Aspen Batch Process Developer在原料药工程设计中的应用研究

基于Aspen Batch Process Developer软件对原料药工程设计进行应用研究。在某原料药项目中,通过软件建立工艺流程模拟模型,分析批次操作时间、年生产批次、年生产规模、物料衡算、设备选型和利用率、公用工程消耗等,在满足生产需求的情况下,达到优化生产排班、设备选型和公用工程量的目的。

A Cooperated Imperialist Competitive Algorithm for Unrelated Parallel Batch Machine Scheduling Problem

This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed,placed in a sandbox,and then the sandbox is positioned on a BPM formoulding.The complexity of the scheduling problem increases due to the consideration of BPM capacity and sandbox volume.To minimize the makespan,a new cooperated imperialist competitive algorithm(CICA)is introduced.In CICA,the number of empires is not a parameter,and four empires aremaintained throughout the search process.Two types of assimilations are achieved:The strongest and weakest empires cooperate in their assimilation,while the remaining two empires,having a close normalization total cost,combine in their assimilation.A new form of imperialist competition is proposed to prevent insufficient competition,and the unique features of the problem are effectively utilized.Computational experiments are conducted across several instances,and a significant amount of experimental results show that the newstrategies of CICAare effective,indicating promising advantages for the considered BPMscheduling problems.

Aspen Batch Process Developer在间歇化工流程模拟与优化中的应用

间歇生产过程具有弹性大、灵活等特点,其市场适应性较强。化工生产中间歇生产过程占相当比例,文章就间歇生产工艺的模拟与优化进行介绍,利用Aspen Batch Process Developer模拟间歇工艺过程,可以快速地得到工艺流程的物料衡算、热量衡算、操作时间、公用工程和成本估算等结果。同时,还可以对模拟结果进行分析,找出制约生产工艺的瓶颈,并对生产周期、生产规模、生产设备等进行优化,提高工艺设计效率,降低生产成本。

Modelling and Multi-Objective Optimal Control of Batch Processes Using Recurrent Neuro-fuzzy Networks

In this paper, the modelling and multi-objective optimal control of batch processes, using a recurrent neuro-fuzzy network, are presented. The recurrent neuro-fuzzy network, forms a ＂global＂ nonlinear long-range prediction model through the fuzzy conjunction of a number of ＂local＂ linear dynamic models. Network output is fed back to network input through one or more time delay units, which ensure that predictions from the recurrent neuro-fuzzy network are long-range. In building a recurrent neural network model, process knowledge is used initially to partition the processes non-linear characteristics into several local operating regions, and to aid in the initialisation of corresponding network weights. Process operational data is then used to train the network. Membership functions of the local regimes are identified, and local models are discovered via network training. Based on a recurrent neuro-fuzzy network model, a multi-objective optimal control policy can be obtained. The proposed technique is applied to a fed-batch reactor.

Batch process monitoring based on WGNPE–GSVDD related and independent variables

In many batch processes, there are related or independence relationships among process variables. The traditional monitoring method usually carries out a single statistical model according to the related or independent method, and in the feature extraction there is not fully taken into account the characterization of fault information, it will make the process monitoring ineffective, so a fault monitoring method based on WGNPE(weighted global neighborhood preserving embedding)–GSVDD(greedy support vector data description) related and independent variables is proposed. First, mutual information method is used to separate the related variables and independent variables. Secondly, WGNPE method is used to extract the local and global structures of the related variables in batch process and highlight the fault information, GSVDD method is used to extract the process information of the independent variables quickly and effectively. Finally, the statistical monitoring model is established to achieve process monitoring based on WGNPE and GSVDD. The effectiveness of the proposed method was verified by the penicillin fermentation process.

ON-LINE PROBLEMS OF MINIMIZING MAKESPAN ON A SINGLE BATCH PROCESSING MACHINE WITH NONIDENTICAL JOB SIZES

The on-line problem of scheduling on a batch processing machine with nonidentical job sizes to minimize makespan is considered. The batch processing machine can process a number of jobs simultaneously as long as the total size of these jobs being processed does not exceed the machine capacity. The processing time of a batch is given by the longest processing time of any job in the batch. Each job becomes available at its arrival time, which is unknown in advance, and its processing time becomes known upon its arrival. The paper deals with two variants： the case only with two distinct arrival times and the general case. For the first case, an on-line algorithm with competitive ratio 119/44 is given. For the latter one, a simple algorithm with competitive ratio 3 is given. For both variants the better ratios can be obtained if the problem satisfies proportional assumption.

