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Effect of preload forces on multidimensional signal dynamic behaviours for battery early safety warning
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作者 Kuijie Li Jiahua Li +10 位作者 Xinlei Gao Yao Lu Depeng Wang Weixin Zhang Weixiong Wu Xuebing Han Yuan-cheng Cao Languang Lu Jinyu Wen Shijie Cheng Minggao Ouyang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第5期484-498,共15页
Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery fa... Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems. 展开更多
关键词 Lithium-ion battery Thermal runaway Preload force Expansionforce Early warning multidimensional signal
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RFFsNet-SEI:a multidimensional balanced-RFFs deep neural network framework for specific emitter identification
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作者 FAN Rong SI Chengke +1 位作者 HAN Yi WAN Qun 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期558-574,F0002,共18页
Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emi... Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emitters and complicate the procedures of identification.In this paper,we propose a deep SEI approach via multidimensional feature extraction for radio frequency fingerprints(RFFs),namely,RFFsNet-SEI.Particularly,we extract multidimensional physical RFFs from the received signal by virtue of variational mode decomposition(VMD)and Hilbert transform(HT).The physical RFFs and I-Q data are formed into the balanced-RFFs,which are then used to train RFFsNet-SEI.As introducing model-aided RFFs into neural network,the hybrid-driven scheme including physical features and I-Q data is constructed.It improves physical interpretability of RFFsNet-SEI.Meanwhile,since RFFsNet-SEI identifies individual of emitters from received raw data in end-to-end,it accelerates SEI implementation and simplifies procedures of identification.Moreover,as the temporal features and spectral features of the received signal are both extracted by RFFsNet-SEI,identification accuracy is improved.Finally,we compare RFFsNet-SEI with the counterparts in terms of identification accuracy,computational complexity,and prediction speed.Experimental results illustrate that the proposed method outperforms the counterparts on the basis of simulation dataset and real dataset collected in the anechoic chamber. 展开更多
关键词 specific emitter identification(SEI) deep learning(DL) radio frequency fingerprint(RFF) multidimensional feature extraction(MFE) variational mode decomposition(VMD)
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AAK Theorem and a Design of Multidimensional BIBO Stable Filters
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作者 Bossoto Bossoto Gabriel Bissanga 《Open Journal of Discrete Mathematics》 2024年第2期9-15,共7页
Rational approximation theory occupies a significant place in signal processing and systems theory. This research paper proposes an optimal design of BIBO stable multidimensional Infinite Impulse Response filters with... Rational approximation theory occupies a significant place in signal processing and systems theory. This research paper proposes an optimal design of BIBO stable multidimensional Infinite Impulse Response filters with a realizable (rational) transfer function thanks to the Adamjan, Arov and Krein (AAK) theorem. It is well known that the one dimensional AAK results give the best approximation of a polynomial as a rational function in the Hankel semi norm. We suppose that the Hankel matrix associated to the transfer function has a finite rank. 展开更多
关键词 multidimensional Filter DESIGN BIBO Stability Optimal AAK Theorem Transfer Function Hankel Matrix
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A Corpus-Based Comparative Multidimensional Analysis of the Two English Translations of Luoyang Jialan Ji
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作者 Qin Gu Ling Chen 《Open Journal of Applied Sciences》 2024年第4期1150-1163,共14页
By using the MD approach, this study aims at making a comparison between the lexical features in W. J. F. Jenner’s and Wang Yitong’s translations of Luoyang Jialan Ji (547 AD) from a multidimensional perspective. St... By using the MD approach, this study aims at making a comparison between the lexical features in W. J. F. Jenner’s and Wang Yitong’s translations of Luoyang Jialan Ji (547 AD) from a multidimensional perspective. Statistics show that both the two translations belong to the General Narrative Exposition Register. However, there are significant discrepancies between the two versions in Dimension 1 “Involved versus Informational Production”, Dimension 4 “Overt Expression of Persuasion” and Dimension 5 “Abstract versus Non-Abstract Information”. The differences