EDSUCh:A robust ensemble data summarization method for effective medical diagnosis

Identifying rare patterns for medical diagnosis is a challenging task due to heterogeneity and the volume of data.Data summarization can create a concise version of the original data that can be used for effective diagnosis.In this paper,we propose an ensemble summarization method that combines clustering and sampling to create a summary of the original data to ensure the inclusion of rare patterns.To the best of our knowledge,there has been no such technique available to augment the performance of anomaly detection techniques and simultaneously increase the efficiency of medical diagnosis.The performance of popular anomaly detection algorithms increases significantly in terms of accuracy and computational complexity when the summaries are used.Therefore,the medical diagnosis becomes more effective,and our experimental results reflect that the combination of the proposed summarization scheme and all underlying algorithms used in this paper outperforms the most popular anomaly detection techniques.

Anomaly Detection Using Data Rate of Change on Medical Data

The identification and mitigation of anomaly data,characterized by deviations from normal patterns or singularities,stand as critical endeavors in modern technological landscapes,spanning domains such as Non-Fungible Tokens(NFTs),cyber-security,and the burgeoning metaverse.This paper presents a novel proposal aimed at refining anomaly detection methodologies,with a particular focus on continuous data streams.The essence of the proposed approach lies in analyzing the rate of change within such data streams,leveraging this dynamic aspect to discern anomalies with heightened precision and efficacy.Through empirical evaluation,our method demonstrates a marked improvement over existing techniques,showcasing more nuanced and sophisticated result values.Moreover,we envision a trajectory of continuous research and development,wherein iterative refinement and supplementation will tailor our approach to various anomaly detection scenarios,ensuring adaptability and robustness in real-world applications.

Reliable Data Collection Model and Transmission Framework in Large-Scale Wireless Medical Sensor Networks

Large-scale wireless sensor networks(WSNs)play a critical role in monitoring dangerous scenarios and responding to medical emergencies.However,the inherent instability and error-prone nature of wireless links present significant challenges,necessitating efficient data collection and reliable transmission services.This paper addresses the limitations of existing data transmission and recovery protocols by proposing a systematic end-to-end design tailored for medical event-driven cluster-based large-scale WSNs.The primary goal is to enhance the reliability of data collection and transmission services,ensuring a comprehensive and practical approach.Our approach focuses on refining the hop-count-based routing scheme to achieve fairness in forwarding reliability.Additionally,it emphasizes reliable data collection within clusters and establishes robust data transmission over multiple hops.These systematic improvements are designed to optimize the overall performance of the WSN in real-world scenarios.Simulation results of the proposed protocol validate its exceptional performance compared to other prominent data transmission schemes.The evaluation spans varying sensor densities,wireless channel conditions,and packet transmission rates,showcasing the protocol’s superiority in ensuring reliable and efficient data transfer.Our systematic end-to-end design successfully addresses the challenges posed by the instability of wireless links in large-scaleWSNs.By prioritizing fairness,reliability,and efficiency,the proposed protocol demonstrates its efficacy in enhancing data collection and transmission services,thereby offering a valuable contribution to the field of medical event-drivenWSNs.

A novel medical image data protection scheme for smart healthcare system

The Internet of Multimedia Things(IoMT)refers to a network of interconnected multimedia devices that communicate with each other over the Internet.Recently,smart healthcare has emerged as a significant application of the IoMT,particularly in the context of knowledge‐based learning systems.Smart healthcare systems leverage knowledge‐based learning to become more context‐aware,adaptable,and auditable while maintain-ing the ability to learn from historical data.In smart healthcare systems,devices capture images,such as X‐rays,Magnetic Resonance Imaging.The security and integrity of these images are crucial for the databases used in knowledge‐based learning systems to foster structured decision‐making and enhance the learning abilities of AI.Moreover,in knowledge‐driven systems,the storage and transmission of HD medical images exert a burden on the limited bandwidth of the communication channel,leading to data trans-mission delays.To address the security and latency concerns,this paper presents a lightweight medical image encryption scheme utilising bit‐plane decomposition and chaos theory.The results of the experiment yield entropy,energy,and correlation values of 7.999,0.0156,and 0.0001,respectively.This validates the effectiveness of the encryption system proposed in this paper,which offers high‐quality encryption,a large key space,key sensitivity,and resistance to statistical attacks.

