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Performance Behaviour Analysis of the Present 3-Level Cache System for Multi-Core Processors
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作者 Muhammad Ali Ismail 《Computer Technology and Application》 2012年第11期729-733,共5页
In this paper, a study related to the expected performance behaviour of present 3-level cache system for multi-core systems is presented. For this a queuing model for present 3-level cache system for multi-core proces... In this paper, a study related to the expected performance behaviour of present 3-level cache system for multi-core systems is presented. For this a queuing model for present 3-level cache system for multi-core processors is developed and its possible performance has been analyzed with the increase in number of cores. Various important performance parameters like access time and utilization of individual cache at different level and overall average access time of the cache system is determined. Results for up to 1024 cores have been reported in this paper. 展开更多
关键词 multi-core memory hierarchy cache access time queuing analysis.
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Research on Multi-Core Processor Analysis for WCET Estimation
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作者 LUO Haoran HU Shuisong +2 位作者 WANG Wenyong TANG Yuke ZHOU Junwei 《ZTE Communications》 2024年第1期87-94,共8页
Real-time system timing analysis is crucial for estimating the worst-case execution time(WCET)of a program.To achieve this,static or dynamic analysis methods are used,along with targeted modeling of the actual hardwar... Real-time system timing analysis is crucial for estimating the worst-case execution time(WCET)of a program.To achieve this,static or dynamic analysis methods are used,along with targeted modeling of the actual hardware system.This literature review focuses on calculating WCET for multi-core processors,providing a survey of traditional methods used for static and dynamic analysis and highlighting the major challenges that arise from different program execution scenarios on multi-core platforms.This paper outlines the strengths and weaknesses of current methodologies and offers insights into prospective areas of research on multi-core analysis.By presenting a comprehensive analysis of the current state of research on multi-core processor analysis for WCET estimation,this review aims to serve as a valuable resource for researchers and practitioners in the field. 展开更多
关键词 real-time system worst-case execution time(WCET) multi-core analysis
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Proposal for sequential Stern-Gerlach experiment with programmable quantum processors
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作者 胡孟军 缪海兴 张永生 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期131-136,共6页
The historical significance of the Stern–Gerlach(SG)experiment lies in its provision of the initial evidence for space quantization.Over time,its sequential form has evolved into an elegant paradigm that effectively ... The historical significance of the Stern–Gerlach(SG)experiment lies in its provision of the initial evidence for space quantization.Over time,its sequential form has evolved into an elegant paradigm that effectively illustrates the fundamental principles of quantum theory.To date,the practical implementation of the sequential SG experiment has not been fully achieved.In this study,we demonstrate the capability of programmable quantum processors to simulate the sequential SG experiment.The specific parametric shallow quantum circuits,which are suitable for the limitations of current noisy quantum hardware,are given to replicate the functionality of SG devices with the ability to perform measurements in different directions.Surprisingly,it has been demonstrated that Wigner’s SG interferometer can be readily implemented in our sequential quantum circuit.With the utilization of the identical circuits,it is also feasible to implement Wheeler’s delayed-choice experiment.We propose the utilization of cross-shaped programmable quantum processors to showcase sequential experiments,and the simulation results demonstrate a strong alignment with theoretical predictions.With the rapid advancement of cloud-based quantum computing,such as BAQIS Quafu,it is our belief that the proposed solution is well-suited for deployment on the cloud,allowing for public accessibility.Our findings not only expand the potential applications of quantum computers,but also contribute to a deeper comprehension of the fundamental principles underlying quantum theory. 展开更多
关键词 sequential Stern-Gerlach quantum circuit quantum processor
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Efficient cache replacement framework based on access hotness for spacecraft processors
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作者 GAO Xin NIAN Jiawei +1 位作者 LIU Hongjin YANG Mengfei 《中国空间科学技术(中英文)》 CSCD 北大核心 2024年第2期74-88,共15页
