The tradeoff between efficiency and model size of the convolutional neural network(CNN)is an essential issue for applications of CNN-based algorithms to diverse real-world tasks.Although deep learning-based methods ha...The tradeoff between efficiency and model size of the convolutional neural network(CNN)is an essential issue for applications of CNN-based algorithms to diverse real-world tasks.Although deep learning-based methods have achieved significant improvements in image super-resolution(SR),current CNNbased techniques mainly contain massive parameters and a high computational complexity,limiting their practical applications.In this paper,we present a fast and lightweight framework,named weighted multi-scale residual network(WMRN),for a better tradeoff between SR performance and computational efficiency.With the modified residual structure,depthwise separable convolutions(DS Convs)are employed to improve convolutional operations’efficiency.Furthermore,several weighted multi-scale residual blocks(WMRBs)are stacked to enhance the multi-scale representation capability.In the reconstruction subnetwork,a group of Conv layers are introduced to filter feature maps to reconstruct the final high-quality image.Extensive experiments were conducted to evaluate the proposed model,and the comparative results with several state-of-the-art algorithms demonstrate the effectiveness of WMRN.展开更多
The learning-based super-resolution reconstruction method inputs a low-resolution image into a network,and learns a non-linear mapping relationship between low-resolution and high-resolution through the network.In thi...The learning-based super-resolution reconstruction method inputs a low-resolution image into a network,and learns a non-linear mapping relationship between low-resolution and high-resolution through the network.In this study,the multi-scale super-resolution reconstruction network is used to fuse the effective features of different scale images,and the non-linear mapping between low resolution and high resolution is studied from coarse to fine to realise the end-to-end super-resolution reconstruction task.The loss of some features of the low-resolution image will negatively affect the quality of the reconstructed image.To solve the problem of incomplete image features in low-resolution,this study adopts the multi-scale super-resolution reconstruction method based on guided image filtering.The high-resolution image reconstructed by the multi-scale super-resolution network and the real high-resolution image are merged by the guide image filter to generate a new image,and the newly generated image is used for secondary training of the multi-scale super-resolution reconstruction network.The newly generated image effectively compensates for the details and texture information lost in the low-resolution image,thereby improving the effect of the super-resolution reconstructed image.Compared with the existing super-resolution reconstruction scheme,the accuracy and speed of super-resolution reconstruction are improved.展开更多
High-resolution medical images have important medical value,but are difficult to obtain directly.Limited by hardware equipment and patient’s physical condition,the resolution of directly acquired medical images is of...High-resolution medical images have important medical value,but are difficult to obtain directly.Limited by hardware equipment and patient’s physical condition,the resolution of directly acquired medical images is often not high.Therefore,many researchers have thought of using super-resolution algorithms for secondary processing to obtain high-resolution medical images.However,current super-resolution algorithms only work on a single scale,and multiple networks need to be trained when super-resolution images of different scales are needed.This definitely raises the cost of acquiring high-resolution medical images.Thus,we propose a multi-scale superresolution algorithm using meta-learning.The algorithm combines a metalearning approach with an enhanced depth of residual super-resolution network to design a meta-upscale module.The meta-upscale module utilizes the weight prediction property of meta-learning and is able to perform the super-resolution task of medical images at any scale.Meanwhile,we design a non-integer mapping relation for super-resolution,which allows the network to be trained under non-integer magnification requirements.Compared to the state-of-the-art single-image super-resolution algorithm on computed tomography images of the pelvic region.The meta-learning multiscale superresolution algorithm obtained a surpassing of about 2%at a smaller model volume.Testing on different parts proves the high generalizability of our algorithm.Multi-scale super-resolution algorithms using meta-learning can compensate for hardware device defects and reduce secondary harm to patients while obtaining high-resolution medical images.It can be of great use in imaging related fields.展开更多
A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes...A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.展开更多
The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit ...The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit faults of Voltage Source Inverter(VSI). The stator current serves as a common indicator for detecting open-circuit faults. Due to the identical changes of the stator current between the open-phase faults in the PMSM and failures of double switches within the same leg of the VSI, this paper utilizes the zero-sequence voltage component as an additional diagnostic criterion to differentiate them.Considering the variable conditions and substantial noise of the ARDS, a novel Multi-resolution Network(Mr Net) is proposed, which can extract multi-resolution perceptual information and enhance robustness to the noise. Meanwhile, a feature weighted layer is introduced to allocate higher weights to characteristics situated near the feature frequency. Both simulation and experiment results validate that the proposed fault diagnosis method can diagnose 25 types of open-circuit faults and achieve more than98.28% diagnostic accuracy. In addition, the experiment results also demonstrate that Mr Net has the capability of diagnosing the fault types accurately under the interference of noise signals(Laplace noise and Gaussian noise).展开更多
Multi-scale system remains a classical scientific problem in fluid dynamics,biology,etc.In the present study,a scheme of multi-scale Physics-informed neural networks is proposed to solve the boundary layer flow at hig...Multi-scale system remains a classical scientific problem in fluid dynamics,biology,etc.In the present study,a scheme of multi-scale Physics-informed neural networks is proposed to solve the boundary layer flow at high Reynolds numbers without any data.The flow is divided into several regions with different scales based on Prandtl's boundary theory.Different regions are solved with governing equations in different scales.The method of matched asymptotic expansions is used to make the flow field continuously.A flow on a semi infinite flat plate at a high Reynolds number is considered a multi-scale problem because the boundary layer scale is much smaller than the outer flow scale.The results are compared with the reference numerical solutions,which show that the msPINNs can solve the multi-scale problem of the boundary layer in high Reynolds number flows.This scheme can be developed for more multi-scale problems in the future.展开更多
Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely exp...Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction block.The residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐resolution.To enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying scenes.To prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained features.Also,a residual learning operation is embedded in the refinement block to prevent long‐term dependency problem.Finally,a construction block is responsible for reconstructing high‐quality images.Designed heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital devices.Experimental results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and complexity.The code of DSRNet can be obtained at https://github.com/hellloxiaotian/DSRNet.展开更多
High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillim...High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.展开更多
We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux reactors.The filter burnup and singl...We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux reactors.The filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy range.The burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme curves.The three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were proven.The neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.展开更多
High resolution of post-stack seismic data assists in better interpretation of subsurface structures as well as high accuracy of impedance inversion. Therefore, geophysicists consistently strive to acquire higher reso...High resolution of post-stack seismic data assists in better interpretation of subsurface structures as well as high accuracy of impedance inversion. Therefore, geophysicists consistently strive to acquire higher resolution seismic images in petroleum exploration. Although there have been successful applications of conventional signal processing and machine learning for post-stack seismic resolution enhancement,there is limited reference to the seismic applications of the recent emergence and rapid development of generative artificial intelligence. Hence, we propose to apply diffusion models, among the most popular generative models, to enhance seismic resolution. Specifically, we apply the classic diffusion model—denoising diffusion probabilistic model(DDPM), conditioned on the seismic data in low resolution, to reconstruct corresponding high-resolution images. Herein the entire scheme is referred to as SeisResoDiff. To provide a comprehensive and clear understanding of SeisResoDiff, we introduce the basic theories of diffusion models and detail the optimization objective's derivation with the aid of diagrams and algorithms. For implementation, we first propose a practical workflow to acquire abundant training data based on the generated pseudo-wells. Subsequently, we apply the trained model to both synthetic and field datasets, evaluating the results in three aspects: the appearance of seismic sections and slices in the time domain, frequency spectra, and comparisons with the synthetic data using real well-logging data at the well locations. The results demonstrate not only effective seismic resolution enhancement,but also additional denoising by the diffusion model. Experimental comparisons indicate that training the model on noisy data, which are more realistic, outperforms training on clean data. The proposed scheme demonstrates superiority over some conventional methods in high-resolution reconstruction and denoising ability, yielding more competitive results compared to our previous research.展开更多
The high pixel resolution is emerging as one of the key parameters for the next-generation displays.Despite the development of various quantum dot(QD)patterning techniques,achieving ultrahigh-resolution(>10,000 pix...The high pixel resolution is emerging as one of the key parameters for the next-generation displays.Despite the development of various quantum dot(QD)patterning techniques,achieving ultrahigh-resolution(>10,000 pixels per inch(PPI))and high-fidelity QD patterns is still a tough challenge that needs to be addressed urgently.Here,we propose a novel and effective approach of orthogonal electric field-induced template-assisted dielectric electrophoretic deposition to successfully achieve one of the highest pixel resolutions of 23090(PPI)with a high fidelity of up to 99%.Meanwhile,the proposed strategy is compatible with the preparation of QD pixels based on perovskite CsPbBr3 and conventional CdSe QDs,exhibiting a wide applicability for QD pixel fabrication.Notably,we further demonstrate the great value of our approach to achieve efficiently electroluminescent QD pixels with a peak external quantum efficiency of 16.5%.Consequently,this work provides a general approach for realizing ultrahighresolution and high-fidelity patterns based on various QDs and a novel method for fabricating QD-patterned devices with high performance.展开更多
Energy-intensive technologies and high-precision research require energy-efficient techniques and materials.Lensbased optical microscopy technology is useful for low-energy applications in the life sciences and other ...Energy-intensive technologies and high-precision research require energy-efficient techniques and materials.Lensbased optical microscopy technology is useful for low-energy applications in the life sciences and other fields of technology,but standard techniques cannot achieve applications at the nanoscale because of light diffraction.Farfield super-resolution techniques have broken beyond the light diffraction limit,enabling 3D applications down to the molecular scale and striving to reduce energy use.Typically targeted super-resolution techniques have achieved high resolution,but the high light intensity needed to outperform competing optical transitions in nanomaterials may result in photo-damage and high energy consumption.Great efforts have been made in the development of nanomaterials to improve the resolution and efficiency of these techniques toward low-energy super-resolution applications.Lanthanide ion-doped upconversion nanoparticles that exhibit multiple long-lived excited energy states and emit upconversion luminescence have enabled the development of targeted super-resolution techniques that need low-intensity light.The use of lanthanide ion-doped upconversion nanoparticles in these techniques for emerging low-energy super-resolution applications will have a significant impact on life sciences and other areas of technology.In this review,we describe the dynamics of lanthanide ion-doped upconversion nanoparticles for superresolution under low-intensity light and their use in targeted super-resolution techniques.We highlight low-energy super-resolution applications of lanthanide ion-doped upconversion nanoparticles,as well as the related research directions and challenges.Our aim is to analyze targeted super-resolution techniques using lanthanide ion-doped upconversion nanoparticles,emphasizing fundamental mechanisms governing transitions in lanthanide ions to surpass the diffraction limit with low-intensity light,and exploring their implications for low-energy nanoscale applications.展开更多
