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Temporal and spatial evolution of global major grain trade patterns
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作者 Ziqi Yin Jiaxuan Hu +3 位作者 Jing Zhang Xiangyang Zhou Lingling Li Jianzhai Wu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期1075-1086,共12页
The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain ... The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks. 展开更多
关键词 grain trade pattern evolution complex network
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Impact of BRICS Trade Facilitation on China's Exports Using Cross-Border E-Commerce
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作者 Longling LI Kaimei CHEN Zijian LONG 《Asian Agricultural Research》 2024年第5期1-7,共7页
With the rapid growth of the global digital economy, cross-border e-commerce, as an emerging form of trade, has gradually become a powerful engine to promote the development of global trade. BRICS is an important forc... With the rapid growth of the global digital economy, cross-border e-commerce, as an emerging form of trade, has gradually become a powerful engine to promote the development of global trade. BRICS is an important force in the global economy, and the progress of the BRICS countries' trade facilitation level has an important impact on the global trade environment. This paper conducts an in-depth study of the dynamic changes in BRICS trade facilitation from 2013 to 2022, and uses an extended gravity model to analyze the specific impact of this change on China's exports using cross-border e-commerce. The results show that although the BRICS countries have made some progress in trade facilitation, the overall level still needs to be improved, and there are obvious differences among member countries. However, the improvement of trade facilitation among BRICS countries has undoubtedly brought significant positive effects to China's exports using cross-border e-commerce. 展开更多
关键词 trade facilitation BRICS Cross-border e-commerce Export trade
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World Trade Organization Reform and the Role of the Global South
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作者 Zhang Jianping 《Contemporary World》 2024年第2期24-28,共5页
Under the impact of unilateralism and protectionism,trade disputes among countries have increased in recent years,bringing uncertainty to global trade and jeopardizing the multilateral trading system.The World Trade O... Under the impact of unilateralism and protectionism,trade disputes among countries have increased in recent years,bringing uncertainty to global trade and jeopardizing the multilateral trading system.The World Trade Organization(WTO)plays a crucial role in the development of the global economy and trade.It also plays a key role in maintaining a fair,open and sustainable international trade environment,and provides a solid foundation for the development of global economy and trade.As the Global South has played an important role in promoting WTO reform and safeguarding the rights and interests of developing countries,it’s important to further strengthen its solidarity,actively participate in the reform of the global trade governance system and promote the building of a more open,fair and balanced global trade environment. 展开更多
关键词 TRADING trade WTO
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Facilitating Trade Across Borders
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作者 Wang Zhe 《China Report ASEAN》 2024年第4期23-25,共3页
“The Government Work Report noted that‘development of the New International Land-Sea Trade Corridor will be accelerated’,”stated Wei Zhaohui,member of the Standing Committee of the 14th National Committee of the C... “The Government Work Report noted that‘development of the New International Land-Sea Trade Corridor will be accelerated’,”stated Wei Zhaohui,member of the Standing Committee of the 14th National Committee of the Chinese People’s Political Consultative Conference(CPPCC)and director-general of the Guangxi International Expo Affairs Bureau,in an interview after the Second Session of the 14th National People’s Congress on March 5. 展开更多
关键词 trade stated INTERVIEW
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How Can Foreign Trade Be Stabilized?
