Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forec...Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells.展开更多
The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spa...The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spatial-temporal structures,and the deep learning model can fully describe the potential semantic structure of human motion.To improve the authenticity of the generated human motion sequences,we propose a multi-task motion generation model that consists of a discriminator and a generator.The discriminator classifies motion sequences into different styles according to their similarity to the mean spatial-temporal templates from motion sequences of 17 crucial human joints in three-freedom degrees.And target motion sequences are created with these styles by the generator.Unlike traditional related works,our model can handle multiple tasks,such as identifying styles and generating data.In addition,by extracting 17 crucial joints from 29 human joints,our model avoids data redundancy and improves the accuracy of model recognition.The experimental results show that the discriminator of the model can effectively recognize diversified movements,and the generated data can correctly fit the actual data.The combination of discriminator and generator solves the problem of low reuse rate of motion data,and the generated motion sequences are more suitable for actual movement.展开更多
ion by proposing multiple levels of cascaded hierarchi-cal structures from the perspective of function,namely,the func-tional decision tree.This method is developed to represent behavioral modeling of air combat syste...ion by proposing multiple levels of cascaded hierarchi-cal structures from the perspective of function,namely,the func-tional decision tree.This method is developed to represent behavioral modeling of air combat systems,and its metamodel,execution mechanism,and code generation can provide a sound basis for function-based behavioral modeling.As a proof of con-cept,an air combat simulation is developed to validate this method and the results show that the fighter Alpha built using the proposed framework provides better performance than that using default scripts.展开更多
Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of ne...Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of new generations of the NEPE propellant with better mechanical properties. Therefore,understanding the effects of NPBA on the deformation and damage evolution of the NEPE propellant is fundamental to material design and applications. This paper studies the uniaxial tensile and stress relaxation responses of the NEPE propellant with different amounts of NPBA. The damage evolution in terms of interface debonding is further investigated using a cohesive-zone model(CZM). Experimental results show that the initial modulus and strength of the NEPE propellant increase with the increasing amount of NPBA while the elongation decreases. Meanwhile, the relaxation rate slows down and a higher long-term equilibrium modulus is reached. Experimental and numerical analyses indicate that interface debonding and crack propagation along filler-matrix interface are the dominant damage mechanism for the samples with a low amount of NPBA, while damage localization and crack advancement through the matrix are predominant for the ones with a high amount of NPBA. Finally, crosslinking density tests and simulation results also show that the effect of the bonding agent is interfacial rather than due to the overall crosslinking density change of the binder.展开更多
Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper opti...Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.展开更多
Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which ...Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study.展开更多
The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intr...The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles,together with loss of cholinergic neurons,synaptic alterations,and chronic inflammation within the brain.These lead to progressive impairment of cognitive function.There is evidence of innate immune activation in AD with microgliosis.Classically-activated microglia(M1 state) secrete inflammatory and neurotoxic mediators,and peripheral immune cells are recruited to inflammation sites in the brain.The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects.Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials.Treatment with immunomodulatory/anti-inflammatory agents early in the disease process,while not preventive,is able to inhibit the inflammatory consequences of both Aβ and tau aggregation.The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD.The majority of the animal studies reviewed had used transgenic models of early-onset AD.More effort needs to be given to creat models of late-onset AD.The effects of a combinational therapy involving two or more of the tested pharmaceutical agents,or one of these agents given in conjunction with one of the cell-based therapies,in an aged animal model of AD would warrant investigation.展开更多