A notable portion of cachelines in real-world workloads exhibits inner non-uniform access behaviors.However,modern cache management rarely considers this fine-grained feature,which impacts the effective cache capacity... A notable portion of cachelines in real-world workloads exhibits inner non-uniform access behaviors.However,modern cache management rarely considers this fine-grained feature,which impacts the effective cache capacity of contemporary high-performance spacecraft processors.To harness these non-uniform access behaviors,an efficient cache replacement framework featuring an auxiliary cache specifically designed to retain evicted hot data was proposed.This framework reconstructs the cache replacement policy,facilitating data migration between the main cache and the auxiliary cache.Unlike traditional cacheline-granularity policies,the approach excels at identifying and evicting infrequently used data,thereby optimizing cache utilization.The evaluation shows impressive performance improvement,especially on workloads with irregular access patterns.Benefiting from fine granularity,the proposal achieves superior storage efficiency compared with commonly used cache management schemes,providing a potential optimization opportunity for modern resource-constrained processors,such as spacecraft processors.Furthermore,the framework complements existing modern cache replacement policies and can be seamlessly integrated with minimal modifications,enhancing their overall efficacy. 展开更多
关键词 spacecraft processors cache management replacement policy storage efficiency memory hierarchy MICROARCHITECTURE
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Thread Private Variable Access Optimization Technique for Sunway High-Performance Multi-core Processors
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作者 Jinying Kong Kai Nie +2 位作者 Qinglei Zhou Jinlong Xu Lin Han 《国际计算机前沿大会会议论文集》 2021年第1期180-189,共10页
The primary way to achieve thread-level parallelism on the Sunwayhigh-performance multicore processor is to use the OpenMP programming technique.To address the problem of low parallelism efficiency caused by slow acce... The primary way to achieve thread-level parallelism on the Sunwayhigh-performance multicore processor is to use the OpenMP programming technique.To address the problem of low parallelism efficiency caused by slow accessto thread private variables in the compilation of Sunway OpenMP programs, thispaper proposes a thread private variable access technique based on privilegedinstructions. The privileged instruction-based thread-private variable access techniquecentralizes the implementation of thread-private variables at the compilerlevel, eliminating the model switching overhead of invoking OS core processingand improving the speed of accessing thread-private variables. On the Sunway1621 server platform, NPB3.3-OMP and SPEC OMP2012 achieved 6.2% and6.8% running efficiency gains, respectively. The results show that the techniquesproposed in this paper can provide technical support for giving full play to theadvantages of Sunway’s high-performance multi-core processors. 展开更多
关键词 Sunway high-performance multi-core processors OpenMP programming technique Privileged instruction-based thread-private variable access technique Sunway 1621 processor
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Parallel Region Reconstruction Technique for Sunway High-Performance Multi-core Processors
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作者 Kai Nie Qinglei Zhou +3 位作者 Hong Qian Jianmin Pang Jinlong Xu Yapeng Li 《国际计算机前沿大会会议论文集》 2021年第1期163-179,共17页
The leading way to achieve thread-level parallelism on the Sunwayhigh-performance multicore processors is to use OpenMP programming techniques.In order to address the problem of low parallel efficiency caused by hight... The leading way to achieve thread-level parallelism on the Sunwayhigh-performance multicore processors is to use OpenMP programming techniques.In order to address the problem of low parallel efficiency caused by highthread group control overhead in the compilation of Sunway OpenMP programs,this paper proposes the parallel region reconstruction technique. The parallelregion reconstruction technique expands the parallel scope of parallel regionsin OpenMP programs by parallel region merging and parallel region extending.Moreover, it reduces the number of parallel regions in OpenMP programs,decreases the overhead of frequent creation and convergence of thread groups,and converts standard fork-join model OpenMP programs to higher performanceSPMD modelOpenMP programs. On the Sunway 1621 server computer, NPB3.3-OMP and SPEC OMP2012 achieved 8.9% and 7.9% running efficiency improvementrespectively through parallel region reconstruction technique. As a result,the parallel region reconstruction technique is feasible and effective. It providestechnical support to fully exploit the multi-core parallelism advantage of Sunway’shigh-performance processors. 展开更多
