BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedatio...BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend.展开更多
With the growth of requirements for data sharing,a novel business model of digital assets trading has emerged that allows data owners to sell their data for monetary gain.In the distributed ledger of blockchain,howeve...With the growth of requirements for data sharing,a novel business model of digital assets trading has emerged that allows data owners to sell their data for monetary gain.In the distributed ledger of blockchain,however,the privacy of stakeholder's identity and the confidentiality of data content are threatened.Therefore,we proposed a blockchainenabled privacy-preserving and access control scheme to address the above problems.First,the multi-channel mechanism is introduced to provide the privacy protection of distributed ledger inside the channel and achieve coarse-grained access control to digital assets.Then,we use multi-authority attribute-based encryption(MAABE)algorithm to build a fine-grained access control model for data trading in a single channel and describe its instantiation in detail.Security analysis shows that the scheme has IND-CPA secure and can provide privacy protection and collusion resistance.Compared with other schemes,our solution has better performance in privacy protection and access control.The evaluation results demonstrate its effectiveness and practicability.展开更多
This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and ...This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and propofol（10 mg/kg） was administrated intravenously. Artery blood samples were collected at various time points after injection, and plasma concentrations of propofol were measured. Pharmacokinetic modeling was performed using Win Nonlin software. Propofol TCI within the acquired parameters integrated was conducted to achieve different anesthetic depths in rabbits, monitored by narcotrend. The pharmacodynamics was analyzed using a sigmoidal inhibitory maximal effect model for narcotrend index（NI） versus effect-site concentration. The results showed the pharmacokinetics of propofol in Japanese white rabbits was best described by a two-compartment model. The target plasma concentrations of propofol required at light anesthetic depth was 9.77±0.23 μg/m L, while 12.52±0.69 μg/m L at deep anesthetic depth. NI was 76.17±4.25 at light anesthetic depth, while 27.41±5.77 at deep anesthetic depth. The effect-site elimination rate constant（ke0） was 0.263/min, and the propofol dose required to achieve a 50% decrease in the NI value from baseline was 11.19 μg/m L（95% CI, 10.25–13.67）. Our results established a new propofol TCI animal model and proved the model controlled the anesthetic depth accurately and stably in rabbits. The study provides a powerful method for exploring general anesthetic mechanisms at different anesthetic depths in vivo.展开更多
We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footpr...We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footprint of 1.1 × 2.1 mm^2 and integrates 7 independent channels each having on-chip polarization control and heterodyne mixing functions. 7 channels of4-Gb/s QPSK baseband signals are delivered via a 2-km multi-core fiber(MCF) and coupled into the chip with a local oscillator(LO) light. The polarization state of each signal light is automatically adjusted and aligned with that of the LO light, and then 7 channels of 28-GHz MMW carrying 4-Gb/s QPSK signals are generated by optical heterodyne beating. Automated polarizationcontrol function of each channel is also demonstrated with ～7-ms tuning time and ～27-dB extinction ratio.展开更多
Inter-regional transmission line fault often results in power flow transferring, tie-line overloading and system islanding. Traditional control methods such asgenerator tripping and load shedding are costly, and also ...Inter-regional transmission line fault often results in power flow transferring, tie-line overloading and system islanding. Traditional control methods such asgenerator tripping and load shedding are costly, and also have undesirable impacts on theloadside. In this paper, a new emergency power control strategy is proposed for multi-channel interconnected system by using the overload capacity of non-fault DC lines. First of all, the capacity of emergency power control can be acquired by critical transmission power of a certain tie-line for stability. Secondly, the shortest electric distance can be calculated by Dijkstra algorithm, and then the priority of emergency control of the DC lines can be obtained by the entropy weight method. When the inter-regional transmission power decreases and the effect of single DC line emergency control is poor, the multi-channel cooperative emergency control strategy is proposed to ensure the system stability. Simulation results verify the effectiveness of the method proposed.展开更多
Diabetes therapy is normally based on discrete insulin infusion that uses long-time interval measurements. Nevertheless, in this paper, a continuous drug infusion closed-loop control system was proposed to avoid the t...Diabetes therapy is normally based on discrete insulin infusion that uses long-time interval measurements. Nevertheless, in this paper, a continuous drug infusion closed-loop control system was proposed to avoid the traditional discrete approaches by automating diabetes therapy. Based on a continuous insulin injection model, two controllers were designed to deal with this plant. The controllers designed in this paper are: proportional integral derivative (PID), and fuzzy logic controllers (FLC). Simulation results have illustrated that the fuzzy logic controller outperformed the PID controller. These results were based on serious disturbances to glucose, such as exercise, delay or noise in glucose sensor and nutrition mixed meal absorption at meal time.展开更多