in Dimension 2 “Narrative versus Non-Narrative Concerns” and Dimension 3 “Explicit versus Situation-Dependent Reference” are not that significant. It is found that in Dimension 1, the information density of Wang’s version is much higher than that of Jenner’s. In Dimension 4, Wang’s version contains more overt persuasive effort than Jenner’s. In Dimension 5, the positive and negative contrast between the two versions indicates that Wang’s version provides information in a more abstract way, whereas Jenner’s in a relatively non-abstract way. Combined with typical examples in the two translation versions, this study is hoped to help better understand the translations of Luoyang Jialan Ji and conduct future studies on the translation styles of the two translators. 展开更多
关键词 Luoyang Jialan Ji multidimensional (MD) Approach W. J. F. Jenner Wang Yitong
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Multidimensional defects tailoring local electron and Mg^(2+) diffusion channels for boosting magnesium storage performance of WO_(3)/MoO_(2)
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作者 Shiqi Ding Yuxin Tian +8 位作者 Jiankang Chen He Lv Amin Wang Jingjie Dai Xin Dai Lei Wang Guicun Li Alan Meng Zhenjiang Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第9期476-485,共10页
Defect engineering presents great promise in addressing lower specific capacity,sluggish diffusion kinetics and poor cycling life issues in energy storage devices.Herein,multidimensional(0D/2D/3D) structural defects a... Defect engineering presents great promise in addressing lower specific capacity,sluggish diffusion kinetics and poor cycling life issues in energy storage devices.Herein,multidimensional(0D/2D/3D) structural defects are constructed in WO_(3)/MoO_(2) simultaneously via competing for and sharing with O atoms during simple hydrothermal process.OD and 2D defects tailor local electron,activating more sites and generating built-in electric fields to yield ion reservoir,meanwhile,3D defect owning lower anisotropic property tailors Mg^(2+) diffusion channels to fully exploit Mg^(2+) adsorbed sites induced by OD and 2D defects,enhance the kinetics and maintain structural stability.Benefitted from synergistic effect of 0D/2D/3D structural defects,the designed WO_(3)/MoO_(2) shows the higher specific capacity(112.8 mA h g^(-1) at 50 mA g^(-1) with average attenuation rate per cycle of 0.068%),superior rate capability and excellent cycling stability(specific capacity retention of 80% after 1500 cycles at 1000 mA g^(-1)).This strategy provides design ideas of introducing multidimensional structural defects for tailoring local electron and microstructure to improve energy storage property. 展开更多
关键词 multidimensional defects Local electron tailoring HETEROSTRUCTURE Cathode Magnesium ions batteries
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Soil water content and nitrogen differentially correlate with multidimensional leaf traits of two temperate broadleaf species
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作者 Ming-Yue Jin Daniel J.Johnson +2 位作者 Guang-Ze Jin Qing-Xi Guo Zhi-Li Liu 《Plant Diversity》 SCIE CAS CSCD 2023年第6期694-701,共8页
The variation and correlation of leaf economics and vein traits are crucial for predicting plant ecological strategies under different environmental changes.However,correlations between these two suites of traits and ... The variation and correlation of leaf economics and vein traits are crucial for predicting plant ecological strategies under different environmental changes.However,correlations between these two suites of traits and abiotic factors such as soil water and nitrogen content remain ambiguous.We measured leaf economics and vein traits as well as soil water and nitrogen content for two different shade-tolerant species(Betula platyphylla and Acer mono)in four mixed broadleaved-Korean pine(Pinus koraiensis)forests along a latitudinal gradient in Northeast China.We found that leaf economics traits and vein traits were decoupled in shade-intolerant species,Betula platphylla,but significantly coupled in a shadetolerant species,A.mono.We found stronger correlations among leaf traits in the shade tolerant species than in the shade intolerant species.Furthermore,leaf economic traits were positively correlated with the soil water gradient for both species,whereas vein traits were positively correlated with soil water gradient for the shade intolerant species but negatively correlated in the shade tolerant species.Although economic traits were positively correlated with soil nitrogen gradient in shade intolerant species but not correlated in shade tolerant species,vein traits were negatively correlated with soil nitrogen gradient in shade tolerant species but not correlated in shade intolerant species.Our study provides evidence for distinct correlations between leaf economics and vein traits and local abiotic factors of species differing in light demands.We recommend that the ecological significance of shade tolerance be considered for species when evaluating ecosystem functions and predicting plant responses to environmental changes. 展开更多