Changes and Adjustments:The Rule of Law Response to Medical Institution Data Compliance

Medical institution data compliance is an exogenous product of the digital society,serving as a crucial means to maintain and balance the relationship between data protection and data sharing,as well as individual interests and public interests.The implementation of the Healthy China Initiative greatly benefits from its practical significance.In practice,data from medical institutions takes varied forms,including personally identifiable data collected before diagnosis and treatment,clinical medical data generated during diagnosis and treatment,medical data collected in public health management,and potential medical data generated in daily life.In the new journey of comprehensively promoting the Chinese path to modernization,it is necessary to clarify the shift from an individual-oriented to a societal-oriented value system,highlighting the reinforcing role of the trust concept.Guided by the principle of minimizing data utilization,the focus is on the new developments and changes in medical institution data in the postpandemic era.This involves a series of measures such as fulfilling the obligation of notification and consent,specifying the scope of data collection and usage,strengthening the standardized use of relevant technical measures,and establishing a sound legal responsibility system for data compliance.Through these measures,a flexible and efficient medical institution data compliance system can be constructed.

Privacy-Preserving Healthcare and Medical Data Collaboration Service System Based on Blockchain and Federated Learning

As the volume of healthcare and medical data increases from diverse sources,real-world scenarios involving data sharing and collaboration have certain challenges,including the risk of privacy leakage,difficulty in data fusion,low reliability of data storage,low effectiveness of data sharing,etc.To guarantee the service quality of data collaboration,this paper presents a privacy-preserving Healthcare and Medical Data Collaboration Service System combining Blockchain with Federated Learning,termed FL-HMChain.This system is composed of three layers:Data extraction and storage,data management,and data application.Focusing on healthcare and medical data,a healthcare and medical blockchain is constructed to realize data storage,transfer,processing,and access with security,real-time,reliability,and integrity.An improved master node selection consensus mechanism is presented to detect and prevent dishonest behavior,ensuring the overall reliability and trustworthiness of the collaborative model training process.Furthermore,healthcare and medical data collaboration services in real-world scenarios have been discussed and developed.To further validate the performance of FL-HMChain,a Convolutional Neural Network-based Federated Learning(FL-CNN-HMChain)model is investigated for medical image identification.This model achieves better performance compared to the baseline Convolutional Neural Network(CNN),having an average improvement of 4.7%on Area Under Curve(AUC)and 7%on Accuracy(ACC),respectively.Furthermore,the probability of privacy leakage can be effectively reduced by the blockchain-based parameter transfer mechanism in federated learning between local and global models.

Multi-dimension and multi-modal rolling mill vibration prediction model based on multi-level network fusion

Mill vibration is a common problem in rolling production,which directly affects the thickness accuracy of the strip and may even lead to strip fracture accidents in serious cases.The existing vibration prediction models do not consider the features contained in the data,resulting in limited improvement of model accuracy.To address these challenges,this paper proposes a multi-dimensional multi-modal cold rolling vibration time series prediction model(MDMMVPM)based on the deep fusion of multi-level networks.In the model,the long-term and short-term modal features of multi-dimensional data are considered,and the appropriate prediction algorithms are selected for different data features.Based on the established prediction model,the effects of tension and rolling force on mill vibration are analyzed.Taking the 5th stand of a cold mill in a steel mill as the research object,the innovative model is applied to predict the mill vibration for the first time.The experimental results show that the correlation coefficient(R^(2))of the model proposed in this paper is 92.5%,and the root-mean-square error(RMSE)is 0.0011,which significantly improves the modeling accuracy compared with the existing models.The proposed model is also suitable for the hot rolling process,which provides a new method for the prediction of strip rolling vibration.

Integrated data mining and network pharmacology to discover a novel traditional Chinese medicine prescription against diabetic retinopathy and reveal its mechanism

Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with diabetes.Traditional Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating DR.This study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)simulation.Method:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data mining.Subsequently,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core pathways.Finally,molecular docking and MD simulation were employed to validate the findings from network pharmacology.Result:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney channels.Notably,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis Radix.Twenty core active ingredients and ten core targets of the novel TCM prescription for treating DR were screened.Moreover,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling pathway.Finally,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core targets.Conclusions:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating DR.These findings provide a scientific basis and novel insights into the development of drugs for DR prevention and treatment.

