Robust Digital Predistortion for LTE/5G Power Amplifiers Utilizing Negative Feedback Iteration

A robust digital predistortion(DPD)technique utilizing negative feedback iteration is introduced for linearizing power amplifiers(PAs)in long term evolution(LTE)/5G systems.Different from the conventional direct learning and indirect learning structure,the proposed DPD suggests a two-step method to identify the predistortion.Firstly,a negative feedback based iteration is used to estimate the optimal DPD signal.Then the corresponding DPD parameters are extracted by forward modeling with the input signal and optimal DPD signal.The iteration can be applied to both single-band and dual-band PAs,which will achieve superior linear performance than the conventional direct learning DPD while having a relatively low computational complexity.The measurement is carried out on a broadband Doherty PA(DPA)with a 200 MHz bandwidth LTE signal at 2.1 GHz,and on a 5G DPA with two 10 MHz LTE signals at 3.4/3.6 GHz for validation in dual-band scenarios.

Alterative wire-feed system based on arc voltage negative feedback

Waveform control method was commonly adopted to reduce the spatter of CO2 arc welding and improve the weld formation. It certainly would reduce the self-regulation ability of arc due to the adoption of segmented constant current control which especially led to arc＂ blowout with the abrupt change oat＂ arc＂ length or downward welding. Therefore alterative wire-feed system based on arc voltage negative feedback was put forward to improve the .stability of arc＂ length in this paper. Double closed-loop and double fuzzy P1 regulation were adopted in this system. Fuzzy control of induced voltage was adopted in the inner-loop which improved the stability and fast response of wire-feed system. Fuzz）＂ control of arc＂ voltage negative feedback was used in the outer-loop whose output .served as the input of negative feedback regulation of inner-loop induced voltage. This method could remain arc＂ length and weld penetration unchan, ged on the basils of reducing spatter and improving formation and it was proved by downward welding tests.

Negative Feedback in the Polar Ice System

One of the ingredients of the anthropogenic global warming hypothesis is the existence of large positive feedback in the climate system. An example is polar ice that, once melted, turns into blacker water that will increase radiation absorption and this rein-forces the melting. This causes a run-away scenario with a point of no return. Here it is shown that the polar ice can also have negative feedback aspects, where a melting of polar ice will cause it to reappear.

Analysis of positive feedback in the control of movement

Over the past three decades, neurophysiologists studying the neural circuitry responsible for control of skeletal muscles have developed several different general theories of sensorimotor control. These have usually invoked one or more of the sources of proprioceptive signals (e.g. muscle spindle and Golgi tendon organ afferents) in positive or negative feed-back loops to the homonymous alpha motoneurones. In this paper we consider to analyze the role of posi-tive feedback in combination of negative feedback due to important role of them in stabilizing the neu-romuscular system.

Solid-state wideband GaN HEMT power amplifier with a novel negative feedback structure

The design and fabrication of an ultra-broadband power amplifier based on a GaN HEMT, which operates in the frequency range from 3 to 8 GHz, is presented in this paper. A TGF2023-02 GaN HEMT chip from Tri Quint is adopted and modeled. A novel negative feedback structure is applied in the circuit. The measured results show that the amplifier module has a wide range frequency response that is almost consistent with those of simulation at frequencies from 3 to 6.5 GHz. The measured power gain is greater than 7 dB between 3 and 6.5 GHz.The saturated output power is 38.5 dBm under DC bias of Vds =D28 V, Vgs D =-3：5 V at the frequency of 5.5 GHz.

反馈类型的判断方法

反馈类型的判断和引入是电路分析和设计的重点和难点，本文就各种反馈类型的判断方法进行了详细的阐述。

Temporal Structures of the North Atlantic Oscillation and Its Impact on the Regional Climate Variability

In this study, the temporal structure of the variation of North Atlantic Oscillation （NAO） and its impact on regional climate variability are analyzed using various datasets. The results show that blocking formations in the Atlantic region are sensitive to the phase of the NAO. Sixty-seven percent more winter blocking days are observed during the negative phase compared to the positive phase of the NAO. The average length of blocking during the negative phase is about 11 days, which is nearly twice as long as the 6-day length observed during the positive phase of the NAO. The NAO-related differences in blocking frequency and persistence are associated with changes in the distribution of the surface air temperature anomaly, which, to a large extent, is determined by the phase of the NAO. The distribution of regional cloud amount is also sensitive to the phase of the NAO. For the negative phase, the cloud amounts are significant, positive anomalies in the convective zone in the Tropics and much less cloudiness in the mid latitudes. But for the positive phase of the NAO, the cloud amount is much higher in the mid-latitude storm track region. In the whole Atlantic region, the cloud amount shows a decrease with the increase of surface air temperature. These results suggest that there may be a negative feedback between the cloud amount and the surface air t.emperature in the Atlantic region.

