BACKGROUND Gastric cancer(GC)is the most common malignant tumor and ranks third for cancer-related deaths among the worldwide.The disease poses a serious public health problem in China,ranking fifth for incidence and ...BACKGROUND Gastric cancer(GC)is the most common malignant tumor and ranks third for cancer-related deaths among the worldwide.The disease poses a serious public health problem in China,ranking fifth for incidence and third for mortality.Knowledge of the invasive depth of the tumor is vital to treatment decisions.AIM To evaluate the diagnostic performance of double contrast-enhanced ultrasonography(DCEUS)for preoperative T staging in patients with GC by comparing with multi-detector computed tomography(MDCT).METHODS This single prospective study enrolled patients with GC confirmed by preoperative gastroscopy from July 2021 to March 2023.Patients underwent DCEUS,including ultrasonography(US)and intravenous contrast-enhanced ultrasonography(CEUS),and MDCT examinations for the assessment of preoperative T staging.Features of GC were identified on DCEUS and criteria developed to evaluate T staging according to the 8th edition of AJCC cancer staging manual.The diagnostic performance of DCEUS was evaluated by comparing it with that of MDCT and surgical-pathological findings were considered as the gold standard.RESULTS A total of 229 patients with GC(80 T1,33 T2,59 T3 and 57 T4)were included.Overall accuracies were 86.9%for DCEUS and 61.1%for MDCT(P<0.001).DCEUS was superior to MDCT for T1(92.5%vs 70.0%,P<0.001),T2(72.7%vs 51.5%,P=0.041),T3(86.4%vs 45.8%,P<0.001)and T4(87.7%vs 70.2%,P=0.022)staging of GC.CONCLUSION DCEUS improved the diagnostic accuracy of preoperative T staging in patients with GC compared with MDCT,and constitutes a promising imaging modality for preoperative evaluation of GC to aid individualized treatment decision-making.展开更多
为了探究金葡素SEC2(Staphylococcal enterotoxins C 2)改构蛋白2M-118对小鼠的致呕吐、致热毒性和免疫原性作用,将BALB/c小鼠分为正常组、2M-118腹腔给药组和灌胃给药组,每组10只;通过观察小鼠给药前后状态变化及记录小鼠体质量和体温...为了探究金葡素SEC2(Staphylococcal enterotoxins C 2)改构蛋白2M-118对小鼠的致呕吐、致热毒性和免疫原性作用,将BALB/c小鼠分为正常组、2M-118腹腔给药组和灌胃给药组,每组10只;通过观察小鼠给药前后状态变化及记录小鼠体质量和体温,评价2M-118对小鼠的致呕吐和致热毒性;采用MTT法检测2M-118对小鼠脾淋巴细胞增殖的影响;由ELISA法检测小鼠给药2M-118后血清产生中和抗体的情况。结果表明,2M-118并未致小鼠呕吐或致小鼠体温升高;2M-118可以刺激小鼠脾淋巴细胞增殖,促进脾组织中IFN-γ、TNF-α和IL-2等细胞因子的表达,并刺激机体产生针对2M-118的中和抗体。展开更多
千呼万唤始出来,美国证券交易委员会(SEC)去年3月终于向世人公布了气候风险披露的草案——《加强和规范服务于投资者的气候相关披露》(SEC Proposes Rules to Enhance and Standarize Clime-Related Disclosures for Investors,No.33-11...千呼万唤始出来,美国证券交易委员会(SEC)去年3月终于向世人公布了气候风险披露的草案——《加强和规范服务于投资者的气候相关披露》(SEC Proposes Rules to Enhance and Standarize Clime-Related Disclosures for Investors,No.33-11042,以下简称“SEC草案”或“草案”。第33-11042号公告在S-K条例中增加了一个新的子部分,其中描述了注册人必须在SEC报告和招股说明书中提交与气候有关的信息。)展开更多
基金This study was reviewed and approved by the Ethics Committee of Sun Yat-sen University Cancer Center(Approval No.B2023-219-03).
文摘BACKGROUND Gastric cancer(GC)is the most common malignant tumor and ranks third for cancer-related deaths among the worldwide.The disease poses a serious public health problem in China,ranking fifth for incidence and third for mortality.Knowledge of the invasive depth of the tumor is vital to treatment decisions.AIM To evaluate the diagnostic performance of double contrast-enhanced ultrasonography(DCEUS)for preoperative T staging in patients with GC by comparing with multi-detector computed tomography(MDCT).METHODS This single prospective study enrolled patients with GC confirmed by preoperative gastroscopy from July 2021 to March 2023.Patients underwent DCEUS,including ultrasonography(US)and intravenous contrast-enhanced ultrasonography(CEUS),and MDCT examinations for the assessment of preoperative T staging.Features of GC were identified on DCEUS and criteria developed to evaluate T staging according to the 8th edition of AJCC cancer staging manual.The diagnostic performance of DCEUS was evaluated by comparing it with that of MDCT and surgical-pathological findings were considered as the gold standard.RESULTS A total of 229 patients with GC(80 T1,33 T2,59 T3 and 57 T4)were included.Overall accuracies were 86.9%for DCEUS and 61.1%for MDCT(P<0.001).DCEUS was superior to MDCT for T1(92.5%vs 70.0%,P<0.001),T2(72.7%vs 51.5%,P=0.041),T3(86.4%vs 45.8%,P<0.001)and T4(87.7%vs 70.2%,P=0.022)staging of GC.CONCLUSION DCEUS improved the diagnostic accuracy of preoperative T staging in patients with GC compared with MDCT,and constitutes a promising imaging modality for preoperative evaluation of GC to aid individualized treatment decision-making.
文摘为了探究金葡素SEC2(Staphylococcal enterotoxins C 2)改构蛋白2M-118对小鼠的致呕吐、致热毒性和免疫原性作用,将BALB/c小鼠分为正常组、2M-118腹腔给药组和灌胃给药组,每组10只;通过观察小鼠给药前后状态变化及记录小鼠体质量和体温,评价2M-118对小鼠的致呕吐和致热毒性;采用MTT法检测2M-118对小鼠脾淋巴细胞增殖的影响;由ELISA法检测小鼠给药2M-118后血清产生中和抗体的情况。结果表明,2M-118并未致小鼠呕吐或致小鼠体温升高;2M-118可以刺激小鼠脾淋巴细胞增殖,促进脾组织中IFN-γ、TNF-α和IL-2等细胞因子的表达,并刺激机体产生针对2M-118的中和抗体。
文摘千呼万唤始出来,美国证券交易委员会(SEC)去年3月终于向世人公布了气候风险披露的草案——《加强和规范服务于投资者的气候相关披露》(SEC Proposes Rules to Enhance and Standarize Clime-Related Disclosures for Investors,No.33-11042,以下简称“SEC草案”或“草案”。第33-11042号公告在S-K条例中增加了一个新的子部分,其中描述了注册人必须在SEC报告和招股说明书中提交与气候有关的信息。)