Data Masking for Chinese Electronic Medical Records with Named Entity Recognition

With the rapid development of information technology,the electronifi-cation of medical records has gradually become a trend.In China,the population base is huge and the supporting medical institutions are numerous,so this reality drives the conversion of paper medical records to electronic medical records.Electronic medical records are the basis for establishing a smart hospital and an important guarantee for achieving medical intelligence,and the massive amount of electronic medical record data is also an important data set for conducting research in the medical field.However,electronic medical records contain a large amount of private patient information,which must be desensitized before they are used as open resources.Therefore,to solve the above problems,data masking for Chinese electronic medical records with named entity recognition is proposed in this paper.Firstly,the text is vectorized to satisfy the required format of the model input.Secondly,since the input sentences may have a long or short length and the relationship between sentences in context is not negligible.To this end,a neural network model for named entity recognition based on bidirectional long short-term memory(BiLSTM)with conditional random fields(CRF)is constructed.Finally,the data masking operation is performed based on the named entity recog-nition results,mainly using regular expression filtering encryption and principal component analysis(PCA)word vector compression and replacement.In addi-tion,comparison experiments with the hidden markov model(HMM)model,LSTM-CRF model,and BiLSTM model are conducted in this paper.The experi-mental results show that the method used in this paper achieves 92.72%Accuracy,92.30%Recall,and 92.51%F1_score,which has higher accuracy compared with other models.

Ensemble Deep Learning with Chimp Optimization Based Medical Data Classification

Eye state classification acts as a vital part of the biomedical sector,for instance,smart home device control,drowsy driving recognition,and so on.The modifications in the cognitive levels can be reflected via transforming the electro-encephalogram(EEG)signals.The deep learning(DL)models automated extract the features and often showcased improved outcomes over the conventional clas-sification model in the recognition processes.This paper presents an Ensemble Deep Learning with Chimp Optimization Algorithm for EEG Eye State Classifi-cation(EDLCOA-ESC).The proposed EDLCOA-ESC technique involves min-max normalization approach as a pre-processing step.Besides,wavelet packet decomposition(WPD)technique is employed for the extraction of useful features from the EEG signals.In addition,an ensemble of deep sparse autoencoder(DSAE)and kernel ridge regression(KRR)models are employed for EEG Eye State classification.Finally,hyperparameters tuning of the DSAE model takes place using COA and thereby boost the classification results to a maximum extent.An extensive range of simulation analysis on the benchmark dataset is car-ried out and the results reported the promising performance of the EDLCOA-ESC technique over the recent approaches with maximum accuracy of 98.50%.

Energy Aware Clustering with Medical Data Classification Model in IoT Environment

With the exponential developments of wireless networking and inexpensive Internet of Things(IoT),a wide range of applications has been designed to attain enhanced services.Due to the limited energy capacity of IoT devices,energy-aware clustering techniques can be highly preferable.At the same time,artificial intelligence(AI)techniques can be applied to perform appropriate disease diagnostic processes.With this motivation,this study designs a novel squirrel search algorithm-based energy-aware clustering with a medical data classification(SSAC-MDC)model in an IoT environment.The goal of the SSAC-MDC technique is to attain maximum energy efficiency and disease diagnosis in the IoT environment.The proposed SSAC-MDC technique involves the design of the squirrel search algorithm-based clustering(SSAC)technique to choose the proper set of cluster heads(CHs)and construct clusters.Besides,the medical data classification process involves three different subprocesses namely pre-processing,autoencoder(AE)based classification,and improved beetle antenna search(IBAS)based parameter tuning.The design of the SSAC technique and IBAS based parameter optimization processes show the novelty of the work.For show-casing the improved performance of the SSAC-MDC technique,a series of experiments were performed and the comparative results highlighted the supremacy of the SSAC-MDC technique over the recent methods.

Research on a Fog Computing Architecture and BP Algorithm Application for Medical Big Data