Modeling and Optimization for Scheduling of Chemical Batch Processes

化学的批过程在化学生产变得重要。在这些过程，大量化学产品被生产在日常生命满足人的要求。最近，经济全球化导致了在传统的化学过程工业种世界范围的比赛。以便在全球市场保持竞争，每个公司必须优化它的生产管理并且为市场变化建立一个反应系统。安排是在化学过程的生产管理的核心。这篇论文的目标是在这个挑战性的区域考察最近的开发。安排问题和优化方法的批的分类被介绍。六个典型模型的比较从文学在一个一般基准例子被显示出。最后，在未来研究的挑战和应用被讨论。

An Anticipatory Terminal Iterative Learning Control Approach with Applications to Constrained Batch Processes

This work presents an anticipatory terminal iterative learning control scheme for a class of batch processes, where only the final system output is measurable and the control input is constant in each operations. The proposed approach works well with input constraints provided that the desired control input with respect to the desired trajectory is within the saturation bound. The tracking error convergence is established with rigorous mathematical analysis. Simulation results are provided to show the effectiveness of the proposed approach.

Online Batch Process Monitoring Based on Just-in-Time Learning and Independent Component Analysis

A new method was developed for batch process monitoring in this paper.In the developed method,just-in-time learning(J1TL) and independent component analysis(ICA) were integrated to build JITL-ICA monitoring scheme.JITL was employed to tackle with the characteristics of batch process such as inherent timevarying dynamics,multiple operating phases,and especially the case of uneven length stage.According to new coming test data,the most correlated segmentation was obtained from batch-wise unfolded training data by JITL.Then,ICA served as the principal components extraction approach.Therefore,the non-Gaussian distributed data can also be addressed under this modeling framework.The effectiveness and superiority of JITL-ICA based monitoring method was demonstrated by fed-batch penicillin fermentation.

On-line Batch Process Monitoring with Improved Multi-way Independent Component Analysis

In the past decades, on-line monitoring of batch processes using multi-way independent component analysis (MICA) has received considerable attention in both academia and industry. This paper focuses on two troublesome issues concerning selecting dominant independent components without a standard criterion and determining the control limits of monitoring statistics in the presence of non-Gaussian distribution. To optimize the number of key independent components, we introduce a novel concept of system deviation, which is able to evaluate the reconstructed observations with different independent components. The monitored statistics are transformed to Gaussian distribution data by means of Box-Cox transformation, which helps readily determine the control limits. The proposed method is applied to on-line monitoring of a fed-batch penicillin fermentation simulator, and the experimental results indicate the advantages of the improved MICA monitoring compared to the conventional methods.

Optimal Iterative Learning Control for Batch Processes Based on Linear Time-varying Perturbation Model

为在批的产品质量的追踪的控制的最佳的反复的学习控制(ILC ) 策略处理的 batch-to-batch 被介绍。线性变化时间的不安(LTVP ) 模型在名字的轨道附近为产品质量被造。到模型植物失配的地址问题，在以前的成批处理的模型预言错误为当前的成批处理被加到模型预言。然后追踪错误转变模型能被造，并且有直接错误反馈的 ILC 法律明确地被获得。一条严密定理被建议，到证明在 ILC 下面追踪错误的集中。建议方法论在一个典型的批反应堆和轨道追踪的表演被 ILC 逐渐地改进的结果表演上被说明。

Iterative Learning Model Predictive Control for a Class of Continuous/Batch Processes

一个反复的学习模型预兆的控制(ILMPC ) 技术被用于 continuous/batch 过程的一个班。如此的过程被产生周期的强壮的骚乱到连续过程的批过程的操作描绘，传统的规章的控制器是不能的消除这些周期的骚乱。ILMPC 集成处理重复信号和灵活性的反复的学习控制(ILC ) 的特征为预兆的控制(MPC ) 建模。由联机监视，批的操作地位处理，事件驱动为批的反复的学习算法重复骚乱被开始，软限制被调整象可行区域及时离开需要的操作地区。一个工业应用程序的结果证明建议 ILMPC 方法为 continuous/batch 进程的一个类是有效的。

Just-in-time learning based integrated MPC-ILC control for batch processes

Considering the two-dimension(2 D) characteristic and the unknown optimal trajectory problem of the batch processes, an integrated model predictive control-iterative learning control(MPC-ILC) for batch processes is proposed in this paper. Firstly, the batch-axis information and time-axis information are combined into one quadratic performance index. It implies the integration of ILC and MPC algorithm idea, which leads to superior tracking performance and better robustness against disturbance and uncertainty. To address the problem of the unknown optimal trajectory, both time-varying prediction horizon and end product quality control are employed. Moreover, an integrated 2 D just-in-time learning(JITL) model is used to improve the predictive accuracy. Furthermore, rigorous description and proof are presented to prove the convergence and tracking performance of the proposed MPC-ILC strategy. The simulation results show the effectiveness of the proposed method.

Batch Process Modelling and Optimal Control Based on Neural Network Model

This paper presents several neural network based modelling, reliable optimal control, and iterative learning control methods for batch processes. In order to overcome the lack of robustness of a single neural network, bootstrap aggregated neural networks are used to build reliable data based empirical models. Apart from improving the model generalisation capability, a bootstrap aggregated neural network can also provide model prediction confidence bounds. A reliable optimal control method by incorporating model prediction confidence bounds into the optimisation objective function is presented. A neural network based iterative learning control strategy is presented to overcome the problem due to unknown disturbances and model-plant mismatches. The proposed methods are demonstrated on a simulated batch polymerisation process.