Parkinson’s disease(PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are pre...Parkinson’s disease(PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are present in the substantia nigra,with the nerve terminals being in the striatum.Both innate and adaptive immune responses may contribute to dopaminergic neurodegeneration and disease progression is potentially linked to these.Studies in the last twenty years have indicated an important role for neuroinflammation in PD through degeneration of the nigrostriatal dopaminergic pathway.Characteristic of neuroinflammation is the activation of brain glial cells,principally microglia and astrocytes that release various soluble factors.Many of these factors are proinflammatory and neurotoxic and harmful to nigral dopaminergic neurons.Recent studies have identified several different agents with immunomodulatory properties that protected dopaminergic neurons from degeneration and death in animal models of PD.All of the agents were effective in reducing the motor deficit and alleviating dopaminergic neurotoxicity and,when measured,preventing the decrease of dopamine upon being administered therapeutically after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,6-hydroxydopamine,rotenone-lesioning or delivery of adeno-associated virus-α-synuclein to the ventral midbrain of animals.Some of these agents were shown to exert an anti-inflammatory action,decrease oxidative stress,and reduce lipid peroxidation products.Activation of microglia and astrocytes was also decreased,as well as infiltration of T cells into the substantia nigra.Pretreatment with fingolimod,tanshinoine I,dimethyl fumarate,thalidomide,or cocaine-and amphetamine-regulated transcript peptide as a preventive strategy ameliorated motor deficits and nigral dopaminergic neurotoxicity in brain-lesioned animals.Immunomodulatory agents could be used to treat patients with early clinical signs of the disease or potentially even prior to disease onset in those identified as having pre-disposing risk,including genetic factors.展开更多
It is essential to learn the temporal and spatial concentration distributions and variations of seeding agents in cloud seeding of precipitation enhancement. A three-dimensional puff trajectory model incorporating a m...It is essential to learn the temporal and spatial concentration distributions and variations of seeding agents in cloud seeding of precipitation enhancement. A three-dimensional puff trajectory model incorporating a mesoscale nonhydrostatic model has been formulated, and is applied to simulating the transporting and diffusive characteristics of multiple line sources of seeding agents within super-cooled stratus. Several important factors are taken into consideration that affect the diffusion of seeding materials such as effects of topography and vertical wind shear, temporal and spatial variation of seeding parameters and wet deposition. The particles of seeding agents are assumed to be almost inert, they have no interaction with the particles of the cloud or precipitation except that they are washed out by precipitation. The model validity is demonstrated by the analyses and comparisons of model results, and checked by the sensitivity experiments of diffusive coefficients and atmospheric stratification. The advantage of this model includes not only its exact reflection of heterogeneity and unsteadiness of background fields, but also its good simulation of transport and diffusion of multiple line sources. The horizontal diffusion rate and the horizontal transport distance have been proposed that they usually were difficult to obtain in other models. In this simulation the horizontal diffusion rate is 0.82 m s(-1) for average of one hour, and the horizontal average transport distance reaches 65 km after 1 4 which are closely related to the background Fields.展开更多
Collision avoidance decision-making models of multiple agents in virtual driving environment are studied. Based on the behavioral characteristics and hierarchical structure of the collision avoidance decision-making i...Collision avoidance decision-making models of multiple agents in virtual driving environment are studied. Based on the behavioral characteristics and hierarchical structure of the collision avoidance decision-making in real life driving, delphi approach and mathematical statistics method are introduced to construct pair-wise comparison judgment matrix of collision avoidance decision choices to each collision situation. Analytic hierarchy process (AHP) is adopted to establish the agents' collision avoidance decision-making model. To simulate drivers' characteristics, driver factors are added to categorize driving modes into impatient mode, normal mode, and the cautious mode. The results show that this model can simulate human's thinking process, and the agents in the virtual environment can deal with collision situations and make decisions to avoid collisions without intervention. The model can also reflect diversity and uncertainly of real life driving behaviors, and solves the multi-objective, multi-choice ranking priority problem in multi-vehicle collision scenarios. This collision avoidance model of multi-agents model is feasible and effective, and can provide richer and closer-to-life virtual scene for driving simulator, reflecting real-life traffic environment more truly, this model can also promote the practicality of driving simulator.展开更多
Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abil...Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abilities to react and make decision, the whole system will evolve to new conditions in response to policy change. Compared with different scenarios, it can be concluded that when raising taxation ratio, sectoral scale will shrink to some extent. But supported by government expenditure, certain sectors could be kept in comparatively larger production scale.展开更多
This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model r...This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model reconciles empirically-observed price overreactions to fake news with empirically-observed price underreactions to real news,and predicts a novel secondary impact of fake news:that fake news in a security amplifies underreactions to subsequent real news for the security.Evaluating the model against a large-sample event study of the 2019 Chinese ADR Delisting Threat fake news and debunking event,this paper finds strong qualitative validation for its model’s dynamics and predictions.展开更多