Although the Internet of Things has been widely applied,the problems of cloud computing in the application of digital smart medical Big Data collection,processing,analysis,and storage remain,especially the low efficiency of medical diagnosis.And with the wide application of the Internet of Things and Big Data in the medical field,medical Big Data is increasing in geometric magnitude resulting in cloud service overload,insufficient storage,communication delay,and network congestion.In order to solve these medical and network problems,a medical big-data-oriented fog computing architec-ture and BP algorithm application are proposed,and its structural advantages and characteristics are studied.This architecture enables the medical Big Data generated by medical edge devices and the existing data in the cloud service center to calculate,compare and analyze the fog node through the Internet of Things.The diagnosis results are designed to reduce the business processing delay and improve the diagnosis effect.Considering the weak computing of each edge device,the artificial intelligence BP neural network algorithm is used in the core computing model of the medical diagnosis system to improve the system computing power,enhance the medical intelligence-aided decision-making,and improve the clinical diagnosis and treatment efficiency.In the application process,combined with the characteristics of medical Big Data technology,through fog architecture design and Big Data technology integration,we could research the processing and analysis of heterogeneous data of the medical diagnosis system in the context of the Internet of Things.The results are promising:The medical platform network is smooth,the data storage space is sufficient,the data processing and analysis speed is fast,the diagnosis effect is remarkable,and it is a good assistant to doctors’treatment effect.It not only effectively solves the problem of low clinical diagnosis,treatment efficiency and quality,but also reduces the waiting time of patients,effectively solves the contradiction between doctors and patients,and improves the medical service quality and management level.

A Novel Computationally Efficient Approach to Identify Visually Interpretable Medical Conditions from 2D Skeletal Data

Timely identification and treatment of medical conditions could facilitate faster recovery and better health.Existing systems address this issue using custom-built sensors,which are invasive and difficult to generalize.A low-complexity scalable process is proposed to detect and identify medical conditions from 2D skeletal movements on video feed data.Minimal set of features relevant to distinguish medical conditions:AMF,PVF and GDF are derived from skeletal data on sampled frames across the entire action.The AMF(angular motion features)are derived to capture the angular motion of limbs during a specific action.The relative position of joints is represented by PVF(positional variation features).GDF(global displacement features)identifies the direction of overall skeletal movement.The discriminative capability of these features is illustrated by their variance across time for different actions.The classification of medical conditions is approached in two stages.In the first stage,a low-complexity binary LSTM classifier is trained to distinguish visual medical conditions from general human actions.As part of stage 2,a multi-class LSTM classifier is trained to identify the exact medical condition from a given set of visually interpretable medical conditions.The proposed features are extracted from the 2D skeletal data of NTU RGB+D and then used to train the binary and multi-class LSTM classifiers.The binary and multi-class classifiers observed average F1 scores of 77%and 73%,respectively,while the overall system produced an average F1 score of 69%and a weighted average F1 score of 80%.The multi-class classifier is found to utilize 10 to 100 times fewer parameters than existing 2D CNN-based models while producing similar levels of accuracy.

An Improved Steganographic Scheme Using the Contour Principle to Ensure the Privacy of Medical Data on Digital Images

With the improvement of current online communication schemes,it is now possible to successfully distribute and transport secured digital Content via the communication channel at a faster transmission rate.Traditional steganography and cryptography concepts are used to achieve the goal of concealing secret Content on a media and encrypting it before transmission.Both of the techniques mentioned above aid in the confidentiality of feature content.The proposed approach concerns secret content embodiment in selected pixels on digital image layers such as Red,Green,and Blue.The private Content originated from a medical client and was forwarded to a medical practitioner on the server end through the internet.The K-Means clustering principle uses the contouring approach to frame the pixel clusters on the image layers.The content embodiment procedure is performed on the selected pixel groups of all layers of the image using the Least Significant Bit(LSB)substitution technique to build the secret Content embedded image known as the stego image,which is subsequently transmitted across the internet medium to the server end.The experimental results are computed using the inputs from“Open-Access Medical Image Repositories(aylward.org)”and demonstrate the scheme’s impudence as the Content concealing procedure progresses.

Importance of Features Selection,Attributes Selection,Challenges and Future Directions for Medical Imaging Data:A Review

In the area of pattern recognition and machine learning,features play a key role in prediction.The famous applications of features are medical imaging,image classification,and name a few more.With the exponential growth of information investments in medical data repositories and health service provision,medical institutions are collecting large volumes of data.These data repositories contain details information essential to support medical diagnostic decisions and also improve patient care quality.On the other hand,this growth also made it difficult to comprehend and utilize data for various purposes.The results of imaging data can become biased because of extraneous features present in larger datasets.Feature selection gives a chance to decrease the number of components in such large datasets.Through selection techniques,ousting the unimportant features and selecting a subset of components that produces prevalent characterization precision.The correct decision to find a good attribute produces a precise grouping model,which enhances learning pace and forecast control.This paper presents a review of feature selection techniques and attributes selection measures for medical imaging.This review is meant to describe feature selection techniques in a medical domainwith their pros and cons and to signify its application in imaging data and data mining algorithms.The review reveals the shortcomings of the existing feature and attributes selection techniques to multi-sourced data.Moreover,this review provides the importance of feature selection for correct classification of medical infections.In the end,critical analysis and future directions are provided.