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作者 Zhao Ailing 《China's Foreign Trade》 2024年第2期32-34,共3页
At an economy-themed press conference held on the day of the Second Session of the 14th National People's Congress,Minister of Commerce Wang Wentao admitted that the situation of foreign trade situation is still&q... At an economy-themed press conference held on the day of the Second Session of the 14th National People's Congress,Minister of Commerce Wang Wentao admitted that the situation of foreign trade situation is still"very severe"this year.When it comes to the future policies for stabilizing foreign trade,Wang Wentao said that the government will provide better financial services forforeign trade enterprises. 展开更多
关键词 trade ENTERPRISES admitted
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Policies Aiming at Stabilizing Foreign Trade Continue to Work
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作者 Lily Wang 《China's Foreign Trade》 2024年第3期23-25,共3页
On May 30,t he Ch ina Council for the Promotion of International Trade(CCPIT)held a regular press conference.Zhao Ping,the spokesperson for the CCPIT,said that since the beginning of this year,the number of issued ATA... On May 30,t he Ch ina Council for the Promotion of International Trade(CCPIT)held a regular press conference.Zhao Ping,the spokesperson for the CCPIT,said that since the beginning of this year,the number of issued ATA Carnets has increased significantly,reflecting the fact that China’s foreign trade policy portfolio is taking effect,foreign trade enterprises have been more active,and their motivation and enthusiasm for expanding the international market have continued to rise. 展开更多
关键词 trade ENTERPRISES continued
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The Tenth Anniversary of Free Trade Pilot Zones in China:Fundamental Experiences and Enhancement Strategies
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作者 Pei Changhong 《China Economist》 2024年第3期2-20,共19页
Since the 18th National Congress of the Communist Party of China,the country has established 21 Free Trade Pilot Zones(FTZs),achieving significant pioneering results in reform and opening up and creating a strong demo... Since the 18th National Congress of the Communist Party of China,the country has established 21 Free Trade Pilot Zones(FTZs),achieving significant pioneering results in reform and opening up and creating a strong demonstrative effect nationwide.The basic experience from a decade of FTZs includes:adhering to the centralized and unified leadership of the CPC Central Committee;combining top-level design with encouragement of grassroots innovation;leveraging the distinct characteristics and strengths of FTZs to form a differentiated development pattern;maintaining the integration of opening up with domestic reforms;using openness to drive reforms;and organically combining openness with national security assurance.Under the current and future new circumstances,China’s FTZs face new challenges and tasks.In accordance with the directives of the 20th National Congress of the Communist Party of China,an enhancement strategy for the FTZs needs to be implemented.This involves the following:First,accurately understanding and responding to the changing situation to create strategic opportunities.Second,shifting paradigms to implement innovation-driven strategies,using the new development pattern concept to guide the reform experiments and construction of the FTZs.Third,granting more autonomy to FTZs for reforms,pursuing progress while maintaining stability,and solidly advancing the reform experiments in the FTZs.Fourth,orderly expanding the opening up of the service sector and cautiously advancing the internationalization of the renminbi.Fifth,promoting innovative development in trade to build a strong trade nation.Sixth,establishing synergy with bilateral FTZs,Belt and Road cooperation,and national diplomatic strategies to enhance the linkage effect. 展开更多
关键词 Tenth anniversary of Free trade Pilot Zones experience summary enhancement strategy conception
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Analysis of the Impact of Technical Trade Barriers on the Export of Toys-Based on Analysis of Zhejiang,China
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作者 LIU Ningning CHEN Xiaoxi 《Chinese Business Review》 2024年第1期37-46,共10页
Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This art... Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This article aims to explore the impact of technical trade barriers on toy exports in Zhejiang Province and analyze countermeasures.Through literature review and some empirical analysis,it is found that technical trade barriers have greatly promoted the development of Zhejiang’s toy industry;however,they have also subjected it to impacts and pressures such as cost and technology.In response to the impact of technical trade barriers on toy exports,this article proposes corresponding countermeasures to avoid such barriers:firstly,establish a quality management system that complies with export product regulations to ensure that the products produced can meet international requirements and standards;secondly,reduce dependence on overseas markets;then enhance one’s own technology,and strengthen product innovation,in order to enhance the international competitiveness of the product and oneself;in addition,we should also explore diversified markets and expand the sales channels and coverage of our products. 展开更多