A robust decentralized H∞ control problem was considered for uncertain multi-channel discrete-time systems with time-delay. The uncertainties were assumed to be time-invariant, norm-bounded, and exist in the system, ...A robust decentralized H∞ control problem was considered for uncertain multi-channel discrete-time systems with time-delay. The uncertainties were assumed to be time-invariant, norm-bounded, and exist in the system, the time-delay and the output matrices. Dynamic output feedback was focused on. A sufficient condition for the multi-channel uncertain discrete time-delay system to be robustly stabilizable with a specified disturbance attenuation level was derived based on the theorem of Lyapunov stability theory. By setting the Lyapunov matrix as block diagonal appropriately according to the desired order of the controller, the problem was reduced to a linear matrix inequality (LMI) which is sufficient to existence condition but much more tractable. An example was given to show the efficiency of this method.展开更多
This research describes an integrated multi-channel high accuracy current control LED （light emitting diode） driver with low dropout regulator implemented in a 0.35μm TSMC 2P4M CMOS process. With the new trend of b...This research describes an integrated multi-channel high accuracy current control LED （light emitting diode） driver with low dropout regulator implemented in a 0.35μm TSMC 2P4M CMOS process. With the new trend of backlighting applications for mobile electronics and portable devices requiring a smaller size, lower cost, lesser noise and accurate current control LED driver, it came up with the idea of integrating more than one design features within a single chip. The analysis of using a capacitor-less low dropout regulator to power the constant current source has been explored, with the implementation of wide range battery voltage of 3 V to 5 V. Possible load current variations were introduced and verified to output a fixed voltage of 2.8 V. A regulated cascode current mirror structure forms the multi-channel configuration string of LED＇s; the design ensures a current matching of less than 1% error and achieves a high accuracy current control of less than 1% error, regardless of the LED＇s forward voltage variation. Moreover, for high end portable device with multimedia applications, dimming frequency can be set to 10 MHz. In addition, a switching output is a better approach for managing LED＇s contrast and brightness adjustment as well as maximizing power consumption, ensuring longer life for driving string of LEDs.展开更多
A physically accurate and computationally effective pure finite element method （FEM） was developed to simulate the isothermal resin infusing process. The FEM was based on conservation of resin muss at and instant of...A physically accurate and computationally effective pure finite element method （FEM） was developed to simulate the isothermal resin infusing process. The FEM was based on conservation of resin muss at and instant of time and was objective of resin film infusion （RFI） fiber impregnation and mold filling . The developed computer code was able to simulate the resin infusing visually. A numerical example presented here demonstrated that compared with traditional finite element/ control-volume （FE/CV）, and FEM was physically accurate and computationally efficient.展开更多
文摘BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend.
基金supported by National Key Research and Development Plan in China(Grant No.2020YFB1005500)Beijing Natural Science Foundation(Grant No.M21034)BUPT Excellent Ph.D Students Foundation(Grant No.CX2023218)。
文摘With the growth of requirements for data sharing,a novel business model of digital assets trading has emerged that allows data owners to sell their data for monetary gain.In the distributed ledger of blockchain,however,the privacy of stakeholder's identity and the confidentiality of data content are threatened.Therefore,we proposed a blockchainenabled privacy-preserving and access control scheme to address the above problems.First,the multi-channel mechanism is introduced to provide the privacy protection of distributed ledger inside the channel and achieve coarse-grained access control to digital assets.Then,we use multi-authority attribute-based encryption(MAABE)algorithm to build a fine-grained access control model for data trading in a single channel and describe its instantiation in detail.Security analysis shows that the scheme has IND-CPA secure and can provide privacy protection and collusion resistance.Compared with other schemes,our solution has better performance in privacy protection and access control.The evaluation results demonstrate its effectiveness and practicability.
基金supported by a grant from Shenzhen Baoan Hospital Affiliated to Southern Medical University
文摘This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and propofol（10 mg/kg） was administrated intravenously. Artery blood samples were collected at various time points after injection, and plasma concentrations of propofol were measured. Pharmacokinetic modeling was performed using Win Nonlin software. Propofol TCI within the acquired parameters integrated was conducted to achieve different anesthetic depths in rabbits, monitored by narcotrend. The pharmacodynamics was analyzed using a sigmoidal inhibitory maximal effect model for narcotrend index（NI） versus effect-site concentration. The results showed the pharmacokinetics of propofol in Japanese white rabbits was best described by a two-compartment model. The target plasma concentrations of propofol required at light anesthetic depth was 9.77±0.23 μg/m L, while 12.52±0.69 μg/m L at deep anesthetic depth. NI was 76.17±4.25 at light anesthetic depth, while 27.41±5.77 at deep anesthetic depth. The effect-site elimination rate constant（ke0） was 0.263/min, and the propofol dose required to achieve a 50% decrease in the NI value from baseline was 11.19 μg/m L（95% CI, 10.25–13.67）. Our results established a new propofol TCI animal model and proved the model controlled the anesthetic depth accurately and stably in rabbits. The study provides a powerful method for exploring general anesthetic mechanisms at different anesthetic depths in vivo.
