随着油气勘探程度的不断提高,已陆续发现一些以火山岩和火山碎屑岩为储集层的油气田。但是,由于火山岩对地震信号屏蔽作用明显,地震波在不同层系、不同类型火山岩中的速度差异大,导致火山岩发育区的速度建模和成像极其困难。EP地区处于...随着油气勘探程度的不断提高,已陆续发现一些以火山岩和火山碎屑岩为储集层的油气田。但是,由于火山岩对地震信号屏蔽作用明显,地震波在不同层系、不同类型火山岩中的速度差异大,导致火山岩发育区的速度建模和成像极其困难。EP地区处于阳江—一统断裂带,资源潜力大,且发育大量构造圈闭,同时,该地区发育古近系及上覆地层的多期火山岩,以往处理成果中火山岩内幕成像不清晰,难以刻画火山岩相和准确评估火山岩对油气生、储、盖条件的影响。为此,针对火山岩多次波压制、火山岩下弱信号恢复、火山岩速度精细刻画等方面的关键问题开展新的处理技术探索。首先采用MWD(Model based Water-layer related Demultiple)技术预测火山岩多次波;然后利用AVO剩余振幅补偿和低频算子外推随机噪声衰减技术提高火山岩下弱信号质量;最后,联合应用初至波层析和反射波网格层析技术构建精确的叠前深度偏移速度模型。重处理后的叠前深度偏移成果显示,火山岩及下伏地层成像质量显著提高,表明所提重处理技术方案对提高火山岩发育区地震成像质量有较好的借鉴意义。展开更多
AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enro...AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable.展开更多
Irregular surface flattening,which is based on a boundary conforming grid and the transformation between curvilinear and Cartesian coordinate systems,is a mathematical method that can elegantly handle irregular surfac...Irregular surface flattening,which is based on a boundary conforming grid and the transformation between curvilinear and Cartesian coordinate systems,is a mathematical method that can elegantly handle irregular surfaces,but has been limited to obtaining first arrivals only.By combining a multistage scheme with the fast-sweeping method(FSM,the method to obtain first-arrival traveltime in curvilinear coordinates),the reflected waves from a crustal interface can be traced in a topographic model,in which the reflected wavefront is obtained by reinitializing traveltimes in the interface for upwind branches.A local triangulation is applied to make a connection between velocity and interface nodes.Then a joint inversion of first-arrival and reflection traveltimes for imaging seismic velocity structures in complex terrains is presented.Numerical examples all perform well with different seismic velocity models.The increasing topographic complexity and even use of a high curvature reflector in these models demonstrate the reliability,accuracy and robustness of the new working scheme;checkerboard testing illustrates the method's high resolution.Noise tolerance testing indicates the method's ability to yield practical traveltime tomography.Further development of the multistage scheme will allow other later arrivals to be traced and used in the traveltime inversion.展开更多
AIM:To present the outcome of modified grid laser photocoagulation(GLP)in diffuse diabetic macular edema(DDME)in eyes without extrafoveal and/or vitreofoveal traction.METHODS:Inclusion criteria for the retrospective s...AIM:To present the outcome of modified grid laser photocoagulation(GLP)in diffuse diabetic macular edema(DDME)in eyes without extrafoveal and/or vitreofoveal traction.METHODS:Inclusion criteria for the retrospective study were DDME eyes of patients with typeⅡdiabetes mellitus that had≥4 months of follow-up following GLP.Only one eye per patient was analyzed.Using 3-D spectral-domain optical coherence tomography(3-D SDOCT),eyes that had either extrafoveal or vitreofoveal traction,or had been previously treated by an intravitreal medication(s)were excluded.Treated DDME eyes were divided into 4 groups:A)"Classic"DDME that involved the central macula;B)edema did not involve the macular center;C)eyes associated with central epiretinal membrane(ERM);D)DDME that was associated with macular capillary dropout≥2 disc-diameter(DD).RESULTS:GLP outcome in 35 DDME eyes after 4-24(mean,13.1±6.9)months was as follows:Group A)18eyes with"classic"DDME.Following one or 2(mean,1.2)GLP treatments,best-corrected visual