In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological a...In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.展开更多
Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this pa...Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this paper,the two components were separated.The monomeric compound was purified and its cytotoxic activity was determined.Methods:Silica gel column chromatography,ODS column chromatography,preparative thin layer chromatography,preparative and semi-preparative HPLC methods were used to separate and purify the total heptane components and total flavonoid components of galangal.Structures of compounds were identified by 1H-NMR,13C-NMR modern spectroscopic techniques combined with literature.The cytotoxic activity of the isolated compounds against MDA-MB-231(breast cancer),HepG-2(liver cancer)and MKN-45(gastric cancer)cells was tested by CCK-8 method.Results:Six compounds were isolated from the total heptane fractions of galangal,and three compounds were isolated from the total flavonoids of galangal.Their structures were identified as:5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one(1),(E)-7-(4-hydr-oxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one(2),5-hydroxy-1,7-diphenylheptan-3-one(3)7-(4-hydroxyphenyl)-5-methoxy-1-phenylheptan-3-one(4),(E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(5),(E)-1,7-diphenylhept-4-en-3-one(6),pinocembrin(7),galangin(8),3-O-methylgalangin(9).Conclusion:Compounds 1-6 were isolated from the total heptane components of galangal,and compounds 7-9 were isolated from the total flavonoids of galangal.The results of CCK-8 showed that compounds 2,3,5,6,7 and 8 had weak antitumor activity.展开更多
The impact of low-quality irrigation water on plant development has garnered significant attention from researchers. In light of this, two field experiments were conducted to evaluate the performance, yield, oil produ...The impact of low-quality irrigation water on plant development has garnered significant attention from researchers. In light of this, two field experiments were conducted to evaluate the performance, yield, oil production and composition, as well as active constituents of Rocket(Eruca sativa Mill) cultivated in calcareous soil under saline water irrigation. Foliar sprays containing condensed molasses soluble(CMS), zinc(Zn), and boron(B) alone or in combination were used for irrigation. The data obtained from measuring various parameters of Rocket following foliar spraying with CMS, Zn, B or their combinations demonstrated that most treatments resulted in a significant increase in these parameters. The highest values for most measurements were observed when foliar application included all three components(CMS + Zn + B), resulting in a seed yield of 184.6 g/m2and an oil content of 675.3 kg/ha. Compared to the control group, the macronutrient content of N, P, K, Mg, and Ca increased by 34.4%, 56%, 42%, 45%, and 39% respectively in the seeds treated with these components.Furthermore, carbohydrates, proteins, phenolics flavonoids, and antioxidants showed increases of 24%, 34%,21%, 43%, and 28% respectively compared to the control group. Gas-liquid chromatography analysis identified ten components present in the seed oil characterized by higher unsaturated fatty acids ranging from 81.28% to92.28% and lower saturated fatty acids ranging from 6.72% to 8.21%. Therefore, foliar spray application including CMS, zinc, and boron can help alleviate salinity effects on Rocket plants grown under saline water irrigation conditions while improving growth, yield, oil production, and nutritional content such as total carbohydrates, proteins, and macronutrients levels.展开更多
Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholi...Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.展开更多
A new chalcone glycoside, butein-4-methoxyl-4′-O-(6"-O-acetyl)-β-D-glucopyranoside(2), along with seven known compounds, namely, quercitrin(1), luteolin-7-O-β-D-glucopyranoside(3), butein-4'-O-β-D-glucop...A new chalcone glycoside, butein-4-methoxyl-4′-O-(6"-O-acetyl)-β-D-glucopyranoside(2), along with seven known compounds, namely, quercitrin(1), luteolin-7-O-β-D-glucopyranoside(3), butein-4'-O-β-D-glucopyranoside(4), butein-4-methoxyl-4'-O-β-D-glucopyranoside(5), butin-7-O-β-D-glucopyranoside(6), isoquercitrin(7), and sulfurein(8) was isolated from aerial parts of Bidens ceruna L. Their structures were elucidated on the basis of spectroscopic studies. Compounds 1-8 were tested for their DPPH radical scavenging activity and, except compounds 2 and 5, other compounds showed scavenging activitv.展开更多
