Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effe...Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effects, similar to the thermal action of conventional hyperthermia combined with ionizing radiation (radiotherapy). The electric field and the radiofrequency current produced both the thermal and nonthermal processes. The thermal effects produce the elevated temperature as a thermal background to optimize the nonthermal impacts. The low frequency amplitude modulation ensures accurate targeting and promotes immunogenic cell death to develop the tumor specific memory T cells disrupting the malignant cells by immune surveillance. This process (abscopal effect) works like a vaccination. The low frequency amplitude modulation is combined in the new method with the high power pulses for short time, increasing the tumor distortion ability of the electric field. The new modulation combination has much deeper penetration triplicating the active thickness of the effective treatment. The short pulse absorption increases the safety and decreases the thermal toxicity of the treatment, making the treatment safer. The increased power allows for reduced treatment time with the prescribed dose.展开更多
The new 1 kW power module for ADS project needs the optimization of cooling design including water flow and tunnel layout, and the water flow of three tons per hour was chosen to be a goal for a 20 kW power source.Acc...The new 1 kW power module for ADS project needs the optimization of cooling design including water flow and tunnel layout, and the water flow of three tons per hour was chosen to be a goal for a 20 kW power source.According to analysis from the insertion and integrated loss, about 24 modules were integrated into the rated power. Thus, every module has a cooling flow of 2.1 L/min for RF heat load and power supply loss, which is very hard to achieve if no special consideration and techniques. A new thermal simulation method was introduced for thermal analysis of cooling plate through CST multi-physics suite,especially for temperature of power LDMOS transistor.Some specific measures carried out for the higher heat transfer were also presented in this paper.展开更多
This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the of...This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the off-axis integrated cavity output spectroscopy technique,and a high-precision dual modulation OA-ICOS(RF-WM-OA-ICOS)system was established.The two laser beams were coupled into one laser beam that was applied incident to the cavity of RF-WM-OA-ICOS system.The second harmonic signals of CH_(4)and CO_(2)gas simultaneously appeared in the rising or falling edge of a triangular wave.This method was used to measure CH_(4)and CO_(2)with different concentrations.The results indicated that the proposed system has high stability and can accurately and simultaneously measure the concentrations of CH_(4)and CO_(2),with an optimal integration time of 220 s.The minimum detection limit was 10 ppb for CH_(4)and 1.5 ppm for CO_(2).The corresponding noise equivalent absorption sensitivity values were calculated as 2.67×10^(-13)cm^(-1)·Hz^(-1/2)and 5.18×10^(-11)cm^(-1)·Hz^(-1/2),respectively.The proposed dual-component gas simultaneous detection method can also be used for high-precision simultaneous detection of other gases.Therefore,this study may serve as a reference for developing portable multicomponent gas analyzers.展开更多
依据欧洲电信标准协会(ETSI)提出的ETSI EN 300 401标准,设计了一种高性能DAB接收终端RF接收模块的设计方法,实现了DAB信号稳定同步和接收,达到了高灵敏度和低功耗,在移动速度达到200 km/h时能够稳定接收。该设计方法已经用于批量生产的...依据欧洲电信标准协会(ETSI)提出的ETSI EN 300 401标准,设计了一种高性能DAB接收终端RF接收模块的设计方法,实现了DAB信号稳定同步和接收,达到了高灵敏度和低功耗,在移动速度达到200 km/h时能够稳定接收。该设计方法已经用于批量生产的DAB接收终端中。展开更多
The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator frequencies.In this paper,non-ideal factors thatinfluence t...The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator frequencies.In this paper,non-ideal factors thatinfluence the performance of the quadrature modulator are considered,and solutions are accordingly taken inthe quadrature modulator design.A high-linear RF quadrature modulator with improved sideband suppressionand carrier leakage performance is presented in this work.The quadrature modulator implemented in the0.18-μm SiGe process uses the current bleeding technique to improve the general performance of the doublebalanced active Gilbert mixers.An on-chip prescaler followed by two cascaded limiting amplifiers is designed toprovide accurate quadrature local oscillator signals.Predrivers at quadrature baseband signal input ports areproposed to eliminate DC offsets.The measured sideband suppression achieves a performance of better than−43 dBc and carrier leakage is less than−38 dBm over the output RF frequency range of 30 MHz to 2.15 GHz.The output 1 dB compression point equals 11.4 dBm at 800 MHz.展开更多
文摘Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effects, similar to the thermal action of conventional hyperthermia combined with ionizing radiation (radiotherapy). The electric field and the radiofrequency current produced both the thermal and nonthermal processes. The thermal effects produce the elevated temperature as a thermal background to optimize the nonthermal impacts. The low frequency amplitude modulation ensures accurate targeting and promotes immunogenic cell death to develop the tumor specific memory T cells disrupting the malignant cells by immune surveillance. This process (abscopal effect) works like a vaccination. The low frequency amplitude modulation is combined in the new method with the high power pulses for short time, increasing the tumor distortion ability of the electric field. The new modulation combination has much deeper penetration triplicating the active thickness of the effective treatment. The short pulse absorption increases the safety and decreases the thermal toxicity of the treatment, making the treatment safer. The increased power allows for reduced treatment time with the prescribed dose.