Cognitive inflexibility in Japanese adolescents and adults with autism spectrum disorders

AIM: To investigate executive function in Japanese adolescents and adults with autism spectrum disorders(ASD) compared to Japanese controls.METHODS: Thirty-three individuals with ASD and 33 controls participated. The ASD and control groups' demographic variables were matched for gender(male/female: 20/13 vs 20/13), age(26.1 ± 11.5 vs 26.8 ± 9.6), years of education(13.2 ± 2.9 vs 14.2 ± 1.9), full-scale intelligence quotient(IQ)(103.0 ± 16.7 vs 103.7 ± 14.7), performance IQ(96.2 ± 16.1 vs 97.8 ± 15.0), and verbal IQ(107.9 ± 16.3 vs 107.7 ± 14.4). Participants performed the Wisconsin Card Sorting Test(WCST), which assesses the executive processes involved in problem solving and cognitive flexibility, and the Continuous Performance Test(CPT), which assesses attention and impulsivity. Symptoms were assessed by the Autism-Spectrum Quotient Japanese version(AQ-J). First, we compared the scores of the WCST between the groups using a Mann-Whitney U-test and conducted an analysis of covariance for the variables with the scores of category archives and CPT scores as covariates. Second, we analyzed the correlation between the scores of the WCST and the AQ-J in the ASD group using Pearson's r.RESULTS: The total errors(TE) and the percentages of perseverative errors of the Milner type(%PEM) and Nelson type(%PEN) among the TE in the ASD group were significantly worse compared with the control group(ASD vs Control, respectively: TE: 16.0 ± 6.2 vs 12.6 ± 3.5, P = 0.012; %PEM: 11.7 ± 10.7 vs 6.6 ± 8.9, P = 0.037; %PEN: 20.1 ± 14.5 vs 8.7 ± 10.4, P = 0.0011). In contrast, no significant difference was observed between the two groups in the scores of categories achieved on the WCST or the CPT. An analysis of covariance revealed significant differences between the groups in the %PEN scores(P = 0.0062) but not in the TE or the %PEM scores. These results suggest that Japanese adolescents and adults with ASD have cognitive inflexibility. Furthermore, our results suggest that Japanese adolescents and adults with ASD may have difficulties using negative feedback because perseverative errors of the Nelson type indicate persistence in choosing the incorrect reaction. By contrast, there was no significant correlation between the WCST and AQ-J scores.CONCLUSION: We confirmed the presence of cognitive inflexibility in Japanese adolescents and adults with ASD. Our results also indicated that subjects with ASD may not use negative feedback effectively.

Research Status and Key Technologies of Geo-Electromagnetic Magnetic Induction Sensor

According to different applications,the performance parameters of the several Geo-Electromagnetic Magnetic Induction Sensors( GEMISs) which are the most representative in the world are compared. After discussing the several key technologies for improving the performance of GEMISs,the main conclusions are as follows: the application bandwidth can be expanded by adopting flux negative feedback( 1 m Hz-10 k Hz);"laminated"core structure is useful for suppressing eddy current loss; the effective permeability of the core has increased observably after adding flux concentrators to the two ends of the core; the chopper amplifier is a useful method to suppress 1/f noise for reducing the GEMIS's output noise; the indoor calibration scheme based on"long straight solenoid"proposed to obtain sensor sensitivity. Accordingly,the problem how to reduce the noise of GEMIS is urgent need to be solved,which will improve the performance of GEMIS. And there is plenty of work requires further study on parameters ' optimization of coil and core. In the future,miniaturization,intelligence and three-axis measurement are the development directions of GEMIS.

Tropical cyclone, as powerful natural self-oscillatory systems, and wind-energetic a way of struggle against it—The analysis of a cyclone from a position of the theory of vibrations

It is considered three phases of development of a tropical cyclone: the origin, the steady-state regime and the termination, coinciding with three phases of self-oscillatory process: oscillation buid-up, dynamic balance and failure of self-oscillations. The rough size of energy of a cyclone, as column of air rotating with high speed, at initial and final stages of development and comparison of the received sizes with nuclear and hydrogen bombs is calculated. The model of the electronic oscillator with negative active conductivity by the numerical solution of the equation of the Van-der-Pol is analyzed. Formal coincidence of transient in this model with increase of capacity of vortical air formation, that allows to make mnemonic model of a cyclone in the form of volume self-oscillatory system is shown. The numerical solution of the made equations allows to construct schedules of dynamic process for each of particles of the investigated environment. The general recipe on restraint of development of a cyclone by compulsory entering into it of attenuation is given. Realization of this recipe by means of group of platforms with powerful wind-electrogenerator and the fans and uses of a principle of negative feedback is shown. The results of laboratory experiment confirming idea, taken as a principle struggle against an arising air whirlwind, by transformation of a laminar stream in chaotic, turbulent are resulted. For fuller check offered a wind-energetic method of struggle against a cyclone carrying out of more scale experiment is necessary.

