The study of river dynamics requires knowledge of physical parameters, such as porosity, permeability, and wave propagation velocity, of river-bottom sediments. To do so, sediment properties are determined on mechanic...The study of river dynamics requires knowledge of physical parameters, such as porosity, permeability, and wave propagation velocity, of river-bottom sediments. To do so, sediment properties are determined on mechanically sampled specimens and from subbottom profiling. However, mechanical sampling introduces disturbances that affect test results, with the exception of grain-size distribution. In this study, we perform inversion of acoustic data using the grain-size distribution of mechanically sampled specimens and the relation between porosity and permeability from the Kozeny-Carman equation as prior information. The wave reflection coefficient of the water-silt interface is extracted from the raw subbottom profile. Based on the effective density fluid model, we combine the Kozeny-Carman equation and the wave reflection coefficient. We use experimental data from two Yellow River reservoirs to obtain the wave velocity and density of multiple sections and their spatial variations, and find that the inversion and testing results are in good agreement.展开更多
The pilot test of infilling polymer-surfactant-preformed particle gel(PPG)flooding has been successfully implemented after polymer flooding in Ng3 block of Gudao Oilfield in China.However,the production characteristic...The pilot test of infilling polymer-surfactant-preformed particle gel(PPG)flooding has been successfully implemented after polymer flooding in Ng3 block of Gudao Oilfield in China.However,the production characteristics and displacement mechanisms are still unclear,which restricts its further popularization and application.Aiming at this problem,this paper firstly analyzes the production performance of the pilot test and proposed four response types according to the change of water cut curves,including W-type,U-type,V-type response,and no response.Furthermore,the underlying reasons of these four types are analyzed from the aspects of seepage resistance and sweep efficiency.The overall sweep efficiency of gradual-rising W-type,gradual-decreasing W-type,and early V-type response increases from 0.81 to 0.93,0.55 to 0.89,and 0.94 to 1,respectively.And the sum of seepage resistance along the connection line between production well and injection well for U-type and delayed V-type response increases from 0.0994 to 0.2425,and 0.0677 to 0.1654,respectively.Then,the remaining oil distribution after polymer flooding is summarized into four types on the basis of production and geological characteristics,namely disconnected remaining oil,streamline unswept remaining oil,rhythm remaining oil,and interlayer-controlled remaining oil.Furthermore,the main displacement mechanisms for each type are clarified based on the dimensionless seepage resistance and water absorption profile.Generally,improving connectivity by well pattern infilling is the most important for producing disconnected remaining oil.The synergistic effect of well pattern infilling and polymer-surfactant-PPG flooding increases the dimensionless seepage resistance of water channeling regions and forces the subsequent injected water to turn to regions with streamline unswept remaining oil.The improvement of the water absorption profile by polymer-surfactant-PPG flooding and separated layer water injection contributes to displacing rhythm remaining oil and interlayer-controlled remaining oil.Finally,the paper analyzes the relationships between the remaining oil distribution after polymer flooding and production characteristics of infilling polymer-surfactant-PPG flooding.The study helps to deepen the understanding of infilling polymer-surfactant-PPG flooding and has reference significance for more commercial implementations in the future.展开更多
The comparison results of three beach profile data repeatedly measured before and after the typhoon in Shuidong Bay,west Guangdong province which show that there are significant differences in beach profile erosion an...The comparison results of three beach profile data repeatedly measured before and after the typhoon in Shuidong Bay,west Guangdong province which show that there are significant differences in beach profile erosion and response process.And the changes of beach profile can be divided into:strong downward overall low shoreline regressive type and overall slight erosion shoreline regressive type.Application of the modified mildslope equation along three beach profile are simulated wave high reflection to the sea side,to the section vertical shore pressure gradient and including water roll force and radiation stress,the vertical shore forces one dimensional profile along the momentum conservation equation(radiation stress and water roll force)bottom friction and lateral mixing reaction between numerical solution,the momentum conservation equations of the wave increases the water flow velocity and section along the profile distribution of wave height and related forces.The analysis shows that the extent and difference of coastal erosion depend on the shoreline erosion mode stimulated by the maximum surge water of the coastal current and the maximum velocity of the coastal current and the dynamic state of the profile topography under the action of the profile location,morphology and incident wave elements.展开更多
