Multi-functional photonic spin Hall effect sensor controlled by phase transition

Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.

One-step spraying method to construct superhydrophobic magnesium surface with extraordinary robustness and multi-functions

The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facilely fabricate the robust coating with multi-functions on magnesium alloys.The as-sprayed magnesium alloys surface is superhydrophobic with a static water contact angle(WCA)of 157.0°and a roll-off angle of 6.0°.Such surface has excellent mechanical,chemical and thermal stabilities,even undergoing various physical and chemical damages,including sand impact(10 gmin^(-1),≥20 min),water impact(2 impacts s^(-1),≥180 min),abrasion(1.00 kPa,≥25 cycles),peeling(≥2.15 kPa),high temperature(200°C,≥24 h),strong acidic/salty/basic media(p H=113)and organic-solvent immersion(ethanol and n-hexane,≥24 h),demonstrating brilliant robustness.Notably,the surface displays multi-functions of corrosion protection,anti-fouling and heat insulation,which will undoubtedly promote the much wider applications of magnesium alloys.

Design of Drilling and Riveting Multi-functional End Effector for CFRP and Aluminum Components in Robotic Aircraft Assembly

To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.

Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer

Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.

Multi-functional optical fiber sensor system based on a dense wavelength division multiplexer

We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.

A design and application of compound multi-functional sensor in wood-based panel processing

A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in details. The operational principles of different sensors, technical flow of manufacturing, development of software systems of special functions, and the assessments of technical specification were also be introduced. This sensor adopted many new technologies, such as the applications of piezoresistant effect and heat sensitive effect can effectively measure the pressure and temperature, digital signal processing technology was used to extract and treat signals, and resist interference, encapsulation technology was used to keep the normal run of sensor under a harsh environment. Thus, the on-line compound multi-functional temperature/pressure sensor can be applied better to supervise the production of wood-based panels. All technical specifications of the compound multi-functional sensor were tested and the results met the requirements of the equipments.

Quasi-distribution Appraisal about Finite Element Analysis of Multi-functional Structure Made of Honeycomb Sandwich Materials

A new appraisal method（QDA, quasi-distribution appraisal） which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-section Bezier curve. It is established by simulating the distribution histogram data obtained from the numerical finite element analysis values of a satellite component with sub-section Bezier curve. Being dealt with area normalization method, the simulation curve could be regarded as a kind of probability density function（PDF）, its mathematical expectation and the variance could be used to evaluate the result of finite element analysis. Numerical experiments have indicated that the QDA method demonstrates the intrinsic characteristics of the finite element analysis of multi-functional structure made of honeycomb sandwich materials, as an appraisal method, it is effective and feasible.

Fiber-Loop Ringdown Multi-Function Sensors

We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimental results. It has great potential for sensor applications.

Considering calcium-binding proteins in invertebrates: multi-functional proteins that shape neuronal growth

Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.

Analysis of Dynamic Cross Response between Spindles in a Dual Spindle Type Multi-Functional Turning Machine

In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.

Design and Development of a Multi-functional Laparoscopic Device

This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices.

Design and Development of a Forest Nursery, for the Enhancement of Multi-Functional Agriculture and for a Didactical Purpose

The experimental idea of the present project was elaborated in order to create a structure where different categories and institutions could collaborate, with the common aim to develop a sustainable and profitable agriculture in mountain and marginal areas. The target was the recovering of an abandoned agricultural site, throughout its re-organisation, re-qualification and auto-sustainability, involving local citizens. This approach was based on three further broad functions such as environmental, economic and social purposes. This cooperation, that allows the capitalization of local knowledge and the forging of relationships between local and external sources of expertise, information and advice, is fundamental to the future of existing rural communities, in particular in mountain areas. The model proposed, with the elaboration of a management software and technical agronomic sheets, could be an incentive for the activities already present in that region and to stimulate new ones. The enhancing of the native ecological system, the biodiversity tutelage and the valorization of the knowledge of the territory is the basic requirement for the successful of any land management.

Multi-Functioning in Virtual Monitoring of Thin-Walled Bridges

Multi-functioning in virtual monitoring and assessment of ultimate dynamics of thin-walled bridges is treated in present paper. The approach enables multiple functions in virtual monitoring of the bridges made of integrated thin-walled members with their hierarchical configuration. Theoretical, numerical and experimental in situ assessments of the problem are presented. Some results of structural application are submitted.