acuity(BCVA)improved by 1-2 Snellen lines in 44.4%(8/18)of eyes,and worsened by 1 line in 11.1%(2/18).Central macular thickness(CMT)improved by 7%-49%(mean,26.6%)in77.8%(14/18)of eyes.Causes of CMT worsening(n=4)were commonly explainable,predominantly(n=3)associated with emergence of extrafoveal traction,5-9months post-GLP.Group B)GLP(s)in DDME that did not involve the macular center(n=6)resulted in improved BCVA by 1-2 lines in 2 eyes.However,the central macula became involved in the edema process after the GLP in 3(50%)eyes,associated with an emergence of extrafoveal traction in one of these eyes 4months following the GLP.Group C)GLP failed in all 5eyes associated with central ERM.Group D)GLP was of partial benefit in 2 of 6 treated eyes with macular capillary dropout≥2DD.CONCLUSION:Eyes with DDME that involved the macular center were found to achieve favourable outcomes after GLP(s)during mid-term follow-up,unless complicated pre-GLP or post-GLP by vltreoretinal interface abnormalities,often extrafoveal traction or ERM,or by capillary dropout≥2DD.Prospective studies with larger cohorts are required.展开更多
To achieve a maximum compression of system matrix in positron emission tomography (PET) image reconstruction, we proposed a polygonal image pixel division strategy in accordance with rotationally symmetric PET geometr...To achieve a maximum compression of system matrix in positron emission tomography (PET) image reconstruction, we proposed a polygonal image pixel division strategy in accordance with rotationally symmetric PET geometry. Geometrical definition and indexing rule for polygonal pixels were established. Image conversion from polygonal pixel structure to conventional rectangular pixel structure was implemented using a conversion matrix. A set of test images were analytically defined in polygonal pixel structure, converted to conventional rectangular pixel based images, and correctly displayed which verified the correctness of the image definition, conversion description and conversion of polygonal pixel structure. A compressed system matrix for PET image recon was generated by tap model and tested by forward-projecting three different distributions of radioactive sources to the sinogram domain and comparing them with theoretical predictions. On a practical small animal PET scanner, a compress ratio of 12.6:1 of the system matrix size was achieved with the polygonal pixel structure, comparing with the conventional rectangular pixel based tap-mode one. OS-EM iterative image reconstruction algorithms with the polygonal and conventional Cartesian pixel grid were developed. A hot rod phantom was detected and reconstructed based on these two grids with reasonable time cost. Image resolution of reconstructed images was both 1.35 mm. We conclude that it is feasible to reconstruct and display images in a polygonal image pixel structure based on a compressed system matrix in PET image reconstruction.展开更多
文摘随着油气勘探程度的不断提高,已陆续发现一些以火山岩和火山碎屑岩为储集层的油气田。但是,由于火山岩对地震信号屏蔽作用明显,地震波在不同层系、不同类型火山岩中的速度差异大,导致火山岩发育区的速度建模和成像极其困难。EP地区处于阳江—一统断裂带,资源潜力大,且发育大量构造圈闭,同时,该地区发育古近系及上覆地层的多期火山岩,以往处理成果中火山岩内幕成像不清晰,难以刻画火山岩相和准确评估火山岩对油气生、储、盖条件的影响。为此,针对火山岩多次波压制、火山岩下弱信号恢复、火山岩速度精细刻画等方面的关键问题开展新的处理技术探索。首先采用MWD(Model based Water-layer related Demultiple)技术预测火山岩多次波;然后利用AVO剩余振幅补偿和低频算子外推随机噪声衰减技术提高火山岩下弱信号质量;最后,联合应用初至波层析和反射波网格层析技术构建精确的叠前深度偏移速度模型。重处理后的叠前深度偏移成果显示,火山岩及下伏地层成像质量显著提高,表明所提重处理技术方案对提高火山岩发育区地震成像质量有较好的借鉴意义。
基金Supported by Natinoal Academy of Medical Sciences, Bir Hospital, Nepal
文摘AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable.
