The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric a...The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric and natural gas systems,it is critical to enhance the load restoration capability of both systems.This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming(MISOCP)model.The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems,minimizing the total system load loss cost and repair time.In addition,a bi-directional gas flow model is used to describe the natural gas system,which can provide the RIENGS with more flexibility for load restoration during natural gas system failure.Finally,the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20.展开更多
Following injury in central nervous system(CNS),there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.T...Following injury in central nervous system(CNS),there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.The proliferation of a large number of astrocytes results in the formation of glial scar.展开更多
The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applie...The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applies image repair strategies to Qingdao municipal government departments' attempt to restore its damaged image in crisis communication.Through a discourse analysis,it is found that the government departments mainly adopt the following strategies: denial,evasion of responsibility(defeasibility),reduction of offensiveness(bolstering,compensation),corrective action and mortification.Then we evaluate the effectiveness of this image repair effort.展开更多
A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of a...A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of accidental load. This model takes the safety grade of a structural system as the state variable of repairing strategies, and incorporates economic factors including expected repair cost, property loss due to structure failure, goods and material loss due to structure failure, loss of production interrupt due to structure failure, and inspection cost in decision making. It is found that the optimal repairing strategies are sensitive to the probability of accidental loads as well as the failure costs. The practicality of the model is demonstrated by an example.展开更多
Neuronal regeneration in the peripheral nervous system arises via a synergistic interplay of neurotrophic factors,integrins,cytoskeletal proteins,mechanical cues,cytokines,stem cells,glial cells and astrocytes.
背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed...背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed数据库2000-2023年发表的文献,英文检索词为“gradient,bone regeneration,scaffold”,最终筛选后对76篇文献进行分析总结。结果与结论:①作为骨骼系统组织高效、高质量修复的重要手段,梯度人工骨修复支架目前针对骨组织、骨-软骨、肌腱-骨组织的天然梯度特征进行了仿生设计,这些支架能够一定程度地从结构、成分上模拟原生组织的细胞外基质,从而促进细胞黏附、迁移、增殖和分化,促进受损组织向原生状态再生恢复。②先进制造技术为梯度人工骨修复支架制备提供了更多可能;目前已经开发了通过空间差异化纤维排布和生物活性物质加载构建的梯度电纺纤维支架;分层叠加、分级孔隙率与生物3D打印技术制造的梯度3D打印支架;原位分层注射、简单逐层叠加、冷冻干燥法制造的梯度水凝胶支架;另外还包括其他方式或多方法联用的支架;这些支架在体外实验中展示了良好的生物相容性,在小型动物实验中能够加速组织再生并且观察到组织学结构明显改善。③目前开发的梯度人工骨修复支架仍需进一步优化,提高在梯度尺度上的匹配性,进一步明确材料与组织相互作用,避免降解产物导致的副反应等问题,未来需要结合相关学科优势与临床需求进一步优化。展开更多
Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials ...Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some regenerative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.展开更多
Low back pain has become more prevalent in recent years,causing enormous economic burden for society and government.Common therapies used in clinics including conservative treatment and surgery can only relieve pain.S...Low back pain has become more prevalent in recent years,causing enormous economic burden for society and government.Common therapies used in clinics including conservative treatment and surgery can only relieve pain.Subsequent cell-based treatment such as mesenchymal stem cell transplantation poses problems such as short duration of therapeutic effect and tumorigenesis.Recently,the discovery and identification of stem cell niche and stem/progenitor cells in intervertebral disc bring increased attention to endogenous repair strategy.Therefore,we review the studies involving endogenous repair strategy and present the characteristics and current status of this treatment.Meanwhile,we also discuss the strategy and perspective of endogenous repair strategy in future.展开更多
Food safety is one of the top issues for Chinese consumers. In the summer of 2014,Shanghai-based Husi Food Co Ltd was mired in a food-safety scandal. OSI Group responded to this situation by releasing statements and h...Food safety is one of the top issues for Chinese consumers. In the summer of 2014,Shanghai-based Husi Food Co Ltd was mired in a food-safety scandal. OSI Group responded to this situation by releasing statements and holding China press conference. This study focused on OSI Group's image repair strategies employed in the scandal in Chinese context. A content analysis revealed that OSI Group's image repair relied primarily on six strategies: defeasibility( appalled by the event),bolstering( factory in Henan is state-of-art),minimization( it was an isolated event),corrective action( thorough internal investigation),and mortification( sincerely apologized),and attacking the accuser( launched OSI Food Safety Education Campaign). Basically,OSI Group's mortification without compensation doomed its efforts to failure.Implications for implementing image repair strategies with the combination of crisis types are addressed.展开更多