基金supported by the National Key R&D Pro-gram of China under Grant 2016YFB0402501in part by the Natural Science Foundation of China under grant 61605112Open Fund of IPOC under grant BUPT
文摘We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footprint of 1.1 × 2.1 mm^2 and integrates 7 independent channels each having on-chip polarization control and heterodyne mixing functions. 7 channels of4-Gb/s QPSK baseband signals are delivered via a 2-km multi-core fiber(MCF) and coupled into the chip with a local oscillator(LO) light. The polarization state of each signal light is automatically adjusted and aligned with that of the LO light, and then 7 channels of 28-GHz MMW carrying 4-Gb/s QPSK signals are generated by optical heterodyne beating. Automated polarizationcontrol function of each channel is also demonstrated with ～7-ms tuning time and ～27-dB extinction ratio.
文摘Inter-regional transmission line fault often results in power flow transferring, tie-line overloading and system islanding. Traditional control methods such asgenerator tripping and load shedding are costly, and also have undesirable impacts on theloadside. In this paper, a new emergency power control strategy is proposed for multi-channel interconnected system by using the overload capacity of non-fault DC lines. First of all, the capacity of emergency power control can be acquired by critical transmission power of a certain tie-line for stability. Secondly, the shortest electric distance can be calculated by Dijkstra algorithm, and then the priority of emergency control of the DC lines can be obtained by the entropy weight method. When the inter-regional transmission power decreases and the effect of single DC line emergency control is poor, the multi-channel cooperative emergency control strategy is proposed to ensure the system stability. Simulation results verify the effectiveness of the method proposed.
文摘Diabetes therapy is normally based on discrete insulin infusion that uses long-time interval measurements. Nevertheless, in this paper, a continuous drug infusion closed-loop control system was proposed to avoid the traditional discrete approaches by automating diabetes therapy. Based on a continuous insulin injection model, two controllers were designed to deal with this plant. The controllers designed in this paper are: proportional integral derivative (PID), and fuzzy logic controllers (FLC). Simulation results have illustrated that the fuzzy logic controller outperformed the PID controller. These results were based on serious disturbances to glucose, such as exercise, delay or noise in glucose sensor and nutrition mixed meal absorption at meal time.
基金Project(60634020) supported by the National Natural Science Foundation of ChinaProject(07JJ6138) supported by Natural Science Foundation of Hunan Province, ChinaProject(20060390883) supported by the Postdoctoral Science Foundation of China
文摘A robust decentralized H∞ control problem was considered for uncertain multi-channel discrete-time systems with time-delay. The uncertainties were assumed to be time-invariant, norm-bounded, and exist in the system, the time-delay and the output matrices. Dynamic output feedback was focused on. A sufficient condition for the multi-channel uncertain discrete time-delay system to be robustly stabilizable with a specified disturbance attenuation level was derived based on the theorem of Lyapunov stability theory. By setting the Lyapunov matrix as block diagonal appropriately according to the desired order of the controller, the problem was reduced to a linear matrix inequality (LMI) which is sufficient to existence condition but much more tractable. An example was given to show the efficiency of this method.
文摘This research describes an integrated multi-channel high accuracy current control LED （light emitting diode） driver with low dropout regulator implemented in a 0.35μm TSMC 2P4M CMOS process. With the new trend of backlighting applications for mobile electronics and portable devices requiring a smaller size, lower cost, lesser noise and accurate current control LED driver, it came up with the idea of integrating more than one design features within a single chip. The analysis of using a capacitor-less low dropout regulator to power the constant current source has been explored, with the implementation of wide range battery voltage of 3 V to 5 V. Possible load current variations were introduced and verified to output a fixed voltage of 2.8 V. A regulated cascode current mirror structure forms the multi-channel configuration string of LED＇s; the design ensures a current matching of less than 1% error and achieves a high accuracy current control of less than 1% error, regardless of the LED＇s forward voltage variation. Moreover, for high end portable device with multimedia applications, dimming frequency can be set to 10 MHz. In addition, a switching output is a better approach for managing LED＇s contrast and brightness adjustment as well as maximizing power consumption, ensuring longer life for driving string of LEDs.
基金Funded bythe National Natural Science Foundation of China(No50573060)
文摘A physically accurate and computationally effective pure finite element method （FEM） was developed to simulate the isothermal resin infusing process. The FEM was based on conservation of resin muss at and instant of time and was objective of resin film infusion （RFI） fiber impregnation and mold filling . The developed computer code was able to simulate the resin infusing visually. A numerical example presented here demonstrated that compared with traditional finite element/ control-volume （FE/CV）, and FEM was physically accurate and computationally efficient.
