congolese population is organised into households, which are thus headed by a chief who ensures the social well-being, development and integration into working life of the individuals in his charge. This study examines the functional principles of new housing design as an instrument for transforming the (current) failing economy into a strong and resilient one. Accordingly, a literature review of the practice of designing and building housing in human settlements in the Congo revealed the state of the art on this subject. An analysis of the existing housing stock from a demographic, social and economic point of view made it possible to identify the most common household sizes and numbers, as well as the lifestyle processes that determine the need for developed space. To this end, the experimental method was used to propose configuration plans for various new types of dwelling. To this end, the study highlighted the link between people’s standard of living and the effectiveness of their involvement in the local economy. To achieve the aims of the National Development Plan (NDP), particular attention must be paid to solving the housing problem. The existing housing stock actively contributes to the problems associated with unemployment and insecurity. Functional principles for the design of new types of housing have been developed. Four model types are proposed in line with the demographic structure of the population, their socio-economic characteristics and their lifestyle. 展开更多
关键词 Congolese Households New types of Lodging Human Settlements Resilient Local Economy Households Resilient Endogenous Economy Logement CONCEPTION
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Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1
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作者 Roberto Piacentini Claudio Grassi 《Neural Regeneration Research》 SCIE CAS 2025年第2期416-423,共8页
Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not complet... Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions. 展开更多
关键词 herpes simplex virus type 1 interleukin MICROGLIA NEUROINFLAMMATION synaptic dysfunction
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Focus on laboratory tests related to the pathological types of lupus nephritis to implement renal biopsy as early as possible:clinical and pathological analysis of 217 cases of single center lupus nephritis
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作者 Xiao-Yu Wang Hong-Dong Li +2 位作者 Bo-Wen Tian Ping Wei Shu-Mei Shi 《Clinical Research Communications》 2024年第3期43-47,共5页
Objective:To analyze the clinical and laboratory indices of patients with lupus nephritis(LN)of different pathological types and explore the related factors of LN pathological classification,it is helpful to grasp the... Objective:To analyze the clinical and laboratory indices of patients with lupus nephritis(LN)of different pathological types and explore the related factors of LN pathological classification,it is helpful to grasp the timing of renal biopsy.Methods:The clinical manifestations,laboratory parameters and renal pathological types of LN patients in recent 20 years were analyzed retrospectively by SPSS 26.0 software.Results:In this study,the first three pathological types were V,IV,V+IV;latent nephritis was common in type II and V;nephritic syndrome was common in type V;nephrotic syndrome was common in type V+IV;chronic renal insufficiency group was mostly type IV;pathological types were correlated with serum creatinine,C3,albumin and erythrocyte sedimentation rate(r=0.315,P<0.001),and serum creatinine was moderately correlated(r=0.315,P<0.001);AI,CI and SLEDAI scores were significantly different among LN patients of different pathological types.Conclusion:LN is closely related to clinical pathology,clinical manifestations,comprehensive analysis of laboratory indicators and SLEDAI score to make a preliminary prediction of LN pathological type,help to initially assess the severity of pathology,improve the timing of renal biopsy implementation,optimize the timing of treatment. 展开更多
关键词 systemic lupus erythematosus lupus nephritis clinical features pathological types
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Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance
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作者 Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki 《Neural Regeneration Research》 SCIE CAS 2025年第11期3113-3123,共11页
Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close rel... Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms.Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological processes.The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed. 展开更多
关键词 brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling NEURODEGENERATION Parkinson's disease targeted therapy
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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures
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作者 Yao Yuan Lingqi Yu +8 位作者 Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang 《Neural Regeneration Research》 SCIE CAS 2025年第1期265-276,共12页
Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in viv... Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause CMT2.Mutations located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)model.In addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive control.Of these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut allele.We found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in Drosophila.Flies heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal morphology.These Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump. 展开更多
关键词 ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump
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基于K-prototypes的混合属性数据聚类算法改进
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作者 倪丹 李泽文 《科技创新与应用》 2024年第28期31-34,38,共5页