关键词 Leaf trait multidimensionality Economics traits Vein traits Soil water content Soil total nitrogen Shade tolerance
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Psychometric Properties among Japanese Women Based on the Multidimensional Assessment of Women’s Experience of Childbirth
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作者 Megumi Sato 《Open Journal of Nursing》 2023年第11期718-734,共17页
Aims/Background: Perceived experiences of childbirth are important for mothers as they affect their self-esteem, mother-child interactions, subsequent mother-child bonding, and their desire for another child. This stu... Aims/Background: Perceived experiences of childbirth are important for mothers as they affect their self-esteem, mother-child interactions, subsequent mother-child bonding, and their desire for another child. This study examined the factor structure and construct validity of Salmon and Drew’s Multidimensional Assessment of Women’s Experience of Childbirth (MAWEC) in Japanese. Design/Methods: This study conducted a questionnaire survey using the Japanese version of the MAWEC and other variables with 759 women with infants in Japan. The participants’ mean (standard deviation [SD], range) age was 31.9 (5.3, 18 - 46) years. A total of 353 (46.5%) participants were primiparous and 384 (50.6%) were multiparous, and 22 (2.9%) did not answer. The data were randomly divided into two groups for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) and separately analyzed the positive- and negative-worded items. I conducted EFA using the maximum-likelihood method with PROMAX rotation from one-through two- and three-factor structures. Different factor structure models were compared in terms of CFAs using, as indicator of goodness-of-fit, chi-square/df, comparative fit index (CFI), and root mean square of error approximation (RMSEA). Results: This study showed that a bifactor model for the MAWEC with four subscales (positive emotion, positive coping, negative emotion, and negative coping) fit the data the best. These four subscales were associated with demographic, obstetric, neonatal, and feeding characteristics. For example, primiparas were more vulnerable to coping aspects of perceived childbirth experiences, including sense of mastery over the delivery process and ability to enjoy the delivery. Gestational age at birth was associated with emotional aspects of perceived childbirth experiences. Conclusion: The Japanese version of the MAWEC consists of four aspects regarding perceived childbirth experience. Perinatal health professionals may examine women’s childbirth experiences from these four perspectives. . 展开更多
关键词 Childbirth Experience Factor Structure Validity multidimensional Assessment Japanese Women
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Multidimensional Hybrid Architecture Encapsulating Cobalt Oxide Nanoparticles into Carbon Nanotube Branched Nitrogen-Doped Reduced Graphene Oxide Networks for Lithium–Sulfur Batteries 被引量:4
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作者 Jeong Seok Yeon Young Hun Ko +3 位作者 Tae Ho Park Hyunyoung Park Jongsoon Kim Ho Seok Park 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2022年第2期555-564,共10页
Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable cost.However,several limitatio... Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable cost.However,several limitations of LSBs such as the lithium polysulfide shuttle,large volume expansion,and low electrical conductivity of sulfur need to be resolved for practical applications.To address these limitations,herein,a multidimensional architectured hybrid(Co@CNT/nG),where Co_(3)O_(4) nanoparticles are encapsulated into threedimensional(3D)porous N-doped reduced graphene oxide interconnected with carbon nanotube(CNT)branches,is synthesized through a simple pyrolysis method.The synergistic effect achieved through the homogeneously distributed and encapsulated Co_(3)O_(4) nanoparticles,the interconnected CNT branches,and the 3D hierarchical porous structure and N-doping of Co@CNT/nG significantly suppresses the shuttle effect of lithium polysulfides and enhances the conversion redox kinetics for the improved sulfur utilization.We validate this effect through various measurements including symmetric cells,Li_(2)S nucleation,shuttle currents,Tafel slopes,diffusion coefficients,and post-mortem analyses.Importantly,Co@CNT/nG-70S-based LSB cells achieve a high-specific capacity of 1193.1 mAh g^(−1) at 0.1 C and a low capacity decay rate of 0.030%per cycle for 700 cycles at 5 C,delivering a high areal capacity of 5.62 mAh cm^(−2) even with a loading of 6.5 mg cm^(−2). 展开更多