The Phellinus mushrooms have been known for its immunomodulatory, hypolipidemic, and anticancer activities. In the current work, the chemical constituents of two Phellinus mushrooms, Phellinus pini 141016# and Phellin...The Phellinus mushrooms have been known for its immunomodulatory, hypolipidemic, and anticancer activities. In the current work, the chemical constituents of two Phellinus mushrooms, Phellinus pini 141016# and Phellinus sp. 150802#, which were collected in Foshan city, Guangdong province, were investigated preliminarily by pre-test tube method and by comparison with the known natural compounds from Phellinus pini, and their antioxidant activities were evaluated by the biochemical assay of hydroxyl and 2,2-diphenyl-1-pricylhydrazyl (DPPH) radicals scavenging activity in vitro. The results show that both the two Phellinus mushrooms contain phenolics, alkaloids, lactones, steroids and terpenoids, and have potent antioxidant activities. The IC50 values of DPPH radicals and hydroxyl radicals for Phellinus pini 141016# were 74.37 μg/mL and 59.69 μg/mL, respectively, and the IC50 values of DPPH radicals and hydroxyl radicals for Phellinus sp. 150802# were 98.95 μg/mL and 165.47 μg/mL, respectively. They are comparable to the antioxidant activity of the standard antioxidant ascorbic acid.展开更多
Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and...Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment.Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.展开更多
Objective:To determine the chemical composition of essential oils and lipid constituents of Ballola andreuzziana(B.andreuzziana),Teucrium zanonii(T.zanonii) and Verbena tenuisecta(V. tenuisecta) growing in Libya,and t...Objective:To determine the chemical composition of essential oils and lipid constituents of Ballola andreuzziana(B.andreuzziana),Teucrium zanonii(T.zanonii) and Verbena tenuisecta(V. tenuisecta) growing in Libya,and to test the antibacterial activity of different extracts of Teucrium zanonii.Methods:The volatile oils of all plants were extracted by hydrodistillation method and analyzed by GC/MS method.The lipid constituents of plants were obtained by extraction with petroleum ether and fractionated into fatty alcohols,fatty acids and unsapoinfiable matters. Antibacterial activity of T.zanonii extracts and antioxidant activity of different extracts of T. zanonii were also studied.Results:The volate oil of B.andreuzziana was found to consists of 20 compounds in which caryophyllin is the main one(63.1%),the volatile oil of T.zanonii consists of 74 compounds in which germacrene-D was the main compound,while the volatile oil of V. tenuisecta consists of 13 compounds with l-octen-3- ol as a major constituent(52.87%).The study of antimicrobial activity of different extracts of V.tenuisecta showed that,both methanol and butanol extracts exhibited the highest activity against Mycobacterium phlei(M.pblei) and Candida albicans(C.albicans) respectively,while petroleum ether,fatty alcohols and unsaponifiable fractions had no antimicrobial activity against all the tested microorganisms. Investigation of the antioxidant activity of different extracts of T.zanonii using DPPH method proved that,the ethyl acetate and butanol fractions showed the highest activity where the inhibition percentage(1%) are 93.6 and 92.1 respectively.Conclusions:This is the first report about the volatile oils of these plants where T.zanonii have the highest content and the highest number of the identified compounds.The study of antioxidant T.zanonii extracts proved that,the ethyl acetate,butanol and aqueous extracts have the highest antioxidant activity.Methanol and butanol extracts of V.tenuisecta exhibited the highest activity against M.phlei and C.albicans respectively.展开更多
Lonicerae flos,a widely used traditional Chinese medicine(TCM),has been used for several thousand years in China.As a famous traditional Chinese herbal medicine,it was used as heat-clearing drug and alexipharmic agent...Lonicerae flos,a widely used traditional Chinese medicine(TCM),has been used for several thousand years in China.As a famous traditional Chinese herbal medicine,it was used as heat-clearing drug and alexipharmic agent and was widely cultivated in Hunan province.L.flos mainly contains biologically active compounds such as caffeic acid derivatives,essential oil,flavonoids,iridoid glycosides and terpenoids.A range of biological activities has been reported from plant extracts including anti-inflammatory,antitumor,antioxidant,antiallergy,immunomodulating and antibacterial activity.In this study,the author investigated ancient books of TCM and nowadays reports,summarized the chemical constituents,biological activity of L.flos to provide a comprehensive systematic review.展开更多