关键词 technical trade barriers Zhejiang Province export of toys countermeasure analysis
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An analysis of agarwood trade patterns,historical perspectives,and species identification challenges:repercussions for importing nations
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作者 Zhao-Qi Xie Jun-Yu Xu +1 位作者 Muhammad Rafiq Chun-Song Cheng 《TMR Modern Herbal Medicine》 CAS 2024年第1期1-10,共10页
Background:Agarwood,primarily derived from the Aquilaria and Gyrinops genera,holds significant economic importance.However,there is a lack of comprehensive investigations providing guidance to importing nations regard... Background:Agarwood,primarily derived from the Aquilaria and Gyrinops genera,holds significant economic importance.However,there is a lack of comprehensive investigations providing guidance to importing nations regarding cultivation quantities and expected yields of Agarwood from distinct species.This study aims to address this gap by exploring the historical context and trade evolution of Agarwood,highlighting its global importance,and the challenges associated with securing accurate species information.Method:On-site visits to Agarwood cultivation sites were conducted to gain a nuanced understanding of Aquilaria species and their cultivation requirements.Additionally,a thorough analysis of global export and import data for Agarwood products over the last decade was undertaken.Results:China Mainland emerged as the leading exporter of Agarwood,averaging an annual export value of USD 1 million.India’s substantial exports challenge the prevailing notion of limited Agarwood production within its borders.Hong Kong and Singapore are pivotal distribution hubs,while Hong Kong and Taipei feature prominently as import destinations.Our analysis uncovers anomalies in the representation of Agarwood producers from 2001 to 2008,suggesting potential misclassification of Aquilaria Agarwood as Gyrinops in global export information.These findings underscore the urgency of investigating classification and reporting practices in the Agarwood trade.Furthermore,A.filaria emerges as a notable source,while A.malaccensis is decline in prominence.Conclusion:This study provides crucial insights for policymakers,stakeholders,and industry players seeking to make informed decisions in the Agarwood trade landscape.The results highlight the need for accurate species identification,classification,and reporting practices to ensure sustainable cultivation and trade of Agarwood. 展开更多
关键词 AGARWOOD import and export trends global trade field visits industry analysis
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Analysis of the Characteristics and Development Direction of Services Trade in Shandong Province of China
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作者 Huiqian Yu 《Proceedings of Business and Economic Studies》 2024年第1期139-144,共6页
Shandong is a significant province for foreign trade in China;however,it still faces shortcomings in the development of its service trade,as outlined below.Firstly,the scale of service trade is limited.Shandong’s ser... Shandong is a significant province for foreign trade in China;however,it still faces shortcomings in the development of its service trade,as outlined below.Firstly,the scale of service trade is limited.Shandong’s service trade volume ranked sixth in China in 2022,lagging considerably behind Shanghai,Guangdong,Beijing,Zhejiang,and Jiangsu.Secondly,the proportion of service trade in Shandong compared to the overall national services trade volume falls below the national average,with the per capita scale even lower than the national average.Thirdly,Shandong’s service trade accounts for less than 10% of the province’s foreign trade,which is 3 percentage points below the national average.The insufficient development of Shandong’s service trade is mainly attributed to the weak performance of its own service industry and the limited scale of attracting foreign services investment.Accelerating the development of producer services in Shandong,promoting the intelligent upgrading of consumer services,and continuously promoting reform and opening up in the service sector will be conducive to achieving high-quality development of services trade in Shandong. 展开更多
关键词 SHANDONG Services trade Productive services trade
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SWOT Analysis and Recommendations for Enhancing Sino-Russian Agricultural Trade Cooperation
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作者 Huilan Fang 《Proceedings of Business and Economic Studies》 2024年第2期163-169,共7页
With the outbreak of the Russian-Ukraine conflict,the changes in agricultural trade between China and Russia are receiving more and more attention.This study analyzes the current status of Sino-Russian agricultural tr... With the outbreak of the Russian-Ukraine conflict,the changes in agricultural trade between China and Russia are receiving more and more attention.This study analyzes the current status of Sino-Russian agricultural trade and employs a SWOT analysis to explore the strengths,weaknesses,opportunities,and threats within their agricultural trading activities.The findings suggest there are opportunities for further optimization and enhancement in the Sino-Russian agricultural trade.Based on this,suggestions proposed include accelerating the development of transportation hubs,facilitating agricultural trade,refining legal frameworks for agricultural exports,and expediting the establishment of economic cooperation zones. 展开更多