关键词 graphene/CNT hybrid lithium-sulfur batteries multidimensional architecture nanoparticle encapsulation redox promoter
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Impact of climate-smart agricultural technology on multidimensional poverty in rural Ethiopia 被引量:3
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作者 Tsegaye Mulugeta HABTEWOLD 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2021年第4期1021-1041,共21页
A large body of empirical literature showed that the adoption of agricultural technologies reduces poverty. However, dominants of those studies so far used one-dimensional income or expenditure-based measures of pover... A large body of empirical literature showed that the adoption of agricultural technologies reduces poverty. However, dominants of those studies so far used one-dimensional income or expenditure-based measures of poverty which may not reflect other types of deprivations. Therefore, the major objective of this study is to examine the impact of adopting climate-smart agricultural technology, which refers to a joint application of row planting methods and the use of chemical fertilizers, on the multidimensional poverty status of rural households in Ethiopia. To estimate the impact of the stated technologies, this study employs propensity score matching and endogenous switching regression methods. To measure the multidimensional poverty index, the study also uses the Alkire and Foster counting approach. Using the Ethiopian Socioeconomic Survey(ESS), collected in 2015-Wave 3, the results of the study show that the adoption of these technologies reduces deprivation score and one of its component, the standard of living part. Regionally, a high reduction in deprivation is observed in Amhara and Oromiya regions. The results also show that the impact is significantly higher in severely deprived households. It is also observed that the reduction in multidimensional poverty due to the technology is through an increase in income/consumption via improvement in production gain. The impact channels more through the non-food expenditure pathway. Finally, this study also sheds light on the effects that technology adoption has on multidimensional poverty reduction. 展开更多
关键词 multidimensional poverty rural poverty technology adoption poverty reduction poverty pathways Ethiopia
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A New Multidimensional Time Series Forecasting Method Based on the EOF Iteration Scheme 被引量:3
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作者 张邦林 刘洁 孙照渤 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 1993年第2期243-247,共5页
In this paper a new .mnultidimensional time series forecasting scheme based on the empirical orthogonal function (EOF) stepwise iteration process is introduced. The scheme is tested in a series of forecast experiments... In this paper a new .mnultidimensional time series forecasting scheme based on the empirical orthogonal function (EOF) stepwise iteration process is introduced. The scheme is tested in a series of forecast experiments of Nino3 SST anomalies and Tahiti-Darwin SO index. The results show that the scheme is feasible and ENSO predictable. 展开更多
关键词 SST A New multidimensional Time Series Forecasting Method Based on the EOF Iteration Scheme Nino EOF
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Applying XML for designing and interchanging information for multidimensional model 被引量:2
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作者 Lu Changhui Deng Su Zhang Weiming 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2005年第4期823-830,共8页
In order to exchange and share information among the conceptual models of data warehouse, and to build a solid base for the integration and share of metadata, a new multidimensional concept model is presented based on... In order to exchange and share information among the conceptual models of data warehouse, and to build a solid base for the integration and share of metadata, a new multidimensional concept model is presented based on XML and its DTD is defined, which can perfectly describe various semantic characteristics of multidimensional conceptual model. According to the multidimensional conceptual modeling technique which is based on UML, the mapping algorithm between the multidimensional conceptual model is described based on XML and UML class diagram, and an application base for the wide use of this technique is given. 展开更多
关键词 data warehouse OLAP multidimensional modeling conceptual model XML UML.