关键词 Sunway high-performance multi-core processors OpenMP programming technique Parallel domain reconstruction technique
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System Architecture of Godson-3 Multi-Core Processors 被引量:7
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作者 高翔 陈云霁 +2 位作者 王焕东 唐丹 胡伟武 《Journal of Computer Science & Technology》 SCIE EI CSCD 2010年第2期181-191,共11页
Godson-3 is the latest generation of Godson microprocessor family. It takes a scalable multi-core architecture with hardware support for accelerating applications including X86 emulation and signal processing. This pa... Godson-3 is the latest generation of Godson microprocessor family. It takes a scalable multi-core architecture with hardware support for accelerating applications including X86 emulation and signal processing. This paper introduces the system architecture of Godson-3 from various aspects including system scalability, organization of memory hierarchy, network-on-chip, inter-chip connection and I/O subsystem. 展开更多
关键词 multi-core processor scalable interconnection cache coherent non-uniform memory access/non-uniform cache access (CC-NUMA/NUCA) MESH CROSSBAR cache coherence reliability availability and serviceability (RAS)
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Parallel computing of discrete element method on multi-core processors 被引量:6
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作者 Yusuke Shigeto Mikio Sakai 《Particuology》 SCIE EI CAS CSCD 2011年第4期398-405,共8页
This paper describes parallel simulation techniques for the discrete element method (DEM) on multi-core processors. Recently, multi-core CPU and GPU processors have attracted much attention in accelerating computer ... This paper describes parallel simulation techniques for the discrete element method (DEM) on multi-core processors. Recently, multi-core CPU and GPU processors have attracted much attention in accelerating computer simulations in various fields. We propose a new algorithm for multi-thread parallel computation of DEM, which makes effective use of the available memory and accelerates the computation. This study shows that memory usage is drastically reduced by using this algorithm. To show the practical use of DEM in industry, a large-scale powder system is simulated with a complicated drive unit. We compared the performance of the simulation between the latest GPU and CPU processors with optimized programs for each processor. The results show that the difference in performance is not substantial when using either GPUs or CPUs with a multi-thread parallel algorithm. In addition, DEM algorithm is shown to have high scalabilitv in a multi-thread parallel computation on a CPU. 展开更多
关键词 Discrete element method Parallel computing multi-core processor GPGPU
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Multi-core optimization for conjugate gradient benchmark on heterogeneous processors
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作者 邓林 窦勇 《Journal of Central South University》 SCIE EI CAS 2011年第2期490-498,共9页
Developing parallel applications on heterogeneous processors is facing the challenges of 'memory wall',due to limited capacity of local storage,limited bandwidth and long latency for memory access. Aiming at t... Developing parallel applications on heterogeneous processors is facing the challenges of 'memory wall',due to limited capacity of local storage,limited bandwidth and long latency for memory access. Aiming at this problem,a parallelization approach was proposed with six memory optimization schemes for CG,four schemes of them aiming at all kinds of sparse matrix-vector multiplication (SPMV) operation. Conducted on IBM QS20,the parallelization approach can reach up to 21 and 133 times speedups with size A and B,respectively,compared with single power processor element. Finally,the conclusion is drawn that the peak bandwidth of memory access on Cell BE can be obtained in SPMV,simple computation is more efficient on heterogeneous processors and loop-unrolling can hide local storage access latency while executing scalar operation on SIMD cores. 展开更多
关键词 multi-core processor NAS parallelization CG memory optimization
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Schedule refinement for homogeneous multi-core processors in the presence of manufacturing-caused heterogeneity
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作者 Zhi-xiang CHEN Zhao-lin LI +2 位作者 Shan CAO Fang WANG Jie ZHOU 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2015年第12期1018-1033,共16页