A Portable Multi-functional Real-time Digital Simulator Dedicated to Protective Relay Testing

The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can be widely used in not only concerning utilities but also manufacturers and research / certification institutes because of its many functions. The hardware architecture and software implementation of the simulator are described. The main features and functions of the simulator are also

悬吊推拿运动技术在改善青少年特发性脊柱侧弯患者椎旁肌不对称性中的作用

目的探讨悬吊推拿运动技术在改善青少年特发性脊柱侧弯(AIS)患者椎旁肌不对称性中的作用。方法选取2021年10月—2023年8月于山东中医药大学第二附属医院康复科就诊并符合纳入标准的AIS患者88例作为研究对象,采用随机数字表法分为对照组和试验组,每组44例。对照组参照德国Schroth脊柱侧弯三维矫正疗法进行常规康复训练,包括手法放松侧弯凹侧椎旁肌肌肉,“臀桥”“小燕飞”力量练习,施罗特体操包括“肌肉圆柱”“旋转坐位运动”“伸展运动”配合成角呼吸。试验组运用悬吊推拿运动技术治疗,主要包括在悬吊设备辅助下调节脊柱位置恢复脊柱中立位,以弹拨、按推等推拿手法往返作用于督脉、膀胱经行整体治疗和凸凹侧椎旁辨证补泻治疗,仰卧位、俯卧位和侧卧位的中立位控制训练,躯干屈伸、旋转、侧屈闭链运动训练。在治疗前和治疗4周后运用肌电生物反馈仪测量患者站立负重时椎旁肌的表面肌电图(sEMG),通过自带软件进行分析,采集均方根(RMS),并计算椎旁肌肉对称指数(PMSI=RMS凸/RMS凹);采用Cobb角评估患者脊柱侧弯的严重程度;采用躯干旋转角度(ATR)评估躯干的旋转程度、脊柱的功能和形态。结果治疗前,2组PMSI值、Cobb角、ATR值比较,差异均无统计学意义(P>0.05)。治疗4周后,试验组PMSI值为1.08(1.04,1.14),Cobb角为5(2,9)°,ATR值为2(1,3)°;对照组PMSI值为1.12(1.09,1.17),Cobb角为8.5(6,10)°,ATR值为2(2,3)°。组内比较,治疗后2组PMSI值均更接近1(P<0.05),Cobb角、ATR值均下降(P<0.05)。组间比较,治疗后试验组PMSI值、Cobb角改善效果均优于对照组,试验组PMSI值更接近1(P<0.05),Cobb角明显更低(P<0.05),但治疗后2组ATR值差异无统计学意义(P>0.05)。结论悬吊推拿运动技术可有效改善椎旁肌不对称性,达到降低患者的Cobb角的矫形目的,值得临床推广应用。

涡轮动力模拟器甩油盘热流模型与流场特性研究

甩油盘作为涡轮动力模拟器(TPS)的重要零件,能有效地促进模拟器内循环系统润滑油的回流,提高轴承的润滑性并降低系统温升,为整机安全可靠运行提供了基础性保障。为了解决TPS内循环系统润滑油的回流问题,对TPS甩油盘及其内部循环流道进行了研究。首先,确定了涡轮动力模拟器轴承发热量及散热系数随转速的变化、甩油盘内部流体控制方程和边界条件;然后,构建了一类TPS甩油盘及其内部循环流道的完整内循环热流模型,并对比了轴承处温度仿真结果与实验结果以确保模型的合理性;最后,数值仿真得到了不同转速下内部循环流道的温度场、压力场和速度场。研究结果表明:转速增加能显著引发系统内最高温度上升,甩油盘作用下的内循环流场温度变化较为平稳,典型工况条件下仿真与实验得到的最高温度相对误差最大为12.3%,表明了热流模型的合理性。研究结果对于指导TPS甩油盘结构设计和提高整机运行安全稳定性具有重要的价值。