关键词 trade scale trade structure SWOT analysis Countermeasures and suggestions
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The Study of Mutual Benefits and Potential in China-Mongolia Agricultural Trade
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作者 Siriguleng Bao 《Proceedings of Business and Economic Studies》 2024年第3期200-205,共6页
This article aims to explore the mutual benefits and potential of agricultural trade between China and Mongolia,analyzing the current situation of agricultural resources,trade history,and policy environment of the two... This article aims to explore the mutual benefits and potential of agricultural trade between China and Mongolia,analyzing the current situation of agricultural resources,trade history,and policy environment of the two countries.The study finds that China-Mongolia agricultural trade shows significant economic complementarity.Trade activities not only promote economic growth in both countries but also deepen social and cultural exchanges.However,technical standards,political risks,and logistics costs remain major challenges facing trade cooperation.By strengthening policy coordination,investing in agricultural technology and infrastructure,and expanding the variety and markets of trade,the potential for cooperation in China-Mongolia agricultural trade can be further enhanced.These measures will help improve the efficiency and benefits of bilateral trade,achieving a win-win development. 展开更多
关键词 Agricultural trade MUTUALITY POTENTIAL Agricultural technology
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Research on the Threshold Effect of China’s Pharmaceutical Export Trade on Internal and External R&D Investment
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作者 Qiao Jiahui Song Yu +1 位作者 Gong Jingran Chen Yuwen 《Asian Journal of Social Pharmacy》 2024年第2期135-146,共12页
Objective To study the threshold effect of export trade on internal and external R&D investment in China’s pharmaceutical industry,and to provide reference for some pharmaceutical enterprises to improve the inves... Objective To study the threshold effect of export trade on internal and external R&D investment in China’s pharmaceutical industry,and to provide reference for some pharmaceutical enterprises to improve the investment.Methods The panel data of pharmaceutical industry in 25 provinces and cities in China from 2009 to 2019 were selected to conduct empirical analysis by establishing a threshold regression model,and a better export trade interval was obtained.Results and Conclusion There is a threshold value for the effect of new product export on both internal and external R&D expenditures,and the threshold values are 845.2788 million yuan and 318.4198 million yuan,respectively.There is a single threshold effect of export trade on both internal and external R&D investment in China’s pharmaceutical industry,and the effect of export trade on internal and external R&D investment changes from negative to positive as the export trade develops from low to high. 展开更多
关键词 pharmaceutical industry threshold effect export trade R&D investment
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分离膜的Trade-off效应及其突破研究进展
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作者 杨誉名 贾子钰 杨春维 《应用化工》 CAS CSCD 北大核心 2024年第6期1466-1468,共3页
综述通过文献调研,对膜材料在水通量与污染物截留效率之间存在的此消彼长的Trade-off效应进行分析,并对近几年国内外突破分离膜Trade-off效应的方法进行了总结。结果表明,膜表面接枝两性离子技术、非溶剂诱导相分离技术、结构改性技术... 综述通过文献调研,对膜材料在水通量与污染物截留效率之间存在的此消彼长的Trade-off效应进行分析,并对近几年国内外突破分离膜Trade-off效应的方法进行了总结。结果表明,膜表面接枝两性离子技术、非溶剂诱导相分离技术、结构改性技术、物理共混技术、表面涂覆技术等可以突破该技术瓶颈。而物理共混技术表现出非常优异的效果,且该技术方法相对简便,无需更新设备,易于实施,制备出的膜材料具有良好的机械性能和产水能力。综述为高效分离膜的开发提供了新的技术思路,为膜技术的应用和推广提供有益的技术借鉴。 展开更多
关键词 trade-off规律 膜材料 表面接枝法 表面涂覆法 掺杂法
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Innovative Exploration and Research on International Exchange and Cooperation Mechanisms under the Background of Hainan Free Trade Port
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作者 Xiaochao Yao 《Proceedings of Business and Economic Studies》 2024年第1期150-154,共5页
In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,... In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,characteristic demands,and potential challenges of its international exchange and cooperation mechanisms.Through a comprehensive analysis of relevant cases,survey questionnaires,and literature,this study aims to provide feasible innovative models and recommendations to promote the sustained development of the Hainan Free Trade Port in the field of international exchange and cooperation,injecting new vitality into China’s economic globalization.This exploration contributes to a deeper understanding of the development of free trade ports and provides insights and references for other countries and regions. 展开更多
关键词 Free trade port International exchange Cooperation mechanism
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Study on the Promotion of Digital Trade to Northeast Asian Regional Economy