Based on the current researches of viewpoints oriented requirements engineering and intelligent agent, we present the concept of viewpoint agent and its abstract model based on a recta-language for muhiviews requireme...Based on the current researches of viewpoints oriented requirements engineering and intelligent agent, we present the concept of viewpoint agent and its abstract model based on a recta-language for muhiviews requirements engineering. It provided a basis for consistency checking and integration of different viewpoint requirements, at the same time, these checking and integration works can automatically realized in virtue of intelligent agent' s autonomy, proactivenes.s and social ability. Finally, we introduce the practical application of the model by the case study of data flow diagram.展开更多
In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process...In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process agent and stock agent. The scheduling agent has three subagents: manager agent (MA),resource agent (RA) and part agent (PA). MA,PA and RA are communicating equally that guarantees agility of the whole MAS system. The part tasks pass between MA,RA and PA as an integer,which can guarantee the consistency of the data. We use a detailed example about shop logistics scheduling in a semiconductor company to explain the principle. In this example,we use two scheduling strategies: FCFS and SPT. The result data indicates that the average flow time and lingering ratio are changed using different strategy. It is proves that the multi-agent scheduling is useful.展开更多
Agile manufacturing execution systems (AMES) are used to help manufacturers optimize shop floor production in an agile way. And the modeling of AMES is the key issue of realizing AMES. This paper presents an agent-bas...Agile manufacturing execution systems (AMES) are used to help manufacturers optimize shop floor production in an agile way. And the modeling of AMES is the key issue of realizing AMES. This paper presents an agent-based approach to AMES modeling. Firstly, the characteristics of AMES and its requirements on modeling are discussed. Secondly, a comparative analysis of modeling methods is carried out, and AMES modeling using an agent-based approach is put forward. Agent-based modeling method not only inherit the favorable features of traditional object-oriented modeling method such as data encapsulation, modularity and so on, but also has the ability to construct intelligent, rational and autonomous agent which can cooperate together to realize the goal of agile operation. A general agent architecture used in AMES modeling is described. Under this architecture, an agent can be divided into domain-independent components and domain-specific components which helps solve problems such as information overload, incomplete information handling and soft decision-making. Furthermore, an AMES model using four types of agents, i.e., interface agent, information agent, resource agent and management agent, is established. Thirdly, a snapshot of AMES model is provided in the case study. Especially, an agent-based cooperating process of task scheduling in AMES is illustrated in detail. Finally, the advantages and disadvantages of this modeling approach are discussed as well.展开更多
This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system...This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system is built,where each agent stands for a vehicle,and it makes its routing selection by considering the shortest path and the minimum congested degree of the target link simultaneously. The agent-based model captures the nonlinear feedback between vehicle routing behaviors and road-network congestion status.Secondly,a hybrid routing selection strategy is provided,which guides the vehicle routes adapting to the realtime road-network congestion status. On this basis, we execute simulation experiments and compare the simulation results of network congestion distribution,by Floyd agent with shortest path strategy and our proposed adaptive agent with hybrid strategy. The simulation results show that our proposed model has reduced the congestion degree of those seriously congested links of road-network. Finally,we execute our model on a real road map. The results finds that those seriously congested roads have some common features such as located at the road junction or near the unique road connecting two areas. And,the results also show an effectiveness of our model on reduction of those seriously congested links in this actual road network. Such a bottom-up congestion control approach with a hybrid congestion optimization perspective will have its significance for actual traffic congestion control.展开更多
A combined method of discrete event and agent based modelling has been applied to the computer modelling and simulation of the tensile strength of one-dimensional fibrous materials (ODFM). This combined method is base...A combined method of discrete event and agent based modelling has been applied to the computer modelling and simulation of the tensile strength of one-dimensional fibrous materials (ODFM). This combined method is based on the concept of discrete event simulation as being applied to the modeling of the structure of the fiber flow and on the concept of agent based modelling for modelling and simulation of the fiber interaction within the structure of the fibrous material. Frictional and traction forces arise as the result of this fiber interaction. A model of the ODFM tensile strength, which is based on the slippage effect, is created and studied in this research. Only frictional and traction forces determine the tensile strength in this kind of the model. The article examines the validation problem of the slippage effect based tensile strength model and questions regarding the strength potential estimation through variation in the parameters of the model.展开更多
基金supported by the Science and Technology Grant No.520120210003,Jibei Electric Power Company of the State Grid Corporation of China。
文摘Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells.