Apostichopus japonicus Selenka is an ideal tonic food that is used traditionally in many Asian countries, and it contains many bioactive substances, such as antioxidant, antimicrobial, and anticancer materials. To con...Apostichopus japonicus Selenka is an ideal tonic food that is used traditionally in many Asian countries, and it contains many bioactive substances, such as antioxidant, antimicrobial, and anticancer materials. To convert waste liquid generated during production into a useful resource, extract from waste liquid was isolated by column chromatography and studied by the pyrogallol autoxidation and 1,10-phenanthroline-Fe^2+ oxidation methods. Results show that the extract scavenged about 91% of the superoxide anion radical at a concentration of 1.4 mg/mL and 24% of the hydroxyl radical at 3.3 mg/mL. Four compounds were isolated and identified from the extract: 2,4-dihydroxy-5-methyl-1,3-azine; 2,4-dihydroxy- 1,3-diazine; 3-O-β-D-quinovopranosyl-(1→2)-4-O-sodium sulfate-β-D-xylopranosyl]-holosta-9(11)-ene313,12β,17α-triol; and 24-ethyl-5α-cholesta-7-ene-3β-O-β-D-xylopyranoside. All of these compounds are known in A. japonicus, and were found in the waste liquid for the first time.展开更多
Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Act...Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.展开更多
[Objectives] To identify chemical constituents and antitumor activities of walnut green husk. [Methods] The column chromatography and recrystallization were used to isolate 13 compounds from walnut green husk, and the...[Objectives] To identify chemical constituents and antitumor activities of walnut green husk. [Methods] The column chromatography and recrystallization were used to isolate 13 compounds from walnut green husk, and their structures were identified by modern spectroscopy. [Results] The 13 kinds of compounds isolated from walnut green husk were identified as 3, 5-dimethoxy-4-hydroxy benzene carbonic-7-O-β-D-pyranglucose(1), myricananin F(2), β-stitosterol(3), oleanolic acid(4), regiolone(5), asiatic acid(6), hederagenin(7), β-daucosterin(8),(4 R)-4,8-dihydroxy-α-tetralone-4-O-β-D-glucopyranoside(9), 3β, 23-dihydroxy-urs-12-en-28-oic acid(10), ursolic acid(11), syringc acid(12), and Juglanoside B(13). Among these, compounds 1, 2, 6, 7, 9, and 10 were all isolated from this genus of plant for the first time. [Conclusions] Through screening for antitumor activity in vitro, it was found that compound 4 showed strong growth inhibitory activity against the proliferation of human hepatoma cells(HepG-2), and compound 9 had certain growth inhibitory activity against the proliferation of human breast cancer cells(MCF-7).展开更多
In recent years,a large number of studies have shown that the effective compounds extracted from Pholidota spp.have pharmacological activities such as anesthesia,analgesia,anti-fatigue,anti-hypoxia,anti-tumor and anti...In recent years,a large number of studies have shown that the effective compounds extracted from Pholidota spp.have pharmacological activities such as anesthesia,analgesia,anti-fatigue,anti-hypoxia,anti-tumor and anti-oxidant.Because of significant activity and small side effects,Pholidota spp.have attracted much attention.In this article,the effective chemical constituents and pharmacological activity of Pholidota spp.are reviewed comprehensively in order to provide reference for the further rational development of Pholidota spp.and development of new drugs.展开更多
Cancer chemoprevention, a desirable and important facet of biomedical research, provides a practical approach to identify potentially useful inhibitors of cancer development, and offers an opporiunity to study the me...Cancer chemoprevention, a desirable and important facet of biomedical research, provides a practical approach to identify potentially useful inhibitors of cancer development, and offers an opporiunity to study the mechanism of carcinogenesis. During the recent Past a number of compounds have been tested for their anticarcinogenic potential specially constituents of our diet. The enzyme γglutamyl transpeptidase (GGT) which catalyses the transfer of glutamyl groups of peptides to other peptides and amino acid and has been proposed as a marker of cell proliferation and neoplasia. It also serves as a tool to evaluate the carcinogenic and cocarcinogenic potential of environmental toxicants. In the present investigations, CGT activity induced by careinogenic polycyclic aromatic hydmiarbons, viz. 7, 12-dimethylbenz(a) anthracene (DMBA) and benzo(a) pyrene (BaP) was significantly inhibited by diallylsulfide (DAS) and indole-3-carbnol (I3C) in mouse skin. DAS and 13C are constituents of garlic and cruciferous vegetables respectively. A significant iIthibition in GGT levels was also observed in a strong mitogen (12-o-tetradecanoyl phorbol-13-acetate) induced activity in mouse skin by pretreatment with DAS/13C. Therefore these dietary constituents seem to be strong modifiers of chemically induced carcinogenesis展开更多
Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans...Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.展开更多
Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemic...Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.展开更多
Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures an...Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.展开更多
Solanum lyratum Thunb.belonging to the family Solanaceae,is a common Chinese herbal medicine in folk.It has been used for the treatment of colds,fever,jaundice hepatitis,cholecystitis,cholelithiasis,nephritis,edema an...Solanum lyratum Thunb.belonging to the family Solanaceae,is a common Chinese herbal medicine in folk.It has been used for the treatment of colds,fever,jaundice hepatitis,cholecystitis,cholelithiasis,nephritis,edema and cancer.Previous phytochemical studies on S.lyratum have led to the identification of many chemical constituents,including steroidal saponins,alkaloids,terpenoids,flavonoids,quinonoids,phenylpropanoids,organic acids and several other kinds of compounds,which showed diverse bioactivities,such as anticancer,anti-inflammatory and antioxidant activities.This paper summarized the primary chemical constituents and pharmacological effects of S.lyratum to provide reference for its further development and utilization.展开更多
Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding,burns and tumor.The congeners have similar effect.This study reviewed the recent research progress on the chemica...Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding,burns and tumor.The congeners have similar effect.This study reviewed the recent research progress on the chemical components and pharmacological activities of the genus Bletilla.The review summarized over 160 compounds isolated from the plants of genus Bletilla,including phenanthrenes,diphenanthrenes,bibenzyls,flavonoids and quinones.The plants of genus Bletilla have potent bioactivities,such as hemostatic activity,effect of promoting wound healing,antitumor activity and anti-inflammatory activity.Although a lot of compounds have been isolated from the genus Bletilla,pharmacological studies have been limited to anti-inflammatory and antibacterial activities.展开更多
Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collater...Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collaterals,clear heat and detoxicate.Its chemical components are complex and abundant,including mainly diterpenoids,sesquiterpenoids and flavonoids.Among them,diterpenoids are the main active components.Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory,anti-tumor,antithrombus and other pharmacological activities.This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases,in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards.展开更多
基金supported by the National Natural Science Foundation of China(81660649),and Innovative Scientific Research Project for Postgraduates of Hainan Medical University(HYYS2020-05)。
文摘In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.
基金Key R&D Projects in Hainan Province(ZDYF2022SHFZ127)National Natural Science Foundation of China(No.81660649)。
文摘Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this paper,the two components were separated.The monomeric compound was purified and its cytotoxic activity was determined.Methods:Silica gel column chromatography,ODS column chromatography,preparative thin layer chromatography,preparative and semi-preparative HPLC methods were used to separate and purify the total heptane components and total flavonoid components of galangal.Structures of compounds were identified by 1H-NMR,13C-NMR modern spectroscopic techniques combined with literature.The cytotoxic activity of the isolated compounds against MDA-MB-231(breast cancer),HepG-2(liver cancer)and MKN-45(gastric cancer)cells was tested by CCK-8 method.Results:Six compounds were isolated from the total heptane fractions of galangal,and three compounds were isolated from the total flavonoids of galangal.Their structures were identified as:5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one(1),(E)-7-(4-hydr-oxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one(2),5-hydroxy-1,7-diphenylheptan-3-one(3)7-(4-hydroxyphenyl)-5-methoxy-1-phenylheptan-3-one(4),(E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(5),(E)-1,7-diphenylhept-4-en-3-one(6),pinocembrin(7),galangin(8),3-O-methylgalangin(9).Conclusion:Compounds 1-6 were isolated from the total heptane components of galangal,and compounds 7-9 were isolated from the total flavonoids of galangal.The results of CCK-8 showed that compounds 2,3,5,6,7 and 8 had weak antitumor activity.