There are issues with flexible DC transmission system such as a lack of control freedom over power flow.In order to tackle these issues,a DC power flow controller(DCPFC)is incorporated into a multi-terminal,flexible D...There are issues with flexible DC transmission system such as a lack of control freedom over power flow.In order to tackle these issues,a DC power flow controller(DCPFC)is incorporated into a multi-terminal,flexible DC power grid.In recent years,a multi-port DC power flow controller based on a modular multi-level converter has become a focal point of research due to its simple structure and robust scalability.This work proposes a model predictive control(MPC)strategy for multi-port interline DC power flow controllers in order to improve their steady-state dynamic performance.Initially,the mathematical model of a multi-terminal DC power grid with a multi-port interline DC power flow controller is developed,and the relationship between each regulated variable and control variable is determined;The power flow controller is then discretized,and the cost function and weight factor are built with numerous control objectives.Sub module sorting method and nearest level approximation modulation regulate the power flow controller;Lastly,theMATLAB/Simulink simulation platformis used to verify the correctness of the establishedmathematicalmodel and the control performance of the suggestedMPC strategy.Finally,it is demonstrated that the control strategy possesses the benefits of robust dynamic performance,multiobjective control,and a simple structure.展开更多
To realize effective utilization of renewable energy sources,a novel polymorphic topology with hybrid control strategy based LLC resonant converter was analyzed and designed in this paper.By combining the merits of a ...To realize effective utilization of renewable energy sources,a novel polymorphic topology with hybrid control strategy based LLC resonant converter was analyzed and designed in this paper.By combining the merits of a full bridge LLC resonant converter,three-level half bridge LLC resonant converter,and variable frequency control mode,the converter realizes an intelligent estimation of input voltage by automatically changing its internal cir-cuit topology.Under this control strategy,different input voltages determine different operation modes.This is achieved in full bridge LLC mode when the input voltage is low.If the input voltage rises to a certain level,it operates in three-level half bridge LLC mode.These switches are digital and entirely carried out by the DSP(Digi-tal Signal Processor),which means that an auxiliary circuit is unnecessary,where a simple strategy of software modification can be utilized.Experimental results of a 500W prototype with 100V~600V input voltage and full load efficiency of up to 92%are developed to verify feasibility and practicability.This type of converter is suitable for applications with an ultra-wide input voltage range,such as wind turbines,photovoltaic generators,bioenergy,and other renewable energy sources.展开更多
基金funded by the Science and Technology Project of State Grid Jilin Electric Power Co.,Ltd.(Project Name:Research onDistributionNetworkResilience Assessment and Improvement Technology for Natural Disaster Areas).
文摘The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric and natural gas systems,it is critical to enhance the load restoration capability of both systems.This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming(MISOCP)model.The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems,minimizing the total system load loss cost and repair time.In addition,a bi-directional gas flow model is used to describe the natural gas system,which can provide the RIENGS with more flexibility for load restoration during natural gas system failure.Finally,the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20.
基金supported by National Basic Research Program of China(973 Program,2014CB542205)Hong Kong RGC grant+2 种基金Hong Kong Health and Medical Research Fundfoundation for Distinguished Young Talents in Higher Education of Guangdong(Yq2013023)the Leading Talents of Guangdong Province(87014002)
文摘Following injury in central nervous system(CNS),there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.The proliferation of a large number of astrocytes results in the formation of glial scar.
文摘The pricey prawn scandal of Qingdao in the 2015 National Day Holiday,not only violates the principle of integrity management,but also seriously damages the image of Qingdao—World Famous Tourist City.This study applies image repair strategies to Qingdao municipal government departments' attempt to restore its damaged image in crisis communication.Through a discourse analysis,it is found that the government departments mainly adopt the following strategies: denial,evasion of responsibility(defeasibility),reduction of offensiveness(bolstering,compensation),corrective action and mortification.Then we evaluate the effectiveness of this image repair effort.
基金Funded by the National Key Project on Basic Research and Applied Research (85-40).
文摘A model of dynamic programming for repairing strategies of concrete structures during a projected service period is proposed, which takes into account the degradation in strength of components and the probability of accidental load. This model takes the safety grade of a structural system as the state variable of repairing strategies, and incorporates economic factors including expected repair cost, property loss due to structure failure, goods and material loss due to structure failure, loss of production interrupt due to structure failure, and inspection cost in decision making. It is found that the optimal repairing strategies are sensitive to the probability of accidental loads as well as the failure costs. The practicality of the model is demonstrated by an example.
基金CSIRO, the ARC and the NHMRC for providing funding that supported this work
文摘Neuronal regeneration in the peripheral nervous system arises via a synergistic interplay of neurotrophic factors,integrins,cytoskeletal proteins,mechanical cues,cytokines,stem cells,glial cells and astrocytes.