In friction stir welding(FSW), pin profile has more influence on material flow especially in welding of dissimilar materials with different yield strengths. In the dissimilar welding of aluminium and copper, the mater...In friction stir welding(FSW), pin profile has more influence on material flow especially in welding of dissimilar materials with different yield strengths. In the dissimilar welding of aluminium and copper, the material flow behaviour is complex to understand and thus a study is needed to reveal the mechanism of flow behaviour and the resultant mechanical properties. Three pin profiles, whorl pin profile(WPP), plain taper pin profile(PTP) and taper treaded pin profile(TTP) were chosen. The effects of pin profile on the microstructure, microhardness and tensile properties were studied. Optical microscope, scanning electron microscope, X-ray diffraction and EDS analysis were used to characterize the microstructural features. Among the three pin profiles, PTP profile results in defect-free stir zone and maximum joint properties of yield strength of 101 MPa, tensile strength of 116 MPa and joint efficiency of 68% compared with the other pin profiles. However, the microhardness plots are more or less identical for all the pin profiles but follows fluctuating trend. This is attributed to the heterogeneous distribution of hard Cu particle. The superior joint properties are mainly attributed to the defect-free stir zone formation and dispersion strengthening.展开更多
The effect of small tool pin profiles on the microstructures and mechanical properties of 6061 aluminum alloy joints using friction stir welding (FSW) technique was investigated. Three different tool pin profiles: ...The effect of small tool pin profiles on the microstructures and mechanical properties of 6061 aluminum alloy joints using friction stir welding (FSW) technique was investigated. Three different tool pin profiles: threaded tapered cylindrical (T1), triangular (T2) and square (T3) were used to produce the joints. The results indicate that the weld joints are notably affected by joining with different tool pin profiles. The triangular tool pin profile produces thebest metallurgicaland mechanical weld properties compared with other tool pin profiles. Besides, the lowest tensile strength and microhardness are obtained for the joint friction stir welded with square tool pin profile. It is observed that the smaller tool pin profile and shoulder diameter lead to narrow region of heat affected zone (HAZ) and a desired level of softening. The fracture surface examination shows that the joints are also affected when welding with different types of tool pin profiles. The fracture surface shows that the triangular specimen fails with a ductile fracture mode during the tensile test, while the brittle fracture modes are observed in the joints fabricated with other tool pin profiles (T1 and T3).展开更多
To get a full understanding of hot extrusion,solid solution treatment and aging process on the Al−0.56Mg−0.63Si alloy,the microstructure and mechanical properties of a U-shaped profile were studied through optical mic...To get a full understanding of hot extrusion,solid solution treatment and aging process on the Al−0.56Mg−0.63Si alloy,the microstructure and mechanical properties of a U-shaped profile were studied through optical microscopy,scanning electrical microscopy,transmission electrical microscopy,hardness,and tensile tests.The coarse equiaxed grains existed near the profile edge as a result of the dynamic recrystallization nucleation and exceeding growth during hot extrusion.The fibrous deformed and sub-structured grains located between the two coarse grain layers,due to the occurrence of work-hardening and dynamic recovery.Perpendicular needle β′′precipitates were distributed inside the grain,and obvious precipitates-free zone appeared after aging treatment.The tensile strength,yield strength and elongation of the aged Al−Mg−Si alloy U-shaped profile were no less than 279.4 MPa,258.6 MPa,and 21.6%,respectively.The fracture morphology showed dimple rupture characteristics.The precipitates and grain boundaries played key role in the strengthening contribution.展开更多