文摘The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spatial-temporal structures,and the deep learning model can fully describe the potential semantic structure of human motion.To improve the authenticity of the generated human motion sequences,we propose a multi-task motion generation model that consists of a discriminator and a generator.The discriminator classifies motion sequences into different styles according to their similarity to the mean spatial-temporal templates from motion sequences of 17 crucial human joints in three-freedom degrees.And target motion sequences are created with these styles by the generator.Unlike traditional related works,our model can handle multiple tasks,such as identifying styles and generating data.In addition,by extracting 17 crucial joints from 29 human joints,our model avoids data redundancy and improves the accuracy of model recognition.The experimental results show that the discriminator of the model can effectively recognize diversified movements,and the generated data can correctly fit the actual data.The combination of discriminator and generator solves the problem of low reuse rate of motion data,and the generated motion sequences are more suitable for actual movement.
基金This work was supported by the National Natural Science Foundation of China(62003359).
文摘ion by proposing multiple levels of cascaded hierarchi-cal structures from the perspective of function,namely,the func-tional decision tree.This method is developed to represent behavioral modeling of air combat systems,and its metamodel,execution mechanism,and code generation can provide a sound basis for function-based behavioral modeling.As a proof of con-cept,an air combat simulation is developed to validate this method and the results show that the fighter Alpha built using the proposed framework provides better performance than that using default scripts.
基金National Natural Science Foundation of China(U22B20131)for supporting this project.
文摘Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of new generations of the NEPE propellant with better mechanical properties. Therefore,understanding the effects of NPBA on the deformation and damage evolution of the NEPE propellant is fundamental to material design and applications. This paper studies the uniaxial tensile and stress relaxation responses of the NEPE propellant with different amounts of NPBA. The damage evolution in terms of interface debonding is further investigated using a cohesive-zone model(CZM). Experimental results show that the initial modulus and strength of the NEPE propellant increase with the increasing amount of NPBA while the elongation decreases. Meanwhile, the relaxation rate slows down and a higher long-term equilibrium modulus is reached. Experimental and numerical analyses indicate that interface debonding and crack propagation along filler-matrix interface are the dominant damage mechanism for the samples with a low amount of NPBA, while damage localization and crack advancement through the matrix are predominant for the ones with a high amount of NPBA. Finally, crosslinking density tests and simulation results also show that the effect of the bonding agent is interfacial rather than due to the overall crosslinking density change of the binder.
基金Supported by Western Project of National Social Science Foundation of China:Research on Governance Mechanism Optimization and Risk Prevention and Control of Credit Cooperation of Farmers Cooperatives in China(16XJY021).
文摘Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.
文摘Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study.
文摘The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles,together with loss of cholinergic neurons,synaptic alterations,and chronic inflammation within the brain.These lead to progressive impairment of cognitive function.There is evidence of innate immune activation in AD with microgliosis.Classically-activated microglia(M1 state) secrete inflammatory and neurotoxic mediators,and peripheral immune cells are recruited to inflammation sites in the brain.The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects.Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials.Treatment with immunomodulatory/anti-inflammatory agents early in the disease process,while not preventive,is able to inhibit the inflammatory consequences of both Aβ and tau aggregation.The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD.The majority of the animal studies reviewed had used transgenic models of early-onset AD.More effort needs to be given to creat models of late-onset AD.The effects of a combinational therapy involving two or more of the tested pharmaceutical agents,or one of these agents given in conjunction with one of the cell-based therapies,in an aged animal model of AD would warrant investigation.