Run-to-run Optimization for Fed-batch Fermentation Process with Swarm Energy Conservation Particle Swarm Optimization Algorithm

An iterative optimization strategy for fed-batch fermentation process is presented by combining a run-to-run optimization with swarm energy conservation particle swarm optimization (SEC-PSO). SEC-PSO, which is designed with the concept of energy conservation, can solve the problem of premature convergence frequently appeared in standard PSO algorithm by partitioning its population into several sub-swarms according to the energy of the swarm and is used in the optimization strategy for parameter identification and operation condition optimization. The run-to-run optimization exploits the repetitive nature of fed-batch processes in order to deal with the optimal problems of fed-batch fermentation process with inaccurate process model and unsteady process state. The kinetic model parameters, used in the operation condition optimization of the next run, are adjusted by calculating time-series data obtained from real fed-batch process in the run-to-run optimization. The simulation results show that the strategy can adjust its kinetic model dynamically and overcome the instability of fed-batch process effectively. Run-to-run strategy with SEC-PSO provides an effective method for optimization of fed-batch fermentation process.

Consequence Identification for Maloperation in Batch Process

Batch processes are important in chemical industry,in which operators usually play a major role and hazards may arise by their inadvertent acts.In this paper,based on hazard and operability study and concept of qualitative simulation,an automatic method for adverse consequence identification for potential maloperation is proposed.The qualitative model for production process is expressed by a novel directed graph.Possible operation deviations from normal operating procedure are identified systematically by using a group of guidewords.The proposed algorithm is used for qualitative simulation of batch processes to identify the effects of maloperations.The method is illustrated with a simple batch process and a batch reaction process.The results show that batch processes can be simulated qualitatively and hazards can be identified for operating procedures including maloperations.After analysis for possible plant maloperations,some measures can be taken to avoid maloperations or reduce losses resulted from maloperations.

An LMI Method to Robust Iterative Learning Fault-tolerant Guaranteed Cost Control for Batch Processes

Based on an equivalent two-dimensional Fornasini-Marchsini model for a batch process in industry, a closed-loop robust iterative learning fault-tolerant guaranteed cost control scheme is proposed for batch processes with actuator failures. This paper introduces relevant concepts of the fault-tolerant guaranteed cost control and formulates the robust iterative learning reliable guaranteed cost controller (ILRGCC). A significant advantage is that the proposed ILRGCC design method can be used for on-line optimization against batch-to-batch process uncertainties to realize robust tracking of set-point trajectory in time and batch-to-batch sequences. For the convenience of implementation, only measured output errors of current and previous cycles are used to design a synthetic controller for iterative learning control, consisting of dynamic output feedback plus feed-forward control. The proposed controller can not only guarantee the closed-loop convergency along time and cycle sequences but also satisfy the H∞performance level and a cost function with upper bounds for all admissible uncertainties and any actuator failures. Sufficient conditions for the controller solution are derived in terms of linear matrix inequalities (LMIs), and design procedures, which formulate a convex optimization problem with LMI constraints, are presented. An example of injection molding is given to illustrate the effectiveness and advantages of the ILRGCC design approach.

Batch process monitoring based on multilevel ICA-PCA

In this paper, we describe a new batch process monitoring method based on multilevel independent component analysis and principal component analysis (MLICA-PCA). Unlike the conventional multi-way principal component analysis (MPCA) method, MLICA-PCA provides a separated interpretation for multilevel batch process data. Batch process data are partitioned into two levels: the within-batch level and the between-batch level. In each level, the Gaussian and non-Gaussian components of process information can be separately extracted. I2, T2 and SPE statistics are individually built and monitored. The new method facilitates fault diagnosis. Since the two variation levels are decomposed, the variables responsible for faults in each level can be identified and interpreted more easily. A case study of the Dupont benchmark process showed that the proposed method was more efficient and interpretable in fault detection and diagnosis, compared to the alternative batch process monitoring method.

A Robust Statistical Batch Process Monitoring Framework and Its Application

In order to reduce the variations of the product quality in batch processes, multivariate statistical process control methods according to multi-way principal component analysis (MPCA) or multi-way projection to latent structure (MPLS) were proposed for on-line batch process monitoring. However, they are based on the decomposition of relative covariance matrix and strongly affected by outlying observations. In this paper, in view of an efficient projection pursuit algorithm, a robust statistical batch process monitoring (RSBPM) framework,which is resistant to outliers, is proposed to reduce the high demand for modeling data. The construction of robust normal operating condition model and robust control limits are discussed in detail. It is evaluated on monitoring an industrial streptomycin fermentation process and compared with the conventional MPCA. The results show that the RSBPM framework is resistant to possible outliers and the robustness is confirmed.