Terahertz heterodyne receivers with high sensitivity and spectral resolution are crucial for various applications.Here,we present a room-temperature atomic terahertz heterodyne receiver that achieves ultrahigh sensiti...Terahertz heterodyne receivers with high sensitivity and spectral resolution are crucial for various applications.Here,we present a room-temperature atomic terahertz heterodyne receiver that achieves ultrahigh sensitivity and frequency resolution.At a signal frequency of 338.7 GHz,we obtain a sensitivity of 2.88±0.09V·cm^(−1)·Hz^(−1/2) for electric field measurements.The calibrated linear dynamical range spans approximately 89 dB,ranging from−110 dBV/cm to−21 dBV/cm.We demodulate a 400 symbol stream encoded in 4-state phase-shift keying,demonstrating excellent phase detection capability.By scanning the frequency of the local oscillator,we realize a terahertz spectrometer with Hz level frequency resolution.This resolution is more than two orders of magnitude higher than that of existing terahertz spectrometers.The demonstrated terahertz heterodyne receiver holds promising potential for working across the entire terahertz spectrum,significantly advancing its practical applications.展开更多
High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost th...High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray source.In conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung radiation.The size of the gamma-ray source is dependent on the dimensional characteristics of the electron beam.Extensive research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in NDT.In our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial resolution.In this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission area.On the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission angle.Under optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm.展开更多
Automatic modulation classification(AMC) technology is one of the cutting-edge technologies in cognitive radio communications. AMC based on deep learning has recently attracted much attention due to its superior perfo...Automatic modulation classification(AMC) technology is one of the cutting-edge technologies in cognitive radio communications. AMC based on deep learning has recently attracted much attention due to its superior performances in classification accuracy and robustness. In this paper, we propose a novel, high resolution and multi-scale feature fusion convolutional neural network model with a squeeze-excitation block, referred to as HRSENet,to classify different kinds of modulation signals.The proposed model establishes a parallel computing mechanism of multi-resolution feature maps through the multi-layer convolution operation, which effectively reduces the information loss caused by downsampling convolution. Moreover, through dense skipconnecting at the same resolution and up-sampling or down-sampling connection at different resolutions, the low resolution representation of the deep feature maps and the high resolution representation of the shallow feature maps are simultaneously extracted and fully integrated, which is benificial to mine signal multilevel features. Finally, the feature squeeze and excitation module embedded in the decoder is used to adjust the response weights between channels, further improving classification accuracy of proposed model.The proposed HRSENet significantly outperforms existing methods in terms of classification accuracy on the public dataset “Over the Air” in signal-to-noise(SNR) ranging from-2dB to 20dB. The classification accuracy in the proposed model achieves 85.36% and97.30% at 4dB and 10dB, respectively, with the improvement by 9.71% and 5.82% compared to LWNet.Furthermore, the model also has a moderate computation complexity compared with several state-of-the-art methods.展开更多
The hands and face are the most important parts for expressing sign language morphemes in sign language videos.However,we find that existing Continuous Sign Language Recognition(CSLR)methods lack the mining of hand an...The hands and face are the most important parts for expressing sign language morphemes in sign language videos.However,we find that existing Continuous Sign Language Recognition(CSLR)methods lack the mining of hand and face information in visual backbones or use expensive and time-consuming external extractors to explore this information.In addition,the signs have different lengths,whereas previous CSLR methods typically use a fixed-length window to segment the video to capture sequential features and then perform global temporal modeling,which disturbs the perception of complete signs.In this study,we propose a Multi-Scale Context-Aware network(MSCA-Net)to solve the aforementioned problems.Our MSCA-Net contains two main modules:(1)Multi-Scale Motion Attention(MSMA),which uses the differences among frames to perceive information of the hands and face in multiple spatial scales,replacing the heavy feature extractors;and(2)Multi-Scale Temporal Modeling(MSTM),which explores crucial temporal information in the sign language video from different temporal scales.We conduct extensive experiments using three widely used sign language datasets,i.e.,RWTH-PHOENIX-Weather-2014,RWTH-PHOENIX-Weather-2014T,and CSL-Daily.The proposed MSCA-Net achieve state-of-the-art performance,demonstrating the effectiveness of our approach.展开更多