文摘Parkinson’s disease(PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are present in the substantia nigra,with the nerve terminals being in the striatum.Both innate and adaptive immune responses may contribute to dopaminergic neurodegeneration and disease progression is potentially linked to these.Studies in the last twenty years have indicated an important role for neuroinflammation in PD through degeneration of the nigrostriatal dopaminergic pathway.Characteristic of neuroinflammation is the activation of brain glial cells,principally microglia and astrocytes that release various soluble factors.Many of these factors are proinflammatory and neurotoxic and harmful to nigral dopaminergic neurons.Recent studies have identified several different agents with immunomodulatory properties that protected dopaminergic neurons from degeneration and death in animal models of PD.All of the agents were effective in reducing the motor deficit and alleviating dopaminergic neurotoxicity and,when measured,preventing the decrease of dopamine upon being administered therapeutically after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,6-hydroxydopamine,rotenone-lesioning or delivery of adeno-associated virus-α-synuclein to the ventral midbrain of animals.Some of these agents were shown to exert an anti-inflammatory action,decrease oxidative stress,and reduce lipid peroxidation products.Activation of microglia and astrocytes was also decreased,as well as infiltration of T cells into the substantia nigra.Pretreatment with fingolimod,tanshinoine I,dimethyl fumarate,thalidomide,or cocaine-and amphetamine-regulated transcript peptide as a preventive strategy ameliorated motor deficits and nigral dopaminergic neurotoxicity in brain-lesioned animals.Immunomodulatory agents could be used to treat patients with early clinical signs of the disease or potentially even prior to disease onset in those identified as having pre-disposing risk,including genetic factors.
文摘It is essential to learn the temporal and spatial concentration distributions and variations of seeding agents in cloud seeding of precipitation enhancement. A three-dimensional puff trajectory model incorporating a mesoscale nonhydrostatic model has been formulated, and is applied to simulating the transporting and diffusive characteristics of multiple line sources of seeding agents within super-cooled stratus. Several important factors are taken into consideration that affect the diffusion of seeding materials such as effects of topography and vertical wind shear, temporal and spatial variation of seeding parameters and wet deposition. The particles of seeding agents are assumed to be almost inert, they have no interaction with the particles of the cloud or precipitation except that they are washed out by precipitation. The model validity is demonstrated by the analyses and comparisons of model results, and checked by the sensitivity experiments of diffusive coefficients and atmospheric stratification. The advantage of this model includes not only its exact reflection of heterogeneity and unsteadiness of background fields, but also its good simulation of transport and diffusion of multiple line sources. The horizontal diffusion rate and the horizontal transport distance have been proposed that they usually were difficult to obtain in other models. In this simulation the horizontal diffusion rate is 0.82 m s(-1) for average of one hour, and the horizontal average transport distance reaches 65 km after 1 4 which are closely related to the background Fields.
基金supported by National Basic Research Program (973 Program,No.2004CB719402)National Natural Science Foundation of China (No.60736019)Natural Science Foundation of Zhejiang Province, China(No.Y105430).
文摘Collision avoidance decision-making models of multiple agents in virtual driving environment are studied. Based on the behavioral characteristics and hierarchical structure of the collision avoidance decision-making in real life driving, delphi approach and mathematical statistics method are introduced to construct pair-wise comparison judgment matrix of collision avoidance decision choices to each collision situation. Analytic hierarchy process (AHP) is adopted to establish the agents' collision avoidance decision-making model. To simulate drivers' characteristics, driver factors are added to categorize driving modes into impatient mode, normal mode, and the cautious mode. The results show that this model can simulate human's thinking process, and the agents in the virtual environment can deal with collision situations and make decisions to avoid collisions without intervention. The model can also reflect diversity and uncertainly of real life driving behaviors, and solves the multi-objective, multi-choice ranking priority problem in multi-vehicle collision scenarios. This collision avoidance model of multi-agents model is feasible and effective, and can provide richer and closer-to-life virtual scene for driving simulator, reflecting real-life traffic environment more truly, this model can also promote the practicality of driving simulator.
文摘Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abilities to react and make decision, the whole system will evolve to new conditions in response to policy change. Compared with different scenarios, it can be concluded that when raising taxation ratio, sectoral scale will shrink to some extent. But supported by government expenditure, certain sectors could be kept in comparatively larger production scale.
文摘This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model reconciles empirically-observed price overreactions to fake news with empirically-observed price underreactions to real news,and predicts a novel secondary impact of fake news:that fake news in a security amplifies underreactions to subsequent real news for the security.Evaluating the model against a large-sample event study of the 2019 Chinese ADR Delisting Threat fake news and debunking event,this paper finds strong qualitative validation for its model’s dynamics and predictions.