RMUS术治疗混合性尿失禁中尿急症、急迫性尿失禁症状的疗效观察

目的探索经阴道经耻骨后无张力尿道中段吊带(RMUS)术治疗混合性尿失禁(MUI)中尿急症、急迫性尿失禁(UUI)症状的疗效。方法回顾性分析2018年1月—2020年12月上海交通大学医学院附属仁济医院采用RMUS术治疗的44例女性MUI患者的临床资料。44例患者术前压力诱发试验、尿道抬举试验均为阳性。27例患者术前完成国际尿失禁咨询委员会女性下尿路症状长问卷(ICIQ-FLUTS-LF)调查,44例患者接受尿动力学(UDS)检查,其中9例(20.5%)出现逼尿肌过度活动(DO)。所有患者RMUS术中均通过解剖定位调整吊带张力。分析手术治疗效果和患者尿失禁改善情况。结果本研究44例患者平均年龄(58.59±9.08)岁,身体质量指数24.71±2.77。术后2年完成电话随访40例,主观治愈率为85.0%(34/40)。在27例完成ICIQ-FLUTS-LF问卷的患者中,手术前后漏尿发生率[100%(27/27)vs.18.5%(5/27)]、压力性尿失禁(SUI)发生率[100%(27/27)vs.18.5%(5/27)]、UUI发生率[70.4%(19/27)vs.29.6%(8/27)]差异均具有统计学意义(P<0.05);患者手术前后夜尿(≥1次)、尿急症、尿痛、排尿踌躇、排尿费力、排尿中断、遗尿发生率差异无统计学意义(P>0.05)。根据术前UDS检查结果进行的患者亚组分析显示,术后2年DO组和无DO组患者的主观治愈率差异有统计学意义[(55.6%(5/9)vs.93.5%(29/31),P<0.05],且两组患者术后SUI发生率[66.7%(4/6)vs.4.8%(1/21)]和UUI发生率[66.7%(4/6)vs.19.0%(4/21)]差异均有统计学意义(P<0.05),但尿急症发生率[66.7%(4/6)vs.33.3%(7/21)]差异无统计学意义(P>0.05)。结论采用RMUS术治疗压力诱发试验和尿道抬举试验阳性的MUI患者有效,术后可改善患者的SUI和UUI症状,但对于尿急症无明显改善。此外,DO组患者术后2年的主观治愈率劣于无DO组。

E-house箱体及吊具的吊装过程受力数值计算

预装式变电站(E-house)作为电网重要的电能传输枢纽,已经被广泛应用。在安装施工过程中,箱体质量、吊具结构、吊装速度等因素均会引起箱体形变的发生,导致设备的损坏。为了解决该问题,对所设计的9.8 m×3.2 m尺寸的E-house箱体及吊具结构进行吊装受力分析,并利用有限元方法分析了吊装结构和箱体的应力变形,确定了吊具和箱体易变形损坏部位。计算结果表明,为减少轴向压力对吊具的影响,钢丝绳安全夹角应控制在60°以内,安全的吊装速度应控制在1 m/s以下。研究结果可以为后续的箱体结构设计与优化提供理论参考。

悬吊训练结合功能电刺激对脑卒中偏瘫上肢功能的影响

目的分析悬吊训练(SET)结合功能电刺激(FES)对脑卒中偏瘫上肢功能的影响。方法选取杭州市红十字会医院2020年11月至2022年12月脑卒中偏瘫患者70例,采用随机抽签法分为3组:实验组24例、对照组A 23例、对照组B 23例。3组均接受常规康复治疗,对照组A给予FES治疗,对照组B给予SET治疗,实验组给予SET联合FES治疗。4周后,比较3组Brunnstrom分期,上肢运动功能(FMA-UE)评分,视觉模拟评分(VAS),改良Barthel指数(MBI),肩关节活动度(前屈、外展、外旋、内旋),肩手肌群平均肌电值(三角肌前束、斜方肌上束)。结果治疗后实验组Brunnstrom V期改善程度大于对照组A、对照组B(P<0.05);治疗后实验组FMA-UE评分、MBI高于对照组A、对照组B,VAS低于对照组A、对照组B(P<0.05);治疗后实验组前屈、外展、外旋、内旋角度大于对照组A、对照组B(P<0.01);治疗后实验组三角肌前束、斜方肌上束平均肌电值高于对照组A、对照组B(P<0.01)。结论SET联合FES治疗脑卒中偏瘫可改善关节活动度,增强肌力,还可减轻患者疼痛程度,改善上肢功能,提升生活活动能力。