A High Dynamic Range GMI Current Sensor

The design and performances of a high dynamic range DC-AC current sensor utilizing Giant Magneto-Impedance (GMI) are presented. The sensor is based on a GMI element with negative feedback. The sensing element is a 30 μm diameter GMI Co-based amorphous wire. It is curled to a toroidal core of 2 cm diameter. A bias magnetic field of about 650 A/m is applied to the GMI element to obtain an asymmetric GMI effect. A strong negative feedback is introduced to ensure linearity in a wide dynamic range. Analog conditioning electronics was fully developed. This includes a square wave oscillator based on an inverter trigger;a peak detector and a high gain amplifier with zero adjust. The GMI element is driven at a 3 MHz frequency and 5 mA peak-to-peak current. The closed-loop operations are investigated and the performances of the sensor are presented. DC current measurements are performed. The sensor exhibits good sensitivity and very good linearity, free from hysteresis, in a wide dynamic range of ±40 A. The sensitivity is about 0.24 V/A and the linearity error is about 0.02% of the full scale (FS). The hysteresis error is smaller than the measurement accuracy. AC current measurements using the developed sensor have also been successfully achieved. The sensor bandwidth in closed-loop was about 1.7 kHz.

A Study on the Molecular Switch of Gene Expression of the Mouse Heart Nuclear DNA Fragments

It is observed by in situ stain that LDH (1 5) ...nNAD + can probably enter the nucleopore and can be bound bound specifically with the genes that encode them. During the in vitro expression, the dilution of heart nuclear DNA fragments could enhance the expression activity of LDH/DNA and the amount of expressed LDH (1 5) is in proportion to the amount of dissociable LDH (1 5) on the LDH/DNA. With the integration of 14C Leu to the proteins, it is also observed that the addition of LDH (1 5) ...nNAD + can suppress the in vitro expression activity of LDH/DNA. AFM observation shows that the regulation sequence at the both ends of active genes may be bound with such active factors as proteins encoded by the genes which probably is the main molecular switch of gene expression and regulation we have been always searching for. Our work shows the prospective application of the combination of AFM and isotope labeling in the research of biological reaction.

OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice

Although both protein arginine methylation(PRMT)and jasmonate(JA)signaling are crucial for regulating plant development,the relationship between these processes in the control of spikelet development remains unclear.In this study,we used the CRISPR/Cas9 technology to generate two OsPRMT6a loss-of-function mutants that exhibit various abnormal spikelet structures.Interestingly,we found that OsPRMT6a can methylate arginine residues in JA signal repressors OsJAZ1 and OsJAZ7.We showed that arginine methylation of OsJAZ1 enhances the binding affinity of OsJAZ1 with the JA receptors OsCOI1a and OsCOI1b in the presence of JAs,thereby promoting the ubiquitination of OsJAZ1 by the SCF^(OsCOI1a/OsCOI1b) complex and degradation via the 26S proteasome.This process ultimately releases OsMYC2,a core transcriptional regulator in the JA signaling pathway,to activate or repress JA-responsive genes,thereby maintaining normal plant(spikelet)development.However,in the osprmt6a-1 mutant,reduced arginine methylation of OsJAZ1 impaires the interaction between OsJAZ1 and OsCOI1a/OsCOI1b in the presence of JAs.As a result,OsJAZ1 proteins become more stable,repressing JA responses,thus causing the formation of abnormal spikelet structures.Moreover,we discovered that JA signaling reduces the OsPRMT6a mRNA level in an OsMYC2-dependent manner,thereby establishing a negative feedback loop to balance JA signaling.We further found that OsPRMT6a-mediated arginine methylation of OsJAZ1 likely serves as a switch to tune JA signaling to maintain normal spikelet development under harsh environmental conditions such as high temperatures.Collectively,our study establishes a direct molecular link between arginine methylation and JA signaling in rice.