属性数据分为数值型数据和分类型数据,一般情况下对于数值型数据运算前要进行标准化处理,但是对于数值型数据差异大的数据,由于大数掩盖小数的影响,按照K-prototypes聚类算法,数值型数据标准化后而且不对相应的分类数据有任何预处理或... 属性数据分为数值型数据和分类型数据,一般情况下对于数值型数据运算前要进行标准化处理,但是对于数值型数据差异大的数据,由于大数掩盖小数的影响,按照K-prototypes聚类算法,数值型数据标准化后而且不对相应的分类数据有任何预处理或者在计算时没有进行任何改变,很可能提高分类数据在聚类中的影响,并且分类型数据并未进一步地细分,不能满足不同要求的混合属性聚类。该文在将数值型数据标准化的基础上,将分类数据细分为二元数据和类型数据,并用相异度系数距离计算分类数据之间的距离,并且赋予二元和类型数据相应的权重,来改进K-prototypes聚类算法,使该算法满足不同要求的混合属性数据聚类,最后通过C#语言,在ArcEngine2010版本上实现。 展开更多
关键词 K-prototypes算法 混合属性 类型数据 相异度系数 加权属性
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Dynamics of Slope Runoff and Soil Erosion of Different Forest Types in Karst Depression 被引量:6
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作者 张喜 连宾 +2 位作者 尹洁 吴永波 崔迎春 《Agricultural Science & Technology》 CAS 2010年第3期166-171,共6页
[Objective] The research was aimed to study the dynamics of slope runoff and soil erosion in different forest types in karst depression.[Method] Precipitation observation sites at the bottom of karst depression and ru... [Objective] The research was aimed to study the dynamics of slope runoff and soil erosion in different forest types in karst depression.[Method] Precipitation observation sites at the bottom of karst depression and runoff observation sites in different forest types were established to monitor regularly the main indices changes of runoff and soil erosion at fixed position in 4 years.[Result] The surface runoff of different forest types appeared singer peak from February to November,with lowest valley from June to July.The runoff coefficient appeared double peaks from February to May and from July to September.The changing coefficient of runoff appeared three peaks from March to April,from July to August and from September to November.The silt concentration appeared one peak from March to May and The erosion modulus appeared double peaks from March to May and from June to August.Runoff showed annually reduced trend with the growth of forests and the development of vegetation layer's structure.There was a positive correlation between the runoff and its silt concentration in different forest types.Precipitation and evaporation had notable positive correlation with the runoff,and similar correlation but not marked with silt concentration.The fitting analysis results of surface runoff and erosion modulus showed that rocky desertification intensified the unevenness of surface runoff and increased the surface runoff and erosion modulus.The penetrability of surface soil in new planted forest was lower than that in young forest,and that in surface soil of different forest types was higher than in bottom soil.[Conclusion] The research provided theoretical basis for the biological management technologies of water and soil conservation and the control of karst rocky desertification in karst regions. 展开更多
关键词 Karst depression Forest types RUNOFF Erosion modulus Affecting factors
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Impact of Fertilizer Types on Photosynthetic and Biological Effects of Direct-seeded Brassica napus at Flowering Stage 被引量:3
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作者 李俊 余常兵 +4 位作者 张春雷 余利平 程雨贵 李玲 马霓 《Agricultural Science & Technology》 CAS 2012年第3期554-557,共4页
[Objective] The aim was to investigate the effects of fertilizer type on di- rect-seeded rapeseed and to explore effective fertilizing. [Method] Four treatments including different types of fertilizers were set in the... [Objective] The aim was to investigate the effects of fertilizer type on di- rect-seeded rapeseed and to explore effective fertilizing. [Method] Four treatments including different types of fertilizers were set in the test. Growth, photosynthesis and chlorophyll fluorescence parameters at flowering stage such as plant height, stem diameter, shoot and root dry matter, net photosynthesis, light energy conversion effi- ciency (Fv/Fm) and SPAD value, were investigated. The effects of fertilizer treat-ments on the yield of rapeseed were evaluated as well. [Result] Both multi-functional fertilizer and controlled release fertilizer could improve plant height, stem diameter, shoot dry matter, SPAD value, net photosynthesis, non-photochemical quenching (NPQ), etc., which helped increase yield and stress resistance. [Conclusion] Both multi-functional fertilizer and controlled release fertilizer could improve yield significantly while multi-functional fertilizer (MFF) was better than controlled release fertilizer (CRF). 展开更多
关键词 Fertilizer type PHOTOSYNTHESIS Biological effects Brassica napus
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Effects of Crops, Soil Types and Irrigation Methods on Digestion Capacity of Biogas Slurry 被引量:5
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作者 高立洪 李平 +1 位作者 韦秀丽 翟逸 《Agricultural Science & Technology》 CAS 2015年第8期1712-1715,共4页
In the research, pot experiment and field testing were conducted to study the effect of different crops, soil types, and irrigation modes on biogas slurry diges- tions. The results showed that when silage maize, sweet... In the research, pot experiment and field testing were conducted to study the effect of different crops, soil types, and irrigation modes on biogas slurry diges- tions. The results showed that when silage maize, sweet sorghum and Chinese cabbage were planted in purple soils, the quantities of digested biogas slurry were of 57, 157.5, and 34.5 t/hm2, respectively, while the quantities of digested biogas slurry were 70.5, 157.5 and 40.5 t/hm2 in yellow soils. Besides, the digested biogas slurries reached 36 and 27 t/hm2 as per flood irrigation and sprinkling irrigation when Chinese cabbages were planted in yellow soils. The research indicated crop variety, soil type, and irrigation method all have effects on farmland digestion of biogas slurry. 展开更多
关键词 CROPS Soil types Irrigation methods Biogas slurry digestion
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