基金by the National Research Centre(NRC)the Fertilization Technology Department as part of the Egypt-German Project“Micronutrient and Other Plant Nutrition Problems”(Coordinator,Prof.Dr M.M.El-Fouly)Medicinal and Aromatic Plants Department,National Research Centre,El-Buhouth St.,12622,Dokki,Cairo,Egypt.
文摘The impact of low-quality irrigation water on plant development has garnered significant attention from researchers. In light of this, two field experiments were conducted to evaluate the performance, yield, oil production and composition, as well as active constituents of Rocket(Eruca sativa Mill) cultivated in calcareous soil under saline water irrigation. Foliar sprays containing condensed molasses soluble(CMS), zinc(Zn), and boron(B) alone or in combination were used for irrigation. The data obtained from measuring various parameters of Rocket following foliar spraying with CMS, Zn, B or their combinations demonstrated that most treatments resulted in a significant increase in these parameters. The highest values for most measurements were observed when foliar application included all three components(CMS + Zn + B), resulting in a seed yield of 184.6 g/m2and an oil content of 675.3 kg/ha. Compared to the control group, the macronutrient content of N, P, K, Mg, and Ca increased by 34.4%, 56%, 42%, 45%, and 39% respectively in the seeds treated with these components.Furthermore, carbohydrates, proteins, phenolics flavonoids, and antioxidants showed increases of 24%, 34%,21%, 43%, and 28% respectively compared to the control group. Gas-liquid chromatography analysis identified ten components present in the seed oil characterized by higher unsaturated fatty acids ranging from 81.28% to92.28% and lower saturated fatty acids ranging from 6.72% to 8.21%. Therefore, foliar spray application including CMS, zinc, and boron can help alleviate salinity effects on Rocket plants grown under saline water irrigation conditions while improving growth, yield, oil production, and nutritional content such as total carbohydrates, proteins, and macronutrients levels.
文摘Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.
文摘A new chalcone glycoside, butein-4-methoxyl-4′-O-(6"-O-acetyl)-β-D-glucopyranoside(2), along with seven known compounds, namely, quercitrin(1), luteolin-7-O-β-D-glucopyranoside(3), butein-4'-O-β-D-glucopyranoside(4), butein-4-methoxyl-4'-O-β-D-glucopyranoside(5), butin-7-O-β-D-glucopyranoside(6), isoquercitrin(7), and sulfurein(8) was isolated from aerial parts of Bidens ceruna L. Their structures were elucidated on the basis of spectroscopic studies. Compounds 1-8 were tested for their DPPH radical scavenging activity and, except compounds 2 and 5, other compounds showed scavenging activitv.
文摘The Phellinus mushrooms have been known for its immunomodulatory, hypolipidemic, and anticancer activities. In the current work, the chemical constituents of two Phellinus mushrooms, Phellinus pini 141016# and Phellinus sp. 150802#, which were collected in Foshan city, Guangdong province, were investigated preliminarily by pre-test tube method and by comparison with the known natural compounds from Phellinus pini, and their antioxidant activities were evaluated by the biochemical assay of hydroxyl and 2,2-diphenyl-1-pricylhydrazyl (DPPH) radicals scavenging activity in vitro. The results show that both the two Phellinus mushrooms contain phenolics, alkaloids, lactones, steroids and terpenoids, and have potent antioxidant activities. The IC50 values of DPPH radicals and hydroxyl radicals for Phellinus pini 141016# were 74.37 μg/mL and 59.69 μg/mL, respectively, and the IC50 values of DPPH radicals and hydroxyl radicals for Phellinus sp. 150802# were 98.95 μg/mL and 165.47 μg/mL, respectively. They are comparable to the antioxidant activity of the standard antioxidant ascorbic acid.
基金supported financially by the Bureau of Science and Technology of Kunming City.
文摘Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment.Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.