Sleep disturbances and predictors of nondeployability among active-duty army soldiers: an odds ratio analysis of medical healthcare data from fiscal year 2018

Background:The impact of sleep disorders on active-duty soldiers’medical readiness is not currently quantified.Patient data generated at military treatment facilities can be accessed to create research reports and thus can be used to estimate the prevalence of sleep disturbances and the role of sleep on overall health in service members.The current study aimed to quantify sleep-related health issues and their impact on health and nondeployability through the analysis of U.S.military healthcare records from fiscal year 2018(FY2018).Methods:Medical diagnosis information and deployability profiles(e-Profiles)were queried for all active-duty U.S.Army patients with a concurrent sleep disorder diagnosis receiving medical care within FY2018.Nondeployability was predicted from medical reasons for having an e-Profile(categorized as sleep,behavioral health,musculoskeletal,cardiometabolic,injury,or accident)using binomial logistic regression.Sleep e-Profiles were investigated as a moderator between other e-Profile categories and nondeployability.Results:Out of 582,031 soldiers,48.4%(n=281,738)had a sleep-related diagnosis in their healthcare records,9.7%(n=56,247)of soldiers had e-Profiles,and 1.9%(n=10,885)had a sleep e-Profile.Soldiers with sleep e-Profiles were more likely to have had a motor vehicle accident(p OR(prevalence odds ratio)=4.7,95%CI 2.63–8.39,P≤0.001)or work/duty-related injury(p OR=1.6,95%CI 1.32–1.94,P≤0.001).The likelihood of nondeployability was greater in soldiers with a sleep e-Profile and a musculoskeletal e-Profile(p OR=4.25,95%CI 3.75–4.81,P≤0.001)or work/dutyrelated injury(p OR=2.62,95%CI 1.63–4.21,P≤0.001).Conclusion:Nearly half of soldiers had a sleep disorder or sleep-related medical diagnosis in 2018,but their sleep problems are largely not profiled as limitations to medical readiness.Musculoskeletal issues and physical injury predict nondeployability,and nondeployability is more likely to occur in soldiers who have sleep e-Profiles in addition to these issues.Addressing sleep problems may prevent accidents and injuries that could render a soldier nondeployable.

Intelligent Electrocardiogram Analysis in Medicine:Data,Methods,and Applications

Electrocardiogram(ECG)is a low-cost,simple,fast,and non-invasive test.It can reflect the heart’s electrical activity and provide valuable diagnostic clues about the health of the entire body.Therefore,ECG has been widely used in various biomedical applications such as arrhythmia detection,disease-specific detection,mortality prediction,and biometric recognition.In recent years,ECG-related studies have been carried out using a variety of publicly available datasets,with many differences in the datasets used,data preprocessing methods,targeted challenges,and modeling and analysis techniques.Here we systematically summarize and analyze the ECGbased automatic analysis methods and applications.Specifically,we first reviewed 22 commonly used ECG public datasets and provided an overview of data preprocessing processes.Then we described some of the most widely used applications of ECG signals and analyzed the advanced methods involved in these applications.Finally,we elucidated some of the challenges in ECG analysis and provided suggestions for further research.

Deletion and Recovery Scheme of Electronic Health Records Based onMedical Certificate Blockchain

The trusted sharing of Electronic Health Records(EHRs)can realize the efficient use of medical data resources.Generally speaking,EHRs are widely used in blockchain-based medical data platforms.EHRs are valuable private assets of patients,and the ownership belongs to patients.While recent research has shown that patients can freely and effectively delete the EHRs stored in hospitals,it does not address the challenge of record sharing when patients revisit doctors.In order to solve this problem,this paper proposes a deletion and recovery scheme of EHRs based on Medical Certificate Blockchain.This paper uses cross-chain technology to connect the Medical Certificate Blockchain and the Hospital Blockchain to real-ize the recovery of deleted EHRs.At the same time,this paper uses the Medical Certificate Blockchain and the InterPlanetary File System(IPFS)to store Personal Health Records,which are generated by patients visiting different medical institutions.In addition,this paper also combines digital watermarking technology to ensure the authenticity of the restored electronic medical records.Under the combined effect of blockchain technology and digital watermarking,our proposal will not be affected by any other rights throughout the process.System analysis and security analysis illustrate the completeness and feasibility of the scheme.