文摘背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed数据库2000-2023年发表的文献,英文检索词为“gradient,bone regeneration,scaffold”,最终筛选后对76篇文献进行分析总结。结果与结论:①作为骨骼系统组织高效、高质量修复的重要手段,梯度人工骨修复支架目前针对骨组织、骨-软骨、肌腱-骨组织的天然梯度特征进行了仿生设计,这些支架能够一定程度地从结构、成分上模拟原生组织的细胞外基质,从而促进细胞黏附、迁移、增殖和分化,促进受损组织向原生状态再生恢复。②先进制造技术为梯度人工骨修复支架制备提供了更多可能;目前已经开发了通过空间差异化纤维排布和生物活性物质加载构建的梯度电纺纤维支架;分层叠加、分级孔隙率与生物3D打印技术制造的梯度3D打印支架;原位分层注射、简单逐层叠加、冷冻干燥法制造的梯度水凝胶支架;另外还包括其他方式或多方法联用的支架;这些支架在体外实验中展示了良好的生物相容性,在小型动物实验中能够加速组织再生并且观察到组织学结构明显改善。③目前开发的梯度人工骨修复支架仍需进一步优化,提高在梯度尺度上的匹配性,进一步明确材料与组织相互作用,避免降解产物导致的副反应等问题,未来需要结合相关学科优势与临床需求进一步优化。
基金supported by the National Natural Science Foundation of China,No.81571213(to BW),No.81800583(to YYX)the 13~(th) Six Talent Peaks Project(C type)of Jiangsu Province of China(to BW)+1 种基金the Medical Science and Technique Development Foundation of Nanjing of China,No.QRX17006(to BW)the Medical Science and Innovation Platform of Nanjing of China,No.ZDX16005(to BW)
文摘Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some regenerative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.
基金National Natural Science Foundation of China,No.81972136National Natural Science Foundation for Young Scholars of China,No.81401830+3 种基金Guangxi Natural Science Foundation General Project,No.2018JJA14775Young Medical Scholars Major Program of Jiangsu Province,No.QNRC2016342Innovation Team Project of Jiangsu Province,No.CXTDB2017004Key Funding Project of Maternal and Child Health Research of Jiangsu Province,No.F201801.
文摘Low back pain has become more prevalent in recent years,causing enormous economic burden for society and government.Common therapies used in clinics including conservative treatment and surgery can only relieve pain.Subsequent cell-based treatment such as mesenchymal stem cell transplantation poses problems such as short duration of therapeutic effect and tumorigenesis.Recently,the discovery and identification of stem cell niche and stem/progenitor cells in intervertebral disc bring increased attention to endogenous repair strategy.Therefore,we review the studies involving endogenous repair strategy and present the characteristics and current status of this treatment.Meanwhile,we also discuss the strategy and perspective of endogenous repair strategy in future.
文摘Food safety is one of the top issues for Chinese consumers. In the summer of 2014,Shanghai-based Husi Food Co Ltd was mired in a food-safety scandal. OSI Group responded to this situation by releasing statements and holding China press conference. This study focused on OSI Group's image repair strategies employed in the scandal in Chinese context. A content analysis revealed that OSI Group's image repair relied primarily on six strategies: defeasibility( appalled by the event),bolstering( factory in Henan is state-of-art),minimization( it was an isolated event),corrective action( thorough internal investigation),and mortification( sincerely apologized),and attacking the accuser( launched OSI Food Safety Education Campaign). Basically,OSI Group's mortification without compensation doomed its efforts to failure.Implications for implementing image repair strategies with the combination of crisis types are addressed.
基金funded by National Natural Science Foundation of China (52177074).
文摘There are issues with flexible DC transmission system such as a lack of control freedom over power flow.In order to tackle these issues,a DC power flow controller(DCPFC)is incorporated into a multi-terminal,flexible DC power grid.In recent years,a multi-port DC power flow controller based on a modular multi-level converter has become a focal point of research due to its simple structure and robust scalability.This work proposes a model predictive control(MPC)strategy for multi-port interline DC power flow controllers in order to improve their steady-state dynamic performance.Initially,the mathematical model of a multi-terminal DC power grid with a multi-port interline DC power flow controller is developed,and the relationship between each regulated variable and control variable is determined;The power flow controller is then discretized,and the cost function and weight factor are built with numerous control objectives.Sub module sorting method and nearest level approximation modulation regulate the power flow controller;Lastly,theMATLAB/Simulink simulation platformis used to verify the correctness of the establishedmathematicalmodel and the control performance of the suggestedMPC strategy.Finally,it is demonstrated that the control strategy possesses the benefits of robust dynamic performance,multiobjective control,and a simple structure.
文摘To realize effective utilization of renewable energy sources,a novel polymorphic topology with hybrid control strategy based LLC resonant converter was analyzed and designed in this paper.By combining the merits of a full bridge LLC resonant converter,three-level half bridge LLC resonant converter,and variable frequency control mode,the converter realizes an intelligent estimation of input voltage by automatically changing its internal cir-cuit topology.Under this control strategy,different input voltages determine different operation modes.This is achieved in full bridge LLC mode when the input voltage is low.If the input voltage rises to a certain level,it operates in three-level half bridge LLC mode.These switches are digital and entirely carried out by the DSP(Digi-tal Signal Processor),which means that an auxiliary circuit is unnecessary,where a simple strategy of software modification can be utilized.Experimental results of a 500W prototype with 100V~600V input voltage and full load efficiency of up to 92%are developed to verify feasibility and practicability.This type of converter is suitable for applications with an ultra-wide input voltage range,such as wind turbines,photovoltaic generators,bioenergy,and other renewable energy sources.