文摘Objective:To determine the chemical composition of essential oils and lipid constituents of Ballola andreuzziana(B.andreuzziana),Teucrium zanonii(T.zanonii) and Verbena tenuisecta(V. tenuisecta) growing in Libya,and to test the antibacterial activity of different extracts of Teucrium zanonii.Methods:The volatile oils of all plants were extracted by hydrodistillation method and analyzed by GC/MS method.The lipid constituents of plants were obtained by extraction with petroleum ether and fractionated into fatty alcohols,fatty acids and unsapoinfiable matters. Antibacterial activity of T.zanonii extracts and antioxidant activity of different extracts of T. zanonii were also studied.Results:The volate oil of B.andreuzziana was found to consists of 20 compounds in which caryophyllin is the main one(63.1%),the volatile oil of T.zanonii consists of 74 compounds in which germacrene-D was the main compound,while the volatile oil of V. tenuisecta consists of 13 compounds with l-octen-3- ol as a major constituent(52.87%).The study of antimicrobial activity of different extracts of V.tenuisecta showed that,both methanol and butanol extracts exhibited the highest activity against Mycobacterium phlei(M.pblei) and Candida albicans(C.albicans) respectively,while petroleum ether,fatty alcohols and unsaponifiable fractions had no antimicrobial activity against all the tested microorganisms. Investigation of the antioxidant activity of different extracts of T.zanonii using DPPH method proved that,the ethyl acetate and butanol fractions showed the highest activity where the inhibition percentage(1%) are 93.6 and 92.1 respectively.Conclusions:This is the first report about the volatile oils of these plants where T.zanonii have the highest content and the highest number of the identified compounds.The study of antioxidant T.zanonii extracts proved that,the ethyl acetate,butanol and aqueous extracts have the highest antioxidant activity.Methanol and butanol extracts of V.tenuisecta exhibited the highest activity against M.phlei and C.albicans respectively.
基金funding support from the Key Laboratory For Quality Evaluation of Bulk Herbs of Hunan Province and national science foundation of China (No.81374062 and No.81673579)
文摘Lonicerae flos,a widely used traditional Chinese medicine(TCM),has been used for several thousand years in China.As a famous traditional Chinese herbal medicine,it was used as heat-clearing drug and alexipharmic agent and was widely cultivated in Hunan province.L.flos mainly contains biologically active compounds such as caffeic acid derivatives,essential oil,flavonoids,iridoid glycosides and terpenoids.A range of biological activities has been reported from plant extracts including anti-inflammatory,antitumor,antioxidant,antiallergy,immunomodulating and antibacterial activity.In this study,the author investigated ancient books of TCM and nowadays reports,summarized the chemical constituents,biological activity of L.flos to provide a comprehensive systematic review.
基金Supported by the National Special Research Fund for Non-Profit Sector(Ocean)(No.201205025-5)
文摘Apostichopus japonicus Selenka is an ideal tonic food that is used traditionally in many Asian countries, and it contains many bioactive substances, such as antioxidant, antimicrobial, and anticancer materials. To convert waste liquid generated during production into a useful resource, extract from waste liquid was isolated by column chromatography and studied by the pyrogallol autoxidation and 1,10-phenanthroline-Fe^2+ oxidation methods. Results show that the extract scavenged about 91% of the superoxide anion radical at a concentration of 1.4 mg/mL and 24% of the hydroxyl radical at 3.3 mg/mL. Four compounds were isolated and identified from the extract: 2,4-dihydroxy-5-methyl-1,3-azine; 2,4-dihydroxy- 1,3-diazine; 3-O-β-D-quinovopranosyl-(1→2)-4-O-sodium sulfate-β-D-xylopranosyl]-holosta-9(11)-ene313,12β,17α-triol; and 24-ethyl-5α-cholesta-7-ene-3β-O-β-D-xylopyranoside. All of these compounds are known in A. japonicus, and were found in the waste liquid for the first time.
基金the National Natural Science Foundation of China(22177139)the Scientific Research Program of Hubei Provincial Department of Education,China(D20183001).
文摘Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.