In order to explore the salt tolerance mechanism of Bacillus cereus LBR-4 with salinity of 14%NaCl,differential proteomic analysis of the whole protein of LBR-4 strain expressed under 14%NaCl high salinity condition a...In order to explore the salt tolerance mechanism of Bacillus cereus LBR-4 with salinity of 14%NaCl,differential proteomic analysis of the whole protein of LBR-4 strain expressed under 14%NaCl high salinity condition and normalculture condition(1%NaCl)was studied by two-dimensional electrophoresis and mass spectrometry.The isoelectric point of most detected proteins was between pH 4-7 and the molecular weight distribution was 10-70 ku.Compared with the normal culture condition,the expression level of 118 protein spots in the whole protein expression map changed significantly(accounting for 25.2%of the total protein spots).The expression level of 78 protein spots increased significantly,including 22 new protein spots that appeared under high salt stress.The expression levels of 40 protein spots decreased significantly,including 18 protein spots that disappeared under high salt stress.By mass spectrometry,six distinct differentially expressed protein spotswere dihydroxy acid dehydratase,cell division protein FtsZ,iron sulfur cluster synthesis protein SufD,unknown carboxylase YngE,hypothetical acetaldehyde dehydrogenase DhaS and phenylalanine acid tRNA ligase alpha subunit.It was speculated that under high salt stress,the cells had protective measures and the secretion of intracellular compatible solutes increased.The iron and sulfur clusters involved in various physiological reactions also activated the stressful suf synthesis pathway,and therate of cell division and reproduction was also slowed down and ensured the normal progress of physiological reactions inthe cells.展开更多
In this study, the four kinetic reaction mechanisms were developed to simulate the formation of pollutant species in CNG fired IC engine. The reactions were generated using EXGAS and coupled with Leed’s NOx reactions...In this study, the four kinetic reaction mechanisms were developed to simulate the formation of pollutant species in CNG fired IC engine. The reactions were generated using EXGAS and coupled with Leed’s NOx reactions to develop four kinetic mechanisms. These reaction mechanisms described the combustion of natural gas at low (below 800 K) to high (above 1000 K) temperature in combustion chamber. The simulation studies predicted that the maximum cylinder pressure was achieved up to 18.0 atm & 40.0 atm under fuel leaner conditions (φ ≈0.6) and fuel rich conditions (φ=1.13 to 1.3) respectively. The simulation based data was compared with the experimental data (when engine was operated at 3000 rpm, φ=1.0, Pinlet=0.67 atm). For fuel rich conditions, high concentrations of CO were observed while NOx levels were lowered while the fuel leaner mixture produced the lower CO emissions and moderate levels of NOx emissions. The NOx and CO profiles depicted that Mechanism-I, Mechanism-II and Mechanism III seemed to be inappropriate for predicting the emissions in due to CNG combustion IC engine. The molded data for Mechanism-IV exhibited closer agreement with experimental measurements. The rate of production analysis identified the important reactions in each mechanism which were contributing in the formation of emission concentrations of pollutant species. Although each proposed mechanism illustrated some discrepancies among the profiles, Mechanism-IV (consisting of 208 reactions and 78 species) showed good agreement with experimental data for pressure, temperature and pollutant species profiles.展开更多
A new thread guide mechanism of a rubbed roving frame is developed, which consists mainly of a plate cam, a linkage and an air bag spring. Characteristics and design parameters of the air spring are explored in this s...A new thread guide mechanism of a rubbed roving frame is developed, which consists mainly of a plate cam, a linkage and an air bag spring. Characteristics and design parameters of the air spring are explored in this study. Based on analyses of winding technology for this kind of package, the kinetic laws of the thread guide is put forward. General design equations of the cam profile are derived, and common kinetic laws of II linkage group which is used for such mechanism design is proposed. It proves theoretically that it is practicable. The experimental results indicate that it can meet the needs of technological demands, and the new thread guide mechanism has been used successfully on textile machines.展开更多
