Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal funct...Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's disease.Microtubule acetylation/deacetylation plays a central role in lysosomal acidification.Here,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's disease.Fu rthermore,we found that treatment with valproic acid markedly enhanced autophagy.promoted clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's disease.Our findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.展开更多
Over recent decades, Gampaha district, Sri Lanka, has experienced significant urbanisation and industrial growth, increasing groundwater demand due to limited and polluted surface water resources. In 2013, a community...Over recent decades, Gampaha district, Sri Lanka, has experienced significant urbanisation and industrial growth, increasing groundwater demand due to limited and polluted surface water resources. In 2013, a community uprising in Rathupaswala, a village in Gampaha district, accused a latex glove manufacturing factory of causing groundwater acidity (pH < 4). This study evaluates the spatial and temporal changes in geochemical parameters across three transects in the southern part of Gampaha district to 1) assess the impact of geological formations on groundwater;2) compare temporal variations in groundwater;and 3) explain acidification via a geochemical model. Seventy-two sample locations were tested for pH, electrical conductivity (EC), and anion concentrations (sulphate, nitrate, chloride and fluoride). Depth to the water table and distance from the sea were measured to study variations across sandy, peaty, lateritic, and crystalline aquifers. Results showed pH readings around 7 for sandy and crystalline aquifers, below 7 for peaty aquifers, and below 5 for lateritic aquifers, with significant water table fluctuations near Rathupaswala area. Principal component analysis revealed three principal components (PCs) explaining 86.0% of the variance. PC1 (40.6%) correlated with pH, EC, and sulphate (saltwater intrusion), while PC2 (32.0%) correlated with nitrates and depth to the water table (anthropogenic nutrient pollution). A geochemical transport model indicated a cone of depression recharged by acidic groundwater from peat-soil aquifers, leading to acidic groundwater in Rathupaswala area. Previous attributions of acidic pH to the over-exploitation of groundwater by the latex factory have been reevaluated;the results suggest natural acidification from prolonged water-rock interactions with iron-rich lateritic aquifers. Groundwater pH is influenced by local climate, geology, topography, and drainage systems. It is recommended that similar water-rock interaction conditions may be present throughout the wet zone of Sri Lanka, warranting detailed studies to confirm this hypothesis.展开更多
Effect of soil acidification on yield of late rice was studied and acid resistance of late rice varieties were compared with 23 late rice varieties as materials in Changsha County, Hunan Province. The results indicate...Effect of soil acidification on yield of late rice was studied and acid resistance of late rice varieties were compared with 23 late rice varieties as materials in Changsha County, Hunan Province. The results indicated that the difference in yield among varieties was obvious, yield in common field was among 5 226.6-9 202.1kg/hm^2, and yield in acidified field was among 3 643.2-7 714. 8 kg/hm^2. Compared with common field, yield of Yueyou 6135, Huayou 18, Jinyou 284 and Ⅱyou 46 increased by 3.24%-26.33% in acidified field, while yield of other varieties decreased by 2.04%-56.79% in acidified field. According to acidification sensitivity, Wufengyou T025, Jinchuyou No.148, Yueyou No.6135, Shenyou No.9586, Xiangfengyou No.103,Zhongyou No.288, Nongxiang No.18, Shanyou No.432, Ⅱ you No.6, and Zhong 9A/R10402 were sensitive to soil acidification; Wuyou No.308, Zhunliangyou No.608,Fengyuanyou No.227, Fengyou No.1167, Fengyuanyou No.299, T you No.272, and Zhong 9A/R9963 were moderately sensitive to soil acidification; Yueyou No.9113,Jinyou No.284, Shenyou No.9588, Huayou No.18, Ⅱ you No.46 and Ⅱ you No.3027 were slightly sensitive to soil acidification展开更多