On the design of an AI-driven secure communication scheme for internet of medical things environment

The Internet of Medical Things(IoMT)is a collection of smart healthcare devices,hardware infrastructure,and related software applications,that facilitate the connection of healthcare information technology system via the Internet.It is also called IoT in healthcare,facilitating secure communication of remote healthcare devices over the Internet for quick and flexible analysis of healthcare data.In other words,IoMT is an amalgam of medical devices and applications,which improves overall healthcare outcomes.However,this system is prone to securityand privacy-related attacks on healthcare data.Therefore,providing a robust security mechanism to prevent the attacks and vulnerability of IoMT is essential.To mitigate this,we proposed a new Artificial-Intelligence envisioned secure communication scheme for IoMT.The discussed network and threat models provide details of the associated network arrangement of the IoMT devices and attacks relevant to IoMT.Furthermore,we provide the security analysis of the proposed scheme to show its security against different possible attacks.Moreover,a comparative study of the proposed scheme with other similar schemes is presented.Our results show that the proposed scheme outperforms other similar schemes in terms of communication and computation costs,and security and functionality attributes.Finally,we provide a pragmatic study of the proposed scheme to observe its impact on various network performance parameters.

Study on Yan-Xin Wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

Background:Professor Yan-Xin Wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years,and has achieved excellent clinical results.In order to better inherit Yan-Xin Wang’s academic thoughts.The purpose of this study is to use clinical data to explore the clinical experience of Prof.Yan-Xin Wang in the application of Chinese medicine to treat insomnia patients from the liver,explore the compatibility and medication rules of traditional Chinese medicine,and give more clinical treatment ideas for insomnia.Methods:The general data and prescription information of insomnia patients treated with Chinese herbal medicine by Prof.Yan-Xin Wang from January 1,2021,to December 31,2021,were summarized according to the inclusion and exclusion criteria,and the data were subjected to frequency statistics and drug association rules,complex network diagram analysis and cluster analysis.Results:A total of 159 patients and prescriptions were included in the study,of which 81.1%were women and 18.9%were men,containing 128 herbs;the highest frequency of use was 91.8%for Bupleuri Radix.Six Chinese herbs were used more than 70%of the time,namely Bupleuri Radix,Scutellariae Radix,oyster shell,Glycyrrhizae Radix,Os Draconis,and Ziziphi Spinosae Semen.The top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi,five flavours,and their attributions.The four Qi were mainly calm and warm,the five flavours were mainly bitter and acrid,followed by sweet,and the attributions were mainly to the liver,spleen,and heart meridians.The Chinese medicine association rules set the confidence level>80%and the support level>10%,resulting in 10 two-herb and three-herb associations with the highest confidence level,such as Os Draconis is associated with oyster shell,Platycodonis Radix is associated with Achyranthis Bidentatae Radix,Scutellariae Radix is associated with Bupleuri Radix,Os Draconis,Bupleuri Radix is associated with oyster shell,Os Draconis,Scutellariae Radix is associated with oyster shell,etc.Cluster analysis yielded 3 classes of drug formulas.The complex network diagram shows that the core prescription drugs are composed of Bupleuri Radix,Chuanxiong Rhizoma,Pseudostellariae Radix,Jujubae Fructus,Os Draconis,Coptidis Rhizoma,Scutellariae Radix,Ziziphi Spinosae Semen,Smilacis Glabrae Rhizoma,Cinnamomi Cortex,White Moutan Cortex,Atractylodis Rhizoma,Glycyrrhizae Radix,oyster shell,Rehmanniae Radix Praeparata,Tritici Levis Fructus,Pinelliae Rhizoma Praeparatum,and Cinnamomi Ramulus.Conclusion:Prof.Yan-Xin Wang believes that the main treatment for patients with insomnia is based on the liver,by tonifying the deficiency and supporting the righteousness,mutually regulating the liver and spleen,and calming the mind and nourishing the heart,while adding and subtracting appropriate herbs according to the patient’s co-morbidities,which can significantly improve the patient’s insomnia symptoms.