Background:According to the World Health Organization,about 350 million people worldwide are suffering from depression.It's reported that depression has been linked to several circadian rhythm perturbations,sugges...Background:According to the World Health Organization,about 350 million people worldwide are suffering from depression.It's reported that depression has been linked to several circadian rhythm perturbations,suggesting a disruption of the circadian clock system in affective disorders.The present study investigates the possible molecular mechanism of Shimian granules(SMG)in treating depression via restoring disrupted circadian rhythms.Method:Firstly,network pharmacology approach was used to identify the compounds and potential targets of SMG in TCMIP and BATMAN-TCM database.Secondly,the differential expression genes were obtained by gene expression profiling in GEO database(GSE56931,GSE98793).Further,protein-protein interactions(PPI)network was used to screen out core targets by STRING v11.Moreover,functional enrichment was carried out in DAVID database.Conclusively,the"herbs-compounds-targets-pathways"network was established to explore the mechanism of SMG in the treatment of depression.Result:It was found out that 65 compounds,18 targets and three pathways contributed to SMG in treating depression by regulating disrupted circadian rhythms,which might relate to core targets TNF,IL10,VDR in cAMP and calcium signaling pathway.Conclusion:Network pharmacology combined with gene expression profiling exhibited a powerful means to investigate the possible mechanism of formula,which contributes to theoretical basis for further study of SMG in the treatment of depression.展开更多
In this study, the design of an automatic ROM-Exercise machine that is constructed witha planar multililnk mechamsm consisting of only revolute pairs is investigated. Namely, equations thatdetermine the minimum moving...In this study, the design of an automatic ROM-Exercise machine that is constructed witha planar multililnk mechamsm consisting of only revolute pairs is investigated. Namely, equations thatdetermine the minimum moving spaces and relative positions of link required to construct the legmechanism are formulated with consideration of transform functions. For the leg mechanism that isconstructed with a planar eleven-link mechanism, arrangements of each link and optimum linkprofiles avoided mutual interferences among moving links are determined wb consideration of therelative locations of each link in the same plane during a cycle of motion of the mechanism. Based onthe above analytical results, an automatic ROM-Exercise machine that performs within a minimum moving spaces is proposed as a prachcal example. ms study is carried out as part of the students'computcr education to the graduation thesis, in order to improve their creativity and machine designtechnology skills in coniunction with educational advantages. Significam educational results areobtained by using the design techniques mentioned above.展开更多
Aiming at the problems in current cam profile optimization processes, such as simple dynamics models, limited geometric accuracy and low design automatization level, a new dynamic optimization mode is put forward. Bas...Aiming at the problems in current cam profile optimization processes, such as simple dynamics models, limited geometric accuracy and low design automatization level, a new dynamic optimization mode is put forward. Based on the parameterization modeling technique of MSC. ADAMS platform, the different steps in current mode are reorganized, thus obtaining an upgraded mode called the "parameterized-prototype-based cam profile dynamic optimization mode". A parameterized prototype(PP) of valve mechanism is constructed in the course of dynamic optimization for cam profiles. Practically, by utilizing PP and considering the flexibility of the parts in valve mechanism, geometric accuracy and design automatization are improved.展开更多
基金supported by the Ministry of Water Resources Special Funds for Scientific Research on Public Causes(No.201301024)the Special Funds for Yellow River Institute of Hydraulic Research(No.HKY-JBYW-2016-09 and No.HKYJBYW-2016-29)
文摘The study of river dynamics requires knowledge of physical parameters, such as porosity, permeability, and wave propagation velocity, of river-bottom sediments. To do so, sediment properties are determined on mechanically sampled specimens and from subbottom profiling. However, mechanical sampling introduces disturbances that affect test results, with the exception of grain-size distribution. In this study, we perform inversion of acoustic data using the grain-size distribution of mechanically sampled specimens and the relation between porosity and permeability from the Kozeny-Carman equation as prior information. The wave reflection coefficient of the water-silt interface is extracted from the raw subbottom profile. Based on the effective density fluid model, we combine the Kozeny-Carman equation and the wave reflection coefficient. We use experimental data from two Yellow River reservoirs to obtain the wave velocity and density of multiple sections and their spatial variations, and find that the inversion and testing results are in good agreement.
基金The authors greatly appreciate the financial support of the National Natural Science Foundation of China(Grant No.52104027)the Project supported by the Joint Funds of the National Natural Science Foundation of China(Grant No.U21B2070)the Shandong Provincial Natural Science Foundation(Grant No.ZR2021ME072).