基金financial support for this work contributed by the National Key Research and Development Program of China(grant nos.2016YFC0600302,2016YFC0600101 and 2016YFC0600201)the National Natural Science Foundation of China(grants 41604075,41430213,41574092 and 41474068)
文摘Irregular surface flattening,which is based on a boundary conforming grid and the transformation between curvilinear and Cartesian coordinate systems,is a mathematical method that can elegantly handle irregular surfaces,but has been limited to obtaining first arrivals only.By combining a multistage scheme with the fast-sweeping method(FSM,the method to obtain first-arrival traveltime in curvilinear coordinates),the reflected waves from a crustal interface can be traced in a topographic model,in which the reflected wavefront is obtained by reinitializing traveltimes in the interface for upwind branches.A local triangulation is applied to make a connection between velocity and interface nodes.Then a joint inversion of first-arrival and reflection traveltimes for imaging seismic velocity structures in complex terrains is presented.Numerical examples all perform well with different seismic velocity models.The increasing topographic complexity and even use of a high curvature reflector in these models demonstrate the reliability,accuracy and robustness of the new working scheme;checkerboard testing illustrates the method's high resolution.Noise tolerance testing indicates the method's ability to yield practical traveltime tomography.Further development of the multistage scheme will allow other later arrivals to be traced and used in the traveltime inversion.
文摘AIM:To present the outcome of modified grid laser photocoagulation(GLP)in diffuse diabetic macular edema(DDME)in eyes without extrafoveal and/or vitreofoveal traction.METHODS:Inclusion criteria for the retrospective study were DDME eyes of patients with typeⅡdiabetes mellitus that had≥4 months of follow-up following GLP.Only one eye per patient was analyzed.Using 3-D spectral-domain optical coherence tomography(3-D SDOCT),eyes that had either extrafoveal or vitreofoveal traction,or had been previously treated by an intravitreal medication(s)were excluded.Treated DDME eyes were divided into 4 groups:A)"Classic"DDME that involved the central macula;B)edema did not involve the macular center;C)eyes associated with central epiretinal membrane(ERM);D)DDME that was associated with macular capillary dropout≥2 disc-diameter(DD).RESULTS:GLP outcome in 35 DDME eyes after 4-24(mean,13.1±6.9)months was as follows:Group A)18eyes with"classic"DDME.Following one or 2(mean,1.2)GLP treatments,best-corrected visual acuity(BCVA)improved by 1-2 Snellen lines in 44.4%(8/18)of eyes,and worsened by 1 line in 11.1%(2/18).Central macular thickness(CMT)improved by 7%-49%(mean,26.6%)in77.8%(14/18)of eyes.Causes of CMT worsening(n=4)were commonly explainable,predominantly(n=3)associated with emergence of extrafoveal traction,5-9months post-GLP.Group B)GLP(s)in DDME that did not involve the macular center(n=6)resulted in improved BCVA by 1-2 lines in 2 eyes.However,the central macula became involved in the edema process after the GLP in 3(50%)eyes,associated with an emergence of extrafoveal traction in one of these eyes 4months following the GLP.Group C)GLP failed in all 5eyes associated with central ERM.Group D)GLP was of partial benefit in 2 of 6 treated eyes with macular capillary dropout≥2DD.CONCLUSION:Eyes with DDME that involved the macular center were found to achieve favourable outcomes after GLP(s)during mid-term follow-up,unless complicated pre-GLP or post-GLP by vltreoretinal interface abnormalities,often extrafoveal traction or ERM,or by capillary dropout≥2DD.Prospective studies with larger cohorts are required.
基金Supported by Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry and National Natural Science Foundation of China(No.10975086)
文摘To achieve a maximum compression of system matrix in positron emission tomography (PET) image reconstruction, we proposed a polygonal image pixel division strategy in accordance with rotationally symmetric PET geometry. Geometrical definition and indexing rule for polygonal pixels were established. Image conversion from polygonal pixel structure to conventional rectangular pixel structure was implemented using a conversion matrix. A set of test images were analytically defined in polygonal pixel structure, converted to conventional rectangular pixel based images, and correctly displayed which verified the correctness of the image definition, conversion description and conversion of polygonal pixel structure. A compressed system matrix for PET image recon was generated by tap model and tested by forward-projecting three different distributions of radioactive sources to the sinogram domain and comparing them with theoretical predictions. On a practical small animal PET scanner, a compress ratio of 12.6:1 of the system matrix size was achieved with the polygonal pixel structure, comparing with the conventional rectangular pixel based tap-mode one. OS-EM iterative image reconstruction algorithms with the polygonal and conventional Cartesian pixel grid were developed. A hot rod phantom was detected and reconstructed based on these two grids with reasonable time cost. Image resolution of reconstructed images was both 1.35 mm. We conclude that it is feasible to reconstruct and display images in a polygonal image pixel structure based on a compressed system matrix in PET image reconstruction.