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Optimizing Spray and Combustion in Diesel Engine by Multidimensional Numerical Simulation 被引量:2
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作者 周磊 赵长禄 张付军 《Journal of Beijing Institute of Technology》 EI CAS 2005年第4期406-410,共5页
The calculation of spray and combustion in diesel engines is described by using the softwares FIRE and BOOST. The application of the resulting computational method to the simulation of fuel spray and breakup, mixture ... The calculation of spray and combustion in diesel engines is described by using the softwares FIRE and BOOST. The application of the resulting computational method to the simulation of fuel spray and breakup, mixture formation and combustion in a heavy duty diesel is presented. According to detailed insight into the governing processes provided by the simulation results, various aspects of the dependence of the spray propagation and combustion on the chamber geometry and spray angle are discussed. Then, global cylinderaveraged pressure traces are extracted from the space and time resolved field quantities and compared to incylinder pressure measurements. Finally, an optimized configuration of the chamber geometry and spray angle with a new injection rate of higher injection pressure is proposed. 展开更多
关键词 multidimensional simulation DIESEL spray propagation COMBUSTION chamber geometry
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Analyzing multidimensional measures of poverty and their influences in China's Qinba Mountains 被引量:2
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作者 Wenxian Jiao 《Chinese Journal of Population,Resources and Environment》 2020年第3期214-221,共8页
We use the Alkire–Foster poverty measure and decomposition method to study multidimensional poverty in the Qinling–Daba contiguous poor area of China's Henan Province.We examine absolute,relative,and multidimens... We use the Alkire–Foster poverty measure and decomposition method to study multidimensional poverty in the Qinling–Daba contiguous poor area of China's Henan Province.We examine absolute,relative,and multidimensional poverty focusing on heads of household and family characteristics as constituents of escaping each.We find that the multidimensional poverty index declines to a low level as values of k increase.Combining first-order random dominance with second-order stochastic dominance quickly determines rankings in the multidimensional poverty index.Increasing non-agricultural income emerges as the most important influence on escaping rural poverty,whereas households with elderly and children are at greatest risk for falling into poverty. 展开更多
关键词 Contiguous poor areas Absolute poverty Relative poverty multidimensional poverty Stochastic dominance curve
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PRECISE ASYMPTOTICS IN SELF-NORMALIZED SUMS OF ITERATED LOGARITHM FOR MULTIDIMENSIONALLY INDEXED RANDOM VARIABLES 被引量:3
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作者 Jiang Chaowei Yang Xiaorong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2007年第1期87-94,共8页
In the case of Z+^d(d ≥ 2)-the positive d-dimensional lattice points with partial ordering ≤, {Xk,k∈ Z+^d} i.i.d, random variables with mean 0, Sn =∑k≤nXk and Vn^2 = ∑j≤nXj^2, the precise asymptotics for ∑... In the case of Z+^d(d ≥ 2)-the positive d-dimensional lattice points with partial ordering ≤, {Xk,k∈ Z+^d} i.i.d, random variables with mean 0, Sn =∑k≤nXk and Vn^2 = ∑j≤nXj^2, the precise asymptotics for ∑n1/|n|(log|n|dP(|Sn/Vn|≥ε√log log|n|) and ∑n(logn|)b/|n|(log|n|)^d-1P(|Sn/Vn|≥ε√log n),as ε↓0,is established. 展开更多
关键词 multidimensionally indexed random variable precise asymptotics self-normalized sum Davislaw of large numbers law of iterated logarithm.
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Bayesian Multidimensional Scaling for Location Awareness in Hybrid-Internet of Underwater Things 被引量:2
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作者 Ruhul Amin Khalil Nasir Saeed +2 位作者 Mohammad Inayatullah Babar Tariqullah Jan Sadia Din 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第3期496-509,共14页
Localization of sensor nodes in the internet of underwater things(IoUT)is of considerable significance due to its various applications,such as navigation,data tagging,and detection of underwater objects.Therefore,in t... Localization of sensor nodes in the internet of underwater things(IoUT)is of considerable significance due to its various applications,such as navigation,data tagging,and detection of underwater objects.Therefore,in this paper,we propose a hybrid Bayesian multidimensional scaling(BMDS)based localization technique that can work on a fully hybrid IoUT network where the nodes can communicate using either optical,magnetic induction,and acoustic technologies.These communication technologies are already used for communication in the underwater environment;however,lacking localization solutions.Optical and magnetic induction communication achieves higher data rates for short communication.On the contrary,acoustic waves provide a low data rate for long-range underwater communication.The proposed method collectively uses optical,magnetic induction,and acoustic communication-based ranging to estimate the underwater sensor nodes’final locations.Moreover,we also analyze the proposed scheme by deriving the hybrid Cramer-Rao lower bound(H-CRLB).Simulation results provide a complete comparative analysis of the proposed method with the literature. 展开更多
关键词 Bayesian multidimensional scaling(BMDS) hybrid Cramer-Rao lower bound(H-CRLB) internet of underwater things(IoUT) signals of opportunity(SOA)approach
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EXISTENCE AND NONEXISTENCE FOR THE INITIAL BOUNDARY VALUE PROBLEM OF ONE CLASS OF SYSTEM OF MULTIDIMENSIONAL NONLINEAR SCHRDINGER EQUATIONS WITH OPERATOR AND THEIR SOLITON SOLUTIONS 被引量:3
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作者 郭柏灵 《Acta Mathematica Scientia》 SCIE CSCD 1989年第1期45-56,共12页
The nonlinear interactions between the monochromatic wave have been considered by K. Matsunchi, who also proposed one class of the nonlinear Schrdinger equation system with wave operator. We also obtain the same type ... The nonlinear interactions between the monochromatic wave have been considered by K. Matsunchi, who also proposed one class of the nonlinear Schrdinger equation system with wave operator. We also obtain the same type of equations, which are satisfied by transverse velocity of higher frequency electron, as we study soliton in plasma physics. In this paper, under some condition we study the existence and nonexistence for this equations in the cases possessing different signs in nonlinear term. 展开更多
关键词 DINGER EQUATIONS WITH OPERATOR AND THEIR SOLITON SOLUTIONS EXISTENCE AND NONEXISTENCE FOR THE INITIAL BOUNDARY VALUE PROBLEM OF ONE CLASS OF SYSTEM OF multidimensional NONLINEAR SCHR
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MULTIDIMENSIONAL MULTI-KNOTS PIECEWISE LINEAR SPECTRAL SEQUENCES 被引量:2
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作者 Yan Gu Rui Wang DunyanYan 《Analysis in Theory and Applications》 2010年第4期367-382,共16页
Motivated by representing multidimensional periodic nonlinear and non-stationary signals (functions), we study a class of orthonormal exponential basis for L2(Id) with I := [0, 1), whose exponential parts are pi... Motivated by representing multidimensional periodic nonlinear and non-stationary signals (functions), we study a class of orthonormal exponential basis for L2(Id) with I := [0, 1), whose exponential parts are piecewise linear spectral sequences with p-knots. It is widely applied in time-frequency analysis. 展开更多
关键词 multidimensional piecewise linear spectral sequence orthonormal exponen-tial basis non-constant frequency
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Identification of bioactive anti-angiogenic constitutes targeting tumor endothelial cells in Shenmai Injection using multidimensional pharmacokinetics 被引量:1
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作者 ZHONG Chong-jin JIANG Chao +13 位作者 NI Sui-ying WANG Qi-zhi CHENG Ling-ge WANG Huan ZHANG Qi-xiang LIU Wen-yue ZHANG Jing-wei LIU Jia-li WANG Mu-lan JIN Min SHEN Pei-qiang YAO Xue-quan WANG Guang-ji ZHOU Fang 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期681-682,共2页
