Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming t...Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming to address this challenge,we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers.Among these multi-arylpyrrole derivatives,MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%)when they are encapsulated by an amphiphilic polymer.As a result,the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic signals.The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.展开更多
基金financially supported by the National Natural Science Foundation of China(21875019,21803007,21975020,51803009)the National Key Research and Development Program of China(2018YFA0901800)+1 种基金the Department of Science and Technology of Guangdong Province(2019ZT08Y191)the Shenzhen Science and Technology Program(JSGG20200225151916021)。
文摘Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming to address this challenge,we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers.Among these multi-arylpyrrole derivatives,MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%)when they are encapsulated by an amphiphilic polymer.As a result,the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic signals.The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.