INTRODUCTION Soil acidification due to acid deposition has been one of the major environmental prob-lems concerned by soil scientists and ecologists for the recent 20 years(van Breemen,1990).Soil acidification with a ...INTRODUCTION Soil acidification due to acid deposition has been one of the major environmental prob-lems concerned by soil scientists and ecologists for the recent 20 years(van Breemen,1990).Soil acidification with a marked pH decrease of forest soils within various time intervals hasbeen reported in Germany,Sweden,the Netherlands,Australia and the United展开更多
Both acid precipitation and unreasonable agricultural practices are notorious artificial factors resulting in soil acidification. To sort out reasonable agricultural practices favorable to abating soil acidification, ...Both acid precipitation and unreasonable agricultural practices are notorious artificial factors resulting in soil acidification. To sort out reasonable agricultural practices favorable to abating soil acidification, the task of this study was directed to a long-term field trial in Chongqing, dudng which chemical fertilizer, organic fertilizer were applied to different crop rotations and the soil pH value was measured. The results indicated that all treatments decreased pH value in the 0 to 20 cm soil layer after ten years. Problems were more serious when chlorine-containing fertilizer, excessive chemical fertilizer and mixed fertilizer were applied. It is demonstrated that balance rates of N, P and K fertilizers, application of muck in field are advantageous to abating soil acidification. Oil plants affect soil acidification more than cereal in different crop rotation.展开更多
The soil in Guangxi has been severely acidified,restricting sustainable development of agriculture.In this paper,based on the screening of organic fertilizer additives,a method for the production of acidification-resi...The soil in Guangxi has been severely acidified,restricting sustainable development of agriculture.In this paper,based on the screening of organic fertilizer additives,a method for the production of acidification-resistant organic fertilizer specific for acid red soil improvement was proposed,and the developed acidification-resistant organic fertilizer was used in sugarcane experiment.The results showed that in the treatment that the specific acidification-resistant organic fertilizer was applied,the yield of sugarcane significantly increased,the p H value of soil effectively increased,the physical and chemical properties of soil improved,and the contents of microorganisms and available nutrients in soil increased.展开更多
This study investigated estuarine acidification, associated with drainage and excavation of acid sulfate soils, in areas used for commercial cultivation of Sydneyrock oysters (Saccostrea glomerata). Regular measuremen...This study investigated estuarine acidification, associated with drainage and excavation of acid sulfate soils, in areas used for commercial cultivation of Sydneyrock oysters (Saccostrea glomerata). Regular measurements of pH and electrical conductivity were collected in oyster cultivation areas and acidified reaches of the Hastings River estuary and Port Stephens estuary located on the mid north coast of New South Wales, Australia. Water quality information from acidified floodplain drains was also collected in theHastingsRiverfollowing heavy rainfall. Both estuaries experienced acidification of tributaries following periods of heavy rainfall. Drain outflow waters were acidic展开更多
For the purpose of evaluating the role of ligand exchange of sulfate ions in retarding the rate of acidification of variable charge soils, the changes in pH after the addition of different amounts of HNO_3 or H_2SO_4 ...For the purpose of evaluating the role of ligand exchange of sulfate ions in retarding the rate of acidification of variable charge soils, the changes in pH after the addition of different amounts of HNO_3 or H_2SO_4 to representative soils of China were measured. A difrerence between pH changes caused by the two kinds of acids was observed only for variable charge soils and kaolinite, but not for consted charge soils and bentonite. The larger the proportion