Objective The aiom of the study was to compare the impacts of two types of multileaf collimators(MLC) [standard MLC with a width of 10 mm(s MLC) and micro-MLC with a width of 5 mm(m MLC)] on volumetric modulated arc t...Objective The aiom of the study was to compare the impacts of two types of multileaf collimators(MLC) [standard MLC with a width of 10 mm(s MLC) and micro-MLC with a width of 5 mm(m MLC)] on volumetric modulated arc therapy(VMAT) planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the s MLC and m MLC. Histogram-based dose-volume parameters of the planning target volume(PTV) [conformity index(CI) and homogeneous index(HI)] and organs-at-risk were compared for VMAT plans with s MLC(s MLC-VMAT) and m MLC(m MLC-VMAT). Results The m MLC-VMAT plans were more efficient(average delivery time: 2.67±1.49 min) than the s MLC-VMAT plans(average delivery time: 4.21 ± 2.03 min; P < 0.05). Moreover, compared to the s MLC plans, the m MLC plans demonstrated advantages in the dose coverage of the PTV(CI 0.75 ± 0.08 vs 0.73 ± 0.09; HI 1.09 ± 0.02 vs 1.10 ± 0.02), although the difference was not statistically significant(P > 0.05). In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving > 20 Gy(V20; 54.72 ± 27.08 vs 58.52 ± 29.30) and > 30 Gy(V30; 42.74 ± 27.86 vs 46.86 ± 31.49) radiation, respectively, was observed for the m MLC plans(P < 0.05). Conclusion Comparing s MLC-VMAT and m MLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of m MLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for malignant pleural mesothelioma.展开更多
目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 m...目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 mm MLC的Varian CX型加速器进行IMRT设计。比较两组计划的靶区均匀性指数(HI)、适形度指数(CI)、最大剂量、最小剂量、平均剂量以及危及器官剂量体积直方图的指标差异。结果配置5 mm MLC的Siemens Artiste加速器计划的靶区CI为0.88±0.02,优于配置10 mm MLC的Varian CX型加速器计划的0.85±0.03,差异有统计学意义(P=0.04);5 mm MLC和10 mm MLC计划靶区的HI分别为1.06±0.01和1.06±0.01,最大剂量分别为(64.54±6.10)Gy和(64.59±6.00)Gy,最小剂量分别为(51.60±5.94)Gy和(51.29±5.66)Gy,差异均无统计学意义(P>0.05)。两组计划的危及器官包括肺V_5、肺V_(20)、肺平均剂量、心脏平均剂量、脊髓最大剂量的差异均无统计学意义(P>0.05)。结论选择配置5 mm叶片宽度的Siemens Artiste加速器在完成肺癌IMRT计划中能更好地提高靶区适形度。展开更多
目的对微光刀立体定向放射治疗系统(Dual Camera 2 mm Stereotactic Radiosurgerg,D2SRS)临床剂量学可靠性进行测试、研究。方法随机选取20例已接受放射治疗的病例,其中包括7例颅内肿瘤、6例肺部肿瘤和7例肝癌病例,将20例病例的CT图像和...目的对微光刀立体定向放射治疗系统(Dual Camera 2 mm Stereotactic Radiosurgerg,D2SRS)临床剂量学可靠性进行测试、研究。方法随机选取20例已接受放射治疗的病例,其中包括7例颅内肿瘤、6例肺部肿瘤和7例肝癌病例,将20例病例的CT图像和RT Structures通过DICOM网络分别传输至雷泰Ti GRT计划系统和Eclipse11.0计划系统,进行放射治疗计划设计,统计两组靶区及危及器官的剂量学参数并进行统计学分析,将两组调强计划分别进行绝对剂量和二维面剂量验证,并比较两组计划的绝对剂量和二维平面剂量验证结果。结果两组计划均能满足临床剂量要求,靶区剂量学参数D_(98)、D_(50)、D_(02)、CI以及HI均无统计学差异(P>0.05);危及器官受照剂量如全脑、心脏、食管、肝脏和肾脏的D_(mean)、脑干和脊髓D_(max)、双肺V_(20)等剂量学参数均无统计学差异(P>0.05);Eclipse与Ti GRT两组计划的验证结果显示,点剂量误差统计结果为(0.70±1.44,0.57±1.86,t=0.268,P=0.796);二维面剂量Gamma分析统计结果为(96.8%±0.9%,97.3%±1.2%,t=2.031,P=0.056)。结论D2SRS在剂量精确性上达到同类型进口设备相似水平。展开更多