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作者 Yating Mo Zhaoxia Zhang 《Proceedings of Business and Economic Studies》 2024年第1期162-168,共7页
Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating e... Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating every aspect of production and life.This penetration presents a rare opportunity for the development of digital trade and catalyzes innovation in traditional trade patterns.This paper first analyzes the inevitability of digital trade development in Northeast Asia.Secondly,it delves into the challenges faced by digital trade development and explores in-depth the promotion strategy for digital trade’s impact on the economic development of the Northeast Asia region,providing insights from various perspectives for reference. 展开更多
关键词 Digital trade Northeast Asian regional economy PROMOTION
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Trade-Offs and Synergie Effects of Regulating Ecosystem Services along an Climatic Gradient in Slovakia
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作者 Jarmila Makovníková Stanislav Kološta Boris Pálka 《Journal of Geoscience and Environment Protection》 2024年第6期135-150,共16页
This study aims to assess the synergies and trade-offs of regulating ecosystem services. Ecosystem services are non-linearly interconnected and changes in one service can positively or negatively affect another. We ev... This study aims to assess the synergies and trade-offs of regulating ecosystem services. Ecosystem services are non-linearly interconnected and changes in one service can positively or negatively affect another. We evaluated ecosystem services based on biophysical indicators using an expert scoring system that determines the corresponding soil functions and is part of the existing databases available in Slovakia. This methodological combination enabled us to provide unique mapping and assessment of ecosystem services within Slovakia. Correlation analysis between individual regulating ecosystem services and climate regions, slope, texture, and altitude confirm the statistically significant influence of climate and slope in all agricultural land, arable land, and grassland ecosystems. Statistically significant synergistic effects were established between the regulation of the water regime and the regulation of soil erosion within each climate region, apart from the very warm climate region. Only in a very warm climate region was potential of regulating ecosystem services mutually beneficial for soil erosion control and soil cleaning potential (immobilization of inorganic pollutants). 展开更多
关键词 Agroecosystem Services Climatic Zone MAPPING trade-Offs SYNERGIES
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One-step spraying method to construct superhydrophobic magnesium surface with extraordinary robustness and multi-functions 被引量:5
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作者 Lingjie Li Xia Li +5 位作者 Jinlong Chen Lei Liu Jinglei Lei Nianbing Li Gao Liu Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第2期668-675,共8页
The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facil... The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facilely fabricate the robust coating with multi-functions on magnesium alloys.The as-sprayed magnesium alloys surface is superhydrophobic with a static water contact angle(WCA)of 157.0°and a roll-off angle of 6.0°.Such surface has excellent mechanical,chemical and thermal stabilities,even undergoing various physical and chemical damages,including sand impact(10 gmin^(-1),≥20 min),water impact(2 impacts s^(-1),≥180 min),abrasion(1.00 kPa,≥25 cycles),peeling(≥2.15 kPa),high temperature(200°C,≥24 h),strong acidic/salty/basic media(p H=113)and organic-solvent immersion(ethanol and n-hexane,≥24 h),demonstrating brilliant robustness.Notably,the surface displays multi-functions of corrosion protection,anti-fouling and heat insulation,which will undoubtedly promote the much wider applications of magnesium alloys. 展开更多
关键词 Magnesium alloy Spraying method SUPERHYDROPHOBICITY ROBUSTNESS multi-functions
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Design of Drilling and Riveting Multi-functional End Effector for CFRP and Aluminum Components in Robotic Aircraft Assembly 被引量:6
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作者 Zhang Lin Tian Wei +4 位作者 Li Dawei Hong Peng Li Zhenyu Zhou Weixue Liao Wenhe 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第3期529-538,共10页
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc... To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength. 展开更多
关键词 robotic aircraft assembly CFRP and aluminum components automatic drilling and riveting multi-functional end effector online detection and adjustment
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Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer 被引量:1
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作者 Yang-Yang Wang Liang Li +4 位作者 Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第2期232-242,共11页
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo... Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer. 展开更多
关键词 Pancreatic cancer Folate receptor multi-functional Macropinocytosis-enhanced BIOCONJUGATE K-RAS PEGYLATION
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