of H_2SO_4 in the HNO_3-H_2SO_4 mixture, the lower the calculated H￣+ ion activities remained in the suspension. The difference in H￣+ ion activities between H_2SO_4 systems and HNO_3 systems was larger for soils with a low base-saturation (BS) percentage than those with a high BS percentage. The removal of free iron oxides from the soil led to a decrease in the difference, while the coating of Fe_2O_3 ona bentonite resulted in a remarkable appearance of the difference. The effect of ligand exchange on the acidity status of the soil varied with the soil type. SurfaCe soils with a hash organic matter content showed a less pronounced effect of ligand exchange than subsoils did. It was estimated that when acid rain chiefly containing H_2SO_4 was deposited on variable charge soils the acidilication rate might be slower by 20%-40% than that when the acid rain chiefly contained HNO_3 for soils with a high organic matter content, and that the rate might be half of that caused by HNO_3 for soils with a low organic matter content, especially for latosols.展开更多
The buffer capacity of lakewaters and streamwaters in Southwesten China. where serious acidic precipitation has been found, and the changes of buffer capacity during the acidification were examined and analyzed. The r...The buffer capacity of lakewaters and streamwaters in Southwesten China. where serious acidic precipitation has been found, and the changes of buffer capacity during the acidification were examined and analyzed. The results show that the valuation of sensitivity to acidification of lakeweters and streamwaters often disagree with the actual circumstance only by the value of buffer capacity. “Acidification capacity”is firstly proposed to assess the sensitivity to acidification in this paper. Compared with other methods, this methods, this method not only can assess the sensitivity to acidification more effectively, but also can predict the time quantitatively when the acidificafion occures in lakewaters or streamwaters due to its consideration for the quantity of various components and their interrelation and interaction as far as possible.展开更多
Results from pot culture (with one-year old Cunninghamia lanceolata and Schima superba) are described. It was found that the biomass production and elongation of C. lanceolata was seriously inhibited at pH 2.0 rain, b...Results from pot culture (with one-year old Cunninghamia lanceolata and Schima superba) are described. It was found that the biomass production and elongation of C. lanceolata was seriously inhibited at pH 2.0 rain, but for S. superba, was not affected markedly. When pH values of experimental rain were higher than 2.0, the root growth of both species was not adversely affected. Aluminium had already accumulated to some degrees in the roots of both trees, and started to affect the root growth of C. lanceolata at pH 2.0 rain. The soil chemistry was also examined. Increased acidity of experimental rain increased the leaching of Ca and Mg. The Al/Ca mol ratio increased from 0.3 to 0.9 in top soil, and in rhizosphere to 1.5 when the pH values of simulated acid rain were 4.5 to 2.0. In this experiment, NO3- fertilization effect was discovered.展开更多
基金supported by the National Natural Science Foundation of China,No.82201582(to QT)Scientific and Technological Research Program of Chongqing Municipal Education Commission,No.KJQN202200457(to QT)+3 种基金General Project of Changqing Natural Science Foundation,No.cstc2021jcyjmsxmX0442(to ZL)CQMU Program for Youth Innovation in Future Medicine,No.W0044(to ZD and GH)Direct Research Project for PhD of Chongqing,No.CSTB2022BSXM-JCX0051(to ZL)the Project of the Top-Notch Talent Cultivation Program For the Graduate Students of Chongqing Medical University,No.BJRC202310(to CG)。
文摘Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's disease.Microtubule acetylation/deacetylation plays a central role in lysosomal acidification.Here,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's disease.Fu rthermore,we found that treatment with valproic acid markedly enhanced autophagy.promoted clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's disease.Our findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.