OBJECTIVE To identify the bioactive anti-angiogenic constitutes targeting tumor endothelial cells(TECs)in Shenmai Injection(SMI).METHEODS For pharmacokinetic(PK)studies,Balb/c mice harboring human colorectal cancer(Lo... OBJECTIVE To identify the bioactive anti-angiogenic constitutes targeting tumor endothelial cells(TECs)in Shenmai Injection(SMI).METHEODS For pharmacokinetic(PK)studies,Balb/c mice harboring human colorectal cancer(LoVo)xenografts were treated with SMI 10 mL·kg^-1 daily for 1 or 8 d.Multidimensional PK profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were investigated.For PD studies,the tumor-bearing mice Intravital multi-photon imaging and CD31 immunofluorescence staining were used to evaluate the number of microves⁃sels and braches.Double staining of CD31 and α-SMA was performed to evaluate pericytes coverage ratios around vessels.ELISA was performed to determine the concentrations of VEGF and FGF in tumor tissues.For synergistic anti-tumor study,the tumor-bearing mice were treated with SMI 10 mL·kg^-1 daily,Rd 5 mg·kg^-1 daily with or without 5-FU 15 mg·kg^-1 every 3 d for 20 d.HPLC-MS/MS was used to determine the concentrations of 5-FU in plasma and tumor tissues.RESULTS SMI decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and improved vascular pericytes coverage(P<0.05).PK studies showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both,plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)ginsenosides.Among PPD ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated injection.In fact,the proportion of Rd in the detectable components of SMI gradually increased in the following order:SMI formula(2.8%),plasma(16.0%),tumor tissues(34.3%),and TECs(40.3%).In vivo bioactivity results showed that Rd 5 mg·kg^-1 daily significantly decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and increased pericytes coverage(P<0.05)while Rd 0.5 mg·kg^-1 daily,Rb1 and Rg1 had no significant effect on them.Rd 5 mg·kg^-1 suppressed the expression of VEGF and FGF simultaneously.Rd 5 mg·kg^-1 enhanced the antitumor effect of 5-FU via increasing the distribution of 5-FU in tumor tissues(P<0.05)in xenograft mice.CONCLUSION Ginsenoside Rd may be the major bioactive anti-angiogenic constituent targeting TECs after SMI treatment. 展开更多
关键词 Shenmai Injection multidimensional pharmacokinetics ginsenoside Rd ANTI-ANGIOGENIC tumor endo⁃thelial cell
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Precise large deviations for sums of random vectors in a multidimensional size-dependent renewal risk model 被引量:1
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作者 SHEN Xin-mei FU Ke-ang ZHONG Xue-ting 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2018年第4期491-502,共12页
Consider a multidimensional renewal risk model, in which the claim sizes {Xk, k ≥1} form a sequence of independent and identically distributed random vectors with nonnegative components that are allowed to be depende... Consider a multidimensional renewal risk model, in which the claim sizes {Xk, k ≥1} form a sequence of independent and identically distributed random vectors with nonnegative components that are allowed to be dependent on each other. The univariate marginal distributions of these vectors have consistently varying tails and finite means. Suppose that the claim sizes and inter-arrival times correspondingly form a sequence of independent and identically distributed random pairs, with each pair obeying a dependence structure. A precise large deviation for the multidimensional renewal risk model is obtained. 展开更多
关键词 Precise large deviation SIZE-DEPENDENT Consistent variation multidimensional risk model Renewal counting process
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Multi-Vehicle Cooperative Positioning Based on Edge-Computed Multidimensional Scaling 被引量:1
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作者 Bin Yang Rui Chen +1 位作者 Bin Li Changle Li 《China Communications》 SCIE CSCD 2021年第6期53-63,共11页
As the basis of location-based services(LBS),positioning is one of the most essential parts in intelligent transportation systems(ITS).Although global positioning system(GPS)has been widely used in vehicle positioning... As the basis of location-based services(LBS),positioning is one of the most essential parts in intelligent transportation systems(ITS).Although global positioning system(GPS)has been widely used in vehicle positioning,it can not achieve lane level positioning accuracy.Motivated by the mature ranging technologies such as radar and ultra-wideband(UWB),several cooperative positioning(CP)methods have been proposed to enhance the accuracy and robustness of GPS.In this paper,we proposed a twostage CP algorithm that combines multidimensional scaling(MDS)and Procrustes analysis for vehicles with GPS information.Specifically,the optimized MDS based on the scaling by majorizing a complicated function(SMACOF)algorithm is first proposed to get the relative coordinates of vehicles which can tackle measurements of different error distributions,then Procrustes analysis is carried out to transform the relative coordinates of vehicles to their absolute coordinates based on GPS information.All the computations are performed at the mobile edge computing node(MECN)for the request of ultra-reliable and low latency communications(URLLC).Simulation results validate that the proposed algorithm can greatly improve the positioning accuracy and robustness for vehicles. 展开更多
关键词 intelligent transportation systems(ITS) Internet of vehicles(IoV) multidimensional scaling(MDS) POSITIONING Procrustes analysis
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