文摘The pilot test of infilling polymer-surfactant-preformed particle gel(PPG)flooding has been successfully implemented after polymer flooding in Ng3 block of Gudao Oilfield in China.However,the production characteristics and displacement mechanisms are still unclear,which restricts its further popularization and application.Aiming at this problem,this paper firstly analyzes the production performance of the pilot test and proposed four response types according to the change of water cut curves,including W-type,U-type,V-type response,and no response.Furthermore,the underlying reasons of these four types are analyzed from the aspects of seepage resistance and sweep efficiency.The overall sweep efficiency of gradual-rising W-type,gradual-decreasing W-type,and early V-type response increases from 0.81 to 0.93,0.55 to 0.89,and 0.94 to 1,respectively.And the sum of seepage resistance along the connection line between production well and injection well for U-type and delayed V-type response increases from 0.0994 to 0.2425,and 0.0677 to 0.1654,respectively.Then,the remaining oil distribution after polymer flooding is summarized into four types on the basis of production and geological characteristics,namely disconnected remaining oil,streamline unswept remaining oil,rhythm remaining oil,and interlayer-controlled remaining oil.Furthermore,the main displacement mechanisms for each type are clarified based on the dimensionless seepage resistance and water absorption profile.Generally,improving connectivity by well pattern infilling is the most important for producing disconnected remaining oil.The synergistic effect of well pattern infilling and polymer-surfactant-PPG flooding increases the dimensionless seepage resistance of water channeling regions and forces the subsequent injected water to turn to regions with streamline unswept remaining oil.The improvement of the water absorption profile by polymer-surfactant-PPG flooding and separated layer water injection contributes to displacing rhythm remaining oil and interlayer-controlled remaining oil.Finally,the paper analyzes the relationships between the remaining oil distribution after polymer flooding and production characteristics of infilling polymer-surfactant-PPG flooding.The study helps to deepen the understanding of infilling polymer-surfactant-PPG flooding and has reference significance for more commercial implementations in the future.
基金Project funded by the National Nature Fund(41371498,42071007)。
文摘The comparison results of three beach profile data repeatedly measured before and after the typhoon in Shuidong Bay,west Guangdong province which show that there are significant differences in beach profile erosion and response process.And the changes of beach profile can be divided into:strong downward overall low shoreline regressive type and overall slight erosion shoreline regressive type.Application of the modified mildslope equation along three beach profile are simulated wave high reflection to the sea side,to the section vertical shore pressure gradient and including water roll force and radiation stress,the vertical shore forces one dimensional profile along the momentum conservation equation(radiation stress and water roll force)bottom friction and lateral mixing reaction between numerical solution,the momentum conservation equations of the wave increases the water flow velocity and section along the profile distribution of wave height and related forces.The analysis shows that the extent and difference of coastal erosion depend on the shoreline erosion mode stimulated by the maximum surge water of the coastal current and the maximum velocity of the coastal current and the dynamic state of the profile topography under the action of the profile location,morphology and incident wave elements.
文摘In friction stir welding(FSW), pin profile has more influence on material flow especially in welding of dissimilar materials with different yield strengths. In the dissimilar welding of aluminium and copper, the material flow behaviour is complex to understand and thus a study is needed to reveal the mechanism of flow behaviour and the resultant mechanical properties. Three pin profiles, whorl pin profile(WPP), plain taper pin profile(PTP) and taper treaded pin profile(TTP) were chosen. The effects of pin profile on the microstructure, microhardness and tensile properties were studied. Optical microscope, scanning electron microscope, X-ray diffraction and EDS analysis were used to characterize the microstructural features. Among the three pin profiles, PTP profile results in defect-free stir zone and maximum joint properties of yield strength of 101 MPa, tensile strength of 116 MPa and joint efficiency of 68% compared with the other pin profiles. However, the microhardness plots are more or less identical for all the pin profiles but follows fluctuating trend. This is attributed to the heterogeneous distribution of hard Cu particle. The superior joint properties are mainly attributed to the defect-free stir zone formation and dispersion strengthening.