文摘Over recent decades, Gampaha district, Sri Lanka, has experienced significant urbanisation and industrial growth, increasing groundwater demand due to limited and polluted surface water resources. In 2013, a community uprising in Rathupaswala, a village in Gampaha district, accused a latex glove manufacturing factory of causing groundwater acidity (pH < 4). This study evaluates the spatial and temporal changes in geochemical parameters across three transects in the southern part of Gampaha district to 1) assess the impact of geological formations on groundwater;2) compare temporal variations in groundwater;and 3) explain acidification via a geochemical model. Seventy-two sample locations were tested for pH, electrical conductivity (EC), and anion concentrations (sulphate, nitrate, chloride and fluoride). Depth to the water table and distance from the sea were measured to study variations across sandy, peaty, lateritic, and crystalline aquifers. Results showed pH readings around 7 for sandy and crystalline aquifers, below 7 for peaty aquifers, and below 5 for lateritic aquifers, with significant water table fluctuations near Rathupaswala area. Principal component analysis revealed three principal components (PCs) explaining 86.0% of the variance. PC1 (40.6%) correlated with pH, EC, and sulphate (saltwater intrusion), while PC2 (32.0%) correlated with nitrates and depth to the water table (anthropogenic nutrient pollution). A geochemical transport model indicated a cone of depression recharged by acidic groundwater from peat-soil aquifers, leading to acidic groundwater in Rathupaswala area. Previous attributions of acidic pH to the over-exploitation of groundwater by the latex factory have been reevaluated;the results suggest natural acidification from prolonged water-rock interactions with iron-rich lateritic aquifers. Groundwater pH is influenced by local climate, geology, topography, and drainage systems. It is recommended that similar water-rock interaction conditions may be present throughout the wet zone of Sri Lanka, warranting detailed studies to confirm this hypothesis.
基金Supported by National Nature Science Foundation of China(31171494)Projects in the National Science&Technology Pillar Program(2011BAD16B01,2012BAD04B10-01,2013BAD07B11-02)~~
文摘Effect of soil acidification on yield of late rice was studied and acid resistance of late rice varieties were compared with 23 late rice varieties as materials in Changsha County, Hunan Province. The results indicated that the difference in yield among varieties was obvious, yield in common field was among 5 226.6-9 202.1kg/hm^2, and yield in acidified field was among 3 643.2-7 714. 8 kg/hm^2. Compared with common field, yield of Yueyou 6135, Huayou 18, Jinyou 284 and Ⅱyou 46 increased by 3.24%-26.33% in acidified field, while yield of other varieties decreased by 2.04%-56.79% in acidified field. According to acidification sensitivity, Wufengyou T025, Jinchuyou No.148, Yueyou No.6135, Shenyou No.9586, Xiangfengyou No.103,Zhongyou No.288, Nongxiang No.18, Shanyou No.432, Ⅱ you No.6, and Zhong 9A/R10402 were sensitive to soil acidification; Wuyou No.308, Zhunliangyou No.608,Fengyuanyou No.227, Fengyou No.1167, Fengyuanyou No.299, T you No.272, and Zhong 9A/R9963 were moderately sensitive to soil acidification; Yueyou No.9113,Jinyou No.284, Shenyou No.9588, Huayou No.18, Ⅱ you No.46 and Ⅱ you No.3027 were slightly sensitive to soil acidification
基金Project supported by the National Natural Science Foundation of China.
文摘INTRODUCTION Soil acidification due to acid deposition has been one of the major environmental prob-lems concerned by soil scientists and ecologists for the recent 20 years(van Breemen,1990).Soil acidification with a marked pH decrease of forest soils within various time intervals hasbeen reported in Germany,Sweden,the Netherlands,Australia and the United
基金Funded by Key Project on Ecologic Environment Protect Plan of Chongqing (20020307)
文摘Both acid precipitation and unreasonable agricultural practices are notorious artificial factors resulting in soil acidification. To sort out reasonable agricultural practices favorable to abating soil acidification, the task of this study was directed to a long-term field trial in Chongqing, dudng which chemical fertilizer, organic fertilizer were applied to different crop rotations and the soil pH value was measured. The results indicated that all treatments decreased pH value in the 0 to 20 cm soil layer after ten years. Problems were more serious when chlorine-containing fertilizer, excessive chemical fertilizer and mixed fertilizer were applied. It is demonstrated that balance rates of N, P and K fertilizers, application of muck in field are advantageous to abating soil acidification. Oil plants affect soil acidification more than cereal in different crop rotation.
基金Supported by Science and Technology Planning Project of Guangxi,China(Guike AD19245169,Guike AD18281072,Guike AA17202037,Guike AB16380164).