文摘Based on the current researches of viewpoints oriented requirements engineering and intelligent agent, we present the concept of viewpoint agent and its abstract model based on a recta-language for muhiviews requirements engineering. It provided a basis for consistency checking and integration of different viewpoint requirements, at the same time, these checking and integration works can automatically realized in virtue of intelligent agent' s autonomy, proactivenes.s and social ability. Finally, we introduce the practical application of the model by the case study of data flow diagram.
基金Supported by the Zhejiang Province Science Foundation of China( M703022)
文摘In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process agent and stock agent. The scheduling agent has three subagents: manager agent (MA),resource agent (RA) and part agent (PA). MA,PA and RA are communicating equally that guarantees agility of the whole MAS system. The part tasks pass between MA,RA and PA as an integer,which can guarantee the consistency of the data. We use a detailed example about shop logistics scheduling in a semiconductor company to explain the principle. In this example,we use two scheduling strategies: FCFS and SPT. The result data indicates that the average flow time and lingering ratio are changed using different strategy. It is proves that the multi-agent scheduling is useful.
文摘Agile manufacturing execution systems (AMES) are used to help manufacturers optimize shop floor production in an agile way. And the modeling of AMES is the key issue of realizing AMES. This paper presents an agent-based approach to AMES modeling. Firstly, the characteristics of AMES and its requirements on modeling are discussed. Secondly, a comparative analysis of modeling methods is carried out, and AMES modeling using an agent-based approach is put forward. Agent-based modeling method not only inherit the favorable features of traditional object-oriented modeling method such as data encapsulation, modularity and so on, but also has the ability to construct intelligent, rational and autonomous agent which can cooperate together to realize the goal of agile operation. A general agent architecture used in AMES modeling is described. Under this architecture, an agent can be divided into domain-independent components and domain-specific components which helps solve problems such as information overload, incomplete information handling and soft decision-making. Furthermore, an AMES model using four types of agents, i.e., interface agent, information agent, resource agent and management agent, is established. Thirdly, a snapshot of AMES model is provided in the case study. Especially, an agent-based cooperating process of task scheduling in AMES is illustrated in detail. Finally, the advantages and disadvantages of this modeling approach are discussed as well.
基金Sponsored by the Natural Science Foundation of Hunan ProvinceChina(Grant No.13JJ3049)the Fundamental Research Funds for the Central Universities(Grant No.2012AA01A301-1)
文摘This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system is built,where each agent stands for a vehicle,and it makes its routing selection by considering the shortest path and the minimum congested degree of the target link simultaneously. The agent-based model captures the nonlinear feedback between vehicle routing behaviors and road-network congestion status.Secondly,a hybrid routing selection strategy is provided,which guides the vehicle routes adapting to the realtime road-network congestion status. On this basis, we execute simulation experiments and compare the simulation results of network congestion distribution,by Floyd agent with shortest path strategy and our proposed adaptive agent with hybrid strategy. The simulation results show that our proposed model has reduced the congestion degree of those seriously congested links of road-network. Finally,we execute our model on a real road map. The results finds that those seriously congested roads have some common features such as located at the road junction or near the unique road connecting two areas. And,the results also show an effectiveness of our model on reduction of those seriously congested links in this actual road network. Such a bottom-up congestion control approach with a hybrid congestion optimization perspective will have its significance for actual traffic congestion control.
文摘A combined method of discrete event and agent based modelling has been applied to the computer modelling and simulation of the tensile strength of one-dimensional fibrous materials (ODFM). This combined method is based on the concept of discrete event simulation as being applied to the modeling of the structure of the fiber flow and on the concept of agent based modelling for modelling and simulation of the fiber interaction within the structure of the fibrous material. Frictional and traction forces arise as the result of this fiber interaction. A model of the ODFM tensile strength, which is based on the slippage effect, is created and studied in this research. Only frictional and traction forces determine the tensile strength in this kind of the model. The article examines the validation problem of the slippage effect based tensile strength model and questions regarding the strength potential estimation through variation in the parameters of the model.