Remote sensing imagery,due to its high altitude,presents inherent challenges characterized by multiple scales,limited target areas,and intricate backgrounds.These inherent traits often lead to increased miss and false...Remote sensing imagery,due to its high altitude,presents inherent challenges characterized by multiple scales,limited target areas,and intricate backgrounds.These inherent traits often lead to increased miss and false detection rates when applying object recognition algorithms tailored for remote sensing imagery.Additionally,these complexities contribute to inaccuracies in target localization and hinder precise target categorization.This paper addresses these challenges by proposing a solution:The YOLO-MFD model(YOLO-MFD:Remote Sensing Image Object Detection withMulti-scale Fusion Dynamic Head).Before presenting our method,we delve into the prevalent issues faced in remote sensing imagery analysis.Specifically,we emphasize the struggles of existing object recognition algorithms in comprehensively capturing critical image features amidst varying scales and complex backgrounds.To resolve these issues,we introduce a novel approach.First,we propose the implementation of a lightweight multi-scale module called CEF.This module significantly improves the model’s ability to comprehensively capture important image features by merging multi-scale feature information.It effectively addresses the issues of missed detection and mistaken alarms that are common in remote sensing imagery.Second,an additional layer of small target detection heads is added,and a residual link is established with the higher-level feature extraction module in the backbone section.This allows the model to incorporate shallower information,significantly improving the accuracy of target localization in remotely sensed images.Finally,a dynamic head attentionmechanism is introduced.This allows themodel to exhibit greater flexibility and accuracy in recognizing shapes and targets of different sizes.Consequently,the precision of object detection is significantly improved.The trial results show that the YOLO-MFD model shows improvements of 6.3%,3.5%,and 2.5%over the original YOLOv8 model in Precision,map@0.5 and map@0.5:0.95,separately.These results illustrate the clear advantages of the method.展开更多
Flurbiprofen(FB),a nonsteroidal anti-inflammatory drug,is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects.However,the racemic nature of its commercially available form...Flurbiprofen(FB),a nonsteroidal anti-inflammatory drug,is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects.However,the racemic nature of its commercially available formulation(Ocufen^(R))limits the full potential of its therapeutic activity,as the(S)-enantiomer is responsible for the desired antiinflammatory effects.Additionally,the limited corneal permeability of FB significantly restricts its bioavailability.In this study,we successfully separated the chiral isomers of FB to obtain the highly active(S)-FB.Subsequently,utilizing ion-pairing technology,we coupled(S)-FB with various counter-ions,such as sodium,diethylamine,trimethamine(TMA),and l-arginine,to enhance its ocular bioavailability.A comprehensive evaluation encompassed balanced solubility,octanol-water partition coefficient,corneal permeability,ocular pharmacokinetics,tissue distribution,and in vivo ocular anti-inflammatory activity of each chiral isomer salt.Among the various formulations,S-FBTMA exhibited superior water solubility(about 1–12 mg/ml),lipid solubility(1<lgP_(ow)<3)and corneal permeability.In comparison to Ocufen^(R),S-FBTMA demonstrated significantly higher in vivo antiinflammatory activity and lower ocular irritability(such as conjunctival congestion and tingling).The findings from this research highlight the potential of chiral separation and ion-pair enhanced permeation techniques in providing pharmaceutical enterprises focused on drug development with a valuable avenue for improving therapeutic outcomes.展开更多
Computer-aided diagnosis of pneumonia based on deep learning is a research hotspot.However,there are some problems that the features of different sizes and different directions are not sufficient when extracting the f...Computer-aided diagnosis of pneumonia based on deep learning is a research hotspot.However,there are some problems that the features of different sizes and different directions are not sufficient when extracting the features in lung X-ray images.A pneumonia classification model based on multi-scale directional feature enhancement MSD-Net is proposed in this paper.The main innovations are as follows:Firstly,the Multi-scale Residual Feature Extraction Module(MRFEM)is designed to effectively extract multi-scale features.The MRFEM uses dilated convolutions with different expansion rates to increase the receptive field and extract multi-scale features effectively.Secondly,the Multi-scale Directional Feature Perception Module(MDFPM)is designed,which uses a three-branch structure of different sizes convolution to transmit direction feature layer by layer,and focuses on the target region to enhance the feature information.Thirdly,the Axial Compression Former Module(ACFM)is designed to perform global calculations to enhance the perception ability of global features in different directions.To verify the effectiveness of the MSD-Net,comparative experiments and ablation experiments are carried out.In the COVID-19 RADIOGRAPHY DATABASE,the Accuracy,Recall,Precision,F1 Score,and Specificity of MSD-Net are 97.76%,95.57%,95.52%,95.52%,and 98.51%,respectively.In the chest X-ray dataset,the Accuracy,Recall,Precision,F1 Score and Specificity of MSD-Net are 97.78%,95.22%,96.49%,95.58%,and 98.11%,respectively.This model improves the accuracy of lung image recognition effectively and provides an important clinical reference to pneumonia Computer-Aided Diagnosis.展开更多
In recent years,the Industrial Internet and Industry 4.0 came into being.With the development of modern industrial intelligent manufacturing technology,digital twins,Web3 and many other digital entity applications are...In recent years,the Industrial Internet and Industry 4.0 came into being.With the development of modern industrial intelligent manufacturing technology,digital twins,Web3 and many other digital entity applications are also proposed.These applications apply architectures such as distributed learning,resource sharing,and arithmetic trading,which make high demands on identity authentication,asset authentication,resource addressing,and service location.Therefore,an efficient,secure,and trustworthy Industrial Internet identity resolution system is needed.However,most of the traditional identity resolution systems follow DNS architecture or tree structure,which has the risk of a single point of failure and DDoS attack.And they cannot guarantee the security and privacy of digital identity,personal assets,and device information.So we consider a decentralized approach for identity management,identity authentication,and asset verification.In this paper,we propose a distributed trusted active identity resolution system based on the inter-planetary file system(IPFS)and non-fungible token(NFT),which can provide distributed identity resolution services.And we have designed the system architecture,identity service process,load balancing strategy and smart contract service.In addition,we use Jmeter to verify the performance of the system,and the results show that the system has good high concurrent performance and robustness.展开更多
基金the National Natural Science Foundation of China(61772149,61866009,61762028,U1701267,61702169)Guangxi Science and Technology Project(2019GXNSFFA245014,ZY20198016,AD18281079,AD18216004)+1 种基金the Natural Science Foundation of Hunan Province(2020JJ3014)Guangxi Colleges and Universities Key Laboratory of Intelligent Processing of Computer Images and Graphics(GIIP202001).
文摘The tradeoff between efficiency and model size of the convolutional neural network(CNN)is an essential issue for applications of CNN-based algorithms to diverse real-world tasks.Although deep learning-based methods have achieved significant improvements in image super-resolution(SR),current CNNbased techniques mainly contain massive parameters and a high computational complexity,limiting their practical applications.In this paper,we present a fast and lightweight framework,named weighted multi-scale residual network(WMRN),for a better tradeoff between SR performance and computational efficiency.With the modified residual structure,depthwise separable convolutions(DS Convs)are employed to improve convolutional operations’efficiency.Furthermore,several weighted multi-scale residual blocks(WMRBs)are stacked to enhance the multi-scale representation capability.In the reconstruction subnetwork,a group of Conv layers are introduced to filter feature maps to reconstruct the final high-quality image.Extensive experiments were conducted to evaluate the proposed model,and the comparative results with several state-of-the-art algorithms demonstrate the effectiveness of WMRN.
文摘The learning-based super-resolution reconstruction method inputs a low-resolution image into a network,and learns a non-linear mapping relationship between low-resolution and high-resolution through the network.In this study,the multi-scale super-resolution reconstruction network is used to fuse the effective features of different scale images,and the non-linear mapping between low resolution and high resolution is studied from coarse to fine to realise the end-to-end super-resolution reconstruction task.The loss of some features of the low-resolution image will negatively affect the quality of the reconstructed image.To solve the problem of incomplete image features in low-resolution,this study adopts the multi-scale super-resolution reconstruction method based on guided image filtering.The high-resolution image reconstructed by the multi-scale super-resolution network and the real high-resolution image are merged by the guide image filter to generate a new image,and the newly generated image is used for secondary training of the multi-scale super-resolution reconstruction network.The newly generated image effectively compensates for the details and texture information lost in the low-resolution image,thereby improving the effect of the super-resolution reconstructed image.Compared with the existing super-resolution reconstruction scheme,the accuracy and speed of super-resolution reconstruction are improved.
基金supported by the National Science Foundation for Young Scientists of China(Grant No.61806060)2019-2021,and the Natural Science Foundation of Heilongjiang Province(LH2019F024)+1 种基金China,2019-2021.We also acknowledge support fromthe Basic andApplied Basic Research Foundation of Guangdong Province(2021A1515220140)the Youth Innovation Project of Sun Yat-sen University Cancer Center(QNYCPY32).
文摘High-resolution medical images have important medical value,but are difficult to obtain directly.Limited by hardware equipment and patient’s physical condition,the resolution of directly acquired medical images is often not high.Therefore,many researchers have thought of using super-resolution algorithms for secondary processing to obtain high-resolution medical images.However,current super-resolution algorithms only work on a single scale,and multiple networks need to be trained when super-resolution images of different scales are needed.This definitely raises the cost of acquiring high-resolution medical images.Thus,we propose a multi-scale superresolution algorithm using meta-learning.The algorithm combines a metalearning approach with an enhanced depth of residual super-resolution network to design a meta-upscale module.The meta-upscale module utilizes the weight prediction property of meta-learning and is able to perform the super-resolution task of medical images at any scale.Meanwhile,we design a non-integer mapping relation for super-resolution,which allows the network to be trained under non-integer magnification requirements.Compared to the state-of-the-art single-image super-resolution algorithm on computed tomography images of the pelvic region.The meta-learning multiscale superresolution algorithm obtained a surpassing of about 2%at a smaller model volume.Testing on different parts proves the high generalizability of our algorithm.Multi-scale super-resolution algorithms using meta-learning can compensate for hardware device defects and reduce secondary harm to patients while obtaining high-resolution medical images.It can be of great use in imaging related fields.
基金This study was supported by the National Natural Science Foundation of China(U22B2075,52274056,51974356).
文摘A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.
基金supported by the Natural Science Foundation of Jiangsu Province (Grant Nos. BK20210347)。
文摘The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit faults of Voltage Source Inverter(VSI). The stator current serves as a common indicator for detecting open-circuit faults. Due to the identical changes of the stator current between the open-phase faults in the PMSM and failures of double switches within the same leg of the VSI, this paper utilizes the zero-sequence voltage component as an additional diagnostic criterion to differentiate them.Considering the variable conditions and substantial noise of the ARDS, a novel Multi-resolution Network(Mr Net) is proposed, which can extract multi-resolution perceptual information and enhance robustness to the noise. Meanwhile, a feature weighted layer is introduced to allocate higher weights to characteristics situated near the feature frequency. Both simulation and experiment results validate that the proposed fault diagnosis method can diagnose 25 types of open-circuit faults and achieve more than98.28% diagnostic accuracy. In addition, the experiment results also demonstrate that Mr Net has the capability of diagnosing the fault types accurately under the interference of noise signals(Laplace noise and Gaussian noise).
文摘Multi-scale system remains a classical scientific problem in fluid dynamics,biology,etc.In the present study,a scheme of multi-scale Physics-informed neural networks is proposed to solve the boundary layer flow at high Reynolds numbers without any data.The flow is divided into several regions with different scales based on Prandtl's boundary theory.Different regions are solved with governing equations in different scales.The method of matched asymptotic expansions is used to make the flow field continuously.A flow on a semi infinite flat plate at a high Reynolds number is considered a multi-scale problem because the boundary layer scale is much smaller than the outer flow scale.The results are compared with the reference numerical solutions,which show that the msPINNs can solve the multi-scale problem of the boundary layer in high Reynolds number flows.This scheme can be developed for more multi-scale problems in the future.
基金the TCL Science and Technology Innovation Fundthe Youth Science and Technology Talent Promotion Project of Jiangsu Association for Science and Technology,Grant/Award Number:JSTJ‐2023‐017+4 种基金Shenzhen Municipal Science and Technology Innovation Council,Grant/Award Number:JSGG20220831105002004National Natural Science Foundation of China,Grant/Award Number:62201468Postdoctoral Research Foundation of China,Grant/Award Number:2022M722599the Fundamental Research Funds for the Central Universities,Grant/Award Number:D5000210966the Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021A1515110079。
文摘Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction block.The residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐resolution.To enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying scenes.To prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained features.Also,a residual learning operation is embedded in the refinement block to prevent long‐term dependency problem.Finally,a construction block is responsible for reconstructing high‐quality images.Designed heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital devices.Experimental results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and complexity.The code of DSRNet can be obtained at https://github.com/hellloxiaotian/DSRNet.
基金support of the National Natural Science Foundation of China(Nos.U20A6001,12002190,11972207,and 11921002)the Fundamental Research Funds for the Central Universities,China(No.SWUKQ22029)the Chongqing Natural Science Foundation of China(No.CSTB2022NSCQ-MSX1635).
文摘High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.
基金supported by Natural Science Foundation of China (No. 12305190)Lingchuang Research Project of China National Nuclear Corporation (CNNC)the Science and Technology on Reactor System Design Technology Laboratory
文摘We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux reactors.The filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy range.The burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme curves.The three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were proven.The neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.
基金supported by the National Natural Science Foundation of China (NSFC): Grant number 42274147。
文摘High resolution of post-stack seismic data assists in better interpretation of subsurface structures as well as high accuracy of impedance inversion. Therefore, geophysicists consistently strive to acquire higher resolution seismic images in petroleum exploration. Although there have been successful applications of conventional signal processing and machine learning for post-stack seismic resolution enhancement,there is limited reference to the seismic applications of the recent emergence and rapid development of generative artificial intelligence. Hence, we propose to apply diffusion models, among the most popular generative models, to enhance seismic resolution. Specifically, we apply the classic diffusion model—denoising diffusion probabilistic model(DDPM), conditioned on the seismic data in low resolution, to reconstruct corresponding high-resolution images. Herein the entire scheme is referred to as SeisResoDiff. To provide a comprehensive and clear understanding of SeisResoDiff, we introduce the basic theories of diffusion models and detail the optimization objective's derivation with the aid of diagrams and algorithms. For implementation, we first propose a practical workflow to acquire abundant training data based on the generated pseudo-wells. Subsequently, we apply the trained model to both synthetic and field datasets, evaluating the results in three aspects: the appearance of seismic sections and slices in the time domain, frequency spectra, and comparisons with the synthetic data using real well-logging data at the well locations. The results demonstrate not only effective seismic resolution enhancement,but also additional denoising by the diffusion model. Experimental comparisons indicate that training the model on noisy data, which are more realistic, outperforms training on clean data. The proposed scheme demonstrates superiority over some conventional methods in high-resolution reconstruction and denoising ability, yielding more competitive results compared to our previous research.
基金supported by the National Key R&D Program of China(Grant Nos.2022YFB3608200 and 2021YFB2802201)the National Natural Science Foundation of China(Grant Nos.62275183 and 62105231)+1 种基金the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20210712)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJA430013)。
文摘The high pixel resolution is emerging as one of the key parameters for the next-generation displays.Despite the development of various quantum dot(QD)patterning techniques,achieving ultrahigh-resolution(>10,000 pixels per inch(PPI))and high-fidelity QD patterns is still a tough challenge that needs to be addressed urgently.Here,we propose a novel and effective approach of orthogonal electric field-induced template-assisted dielectric electrophoretic deposition to successfully achieve one of the highest pixel resolutions of 23090(PPI)with a high fidelity of up to 99%.Meanwhile,the proposed strategy is compatible with the preparation of QD pixels based on perovskite CsPbBr3 and conventional CdSe QDs,exhibiting a wide applicability for QD pixel fabrication.Notably,we further demonstrate the great value of our approach to achieve efficiently electroluminescent QD pixels with a peak external quantum efficiency of 16.5%.Consequently,this work provides a general approach for realizing ultrahighresolution and high-fidelity patterns based on various QDs and a novel method for fabricating QD-patterned devices with high performance.
基金The National Key Research and Development program of China(Grant No.2021YFB2802000 and Grant Nos.2022YFB2804301)the Science and Technology Commission of Shanghai Municipality(Grant No.21DZ1100500)+3 种基金the Shanghai Municipal Science and Technology Major Project,the Shanghai Frontiers Science Center Program(2021-2025 No.20)the National Natural Science Foundation of China(Grant No.61975123 and Grant No.62205208)the China Postdoctoral Science Foundation(3722904001,3722904006)the Shanghai Super Postdoctoral Incentive Scheme(5B22904002,5B22904006).
文摘Energy-intensive technologies and high-precision research require energy-efficient techniques and materials.Lensbased optical microscopy technology is useful for low-energy applications in the life sciences and other fields of technology,but standard techniques cannot achieve applications at the nanoscale because of light diffraction.Farfield super-resolution techniques have broken beyond the light diffraction limit,enabling 3D applications down to the molecular scale and striving to reduce energy use.Typically targeted super-resolution techniques have achieved high resolution,but the high light intensity needed to outperform competing optical transitions in nanomaterials may result in photo-damage and high energy consumption.Great efforts have been made in the development of nanomaterials to improve the resolution and efficiency of these techniques toward low-energy super-resolution applications.Lanthanide ion-doped upconversion nanoparticles that exhibit multiple long-lived excited energy states and emit upconversion luminescence have enabled the development of targeted super-resolution techniques that need low-intensity light.The use of lanthanide ion-doped upconversion nanoparticles in these techniques for emerging low-energy super-resolution applications will have a significant impact on life sciences and other areas of technology.In this review,we describe the dynamics of lanthanide ion-doped upconversion nanoparticles for superresolution under low-intensity light and their use in targeted super-resolution techniques.We highlight low-energy super-resolution applications of lanthanide ion-doped upconversion nanoparticles,as well as the related research directions and challenges.Our aim is to analyze targeted super-resolution techniques using lanthanide ion-doped upconversion nanoparticles,emphasizing fundamental mechanisms governing transitions in lanthanide ions to surpass the diffraction limit with low-intensity light,and exploring their implications for low-energy nanoscale applications.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFA1402004)the Key-Area Research and Development Program of Guangdong Province,China(Grant Nos.2019B030330001 and 2020B0301030008)+2 种基金the National Natural Science Foundation of China(Grant Nos.12225405,12204182,and U20A2074)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301705)the Natural Science Foundation of Guangdong Province,China(Grant No.2022A1515012026).
文摘Terahertz heterodyne receivers with high sensitivity and spectral resolution are crucial for various applications.Here,we present a room-temperature atomic terahertz heterodyne receiver that achieves ultrahigh sensitivity and frequency resolution.At a signal frequency of 338.7 GHz,we obtain a sensitivity of 2.88±0.09V·cm^(−1)·Hz^(−1/2) for electric field measurements.The calibrated linear dynamical range spans approximately 89 dB,ranging from−110 dBV/cm to−21 dBV/cm.We demodulate a 400 symbol stream encoded in 4-state phase-shift keying,demonstrating excellent phase detection capability.By scanning the frequency of the local oscillator,we realize a terahertz spectrometer with Hz level frequency resolution.This resolution is more than two orders of magnitude higher than that of existing terahertz spectrometers.The demonstrated terahertz heterodyne receiver holds promising potential for working across the entire terahertz spectrum,significantly advancing its practical applications.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.12175212,11991071,12004353,11975214,and 11905202)the National Key R&D Program of China(Grant No.2022YFA1603300)+1 种基金the Science Challenge Project(Project No.TZ2018005)the Sciences and Technology on Plasma Physics Laboratory at CAEP(Grant No.6142A04200103).
文摘High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray source.In conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung radiation.The size of the gamma-ray source is dependent on the dimensional characteristics of the electron beam.Extensive research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in NDT.In our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial resolution.In this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission area.On the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission angle.Under optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm.
基金supported by the Beijing Natural Science Foundation (L202003)National Natural Science Foundation of China (No. 31700479)。
文摘Automatic modulation classification(AMC) technology is one of the cutting-edge technologies in cognitive radio communications. AMC based on deep learning has recently attracted much attention due to its superior performances in classification accuracy and robustness. In this paper, we propose a novel, high resolution and multi-scale feature fusion convolutional neural network model with a squeeze-excitation block, referred to as HRSENet,to classify different kinds of modulation signals.The proposed model establishes a parallel computing mechanism of multi-resolution feature maps through the multi-layer convolution operation, which effectively reduces the information loss caused by downsampling convolution. Moreover, through dense skipconnecting at the same resolution and up-sampling or down-sampling connection at different resolutions, the low resolution representation of the deep feature maps and the high resolution representation of the shallow feature maps are simultaneously extracted and fully integrated, which is benificial to mine signal multilevel features. Finally, the feature squeeze and excitation module embedded in the decoder is used to adjust the response weights between channels, further improving classification accuracy of proposed model.The proposed HRSENet significantly outperforms existing methods in terms of classification accuracy on the public dataset “Over the Air” in signal-to-noise(SNR) ranging from-2dB to 20dB. The classification accuracy in the proposed model achieves 85.36% and97.30% at 4dB and 10dB, respectively, with the improvement by 9.71% and 5.82% compared to LWNet.Furthermore, the model also has a moderate computation complexity compared with several state-of-the-art methods.
基金Supported by the National Natural Science Foundation of China(62072334).
文摘The hands and face are the most important parts for expressing sign language morphemes in sign language videos.However,we find that existing Continuous Sign Language Recognition(CSLR)methods lack the mining of hand and face information in visual backbones or use expensive and time-consuming external extractors to explore this information.In addition,the signs have different lengths,whereas previous CSLR methods typically use a fixed-length window to segment the video to capture sequential features and then perform global temporal modeling,which disturbs the perception of complete signs.In this study,we propose a Multi-Scale Context-Aware network(MSCA-Net)to solve the aforementioned problems.Our MSCA-Net contains two main modules:(1)Multi-Scale Motion Attention(MSMA),which uses the differences among frames to perceive information of the hands and face in multiple spatial scales,replacing the heavy feature extractors;and(2)Multi-Scale Temporal Modeling(MSTM),which explores crucial temporal information in the sign language video from different temporal scales.We conduct extensive experiments using three widely used sign language datasets,i.e.,RWTH-PHOENIX-Weather-2014,RWTH-PHOENIX-Weather-2014T,and CSL-Daily.The proposed MSCA-Net achieve state-of-the-art performance,demonstrating the effectiveness of our approach.
基金the Scientific Research Fund of Hunan Provincial Education Department(23A0423).
文摘Remote sensing imagery,due to its high altitude,presents inherent challenges characterized by multiple scales,limited target areas,and intricate backgrounds.These inherent traits often lead to increased miss and false detection rates when applying object recognition algorithms tailored for remote sensing imagery.Additionally,these complexities contribute to inaccuracies in target localization and hinder precise target categorization.This paper addresses these challenges by proposing a solution:The YOLO-MFD model(YOLO-MFD:Remote Sensing Image Object Detection withMulti-scale Fusion Dynamic Head).Before presenting our method,we delve into the prevalent issues faced in remote sensing imagery analysis.Specifically,we emphasize the struggles of existing object recognition algorithms in comprehensively capturing critical image features amidst varying scales and complex backgrounds.To resolve these issues,we introduce a novel approach.First,we propose the implementation of a lightweight multi-scale module called CEF.This module significantly improves the model’s ability to comprehensively capture important image features by merging multi-scale feature information.It effectively addresses the issues of missed detection and mistaken alarms that are common in remote sensing imagery.Second,an additional layer of small target detection heads is added,and a residual link is established with the higher-level feature extraction module in the backbone section.This allows the model to incorporate shallower information,significantly improving the accuracy of target localization in remotely sensed images.Finally,a dynamic head attentionmechanism is introduced.This allows themodel to exhibit greater flexibility and accuracy in recognizing shapes and targets of different sizes.Consequently,the precision of object detection is significantly improved.The trial results show that the YOLO-MFD model shows improvements of 6.3%,3.5%,and 2.5%over the original YOLOv8 model in Precision,map@0.5 and map@0.5:0.95,separately.These results illustrate the clear advantages of the method.
基金financially supported by the National Postdoctoral Foundation of China(No.2023M730375)Liaoning Province Department of Education Project(No.LJKMZ20221365)the State Key Laboratory of Natural and Biomimetic Drugs(No.K202215)。
文摘Flurbiprofen(FB),a nonsteroidal anti-inflammatory drug,is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects.However,the racemic nature of its commercially available formulation(Ocufen^(R))limits the full potential of its therapeutic activity,as the(S)-enantiomer is responsible for the desired antiinflammatory effects.Additionally,the limited corneal permeability of FB significantly restricts its bioavailability.In this study,we successfully separated the chiral isomers of FB to obtain the highly active(S)-FB.Subsequently,utilizing ion-pairing technology,we coupled(S)-FB with various counter-ions,such as sodium,diethylamine,trimethamine(TMA),and l-arginine,to enhance its ocular bioavailability.A comprehensive evaluation encompassed balanced solubility,octanol-water partition coefficient,corneal permeability,ocular pharmacokinetics,tissue distribution,and in vivo ocular anti-inflammatory activity of each chiral isomer salt.Among the various formulations,S-FBTMA exhibited superior water solubility(about 1–12 mg/ml),lipid solubility(1<lgP_(ow)<3)and corneal permeability.In comparison to Ocufen^(R),S-FBTMA demonstrated significantly higher in vivo antiinflammatory activity and lower ocular irritability(such as conjunctival congestion and tingling).The findings from this research highlight the potential of chiral separation and ion-pair enhanced permeation techniques in providing pharmaceutical enterprises focused on drug development with a valuable avenue for improving therapeutic outcomes.
基金supported in part by the National Natural Science Foundation of China(Grant No.62062003)Natural Science Foundation of Ningxia(Grant No.2023AAC03293).
文摘Computer-aided diagnosis of pneumonia based on deep learning is a research hotspot.However,there are some problems that the features of different sizes and different directions are not sufficient when extracting the features in lung X-ray images.A pneumonia classification model based on multi-scale directional feature enhancement MSD-Net is proposed in this paper.The main innovations are as follows:Firstly,the Multi-scale Residual Feature Extraction Module(MRFEM)is designed to effectively extract multi-scale features.The MRFEM uses dilated convolutions with different expansion rates to increase the receptive field and extract multi-scale features effectively.Secondly,the Multi-scale Directional Feature Perception Module(MDFPM)is designed,which uses a three-branch structure of different sizes convolution to transmit direction feature layer by layer,and focuses on the target region to enhance the feature information.Thirdly,the Axial Compression Former Module(ACFM)is designed to perform global calculations to enhance the perception ability of global features in different directions.To verify the effectiveness of the MSD-Net,comparative experiments and ablation experiments are carried out.In the COVID-19 RADIOGRAPHY DATABASE,the Accuracy,Recall,Precision,F1 Score,and Specificity of MSD-Net are 97.76%,95.57%,95.52%,95.52%,and 98.51%,respectively.In the chest X-ray dataset,the Accuracy,Recall,Precision,F1 Score and Specificity of MSD-Net are 97.78%,95.22%,96.49%,95.58%,and 98.11%,respectively.This model improves the accuracy of lung image recognition effectively and provides an important clinical reference to pneumonia Computer-Aided Diagnosis.
基金supported by the National Natural Science Foundation of China(No.92267301).
文摘In recent years,the Industrial Internet and Industry 4.0 came into being.With the development of modern industrial intelligent manufacturing technology,digital twins,Web3 and many other digital entity applications are also proposed.These applications apply architectures such as distributed learning,resource sharing,and arithmetic trading,which make high demands on identity authentication,asset authentication,resource addressing,and service location.Therefore,an efficient,secure,and trustworthy Industrial Internet identity resolution system is needed.However,most of the traditional identity resolution systems follow DNS architecture or tree structure,which has the risk of a single point of failure and DDoS attack.And they cannot guarantee the security and privacy of digital identity,personal assets,and device information.So we consider a decentralized approach for identity management,identity authentication,and asset verification.In this paper,we propose a distributed trusted active identity resolution system based on the inter-planetary file system(IPFS)and non-fungible token(NFT),which can provide distributed identity resolution services.And we have designed the system architecture,identity service process,load balancing strategy and smart contract service.In addition,we use Jmeter to verify the performance of the system,and the results show that the system has good high concurrent performance and robustness.