文摘The soil in Guangxi has been severely acidified,restricting sustainable development of agriculture.In this paper,based on the screening of organic fertilizer additives,a method for the production of acidification-resistant organic fertilizer specific for acid red soil improvement was proposed,and the developed acidification-resistant organic fertilizer was used in sugarcane experiment.The results showed that in the treatment that the specific acidification-resistant organic fertilizer was applied,the yield of sugarcane significantly increased,the p H value of soil effectively increased,the physical and chemical properties of soil improved,and the contents of microorganisms and available nutrients in soil increased.
文摘This study investigated estuarine acidification, associated with drainage and excavation of acid sulfate soils, in areas used for commercial cultivation of Sydneyrock oysters (Saccostrea glomerata). Regular measurements of pH and electrical conductivity were collected in oyster cultivation areas and acidified reaches of the Hastings River estuary and Port Stephens estuary located on the mid north coast of New South Wales, Australia. Water quality information from acidified floodplain drains was also collected in theHastingsRiverfollowing heavy rainfall. Both estuaries experienced acidification of tributaries following periods of heavy rainfall. Drain outflow waters were acidic
文摘For the purpose of evaluating the role of ligand exchange of sulfate ions in retarding the rate of acidification of variable charge soils, the changes in pH after the addition of different amounts of HNO_3 or H_2SO_4 to representative soils of China were measured. A difrerence between pH changes caused by the two kinds of acids was observed only for variable charge soils and kaolinite, but not for consted charge soils and bentonite. The larger the proportion of H_2SO_4 in the HNO_3-H_2SO_4 mixture, the lower the calculated H￣+ ion activities remained in the suspension. The difference in H￣+ ion activities between H_2SO_4 systems and HNO_3 systems was larger for soils with a low base-saturation (BS) percentage than those with a high BS percentage. The removal of free iron oxides from the soil led to a decrease in the difference, while the coating of Fe_2O_3 ona bentonite resulted in a remarkable appearance of the difference. The effect of ligand exchange on the acidity status of the soil varied with the soil type. SurfaCe soils with a hash organic matter content showed a less pronounced effect of ligand exchange than subsoils did. It was estimated that when acid rain chiefly containing H_2SO_4 was deposited on variable charge soils the acidilication rate might be slower by 20%-40% than that when the acid rain chiefly contained HNO_3 for soils with a high organic matter content, and that the rate might be half of that caused by HNO_3 for soils with a low organic matter content, especially for latosols.
文摘The buffer capacity of lakewaters and streamwaters in Southwesten China. where serious acidic precipitation has been found, and the changes of buffer capacity during the acidification were examined and analyzed. The results show that the valuation of sensitivity to acidification of lakeweters and streamwaters often disagree with the actual circumstance only by the value of buffer capacity. “Acidification capacity”is firstly proposed to assess the sensitivity to acidification in this paper. Compared with other methods, this methods, this method not only can assess the sensitivity to acidification more effectively, but also can predict the time quantitatively when the acidificafion occures in lakewaters or streamwaters due to its consideration for the quantity of various components and their interrelation and interaction as far as possible.
文摘Results from pot culture (with one-year old Cunninghamia lanceolata and Schima superba) are described. It was found that the biomass production and elongation of C. lanceolata was seriously inhibited at pH 2.0 rain, but for S. superba, was not affected markedly. When pH values of experimental rain were higher than 2.0, the root growth of both species was not adversely affected. Aluminium had already accumulated to some degrees in the roots of both trees, and started to affect the root growth of C. lanceolata at pH 2.0 rain. The soil chemistry was also examined. Increased acidity of experimental rain increased the leaching of Ca and Mg. The Al/Ca mol ratio increased from 0.3 to 0.9 in top soil, and in rhizosphere to 1.5 when the pH values of simulated acid rain were 4.5 to 2.0. In this experiment, NO3- fertilization effect was discovered.