基金Supported by Project of National Natural Science Foundation(81172953)
文摘[Objectives] To identify chemical constituents and antitumor activities of walnut green husk. [Methods] The column chromatography and recrystallization were used to isolate 13 compounds from walnut green husk, and their structures were identified by modern spectroscopy. [Results] The 13 kinds of compounds isolated from walnut green husk were identified as 3, 5-dimethoxy-4-hydroxy benzene carbonic-7-O-β-D-pyranglucose(1), myricananin F(2), β-stitosterol(3), oleanolic acid(4), regiolone(5), asiatic acid(6), hederagenin(7), β-daucosterin(8),(4 R)-4,8-dihydroxy-α-tetralone-4-O-β-D-glucopyranoside(9), 3β, 23-dihydroxy-urs-12-en-28-oic acid(10), ursolic acid(11), syringc acid(12), and Juglanoside B(13). Among these, compounds 1, 2, 6, 7, 9, and 10 were all isolated from this genus of plant for the first time. [Conclusions] Through screening for antitumor activity in vitro, it was found that compound 4 showed strong growth inhibitory activity against the proliferation of human hepatoma cells(HepG-2), and compound 9 had certain growth inhibitory activity against the proliferation of human breast cancer cells(MCF-7).
文摘In recent years,a large number of studies have shown that the effective compounds extracted from Pholidota spp.have pharmacological activities such as anesthesia,analgesia,anti-fatigue,anti-hypoxia,anti-tumor and anti-oxidant.Because of significant activity and small side effects,Pholidota spp.have attracted much attention.In this article,the effective chemical constituents and pharmacological activity of Pholidota spp.are reviewed comprehensively in order to provide reference for the further rational development of Pholidota spp.and development of new drugs.
文摘Cancer chemoprevention, a desirable and important facet of biomedical research, provides a practical approach to identify potentially useful inhibitors of cancer development, and offers an opporiunity to study the mechanism of carcinogenesis. During the recent Past a number of compounds have been tested for their anticarcinogenic potential specially constituents of our diet. The enzyme γglutamyl transpeptidase (GGT) which catalyses the transfer of glutamyl groups of peptides to other peptides and amino acid and has been proposed as a marker of cell proliferation and neoplasia. It also serves as a tool to evaluate the carcinogenic and cocarcinogenic potential of environmental toxicants. In the present investigations, CGT activity induced by careinogenic polycyclic aromatic hydmiarbons, viz. 7, 12-dimethylbenz(a) anthracene (DMBA) and benzo(a) pyrene (BaP) was significantly inhibited by diallylsulfide (DAS) and indole-3-carbnol (I3C) in mouse skin. DAS and 13C are constituents of garlic and cruciferous vegetables respectively. A significant iIthibition in GGT levels was also observed in a strong mitogen (12-o-tetradecanoyl phorbol-13-acetate) induced activity in mouse skin by pretreatment with DAS/13C. Therefore these dietary constituents seem to be strong modifiers of chemically induced carcinogenesis
文摘Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.
文摘Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.
文摘Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.
文摘Solanum lyratum Thunb.belonging to the family Solanaceae,is a common Chinese herbal medicine in folk.It has been used for the treatment of colds,fever,jaundice hepatitis,cholecystitis,cholelithiasis,nephritis,edema and cancer.Previous phytochemical studies on S.lyratum have led to the identification of many chemical constituents,including steroidal saponins,alkaloids,terpenoids,flavonoids,quinonoids,phenylpropanoids,organic acids and several other kinds of compounds,which showed diverse bioactivities,such as anticancer,anti-inflammatory and antioxidant activities.This paper summarized the primary chemical constituents and pharmacological effects of S.lyratum to provide reference for its further development and utilization.
文摘Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding,burns and tumor.The congeners have similar effect.This study reviewed the recent research progress on the chemical components and pharmacological activities of the genus Bletilla.The review summarized over 160 compounds isolated from the plants of genus Bletilla,including phenanthrenes,diphenanthrenes,bibenzyls,flavonoids and quinones.The plants of genus Bletilla have potent bioactivities,such as hemostatic activity,effect of promoting wound healing,antitumor activity and anti-inflammatory activity.Although a lot of compounds have been isolated from the genus Bletilla,pharmacological studies have been limited to anti-inflammatory and antibacterial activities.
基金This work was supported by the National Natural Science Foundation of China(No.81903789)the China Postdoctoral Science Foundation(No.2020M670675&No.2020M680988)College Student Innovation and Entrepreneurship Training Program(No.S202010163009).
文摘Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collaterals,clear heat and detoxicate.Its chemical components are complex and abundant,including mainly diterpenoids,sesquiterpenoids and flavonoids.Among them,diterpenoids are the main active components.Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory,anti-tumor,antithrombus and other pharmacological activities.This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases,in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards.