The power Internet of Things(IoT)is a significant trend in technology and a requirement for national strategic development.With the deepening digital transformation of the power grid,China’s power system has initiall...The power Internet of Things(IoT)is a significant trend in technology and a requirement for national strategic development.With the deepening digital transformation of the power grid,China’s power system has initially built a power IoT architecture comprising a perception,network,and platform application layer.However,owing to the structural complexity of the power system,the construction of the power IoT continues to face problems such as complex access management of massive heterogeneous equipment,diverse IoT protocol access methods,high concurrency of network communications,and weak data security protection.To address these issues,this study optimizes the existing architecture of the power IoT and designs an integrated management framework for the access of multi-source heterogeneous data in the power IoT,comprising cloud,pipe,edge,and terminal parts.It further reviews and analyzes the key technologies involved in the power IoT,such as the unified management of the physical model,high concurrent access,multi-protocol access,multi-source heterogeneous data storage management,and data security control,to provide a more flexible,efficient,secure,and easy-to-use solution for multi-source heterogeneous data access in the power IoT.展开更多
Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive power.Numerical methods have been widely used to pred...Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive power.Numerical methods have been widely used to predict the landslide runout but a fundamental problem remained is how to determine the reliable numerical parameters.This study proposes a framework to predict the runout of potential landslides through multi-source data collaboration and numerical analysis of historical landslide events.Specifically,for the historical landslide cases,the landslide-induced seismic signal,geophysical surveys,and possible in-situ drone/phone videos(multi-source data collaboration)can validate the numerical results in terms of landslide dynamics and deposit features and help calibrate the numerical(rheological)parameters.Subsequently,the calibrated numerical parameters can be used to numerically predict the runout of potential landslides in the region with a similar geological setting to the recorded events.Application of the runout prediction approach to the 2020 Jiashanying landslide in Guizhou,China gives reasonable results in comparison to the field observations.The numerical parameters are determined from the multi-source data collaboration analysis of a historical case in the region(2019 Shuicheng landslide).The proposed framework for landslide runout prediction can be of great utility for landslide risk assessment and disaster reduction in mountainous regions worldwide.展开更多
Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landsli...Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas.展开更多
Multi-Source data plays an important role in the evolution of media convergence.Its fusion processing enables the further mining of data and utilization of data value and broadens the path for the sharing and dissemin...Multi-Source data plays an important role in the evolution of media convergence.Its fusion processing enables the further mining of data and utilization of data value and broadens the path for the sharing and dissemination of media data.However,it also faces serious problems in terms of protecting user and data privacy.Many privacy protectionmethods have been proposed to solve the problemof privacy leakage during the process of data sharing,but they suffer fromtwo flaws:1)the lack of algorithmic frameworks for specific scenarios such as dynamic datasets in the media domain;2)the inability to solve the problem of the high computational complexity of ciphertext in multi-source data privacy protection,resulting in long encryption and decryption times.In this paper,we propose a multi-source data privacy protection method based on homomorphic encryption and blockchain technology,which solves the privacy protection problem ofmulti-source heterogeneous data in the dissemination ofmedia and reduces ciphertext processing time.We deployed the proposedmethod on theHyperledger platformfor testing and compared it with the privacy protection schemes based on k-anonymity and differential privacy.The experimental results showthat the key generation,encryption,and decryption times of the proposedmethod are lower than those in data privacy protection methods based on k-anonymity technology and differential privacy technology.This significantly reduces the processing time ofmulti-source data,which gives it potential for use in many applications.展开更多
In traditional medicine and ethnomedicine,medicinal plants have long been recognized as the basis for materials in therapeutic applications worldwide.In particular,the remarkable curative effect of traditional Chinese...In traditional medicine and ethnomedicine,medicinal plants have long been recognized as the basis for materials in therapeutic applications worldwide.In particular,the remarkable curative effect of traditional Chinese medicine during corona virus disease 2019(COVID-19)pandemic has attracted extensive attention globally.Medicinal plants have,therefore,become increasingly popular among the public.However,with increasing demand for and profit with medicinal plants,commercial fraudulent events such as adulteration or counterfeits sometimes occur,which poses a serious threat to the clinical outcomes and interests of consumers.With rapid advances in artificial intelligence,machine learning can be used to mine information on various medicinal plants to establish an ideal resource database.We herein present a review that mainly introduces common machine learning algorithms and discusses their application in multi-source data analysis of medicinal plants.The combination of machine learning algorithms and multi-source data analysis facilitates a comprehensive analysis and aids in the effective evaluation of the quality of medicinal plants.The findings of this review provide new possibilities for promoting the development and utilization of medicinal plants.展开更多
In today’s highly competitive retail industry,offline stores face increasing pressure on profitability.They hope to improve their ability in shelf management with the help of big data technology.For this,on-shelf ava...In today’s highly competitive retail industry,offline stores face increasing pressure on profitability.They hope to improve their ability in shelf management with the help of big data technology.For this,on-shelf availability is an essential indicator of shelf data management and closely relates to customer purchase behavior.RFM(recency,frequency,andmonetary)patternmining is a powerful tool to evaluate the value of customer behavior.However,the existing RFM patternmining algorithms do not consider the quarterly nature of goods,resulting in unreasonable shelf availability and difficulty in profit-making.To solve this problem,we propose a quarterly RFM mining algorithmfor On-shelf products named OS-RFM.Our algorithmmines the high recency,high frequency,and high monetary patterns and considers the period of the on-shelf goods in quarterly units.We conducted experiments using two real datasets for numerical and graphical analysis to prove the algorithm’s effectiveness.Compared with the state-of-the-art RFM mining algorithm,our algorithm can identify more patterns and performs well in terms of precision,recall,and F1-score,with the recall rate nearing 100%.Also,the novel algorithm operates with significantly shorter running times and more stable memory usage than existing mining algorithms.Additionally,we analyze the sales trends of products in different quarters and seasonal variations.The analysis assists businesses in maintaining reasonable on-shelf availability and achieving greater profitability.展开更多
Urban functional area(UFA)is a core scientific issue affecting urban sustainability.The current knowledge gap is mainly reflected in the lack of multi-scale quantitative interpretation methods from the perspective of ...Urban functional area(UFA)is a core scientific issue affecting urban sustainability.The current knowledge gap is mainly reflected in the lack of multi-scale quantitative interpretation methods from the perspective of human-land interaction.In this paper,based on multi-source big data include 250 m×250 m resolution cell phone data,1.81×105 Points of Interest(POI)data and administrative boundary data,we built a UFA identification method and demonstrated empirically in Shenyang City,China.We argue that the method we built can effectively identify multi-scale multi-type UFAs based on human activity and further reveal the spatial correlation between urban facilities and human activity.The empirical study suggests that the employment functional zones in Shenyang City are more concentrated in central cities than other single functional zones.There are more mix functional areas in the central city areas,while the planned industrial new cities need to develop comprehensive functions in Shenyang.UFAs have scale effects and human-land interaction patterns.We suggest that city decision makers should apply multi-sources big data to measure urban functional service in a more refined manner from a supply-demand perspective.展开更多
Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manife...Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized disease.Nevertheless,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains unknown.We employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized T2D.Methods:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology databases.Succeeding,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes analysis.And the compound-disease targets-pathway network were constructed to obtain the hub compound.Moreover,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock 1.5.7.Furthermore,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized T2D.Finally,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain reaction.Results:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be quercetin.Consistently,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network analysis.Molecular docking showed that quercetin could bind with the hub genes.Further,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated lipid and atherosclerosis,and/or including NOD-like receptor signaling pathway,and TNF signaling pathway.Ultimately,the quantitative polymerase chain reaction and western blotting analysis showed that quercetin could down-regulated the mRNA and protein experssion of CASP8,CCL2,and AHR.It was consistent with the results in Comparative Toxicogenomics Database databases.Conclusion:These results demonstrated quercetin could inhibit the expression of CASP8,CCL2,AHR in damp-heat internalized T2D,which improves insulin secretion and inhibits lipid and atherosclerosis,as well as/or including NOD-like receptor signaling pathway,and TNF signaling pathway,suggesting that EZECD may be more effective to treat damp-heat internalized T2D.展开更多
[Objectives]To explore the trend of brands towards the design of waist protection products through data mining,and to provide reference for the design concept of the contour of waist protection pillow.[Methods]The str...[Objectives]To explore the trend of brands towards the design of waist protection products through data mining,and to provide reference for the design concept of the contour of waist protection pillow.[Methods]The structural design information of all waist protection equipment was collected from the national Internet platform,and the data were classified and a database was established.IBM SPSS 26.0 and MATLAB 2018a were used to analyze the data and tabulate them in Tableau 2022.4.After the association rules were clarified,the data were imported into Cinema 4D R21 to create the concept contour of waist protection pillow.[Results]The average and standard deviation of the single airbag design were the highest in all groups,with an average of 0.511 and a standard deviation of 0.502.The average and standard deviation of the upper and lower dual airbags were the lowest in all groups,with an average of 0.015 and a standard deviation of 0.120;the correlation coefficient between single airbag and 120°arc stretching was 0.325,which was positively correlated with each other(P<0.01);the correlation coefficient between multiple airbags and 360°encircling fitting was 0.501,which was positively correlated with each other and had the highest correlation degree(P<0.01).[Conclusions]The single airbag design is well recognized by companies,and has received the highest attention among all brand products.While focusing on single airbag design,most brands will consider the need to add 120°arc stretching elements in product design.At the time of focusing on multiple airbag design,some brands believe that 360°encircling fitting elements need to be added to the product,and the correlation between the two is the highest among all groups.展开更多
The study aims to recognize how efficiently Educational DataMining(EDM)integrates into Artificial Intelligence(AI)to develop skills for predicting students’performance.The study used a survey questionnaire and collec...The study aims to recognize how efficiently Educational DataMining(EDM)integrates into Artificial Intelligence(AI)to develop skills for predicting students’performance.The study used a survey questionnaire and collected data from 300 undergraduate students of Al Neelain University.The first step’s initial population placements were created using Particle Swarm Optimization(PSO).Then,using adaptive feature space search,Educational Grey Wolf Optimization(EGWO)was employed to choose the optimal attribute combination.The second stage uses the SVMclassifier to forecast classification accuracy.Different classifiers were utilized to evaluate the performance of students.According to the results,it was revealed that AI could forecast the final grades of students with an accuracy rate of 97%on the test dataset.Furthermore,the present study showed that successful students could be selected by the Decision Tree model with an efficiency rate of 87.50%and could be categorized as having equal information ratio gain after the semester.While the random forest provided an accuracy of 28%.These findings indicate the higher accuracy rate in the results when these models were implemented on the data set which provides significantly accurate results as compared to a linear regression model with accuracy(12%).The study concluded that the methodology used in this study can prove to be helpful for students and teachers in upgrading academic performance,reducing chances of failure,and taking appropriate steps at the right time to raise the standards of education.The study also motivates academics to assess and discover EDM at several other universities.展开更多
Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with diabetes.Traditional Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating DR.Th...Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with diabetes.Traditional Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating DR.This study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)simulation.Method:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data mining.Subsequently,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core pathways.Finally,molecular docking and MD simulation were employed to validate the findings from network pharmacology.Result:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney channels.Notably,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis Radix.Twenty core active ingredients and ten core targets of the novel TCM prescription for treating DR were screened.Moreover,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling pathway.Finally,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core targets.Conclusions:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating DR.These findings provide a scientific basis and novel insights into the development of drugs for DR prevention and treatment.展开更多
In light of the rapid growth and development of social media, it has become the focus of interest in many different scientific fields. They seek to extract useful information from it, and this is called (knowledge), s...In light of the rapid growth and development of social media, it has become the focus of interest in many different scientific fields. They seek to extract useful information from it, and this is called (knowledge), such as extracting information related to people’s behaviors and interactions to analyze feelings or understand the behavior of users or groups, and many others. This extracted knowledge has a very important role in decision-making, creating and improving marketing objectives and competitive advantage, monitoring events, whether political or economic, and development in all fields. Therefore, to extract this knowledge, we need to analyze the vast amount of data found within social media using the most popular data mining techniques and applications related to social media sites.展开更多
The aviation industry is a sector that is developing, changing and growing every day in terms of technological and legal framework. There are generally three factors that enable airlines to hold on to the market. Thes...The aviation industry is a sector that is developing, changing and growing every day in terms of technological and legal framework. There are generally three factors that enable airlines to hold on to the market. These factors are safety, service quality and price. Airline companies can analyze the customers in the market with a focus on price and quality and develop a business model according to their expectations. For example, business class and economy class passenger expectations are different from each other, so the service and price to be offered to them will be different. However, all customers have one common expectation and that is safety. No matter how high quality the service is or how cheap the price is, no one wants to fly with an airline or plane that is not safe. From an airline company’s point of view, an accident or breakdown of one of the company’s aircraft can cause irreparable image loss and financial damage. If we look at past examples, we see that there are many airline companies or maintenance organizations that could not recover after an accident and went bankrupt. Safety is an indispensable factor. Therefore, there is a unit in the sector called the safety management system (SMS), which collects data by taking a proactive and reactive approach. The way and purpose of the safety management system is to take a proactive approach to recognize and prevent unsafe situations before they cause accidents or breakdowns, or to take a reactive approach to find the causes of accidents and breakdowns that have occurred as a result of certain factors and to take the necessary measures to prevent the same situations from happening again in the sector. The field of data mining, which is necessary to predict the future behavior of customers in the field of marketing, is an area that marketing also values. In this study, data mining studies to ensure safety in the aviation industry and the security of customer information in marketing will be emphasized, firstly, the concept and importance of data mining will be mentioned.展开更多
The teaching quality evaluation system based on data mining technology can accurately and fairly identify the core driving factors to improve teaching quality.This method adopts the analysis of big data correlation ru...The teaching quality evaluation system based on data mining technology can accurately and fairly identify the core driving factors to improve teaching quality.This method adopts the analysis of big data correlation rules,including data collection and processing preparation steps,builds the data warehouse of association rules,and then generates an educational quality evaluation framework using the principle of data mining.Based on this,this paper analyzes the construction design and method of the teaching evaluation system under data mining,hoping to provide help for the improvement of the teaching evaluation system and the improvement of teaching quality.展开更多
Background:Using network pharmacology to explore the potential molecular mechanism of traditional Chinese medicine in treating polycystic ovary syndrome(PCOS)with kidney deficiency and blood stasis syndrome.Method:Col...Background:Using network pharmacology to explore the potential molecular mechanism of traditional Chinese medicine in treating polycystic ovary syndrome(PCOS)with kidney deficiency and blood stasis syndrome.Method:Collect the related literature materials of PCOS with kidney deficiency and blood stasis syndrome treated by traditional Chinese medicine in four databases in recent ten years,extract the information of prescriptions and complete the frequency analysis.Traditional Chinese Medicine Systems Pharmacology Database was used to screen out the effective components.Use Online Mendelian Inheritance in Man and other databases to screen PCOS disease targets.The intersection targets obtained by clustering prescription and PCOS disease targets were submitted to STRING database for protein-protein interaction network analysis,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes pathways were analysed by Metascape.Result:There are 155 kinds of traditional Chinese medicines used in the literature.The most commonly utilized ones are Cuscutae Semen,Angelicae Sinensis Radix,and Rehmanniae Radix Praeparata.The results of the cluster analysis indicated that the plants most commonly found throughout the prescription were Leonuri Herba,Lycopi Herba,Dipsaci Radix,etc.GO results show that biological processes include cell reaction to organic nitrogen compounds and cell reaction to nitrogen compounds.The functional display of GO molecule includes cytokine receptor binding,signal receptor regulator activity and so on.Kyoto Encyclopedia of Genes and Genomes results show that the possible mechanisms of action are cancer pathway,an endocrine resistance signal pathway.Conclusion:Through data mining,the cluster prescription for PCOS with kidney deficiency and blood stasis syndrome is Leonuri Herba,Lycopi Herba,Dipsaci Radix,etc.The network pharmacology research of cluster prescription shows that the main drug components for treating PCOS with kidney deficiency and blood stasis syndrome are quercetin,kaempferol,luteolin,tanshinone IIA,etc.,which act on PTGS2,NCOA2,and other targets,and treat PCOS with kidney deficiency and blood stasis syndrome through cancer and endocrine resistance.展开更多
Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable opera...Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable operation of distribution networks and power supplies needed for daily life.Therefore,considering the requirements for distribution network disaster prevention and mitigation,there is an urgent need for in-depth research on risk assessment methods of distribution networks under extreme natural disaster conditions.This paper accessesmultisource data,presents the data quality improvement methods of distribution networks,and conducts data-driven active fault diagnosis and disaster damage analysis and evaluation using data-driven theory.Furthermore,the paper realizes real-time,accurate access to distribution network disaster information.The proposed approach performs an accurate and rapid assessment of cross-sectional risk through case study.The minimal average annual outage time can be reduced to 3 h/a in the ring network through case study.The approach proposed in this paper can provide technical support to the further improvement of the ability of distribution networks to cope with extreme natural disasters.展开更多
The slow traffic system is an important component of urban transportation,and the prerequisite and necessary condition for Beijing to continue promoting“green priority”are establishing a good urban slow traffic syst...The slow traffic system is an important component of urban transportation,and the prerequisite and necessary condition for Beijing to continue promoting“green priority”are establishing a good urban slow traffic system.Shijingshan District of Beijing City is taken as a research object.By analyzing and processing population distribution data,POI data,and shared bicycle data,the shortcomings and deficiencies of the current slow traffic system in Shijingshan District are explored,and corresponding solutions are proposed,in order to provide new ideas and methods for future urban planning from the perspective of data.展开更多
In the first-tier cities,subway has become an important carrier and life focus of people’s daily travel activities.By studying the distribution of POIs of public service facilities around Metro Line 10,using GIS to q...In the first-tier cities,subway has become an important carrier and life focus of people’s daily travel activities.By studying the distribution of POIs of public service facilities around Metro Line 10,using GIS to quantitatively analyze the surrounding formats of subway stations,discussing the functional attributes of subway stations,and discussing the distribution of urban functions from a new perspective,this paper provided guidance and advice for the construction of service facilities.展开更多
Multi-source seismic technology is an efficient seismic acquisition method that requires a group of blended seismic data to be separated into single-source seismic data for subsequent processing. The separation of ble...Multi-source seismic technology is an efficient seismic acquisition method that requires a group of blended seismic data to be separated into single-source seismic data for subsequent processing. The separation of blended seismic data is a linear inverse problem. According to the relationship between the shooting number and the simultaneous source number of the acquisition system, this separation of blended seismic data is divided into an easily determined or overdetermined linear inverse problem and an underdetermined linear inverse problem that is difficult to solve. For the latter, this paper presents an optimization method that imposes the sparsity constraint on wavefields to construct the object function of inversion, and the problem is solved by using the iterative thresholding method. For the most extremely underdetermined separation problem with single-shooting and multiple sources, this paper presents a method of pseudo-deblending with random noise filtering. In this method, approximate common shot gathers are received through the pseudo-deblending process, and the random noises that appear when the approximate common shot gathers are sorted into common receiver gathers are eliminated through filtering methods. The separation methods proposed in this paper are applied to three types of numerical simulation data, including pure data without noise, data with random noise, and data with linear regular noise to obtain satisfactory results. The noise suppression effects of these methods are sufficient, particularly with single-shooting blended seismic data, which verifies the effectiveness of the proposed methods.展开更多
Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Da...Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.展开更多
基金supported by the National Key Research and Development Program of China(grant number 2019YFE0123600)。
文摘The power Internet of Things(IoT)is a significant trend in technology and a requirement for national strategic development.With the deepening digital transformation of the power grid,China’s power system has initially built a power IoT architecture comprising a perception,network,and platform application layer.However,owing to the structural complexity of the power system,the construction of the power IoT continues to face problems such as complex access management of massive heterogeneous equipment,diverse IoT protocol access methods,high concurrency of network communications,and weak data security protection.To address these issues,this study optimizes the existing architecture of the power IoT and designs an integrated management framework for the access of multi-source heterogeneous data in the power IoT,comprising cloud,pipe,edge,and terminal parts.It further reviews and analyzes the key technologies involved in the power IoT,such as the unified management of the physical model,high concurrent access,multi-protocol access,multi-source heterogeneous data storage management,and data security control,to provide a more flexible,efficient,secure,and easy-to-use solution for multi-source heterogeneous data access in the power IoT.
基金supported by the National Natural Science Foundation of China(41977215)。
文摘Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive power.Numerical methods have been widely used to predict the landslide runout but a fundamental problem remained is how to determine the reliable numerical parameters.This study proposes a framework to predict the runout of potential landslides through multi-source data collaboration and numerical analysis of historical landslide events.Specifically,for the historical landslide cases,the landslide-induced seismic signal,geophysical surveys,and possible in-situ drone/phone videos(multi-source data collaboration)can validate the numerical results in terms of landslide dynamics and deposit features and help calibrate the numerical(rheological)parameters.Subsequently,the calibrated numerical parameters can be used to numerically predict the runout of potential landslides in the region with a similar geological setting to the recorded events.Application of the runout prediction approach to the 2020 Jiashanying landslide in Guizhou,China gives reasonable results in comparison to the field observations.The numerical parameters are determined from the multi-source data collaboration analysis of a historical case in the region(2019 Shuicheng landslide).The proposed framework for landslide runout prediction can be of great utility for landslide risk assessment and disaster reduction in mountainous regions worldwide.
基金supported by the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QD032)。
文摘Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas.
基金funded by the High-Quality and Cutting-Edge Discipline Construction Project for Universities in Beijing (Internet Information,Communication University of China).
文摘Multi-Source data plays an important role in the evolution of media convergence.Its fusion processing enables the further mining of data and utilization of data value and broadens the path for the sharing and dissemination of media data.However,it also faces serious problems in terms of protecting user and data privacy.Many privacy protectionmethods have been proposed to solve the problemof privacy leakage during the process of data sharing,but they suffer fromtwo flaws:1)the lack of algorithmic frameworks for specific scenarios such as dynamic datasets in the media domain;2)the inability to solve the problem of the high computational complexity of ciphertext in multi-source data privacy protection,resulting in long encryption and decryption times.In this paper,we propose a multi-source data privacy protection method based on homomorphic encryption and blockchain technology,which solves the privacy protection problem ofmulti-source heterogeneous data in the dissemination ofmedia and reduces ciphertext processing time.We deployed the proposedmethod on theHyperledger platformfor testing and compared it with the privacy protection schemes based on k-anonymity and differential privacy.The experimental results showthat the key generation,encryption,and decryption times of the proposedmethod are lower than those in data privacy protection methods based on k-anonymity technology and differential privacy technology.This significantly reduces the processing time ofmulti-source data,which gives it potential for use in many applications.
基金supported by the National Natural Science Foundation of China(Grant No.:U2202213)the Special Program for the Major Science and Technology Projects of Yunnan Province,China(Grant Nos.:202102AE090051-1-01,and 202202AE090001).
文摘In traditional medicine and ethnomedicine,medicinal plants have long been recognized as the basis for materials in therapeutic applications worldwide.In particular,the remarkable curative effect of traditional Chinese medicine during corona virus disease 2019(COVID-19)pandemic has attracted extensive attention globally.Medicinal plants have,therefore,become increasingly popular among the public.However,with increasing demand for and profit with medicinal plants,commercial fraudulent events such as adulteration or counterfeits sometimes occur,which poses a serious threat to the clinical outcomes and interests of consumers.With rapid advances in artificial intelligence,machine learning can be used to mine information on various medicinal plants to establish an ideal resource database.We herein present a review that mainly introduces common machine learning algorithms and discusses their application in multi-source data analysis of medicinal plants.The combination of machine learning algorithms and multi-source data analysis facilitates a comprehensive analysis and aids in the effective evaluation of the quality of medicinal plants.The findings of this review provide new possibilities for promoting the development and utilization of medicinal plants.
基金partially supported by the Foundation of State Key Laboratory of Public Big Data(No.PBD2022-01).
文摘In today’s highly competitive retail industry,offline stores face increasing pressure on profitability.They hope to improve their ability in shelf management with the help of big data technology.For this,on-shelf availability is an essential indicator of shelf data management and closely relates to customer purchase behavior.RFM(recency,frequency,andmonetary)patternmining is a powerful tool to evaluate the value of customer behavior.However,the existing RFM patternmining algorithms do not consider the quarterly nature of goods,resulting in unreasonable shelf availability and difficulty in profit-making.To solve this problem,we propose a quarterly RFM mining algorithmfor On-shelf products named OS-RFM.Our algorithmmines the high recency,high frequency,and high monetary patterns and considers the period of the on-shelf goods in quarterly units.We conducted experiments using two real datasets for numerical and graphical analysis to prove the algorithm’s effectiveness.Compared with the state-of-the-art RFM mining algorithm,our algorithm can identify more patterns and performs well in terms of precision,recall,and F1-score,with the recall rate nearing 100%.Also,the novel algorithm operates with significantly shorter running times and more stable memory usage than existing mining algorithms.Additionally,we analyze the sales trends of products in different quarters and seasonal variations.The analysis assists businesses in maintaining reasonable on-shelf availability and achieving greater profitability.
基金Under the auspices of Natural Science Foundation of China(No.41971166)。
文摘Urban functional area(UFA)is a core scientific issue affecting urban sustainability.The current knowledge gap is mainly reflected in the lack of multi-scale quantitative interpretation methods from the perspective of human-land interaction.In this paper,based on multi-source big data include 250 m×250 m resolution cell phone data,1.81×105 Points of Interest(POI)data and administrative boundary data,we built a UFA identification method and demonstrated empirically in Shenyang City,China.We argue that the method we built can effectively identify multi-scale multi-type UFAs based on human activity and further reveal the spatial correlation between urban facilities and human activity.The empirical study suggests that the employment functional zones in Shenyang City are more concentrated in central cities than other single functional zones.There are more mix functional areas in the central city areas,while the planned industrial new cities need to develop comprehensive functions in Shenyang.UFAs have scale effects and human-land interaction patterns.We suggest that city decision makers should apply multi-sources big data to measure urban functional service in a more refined manner from a supply-demand perspective.
基金supported by a grant from Hubei Key Laboratory of Diabetes and Angiopathy Program of Hubei University of Science and Technology(2020XZ10)Project of Education Commission of Hubei Province(B2022192).
文摘Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized disease.Nevertheless,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains unknown.We employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized T2D.Methods:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology databases.Succeeding,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes analysis.And the compound-disease targets-pathway network were constructed to obtain the hub compound.Moreover,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock 1.5.7.Furthermore,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized T2D.Finally,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain reaction.Results:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be quercetin.Consistently,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network analysis.Molecular docking showed that quercetin could bind with the hub genes.Further,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated lipid and atherosclerosis,and/or including NOD-like receptor signaling pathway,and TNF signaling pathway.Ultimately,the quantitative polymerase chain reaction and western blotting analysis showed that quercetin could down-regulated the mRNA and protein experssion of CASP8,CCL2,and AHR.It was consistent with the results in Comparative Toxicogenomics Database databases.Conclusion:These results demonstrated quercetin could inhibit the expression of CASP8,CCL2,AHR in damp-heat internalized T2D,which improves insulin secretion and inhibits lipid and atherosclerosis,as well as/or including NOD-like receptor signaling pathway,and TNF signaling pathway,suggesting that EZECD may be more effective to treat damp-heat internalized T2D.
基金Supported by Municipal Public Welfare Science and Technology Project of Zhoushan Science and Technology Bureau,Zhejiang Province(2021C31064).
文摘[Objectives]To explore the trend of brands towards the design of waist protection products through data mining,and to provide reference for the design concept of the contour of waist protection pillow.[Methods]The structural design information of all waist protection equipment was collected from the national Internet platform,and the data were classified and a database was established.IBM SPSS 26.0 and MATLAB 2018a were used to analyze the data and tabulate them in Tableau 2022.4.After the association rules were clarified,the data were imported into Cinema 4D R21 to create the concept contour of waist protection pillow.[Results]The average and standard deviation of the single airbag design were the highest in all groups,with an average of 0.511 and a standard deviation of 0.502.The average and standard deviation of the upper and lower dual airbags were the lowest in all groups,with an average of 0.015 and a standard deviation of 0.120;the correlation coefficient between single airbag and 120°arc stretching was 0.325,which was positively correlated with each other(P<0.01);the correlation coefficient between multiple airbags and 360°encircling fitting was 0.501,which was positively correlated with each other and had the highest correlation degree(P<0.01).[Conclusions]The single airbag design is well recognized by companies,and has received the highest attention among all brand products.While focusing on single airbag design,most brands will consider the need to add 120°arc stretching elements in product design.At the time of focusing on multiple airbag design,some brands believe that 360°encircling fitting elements need to be added to the product,and the correlation between the two is the highest among all groups.
基金supported via funding from Prince Sattam bin Abdulaziz University Project Number(PSAU/2024/R/1445).
文摘The study aims to recognize how efficiently Educational DataMining(EDM)integrates into Artificial Intelligence(AI)to develop skills for predicting students’performance.The study used a survey questionnaire and collected data from 300 undergraduate students of Al Neelain University.The first step’s initial population placements were created using Particle Swarm Optimization(PSO).Then,using adaptive feature space search,Educational Grey Wolf Optimization(EGWO)was employed to choose the optimal attribute combination.The second stage uses the SVMclassifier to forecast classification accuracy.Different classifiers were utilized to evaluate the performance of students.According to the results,it was revealed that AI could forecast the final grades of students with an accuracy rate of 97%on the test dataset.Furthermore,the present study showed that successful students could be selected by the Decision Tree model with an efficiency rate of 87.50%and could be categorized as having equal information ratio gain after the semester.While the random forest provided an accuracy of 28%.These findings indicate the higher accuracy rate in the results when these models were implemented on the data set which provides significantly accurate results as compared to a linear regression model with accuracy(12%).The study concluded that the methodology used in this study can prove to be helpful for students and teachers in upgrading academic performance,reducing chances of failure,and taking appropriate steps at the right time to raise the standards of education.The study also motivates academics to assess and discover EDM at several other universities.
基金supported by the National Natural Science Foundation of China(Grant No.82104701)Science Fund Program for Outstanding Young Scholars in Universities of Anhui Province(Grant No.2022AH030064)+3 种基金Key Project at Central Government Level:the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(Grant No.2060302)Foundation of Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application(Grant No.2021KFKT10)China Agriculture Research System of MOF and MARA(Grant No.CARS-21)Talent Support Program of Anhui University of Chinese Medicine(Grant No.2020rcyb007).
文摘Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with diabetes.Traditional Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating DR.This study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)simulation.Method:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data mining.Subsequently,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core pathways.Finally,molecular docking and MD simulation were employed to validate the findings from network pharmacology.Result:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney channels.Notably,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis Radix.Twenty core active ingredients and ten core targets of the novel TCM prescription for treating DR were screened.Moreover,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling pathway.Finally,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core targets.Conclusions:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating DR.These findings provide a scientific basis and novel insights into the development of drugs for DR prevention and treatment.
文摘In light of the rapid growth and development of social media, it has become the focus of interest in many different scientific fields. They seek to extract useful information from it, and this is called (knowledge), such as extracting information related to people’s behaviors and interactions to analyze feelings or understand the behavior of users or groups, and many others. This extracted knowledge has a very important role in decision-making, creating and improving marketing objectives and competitive advantage, monitoring events, whether political or economic, and development in all fields. Therefore, to extract this knowledge, we need to analyze the vast amount of data found within social media using the most popular data mining techniques and applications related to social media sites.
文摘The aviation industry is a sector that is developing, changing and growing every day in terms of technological and legal framework. There are generally three factors that enable airlines to hold on to the market. These factors are safety, service quality and price. Airline companies can analyze the customers in the market with a focus on price and quality and develop a business model according to their expectations. For example, business class and economy class passenger expectations are different from each other, so the service and price to be offered to them will be different. However, all customers have one common expectation and that is safety. No matter how high quality the service is or how cheap the price is, no one wants to fly with an airline or plane that is not safe. From an airline company’s point of view, an accident or breakdown of one of the company’s aircraft can cause irreparable image loss and financial damage. If we look at past examples, we see that there are many airline companies or maintenance organizations that could not recover after an accident and went bankrupt. Safety is an indispensable factor. Therefore, there is a unit in the sector called the safety management system (SMS), which collects data by taking a proactive and reactive approach. The way and purpose of the safety management system is to take a proactive approach to recognize and prevent unsafe situations before they cause accidents or breakdowns, or to take a reactive approach to find the causes of accidents and breakdowns that have occurred as a result of certain factors and to take the necessary measures to prevent the same situations from happening again in the sector. The field of data mining, which is necessary to predict the future behavior of customers in the field of marketing, is an area that marketing also values. In this study, data mining studies to ensure safety in the aviation industry and the security of customer information in marketing will be emphasized, firstly, the concept and importance of data mining will be mentioned.
文摘The teaching quality evaluation system based on data mining technology can accurately and fairly identify the core driving factors to improve teaching quality.This method adopts the analysis of big data correlation rules,including data collection and processing preparation steps,builds the data warehouse of association rules,and then generates an educational quality evaluation framework using the principle of data mining.Based on this,this paper analyzes the construction design and method of the teaching evaluation system under data mining,hoping to provide help for the improvement of the teaching evaluation system and the improvement of teaching quality.
基金supported by Clinical observation on the treatment of diabetic peripheral neuropathy by supplementing qi,promoting blood circulation and tonifying kidney (grant mumber YJ202324).
文摘Background:Using network pharmacology to explore the potential molecular mechanism of traditional Chinese medicine in treating polycystic ovary syndrome(PCOS)with kidney deficiency and blood stasis syndrome.Method:Collect the related literature materials of PCOS with kidney deficiency and blood stasis syndrome treated by traditional Chinese medicine in four databases in recent ten years,extract the information of prescriptions and complete the frequency analysis.Traditional Chinese Medicine Systems Pharmacology Database was used to screen out the effective components.Use Online Mendelian Inheritance in Man and other databases to screen PCOS disease targets.The intersection targets obtained by clustering prescription and PCOS disease targets were submitted to STRING database for protein-protein interaction network analysis,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes pathways were analysed by Metascape.Result:There are 155 kinds of traditional Chinese medicines used in the literature.The most commonly utilized ones are Cuscutae Semen,Angelicae Sinensis Radix,and Rehmanniae Radix Praeparata.The results of the cluster analysis indicated that the plants most commonly found throughout the prescription were Leonuri Herba,Lycopi Herba,Dipsaci Radix,etc.GO results show that biological processes include cell reaction to organic nitrogen compounds and cell reaction to nitrogen compounds.The functional display of GO molecule includes cytokine receptor binding,signal receptor regulator activity and so on.Kyoto Encyclopedia of Genes and Genomes results show that the possible mechanisms of action are cancer pathway,an endocrine resistance signal pathway.Conclusion:Through data mining,the cluster prescription for PCOS with kidney deficiency and blood stasis syndrome is Leonuri Herba,Lycopi Herba,Dipsaci Radix,etc.The network pharmacology research of cluster prescription shows that the main drug components for treating PCOS with kidney deficiency and blood stasis syndrome are quercetin,kaempferol,luteolin,tanshinone IIA,etc.,which act on PTGS2,NCOA2,and other targets,and treat PCOS with kidney deficiency and blood stasis syndrome through cancer and endocrine resistance.
文摘Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable operation of distribution networks and power supplies needed for daily life.Therefore,considering the requirements for distribution network disaster prevention and mitigation,there is an urgent need for in-depth research on risk assessment methods of distribution networks under extreme natural disaster conditions.This paper accessesmultisource data,presents the data quality improvement methods of distribution networks,and conducts data-driven active fault diagnosis and disaster damage analysis and evaluation using data-driven theory.Furthermore,the paper realizes real-time,accurate access to distribution network disaster information.The proposed approach performs an accurate and rapid assessment of cross-sectional risk through case study.The minimal average annual outage time can be reduced to 3 h/a in the ring network through case study.The approach proposed in this paper can provide technical support to the further improvement of the ability of distribution networks to cope with extreme natural disasters.
基金Sponsored by Beijing Natural Science Foundation General Project(8212009)Construction of Philosophy and Social Sciences Base in Beijing-Research on Beijing Urban Renewal and Comprehensive Management of Old Community En-vironment2023 Education Reform Project of North China University of Technology(108051360023XN264-25).
文摘The slow traffic system is an important component of urban transportation,and the prerequisite and necessary condition for Beijing to continue promoting“green priority”are establishing a good urban slow traffic system.Shijingshan District of Beijing City is taken as a research object.By analyzing and processing population distribution data,POI data,and shared bicycle data,the shortcomings and deficiencies of the current slow traffic system in Shijingshan District are explored,and corresponding solutions are proposed,in order to provide new ideas and methods for future urban planning from the perspective of data.
基金Beijing Municipal Social Science Foundation(22GLC062)Research on service function renewal of Beijing subway station living circle driven by multiple big data.Beijing Municipal Education Commission Social Science Project(KM202010009002)Young YuYou Talents Training Plan of North China University of Technology.
文摘In the first-tier cities,subway has become an important carrier and life focus of people’s daily travel activities.By studying the distribution of POIs of public service facilities around Metro Line 10,using GIS to quantitatively analyze the surrounding formats of subway stations,discussing the functional attributes of subway stations,and discussing the distribution of urban functions from a new perspective,this paper provided guidance and advice for the construction of service facilities.
文摘Multi-source seismic technology is an efficient seismic acquisition method that requires a group of blended seismic data to be separated into single-source seismic data for subsequent processing. The separation of blended seismic data is a linear inverse problem. According to the relationship between the shooting number and the simultaneous source number of the acquisition system, this separation of blended seismic data is divided into an easily determined or overdetermined linear inverse problem and an underdetermined linear inverse problem that is difficult to solve. For the latter, this paper presents an optimization method that imposes the sparsity constraint on wavefields to construct the object function of inversion, and the problem is solved by using the iterative thresholding method. For the most extremely underdetermined separation problem with single-shooting and multiple sources, this paper presents a method of pseudo-deblending with random noise filtering. In this method, approximate common shot gathers are received through the pseudo-deblending process, and the random noises that appear when the approximate common shot gathers are sorted into common receiver gathers are eliminated through filtering methods. The separation methods proposed in this paper are applied to three types of numerical simulation data, including pure data without noise, data with random noise, and data with linear regular noise to obtain satisfactory results. The noise suppression effects of these methods are sufficient, particularly with single-shooting blended seismic data, which verifies the effectiveness of the proposed methods.
基金supported by a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship(021207-00001)from Nanyang Technological University(NTU)Singapore and a Mistletoe Research Fellowship(022522-00001)from the Momental Foundation USA.Jialiu Zeng is supported by a Presidential Postdoctoral Fellowship(021229-00001)from NTU Singapore and an Open Fund Young Investigator Research Grant(OF-YIRG)(MOH-001147)from the National Medical Research Council(NMRC)SingaporeSu Bin Lim is supported by the National Research Foundation(NRF)of Korea(Grant Nos.:2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(Grant No.:HR22C1734).
文摘Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.