Multi-core homogeneous processors have been widely used to deal with computation-intensive embedded applications. However, with the continuous down scaling of CMOS technology, within-die variations in the manufacturin... Multi-core homogeneous processors have been widely used to deal with computation-intensive embedded applications. However, with the continuous down scaling of CMOS technology, within-die variations in the manufacturing process lead to a significant spread in the operating speeds of cores within homogeneous multi-core processors. Task scheduling approaches, which do not consider such heterogeneity caused by within-die variations,can lead to an overly pessimistic result in terms of performance. To realize an optimal performance according to the actual maximum clock frequencies at which cores can run, we present a heterogeneity-aware schedule refining(HASR) scheme by fully exploiting the heterogeneities of homogeneous multi-core processors in embedded domains.We analyze and show how the actual maximum frequencies of cores are used to guide the scheduling. In the scheme,representative chip operating points are selected and the corresponding optimal schedules are generated as candidate schedules. During the booting of each chip, according to the actual maximum clock frequencies of cores, one of the candidate schedules is bound to the chip to maximize the performance. A set of applications are designed to evaluate the proposed scheme. Experimental results show that the proposed scheme can improve the performance by an average value of 22.2%, compared with the baseline schedule based on the worst case timing analysis. Compared with the conventional task scheduling approach based on the actual maximum clock frequencies, the proposed scheme also improves the performance by up to 12%. 展开更多
关键词 Schedule refining multi-core processor HETEROGENEITY Representative chip operating point
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Resources Snapshot Model for Concurrent Transactions in Multi-Core Processors
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作者 赵雷 杨季文 《Journal of Computer Science & Technology》 SCIE EI CSCD 2013年第1期106-118,共13页
Transaction parallelism in database systems is an attractive way of improving transaction performance. There exists two levels of transaction parallelism, inter-transaction level and intra-transaction level. With the ... Transaction parallelism in database systems is an attractive way of improving transaction performance. There exists two levels of transaction parallelism, inter-transaction level and intra-transaction level. With the advent of multi- core processors, new hopes of improving transaction parallelism appear on the scene. The greatest execution efficiency of concurrent transactions comes from the lowest dependencies of them. However, the dependencies of concurrent transactions stand in the way of exploiting parallelism. In this paper, we present Resource Snapshot Model (RSM) for resource modeling in both levels. We propose a non-restarting scheduling algorithm in the inter-transaction level and a processor assignment algorithm in the intra-transaction level in terms of multi-core processors. Through these algorithms, execution performance of transaction streams will be improved in a parallel system with multiple heterogeneous processors that have different number of cores. 展开更多
关键词 multi-core database transaction PARALLELISM CONCURRENCY conflict detection
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An efficient geosciences workflow on multi-core processors and GPUs:a case study for aerosol optical depth retrieval from MODIS satellite data
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作者 Jia Liu Dustin Feld +3 位作者 Yong Xue Jochen Garcke Thomas Soddemann Peiyuan Pan 《International Journal of Digital Earth》 SCIE EI CSCD 2016年第8期748-765,共18页
Quantitative remote sensing retrieval algorithms help understanding the dynamic aspects of Digital Earth.However,the Big Data and complex models in Digital Earth pose grand challenges for computation infrastructures.I... Quantitative remote sensing retrieval algorithms help understanding the dynamic aspects of Digital Earth.However,the Big Data and complex models in Digital Earth pose grand challenges for computation infrastructures.In this article,taking the aerosol optical depth(AOD)retrieval as a study case,we exploit parallel computing methods for high efficient geophysical parameter retrieval.We present an efficient geocomputation workflow for the AOD calculation from the Moderate Resolution Imaging Spectroradiometer(MODIS)satellite data.According to their individual potential for parallelization,several procedures were adapted and implemented for a successful parallel execution on multicore processors and Graphics Processing Units(GPUs).The benchmarks in this paper validate the high parallel performance of the retrieval workflow with speedups of up to 5.x on a multi-core processor with 8 threads and 43.x on a GPU.To specifically address the time-consuming model retrieval part,hybrid parallel patterns which combine the multicore processor’s and the GPU’s compute power were implemented with static and dynamic workload distributions and evaluated on two systems with different CPU–GPU configurations.It is shown that only the dynamic hybrid implementation leads to a greatly enhanced overall exploitation of the heterogeneous hardware environment in varying circumstances. 展开更多
