Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 22...Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 228 patients with possible coronary heart disease who were examined in this hospital between November 2014 and March 2017 were selected, and the CACS levels as well as the serum contents of inflammatory factors and plaque stability indexes in patients with different lesions were determined. Pearson test was used to assess the correlation between CACS level and disease severity in patients with coronary heart disease. Results: The CACS level of triple vessel disease group was higher than that of double vessel disease group and single vessel disease group, and the CACS level of double vessel disease group was higher than that of single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents were higher than those of double vessel disease group and single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents of double vessel disease group were higher than those of single vessel disease group;serum Cys C content of triple vessel disease group was lower than that of double vessel disease group and single vessel disease group, and serum Cys C content of double vessel disease group was lower than that of single vessel disease group. Pearson test showed that the CACS level in patients with coronary heart disease was directly correlated with serum contents of inflammatory factors and plaque stability indexes. Conclusion: The CACS levels in patients with coronary heart disease increase with the aggravation of disease, and the specific CACS level is directly correlated with the degree of inflammatory response and the stability of the plaques.展开更多
目的探讨急性缺血性卒中患者基线侧支循环状态与再灌注治疗预后的关系,并比较阿尔伯特早期卒中计划评分(ASPECTS)、多期CTA评分(mCTAs)和软脑膜侧支评分(rLMCs)的预测价值。方法收集87例接受再灌注治疗的急性缺血性卒中患者的临床资料...目的探讨急性缺血性卒中患者基线侧支循环状态与再灌注治疗预后的关系,并比较阿尔伯特早期卒中计划评分(ASPECTS)、多期CTA评分(mCTAs)和软脑膜侧支评分(rLMCs)的预测价值。方法收集87例接受再灌注治疗的急性缺血性卒中患者的临床资料。采用ASPECTS、mCTAs和rLMCs评分评定基线侧支循环情况。根据90 d mRS评分,将患者分为预后良好组(≤2分)和预后不良组(>2分)。通过单因素及二元Logistic回归分析影响患者预后的独立因素,通过秩相关系数分析三种评分与预后的相关性,并采取ROC曲线比较三种评分的预测价值及截点值。结果与预后良好组比较,预后不良组血糖、总胆固醇、低密度脂蛋白水平及基线mRS评分、治疗前及24 h NIHSS评分、ASPECTS评分、mCTAs评分、rLMCs评分差异有统计学意义(P<0.05~0.01)。Logistic回归分析显示,影响预后不良的变量包括基线mRS(OR=4.786,95%CI:1.449~15.803,P=0.010)、基线NIHSS(OR=1.245,95%CI:1.058~1.466,P=0.008)及rLMCs评分(OR=0.523,95%CI:0.378~0.723,P<0.001)。Spearman相关分析显示,ASPECTS、mCTAs、rLMCs评分与90 d mRS呈负相关(rs=-0.418,rs=-0.611,rs=-0.648;P<0.01)。ROC曲线分析显示,ASPECTS评分、mCTAs评分和rLMCs评分AUC分别为0.706、0.812和0.878,三种评分最佳截点值依次为7.5、2.5和10.5。结论基线侧支循环状态是急性缺血性卒中患者再灌注治疗的独立保护性因素。rLMCs对再灌注治疗预后的预测价值更高,rLMCs≥11分的患者预后更佳。展开更多
文摘Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 228 patients with possible coronary heart disease who were examined in this hospital between November 2014 and March 2017 were selected, and the CACS levels as well as the serum contents of inflammatory factors and plaque stability indexes in patients with different lesions were determined. Pearson test was used to assess the correlation between CACS level and disease severity in patients with coronary heart disease. Results: The CACS level of triple vessel disease group was higher than that of double vessel disease group and single vessel disease group, and the CACS level of double vessel disease group was higher than that of single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents were higher than those of double vessel disease group and single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents of double vessel disease group were higher than those of single vessel disease group;serum Cys C content of triple vessel disease group was lower than that of double vessel disease group and single vessel disease group, and serum Cys C content of double vessel disease group was lower than that of single vessel disease group. Pearson test showed that the CACS level in patients with coronary heart disease was directly correlated with serum contents of inflammatory factors and plaque stability indexes. Conclusion: The CACS levels in patients with coronary heart disease increase with the aggravation of disease, and the specific CACS level is directly correlated with the degree of inflammatory response and the stability of the plaques.
文摘目的探讨急性缺血性卒中患者基线侧支循环状态与再灌注治疗预后的关系,并比较阿尔伯特早期卒中计划评分(ASPECTS)、多期CTA评分(mCTAs)和软脑膜侧支评分(rLMCs)的预测价值。方法收集87例接受再灌注治疗的急性缺血性卒中患者的临床资料。采用ASPECTS、mCTAs和rLMCs评分评定基线侧支循环情况。根据90 d mRS评分,将患者分为预后良好组(≤2分)和预后不良组(>2分)。通过单因素及二元Logistic回归分析影响患者预后的独立因素,通过秩相关系数分析三种评分与预后的相关性,并采取ROC曲线比较三种评分的预测价值及截点值。结果与预后良好组比较,预后不良组血糖、总胆固醇、低密度脂蛋白水平及基线mRS评分、治疗前及24 h NIHSS评分、ASPECTS评分、mCTAs评分、rLMCs评分差异有统计学意义(P<0.05~0.01)。Logistic回归分析显示,影响预后不良的变量包括基线mRS(OR=4.786,95%CI:1.449~15.803,P=0.010)、基线NIHSS(OR=1.245,95%CI:1.058~1.466,P=0.008)及rLMCs评分(OR=0.523,95%CI:0.378~0.723,P<0.001)。Spearman相关分析显示,ASPECTS、mCTAs、rLMCs评分与90 d mRS呈负相关(rs=-0.418,rs=-0.611,rs=-0.648;P<0.01)。ROC曲线分析显示,ASPECTS评分、mCTAs评分和rLMCs评分AUC分别为0.706、0.812和0.878,三种评分最佳截点值依次为7.5、2.5和10.5。结论基线侧支循环状态是急性缺血性卒中患者再灌注治疗的独立保护性因素。rLMCs对再灌注治疗预后的预测价值更高,rLMCs≥11分的患者预后更佳。