基金supported by the ‘‘strategic priority research program’’ of the Chinese Academy of Sciences(No.XDA030205)
文摘The new 1 kW power module for ADS project needs the optimization of cooling design including water flow and tunnel layout, and the water flow of three tons per hour was chosen to be a goal for a 20 kW power source.According to analysis from the insertion and integrated loss, about 24 modules were integrated into the rated power. Thus, every module has a cooling flow of 2.1 L/min for RF heat load and power supply loss, which is very hard to achieve if no special consideration and techniques. A new thermal simulation method was introduced for thermal analysis of cooling plate through CST multi-physics suite,especially for temperature of power LDMOS transistor.Some specific measures carried out for the higher heat transfer were also presented in this paper.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62005108 and 62205134)the National Key Research and Development Program of China(Grant No.2022YFC2807701)the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province,China(Grant Nos.20KJB140009 and 21KJB140008)。
文摘This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the off-axis integrated cavity output spectroscopy technique,and a high-precision dual modulation OA-ICOS(RF-WM-OA-ICOS)system was established.The two laser beams were coupled into one laser beam that was applied incident to the cavity of RF-WM-OA-ICOS system.The second harmonic signals of CH_(4)and CO_(2)gas simultaneously appeared in the rising or falling edge of a triangular wave.This method was used to measure CH_(4)and CO_(2)with different concentrations.The results indicated that the proposed system has high stability and can accurately and simultaneously measure the concentrations of CH_(4)and CO_(2),with an optimal integration time of 220 s.The minimum detection limit was 10 ppb for CH_(4)and 1.5 ppm for CO_(2).The corresponding noise equivalent absorption sensitivity values were calculated as 2.67×10^(-13)cm^(-1)·Hz^(-1/2)and 5.18×10^(-11)cm^(-1)·Hz^(-1/2),respectively.The proposed dual-component gas simultaneous detection method can also be used for high-precision simultaneous detection of other gases.Therefore,this study may serve as a reference for developing portable multicomponent gas analyzers.
基金supported by the National Natural Science Foundation of Jiangsu Province(No.BK20211042)the National Natural Science Foundation of China(No.62174149)。
文摘The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator frequencies.In this paper,non-ideal factors thatinfluence the performance of the quadrature modulator are considered,and solutions are accordingly taken inthe quadrature modulator design.A high-linear RF quadrature modulator with improved sideband suppressionand carrier leakage performance is presented in this work.The quadrature modulator implemented in the0.18-μm SiGe process uses the current bleeding technique to improve the general performance of the doublebalanced active Gilbert mixers.An on-chip prescaler followed by two cascaded limiting amplifiers is designed toprovide accurate quadrature local oscillator signals.Predrivers at quadrature baseband signal input ports areproposed to eliminate DC offsets.The measured sideband suppression achieves a performance of better than−43 dBc and carrier leakage is less than−38 dBm over the output RF frequency range of 30 MHz to 2.15 GHz.The output 1 dB compression point equals 11.4 dBm at 800 MHz.