关键词 Digital earth highperformance computing GPU multi-core hybrid parallel pattern aerosol optical depth retrieval workflow
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Shared Cache Based on Content Addressable Memory in a Multi-Core Architecture
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作者 Allam Abumwais Mahmoud Obaid 《Computers, Materials & Continua》 SCIE EI 2023年第3期4951-4963,共13页
Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to acc... Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors. 展开更多
关键词 multi-core processor shared cache content addressable memory dual port CAM replacement algorithm benchmark program
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Hybridization of Metaheuristics Based Energy Efficient Scheduling Algorithm for Multi-Core Systems
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作者 J.Jean Justus U.Sakthi +4 位作者 K.Priyadarshini B.Thiyaneswaran Masoud Alajmi Marwa Obayya Manar Ahmed Hamza 《Computer Systems Science & Engineering》 SCIE EI 2023年第1期205-219,共15页
The developments of multi-core systems(MCS)have considerably improved the existing technologies in thefield of computer architecture.The MCS comprises several processors that are heterogeneous for resource capacities,... The developments of multi-core systems(MCS)have considerably improved the existing technologies in thefield of computer architecture.The MCS comprises several processors that are heterogeneous for resource capacities,working environments,topologies,and so on.The existing multi-core technology unlocks additional research opportunities for energy minimization by the use of effective task scheduling.At the same time,the task scheduling process is yet to be explored in the multi-core systems.This paper presents a new hybrid genetic algorithm(GA)with a krill herd(KH)based energy-efficient scheduling techni-que for multi-core systems(GAKH-SMCS).The goal of the GAKH-SMCS tech-nique is to derive scheduling tasks in such a way to achieve faster completion time and minimum energy dissipation.The GAKH-SMCS model involves a multi-objectivefitness function using four parameters such as makespan,processor utilization,speedup,and energy consumption to schedule tasks proficiently.The performance of the GAKH-SMCS model has been validated against two datasets namely random dataset and benchmark dataset.The experimental outcome ensured the effectiveness of the GAKH-SMCS model interms of makespan,pro-cessor utilization,speedup,and energy consumption.The overall simulation results depicted that the presented GAKH-SMCS model achieves energy effi-ciency by optimal task scheduling process in MCS. 展开更多
关键词 Task scheduling energy efficiency multi-core systems fitness function MAKESPAN
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Parallel Processing Design for LTE PUSCH Demodulation and Decoding Based on Multi-Core Processor
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作者 Zhang Ziran,Li Jun,Li Changxiao(ZTE Corporation,Shenzhen 518057,P.R.China) 《ZTE Communications》 2009年第1期54-58,共5页
The Long Term Evolution (LTE) system imposes high requirements for dispatching delay.Moreover,very large air interface rate of LTE requires good processing capability for the devices processing the baseband signals.Co... The Long Term Evolution (LTE) system imposes high requirements for dispatching delay.Moreover,very large air interface rate of LTE requires good processing capability for the devices processing the baseband signals.Consequently,the single-core processor cannot meet the requirements of LTE system.This paper analyzes how to use multi-core processors to achieve parallel processing of uplink demodulation and decoding in LTE systems and designs an approach to parallel processing.The test results prove that this approach works quite well. 展开更多
关键词 CORE LTE Parallel Processing Design for LTE PUSCH Demodulation and Decoding Based on multi-core processor Design
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EIA的基于NIT和Multi-Core的面向应用调节架构
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作者 张炯 金惠华 《计算机工程与应用》 CSCD 北大核心 2007年第11期113-116,共4页
资源受限的嵌入式系统中运行的应用程序与运行于桌面系统的应用程序有显著的不同,需要考虑应用本身的需求,也要更多地关注体系结构对于计算所提供的指令级和微指令级的支持。阐述了与嵌入式Intel架构(EIA)研究有关的重要问题,提出了一... 资源受限的嵌入式系统中运行的应用程序与运行于桌面系统的应用程序有显著的不同,需要考虑应用本身的需求,也要更多地关注体系结构对于计算所提供的指令级和微指令级的支持。阐述了与嵌入式Intel架构(EIA)研究有关的重要问题,提出了一个基于Intel多处理器核技术的嵌入式应用处理器解决方案,其核心思想是提供可定制的计算单元用于对特定计算的适应。这个方案与普通多核技术及可配置处理器架构的差别在于通过粗粒度并行机制获得计算资源的定制以便适应嵌入式系统计算的特殊性。 展开更多
关键词 嵌入式系统 测试 嵌入式英特尔架构 可配置处理器
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Speeding up the MATLAB complex networks package using graphic processors 被引量:1
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作者 张百达 唐玉华 +1 位作者 吴俊杰 李鑫 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第9期460-467,共8页