Paradigms and Paradox in the Ethylene Signaling Pathway and Interaction Network

Phytohormone ethylene plays pivotal roles in plant response to developmental and environmental signals. During the past few years, the emerging evidence has led us to a new understanding of the signaling mechanisms and regulatory networks of the ethylene action. In this review, we focus on the major advances made in the past three years, particularly the findings leading to new paradigms and the observations under debate. With the recent demonstration of the regulation of the protein stability of numerous key signaling components including EIN3, ELL1, EIN2, ETR2, EBFI/EBF2, and ETPI/ETP2, we highlight proteasome-dependent protein degradation as an essential regulatory mechanism that is widely adopted in the ethylene signaling pathway. We also discuss the implication of the negative feedback mechanism in the ethylene signaling pathway in light of ethylene-induced ETR2 and EBF2 gene expression. Meanwhile, we summarize the controversy on the involvement of MKK9-MPK3/6 cascade in the ethylene signaling versus biosynthesis pathway, and discuss the possible role of this MAPK module in the ethylene action. Finally, we describe the complex interactions between ethylene and other signaling pathways including auxin, light, and plant innate immunity, and propose that EIN3/ EIL1 act as a convergence point in the ethylene-initiated signaling network.

A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation Pathways in Soybean

Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to ammonia.The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AON).However,how these pathways are integrated and their underlying mechanisms are unclear.Here,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AON pathway.NNC1 interacts with GmNINa,the soybean ortholog of Lotus NODULE INCEPTION(NIN),and hampers its transcriptional activation o i G m RICI and GmRIC2.Importantly,GmNINa acts as a transcriptional activator of miR172c.Intriguingly,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory network.Moreover,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription.Thus,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling,supporting the balance between nodulation and AON in soybean.

Rapamycin in fibrotic diseases： beneficial or detrimental agent？

apamvcin was first isolated from a strain of Sreptomyces hygroscopicus in the early 1970s froma soil sample taken on Easter Island. Because the antiproliferative effects of rapamycin on yeast cell, as well as B and T lymphocytes, it was first identified as an antimicrobial agent with potent immunosuppressive activity and has been used in antirejection therapy.

Mutual regulation between Hippo signaling and actin cytoskeleton

Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation,apoptosis,and differentiation.How Hippo signaling is regulated has been under extensive investigation.Over the past three years,an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector,Yki/Yap/Taz.On the other hand,Hippo signaling negatively regulates actin cytoskeleton organization.This review p rovides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development,and points out outstanding questions for further investigations.

A 40 Gbit/s fully integrated optical receiver analog front-end in 90 nm CMOS

A fully integrated 40 Gbit/s optical receiver analog front-end （AFE） including a transimpedance amplifier （TIA） and a limiting amplifier （LA） for short distance communication is described in this paper. The proposed TIA employs a modified regulated cascode （RGC） configuration as input stage, and adopts a third order interleaving active feedback gain stage. The LA utilizes nested active feedback, negative capacitance, and inductor peaking technology to achieve high voltage gain and wide bandwidth. The tiny photo current received by the receiver AFE is amplified to a single-ended voltage swing of 200 mV（p-p）. Simulation results show that the receiver AFE provides conversion gain of up to 83 dBΩ and bandwidth of 34.7 GHz, and the equivalent input noise current integrated from 1 MHz to 30 GHz is about 6.6 μA（rms）.

Inhibiting pain with pain——A basic neuromechanism of acupuncture analgesia

(i) The structure and function of the meridian (channel and collateral) described by ancient medical doctors may correspond to the blood circulation, nerve control and neurohumoral modulation of modern medicine. (ii) The needling, which can injure the tissue, is a noxious stimulation inducing pain. Acupuncture manipulation, such as lifting and thrusting, twisting and twirling, or electroacupuncture (EA) with the sufferable biggest intensity for patients should be a stronger pain stimulation. The needling sensation of soreness, numbness, distension and heaviness is a deep pain. (iii) There is an intrinsic analgesic system in brain, which centers around the periventricular and periaqueductal grey matter, contains endorphins as possible mediators, goes through the descending inhibition system in medulla oblon-gata, and acts on the gating mechanism in spinal cord. Itcould be producing analgesia while the system is activated. (iv) NRM might be a supraspinal center modulating pain, and the R-S neurons could

Mixed-integrator-based bi-quad cell for designing a continuous time filter

A new mixed-integrator-based bi-quad cell is proposed. An alternative synthesis mechanism of complex poles is proposed compared with source-follower-based bi-quad cells which is designed applying the positive feedback technique. Using the negative feedback technique to combine different integrators, the proposed bi-quad cell synthesizes complex poles for designing a continuous time filter. It exhibits various advantages including compact topology, high gain, no parasitic pole, no CMFB circuit, and high capability. The fourth-order Butterworth lowpass filter using the proposed cells has been fabricated in 0.18μm CMOS technology. The active area occupied by the filter with test buffer is only 200 × 170 μm^2. The proposed filter consumes a low power of 201 μW and achieves a 68.5 dB dynamic range.