基金supported by the grant No.900100338 of the Universiti Malaysia Perlis (Uni MAP)the outstanding support provided by the staff in the School of Materials Engineering in Uni MAP+1 种基金the Centre for Low Carbon Transport and Institute for Vehicle System Engineering in Universiti Teknologi Malaysia (UTM)the School of Materials Engineering and Mineral Resources in Universiti Sains Malaysia (USM)
文摘The effect of small tool pin profiles on the microstructures and mechanical properties of 6061 aluminum alloy joints using friction stir welding (FSW) technique was investigated. Three different tool pin profiles: threaded tapered cylindrical (T1), triangular (T2) and square (T3) were used to produce the joints. The results indicate that the weld joints are notably affected by joining with different tool pin profiles. The triangular tool pin profile produces thebest metallurgicaland mechanical weld properties compared with other tool pin profiles. Besides, the lowest tensile strength and microhardness are obtained for the joint friction stir welded with square tool pin profile. It is observed that the smaller tool pin profile and shoulder diameter lead to narrow region of heat affected zone (HAZ) and a desired level of softening. The fracture surface examination shows that the joints are also affected when welding with different types of tool pin profiles. The fracture surface shows that the triangular specimen fails with a ductile fracture mode during the tensile test, while the brittle fracture modes are observed in the joints fabricated with other tool pin profiles (T1 and T3).
基金financial support of project on reliability and life research of typical components in rail trains (K10TZ20P0500) of CRRC Zhuzhou Electric Locomotive Research Institute.
文摘To get a full understanding of hot extrusion,solid solution treatment and aging process on the Al−0.56Mg−0.63Si alloy,the microstructure and mechanical properties of a U-shaped profile were studied through optical microscopy,scanning electrical microscopy,transmission electrical microscopy,hardness,and tensile tests.The coarse equiaxed grains existed near the profile edge as a result of the dynamic recrystallization nucleation and exceeding growth during hot extrusion.The fibrous deformed and sub-structured grains located between the two coarse grain layers,due to the occurrence of work-hardening and dynamic recovery.Perpendicular needle β′′precipitates were distributed inside the grain,and obvious precipitates-free zone appeared after aging treatment.The tensile strength,yield strength and elongation of the aged Al−Mg−Si alloy U-shaped profile were no less than 279.4 MPa,258.6 MPa,and 21.6%,respectively.The fracture morphology showed dimple rupture characteristics.The precipitates and grain boundaries played key role in the strengthening contribution.
基金Supported by Heilongjiang Province National Science Foundation(LH2020C007)。
文摘In order to explore the salt tolerance mechanism of Bacillus cereus LBR-4 with salinity of 14%NaCl,differential proteomic analysis of the whole protein of LBR-4 strain expressed under 14%NaCl high salinity condition and normalculture condition(1%NaCl)was studied by two-dimensional electrophoresis and mass spectrometry.The isoelectric point of most detected proteins was between pH 4-7 and the molecular weight distribution was 10-70 ku.Compared with the normal culture condition,the expression level of 118 protein spots in the whole protein expression map changed significantly(accounting for 25.2%of the total protein spots).The expression level of 78 protein spots increased significantly,including 22 new protein spots that appeared under high salt stress.The expression levels of 40 protein spots decreased significantly,including 18 protein spots that disappeared under high salt stress.By mass spectrometry,six distinct differentially expressed protein spotswere dihydroxy acid dehydratase,cell division protein FtsZ,iron sulfur cluster synthesis protein SufD,unknown carboxylase YngE,hypothetical acetaldehyde dehydrogenase DhaS and phenylalanine acid tRNA ligase alpha subunit.It was speculated that under high salt stress,the cells had protective measures and the secretion of intracellular compatible solutes increased.The iron and sulfur clusters involved in various physiological reactions also activated the stressful suf synthesis pathway,and therate of cell division and reproduction was also slowed down and ensured the normal progress of physiological reactions inthe cells.
文摘In this study, the four kinetic reaction mechanisms were developed to simulate the formation of pollutant species in CNG fired IC engine. The reactions were generated using EXGAS and coupled with Leed’s NOx reactions to develop four kinetic mechanisms. These reaction mechanisms described the combustion of natural gas at low (below 800 K) to high (above 1000 K) temperature in combustion chamber. The simulation studies predicted that the maximum cylinder pressure was achieved up to 18.0 atm & 40.0 atm under fuel leaner conditions (φ ≈0.6) and fuel rich conditions (φ=1.13 to 1.3) respectively. The simulation based data was compared with the experimental data (when engine was operated at 3000 rpm, φ=1.0, Pinlet=0.67 atm). For fuel rich conditions, high concentrations of CO were observed while NOx levels were lowered while the fuel leaner mixture produced the lower CO emissions and moderate levels of NOx emissions. The NOx and CO profiles depicted that Mechanism-I, Mechanism-II and Mechanism III seemed to be inappropriate for predicting the emissions in due to CNG combustion IC engine. The molded data for Mechanism-IV exhibited closer agreement with experimental measurements. The rate of production analysis identified the important reactions in each mechanism which were contributing in the formation of emission concentrations of pollutant species. Although each proposed mechanism illustrated some discrepancies among the profiles, Mechanism-IV (consisting of 208 reactions and 78 species) showed good agreement with experimental data for pressure, temperature and pollutant species profiles.