The availability of computers and communication networks allows us to gather and analyse data on a far larger scale than previously. At present, it is believed that statistics is a suitable method to analyse networks ... The availability of computers and communication networks allows us to gather and analyse data on a far larger scale than previously. At present, it is believed that statistics is a suitable method to analyse networks with millions, or more, of vertices. The MATLAB language, with its mass of statistical functions, is a good choice to rapidly realize an algorithm prototype of complex networks. The performance of the MATLAB codes can be further improved by using graphic processor units (GPU). This paper presents the strategies and performance of the GPU implementation of a complex networks package, and the Jacket toolbox of MATLAB is used. Compared with some commercially available CPU implementations, GPU can achieve a speedup of, on average, 11.3x. The experimental result proves that the GPU platform combined with the MATLAB language is a good combination for complex network research. 展开更多
关键词 complex networks graphic processors unit MATLAB Jacket Toolbox
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SDN-Based Switch Implementation on Network Processors 被引量:1
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作者 Yunchun Li Guodong Wang 《Communications and Network》 2013年第3期434-437,共4页
Virtualization is the key technology of cloud computing. Network virtualization plays an important role in this field. Its performance is very relevant to network virtualizing. Nowadays its implementations are mainly ... Virtualization is the key technology of cloud computing. Network virtualization plays an important role in this field. Its performance is very relevant to network virtualizing. Nowadays its implementations are mainly based on the idea of Software Define Network (SDN). Open vSwitch is a sort of software virtual switch, which conforms to the OpenFlow protocol standard. It is basically deployed in the Linux kernel hypervisor. This leads to its performance relatively poor because of the limited system resource. In turn, the packet process throughput is very low.In this paper, we present a Cavium-based Open vSwitch implementation. The Cavium platform features with multi cores and couples of hard ac-celerators. It supports zero-copy of packets and handles packet more quickly. We also carry some experiments on the platform. It indicates that we can use it in the enterprise network or campus network as convergence layer and core layer device. 展开更多
关键词 SDN OPEN vSwitch Network processors OpenFlow
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LOGIC STRUCTURE OF PROGRAMMABLE INSTRUCTIONS FOR JAVA PROCESSORS 被引量:2
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作者 Chen Zhirui Tan Hongzhou 《Journal of Electronics(China)》 2009年第5期711-714,共4页
There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable... There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable instruction set is an effective method to gain embedded system's re-configurability. This letter presents a logic module for Java processor to be capable of using programmable instruction set. Cost (area, power, and timing) of the module is trivial. Such module is also reusable for other embedded system solutions besides Java systems. 展开更多
关键词 Programmable instructions Java processor System on Chips (SoCs)
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Enrichment of Fetal Nucleated Red Blood Cells by Multi-core Magnetic Composite Particles for Non-invasive Prenatal Diagnosis 被引量:1
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作者 PAN Ying WANG Qing +7 位作者 HUANG Wen-jun QIAO Feng-1i LIU Yu-ping ZHANG Yu-cheng HAI De-yang DU Ying,ting WANG Wen-yue ZHANG Ai-chen 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第3期443-448,共6页
A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor(anti-CD71), was prepared. The fetal nucleated red blo... A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor(anti-CD71), was prepared. The fetal nucleated red blood cells(FNRBCs) in the peripheral blood of a gravida were rapidly and effectively enriched and separated by the mo- dified multi-core magnetic composite particles in an external magnetic field. The obtained FNRBCs were used for the identification of the fetal sex by means of fluorescence in situ hybridization(FISH) technique. The results demonstrate that the multi-core magnetic composite particles meet the requirements for the enrichment and speration of FNRBCs with a low concentration and the accuracy of detetion for the diagnosis of fetal sex reached to 95%. Moreover, the obtained FNRBCs were applied to the non-invasive diagnosis of Down syndrome and chromosome 3p21 was de- tected. The above facts indicate that the novel multi-core magnetic composite particles-based method is simple, relia- ble and cost-effective and has opened up vast vistas for the potential application in clinic non-invasive prenatal diag- nosis. 展开更多
关键词 Fetal nucleated red blood cell(FNRBC) Prenatal diagnosis NON-INVASIVE multi-core magnetic compositeparticle
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