文摘Objective The aiom of the study was to compare the impacts of two types of multileaf collimators(MLC) [standard MLC with a width of 10 mm(s MLC) and micro-MLC with a width of 5 mm(m MLC)] on volumetric modulated arc therapy(VMAT) planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the s MLC and m MLC. Histogram-based dose-volume parameters of the planning target volume(PTV) [conformity index(CI) and homogeneous index(HI)] and organs-at-risk were compared for VMAT plans with s MLC(s MLC-VMAT) and m MLC(m MLC-VMAT). Results The m MLC-VMAT plans were more efficient(average delivery time: 2.67±1.49 min) than the s MLC-VMAT plans(average delivery time: 4.21 ± 2.03 min; P < 0.05). Moreover, compared to the s MLC plans, the m MLC plans demonstrated advantages in the dose coverage of the PTV(CI 0.75 ± 0.08 vs 0.73 ± 0.09; HI 1.09 ± 0.02 vs 1.10 ± 0.02), although the difference was not statistically significant(P > 0.05). In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving > 20 Gy(V20; 54.72 ± 27.08 vs 58.52 ± 29.30) and > 30 Gy(V30; 42.74 ± 27.86 vs 46.86 ± 31.49) radiation, respectively, was observed for the m MLC plans(P < 0.05). Conclusion Comparing s MLC-VMAT and m MLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of m MLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for malignant pleural mesothelioma.
文摘目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 mm MLC的Varian CX型加速器进行IMRT设计。比较两组计划的靶区均匀性指数(HI)、适形度指数(CI)、最大剂量、最小剂量、平均剂量以及危及器官剂量体积直方图的指标差异。结果配置5 mm MLC的Siemens Artiste加速器计划的靶区CI为0.88±0.02,优于配置10 mm MLC的Varian CX型加速器计划的0.85±0.03,差异有统计学意义(P=0.04);5 mm MLC和10 mm MLC计划靶区的HI分别为1.06±0.01和1.06±0.01,最大剂量分别为(64.54±6.10)Gy和(64.59±6.00)Gy,最小剂量分别为(51.60±5.94)Gy和(51.29±5.66)Gy,差异均无统计学意义(P>0.05)。两组计划的危及器官包括肺V_5、肺V_(20)、肺平均剂量、心脏平均剂量、脊髓最大剂量的差异均无统计学意义(P>0.05)。结论选择配置5 mm叶片宽度的Siemens Artiste加速器在完成肺癌IMRT计划中能更好地提高靶区适形度。
文摘目的对微光刀立体定向放射治疗系统(Dual Camera 2 mm Stereotactic Radiosurgerg,D2SRS)临床剂量学可靠性进行测试、研究。方法随机选取20例已接受放射治疗的病例,其中包括7例颅内肿瘤、6例肺部肿瘤和7例肝癌病例,将20例病例的CT图像和RT Structures通过DICOM网络分别传输至雷泰Ti GRT计划系统和Eclipse11.0计划系统,进行放射治疗计划设计,统计两组靶区及危及器官的剂量学参数并进行统计学分析,将两组调强计划分别进行绝对剂量和二维面剂量验证,并比较两组计划的绝对剂量和二维平面剂量验证结果。结果两组计划均能满足临床剂量要求,靶区剂量学参数D_(98)、D_(50)、D_(02)、CI以及HI均无统计学差异(P>0.05);危及器官受照剂量如全脑、心脏、食管、肝脏和肾脏的D_(mean)、脑干和脊髓D_(max)、双肺V_(20)等剂量学参数均无统计学差异(P>0.05);Eclipse与Ti GRT两组计划的验证结果显示,点剂量误差统计结果为(0.70±1.44,0.57±1.86,t=0.268,P=0.796);二维面剂量Gamma分析统计结果为(96.8%±0.9%,97.3%±1.2%,t=2.031,P=0.056)。结论D2SRS在剂量精确性上达到同类型进口设备相似水平。
