Foreign Experience and Enlightenment of Reimbursement Management of Multi-indication Drugs

Objective To provide reference for China’s medical insurance reimbursement plan of multi-indication drugs.Methods By referring to relevant foreign literature,the implementation process and conditions of different reimbursement management modes of multi-indication drugs were analyzed to provide suggestions for reimbursement of multi-indication drugs in China.Results and Conclusion It is suggested to further explore the suitable conditions and select the corresponding mode in China.Payment standards should be set according to value pricing and budget impact analysis.Besides,data collection and analysis mechanism must be improved.Lastly,reward and punishment mechanism can be adopted to improve management efficiency.

Optimization of Extraction Process for Longan(Dimocarpus longan Lour.)Leaves Using Multi-indicator Comprehensive Evaluation Method

[Objectives]This study aimed to optimize the extraction process of longan(Dimocarpus longan Lour.)leaves by multi-indicator comprehensive evaluation method.[Methods]The contents of gallic acid ethyl ester,astragalin,quercetin,luteolin and kaempferol in longan leaves were determined simultaneously by HPLC.Using the multi-indicator comprehensive evaluation method,the methanol concentration,solid to liquid ratio and extraction time for extraction of longan leaves were optimized by orthogonal test.[Results]The optimal extraction process of longan leaves are as follows:methanol concentration of 100%,solid to liquid ratio of 1∶5,and extraction time of 50 min.[Conclusions]The optimized process is simple and feasible,and it can be used to determine the contents of different ingredients in longan leaves.

Structural optimization design of semi-rigid base asphalt pavement using modulus matching criterion and multi-indicator range analysis

Damage to semi-rigid base asphalt pavement is related to improper matching of the pavement structure moduli.This study mainly focused on the modulus matching of structural layers and the development of a pavement structure optimization method.First,the modulus loss of existing pavement structures was analysed,and a three-dimensional finite element model was established based on the existing pavement.Second,the influence of the modulus of each structural layer on the mechanical response indicators and fatigue life was analysed.Based on the results,a pavement structure design method using the smoothness of the stress-strain curve as the modulus matching criterion of the structural layers was proposed.And it was found that a strain convex point was present and that the stress mutation between the structural layers was significant when the modulus matching of the pavement structure was reasonable.Further,the evaluation indicators were divided into two groups,namely,mechanical indicators and fatigue life indicators.And it was proposed an optimized pavement structure design method based on modulus matching and multi-indicator range analysis.Finally,the optimal modulus combination of pavement structure was determined by this method.The research systematically studied the influence of the modulus of each structural layer on the mechanical response and fatigue life of the pavement,and proposed the concept and specific executive criteria of modulus matching for the first time.Meanwhile,it also provided an effective optimization method for pavement structure design.

Optimization of Quality Control Method and Ethanol Extraction Process of Psoralen and Bergapten in Ficus pandurata

[Objectives]To establish a qualitative identification and content determination method for psoralen and bergapten in the roots and leaves of Ficus pandurata,and the multi-indicator scoring method to optimize the ethanol extraction process for the effective parts of F.pandurata.[Methods]Qualitative identification was carried out by thin-layer chromatography(TLC)and content determination was made by high-performance liquid chromatography(HPLC);the content of psoralen and bergapten and extract yield were used as indicators,to investigate the effects of ethanol volume fraction,solid-to-liquid ratio,extraction time and extraction times on the ethanol extraction process of F.pandurata;multi-indicator scoring method was adopted,orthogonal test method was designed to optimize the extraction process,and verification test was performed.[Results]TLC chart of F.pandurata shows clear spots and good separation;the detected concentrations of psoralen and bergapten in the roots are in the range of 1.02-32.64μg/mL and shows a good linear relationship with the peak area(r=0.9997);these components have not been detected in the leaves,and the precision,RSD of stability and repeatability test is less than 2%;the average recovery rate was 99.8%-100.2%,and the RSD value is 1.12%-1.13%(n=6);the optimized extraction process is to use 50%ethanol as the extraction solvent,the solid-to-liquid ratio of 1∶10,reflux extraction of 3 times,and 1.5 h each time;the results of the three batches of verification tests show that the content of the two indicator components obtained is high,and the average value of the total amount is 0.34 mg/g(RSD=0.30%,n=3).[Conclusions]The established quality control method for F.pandurata is simple,easy,accurate and reproducible;the preferred extraction process is stable and feasible,suitable for the extraction and purification of coumarin effective parts in F.pandurata roots,so it is expected to provide references for further development of F.pandurata.

CONSTRUCTION OF AN INDEX SYSTEM FOR SUSTAINABILITY ASSESSMENT IN SMALLHOLDER FARMING SYSTEMS

Smallholder farming systems are important for global food security,but these faces multiple environmental challenges hindering sustainable development.Although sustainable smallholder agriculture issues have been widely discussed and addressed by scientists globally,harmonized approaches in evaluating sustainability are still lacking.This paper proposes a five-step process for constructing a sustainability assessment method for smallholder farming systems,namely definition of system boundary&functional unit,indicator selection,indicator weighting,indicator conversion,and indicator aggregation.The paper summarizes the state-of-art progresses in agricultural sustainability assessment at different stages,and systematically discussed the benefits and limitations of weighting and aggregation methods.Overall,this evaluation process should be useful by providing rational and comprehensive results for quantifying the sustainability of smallholder farming systems,and will contribute to practice by providing decision-makers with directions for improving sustainable strategies.