文摘A new thread guide mechanism of a rubbed roving frame is developed, which consists mainly of a plate cam, a linkage and an air bag spring. Characteristics and design parameters of the air spring are explored in this study. Based on analyses of winding technology for this kind of package, the kinetic laws of the thread guide is put forward. General design equations of the cam profile are derived, and common kinetic laws of II linkage group which is used for such mechanism design is proposed. It proves theoretically that it is practicable. The experimental results indicate that it can meet the needs of technological demands, and the new thread guide mechanism has been used successfully on textile machines.
基金This research has been financially supported by the Special Support Scheme for Shaanxi Province,and the Subject Innovation Team of Shaanxi University of Chinese Medicine(#2019-YS01)Shaanxi province administration of traditional Chinese medicine(#2021-ZZ-JC018).
文摘Background:According to the World Health Organization,about 350 million people worldwide are suffering from depression.It's reported that depression has been linked to several circadian rhythm perturbations,suggesting a disruption of the circadian clock system in affective disorders.The present study investigates the possible molecular mechanism of Shimian granules(SMG)in treating depression via restoring disrupted circadian rhythms.Method:Firstly,network pharmacology approach was used to identify the compounds and potential targets of SMG in TCMIP and BATMAN-TCM database.Secondly,the differential expression genes were obtained by gene expression profiling in GEO database(GSE56931,GSE98793).Further,protein-protein interactions(PPI)network was used to screen out core targets by STRING v11.Moreover,functional enrichment was carried out in DAVID database.Conclusively,the"herbs-compounds-targets-pathways"network was established to explore the mechanism of SMG in the treatment of depression.Result:It was found out that 65 compounds,18 targets and three pathways contributed to SMG in treating depression by regulating disrupted circadian rhythms,which might relate to core targets TNF,IL10,VDR in cAMP and calcium signaling pathway.Conclusion:Network pharmacology combined with gene expression profiling exhibited a powerful means to investigate the possible mechanism of formula,which contributes to theoretical basis for further study of SMG in the treatment of depression.
文摘In this study, the design of an automatic ROM-Exercise machine that is constructed witha planar multililnk mechamsm consisting of only revolute pairs is investigated. Namely, equations thatdetermine the minimum moving spaces and relative positions of link required to construct the legmechanism are formulated with consideration of transform functions. For the leg mechanism that isconstructed with a planar eleven-link mechanism, arrangements of each link and optimum linkprofiles avoided mutual interferences among moving links are determined wb consideration of therelative locations of each link in the same plane during a cycle of motion of the mechanism. Based onthe above analytical results, an automatic ROM-Exercise machine that performs within a minimum moving spaces is proposed as a prachcal example. ms study is carried out as part of the students'computcr education to the graduation thesis, in order to improve their creativity and machine designtechnology skills in coniunction with educational advantages. Significam educational results areobtained by using the design techniques mentioned above.
文摘Aiming at the problems in current cam profile optimization processes, such as simple dynamics models, limited geometric accuracy and low design automatization level, a new dynamic optimization mode is put forward. Based on the parameterization modeling technique of MSC. ADAMS platform, the different steps in current mode are reorganized, thus obtaining an upgraded mode called the "parameterized-prototype-based cam profile dynamic optimization mode". A parameterized prototype(PP) of valve mechanism is constructed in the course of dynamic optimization for cam profiles. Practically, by utilizing PP and considering the flexibility of the parts in valve mechanism, geometric accuracy and design automatization are improved.