Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells

Regenerative medicine by cell transplantation is a novel therapy for treating end-stage organ failure and tissue damage. Cell-based therapy based on the transplantation of neural stem/progenitor cells （NSPCs） represents an attractive strategy for the treatment of neurodegenerative diseases, but obtaining large numbers of these cells is difficult and their differentiation potential is strictly restricted in a spatiotemporally-regulated manner during central nervous system （CNS） development. Therefore, embryonic stem cells and induced pluripotent stem cells represent an attractive alternative for cell-transplantation therapy in regenerative medicine.

Enabling Reachability Across Multiple Domains Without Controller Synchronization in SDN

Software-defined networking(SDN)makes network agile and flexible due to its programmable approach.An extensive network has multiple domains in SDN for the scalability and performance of the network.However,the inter-domain link is also crucial for the stability of the entire network on the data plane layer.More than one inter-domain connection enhances the scalability of the data plane layer.However,it faces a reachability problem with the principal root,which causes forwarding loops and packet drops in the network,thereby degrading network performance.The proposed solution is a multiple controller architecture;however,this approach increases the complexity and affects network performance.Thus,in this study,we propose a framework that avoids forwarding loops and packet drops without the synchronization of multiple-domain controllers in the network using an avoid loop with test packet scheme.Moreover,we collect the link status for improved routing and load balancing for the upcoming flow across inter-domain links to prevent congestion and increase throughput in real time.Our proposed methodology can significantly reduce the controller workload against multiple controller architecture,minimize flow setup latency,and improve throughput.

Adaptive leader follower control for multiple quadrotors via multiple surfaces control

Based on the multiple surface and fixed undirected communication topology, the adaptive leader follower contrul for multiple quadrotors is discussed. Our approach is based on leader follower architecture. Multiple surface control （MSC） is used to design consensus controller to make multiple quadrotors construct a formation during flying with the presence of uncertainty item caused by the ground effect during landing or taking off. Simulation results are presented to validate the effectiveness of the proposed controller.

A ROBUST FLOW CALCULATION TECHNIQUE WITH MULTIPLE FINITE CONTROL VOLUMES

The control volume method gives the forces which act on the system, but not necessarily the wall pressure of the system. The author has made an attempt to develop a control volume method which makes it possible to obtain the wall pressure of the control volume. The 2-D inviscid incompressible steady duct flow is considered. The conservation equations in integral form are discretized for a control volume. The circulation along the control surface is expressed as a nonlinear function of the vertical velocity component at the inlet and is set equal to zero for the inviscid flow. The equation is solved by the Newton method, and the other aerodynamic properties can be obtained. The calculated results have been compared to the experiment and the agreement has been found fairly satisfactory.

CONVEX CONTROLLER DESIGN APPLIED TO AC INDUCTION MOTOR TO SATISFY MULTIPLE SIMULTANEOUS SPECIFICATIONS

The application of a closed-loop specification oriented feedback control design method, which addresses the design of controllers to satisfy multiple simultaneous conflicting closed-loop performance specifications is presented. The proposed approach is well suited to the design of controllers which must meet a set of conflicting performance specifications. Gain tuning is central to the design process, however, the tuning process is greatly simplified over that presented by the problem of tuning a PID controller for example. The proposed control method is applied to an AC induction motor, with an inner-loop flux vector controller applied to design a position control system. Experimental results verify the effectiveness of this method.

Load Balancing Algorithm for Migrating Switches in Software-Dened Vehicular Networks

In Software-Dened Networks(SDN),the divergence of the control interface from the data plane provides a unique platform to develop a programmable and exible network.A single controller,due to heavy load trafc triggered by different intelligent devices can not handle due to it’s restricted capability.To manage this,it is necessary to implement multiple controllers on the control plane to achieve quality network performance and robustness.The ow of data through the multiple controllers also varies,resulting in an unequal distribution of load between different controllers.One major drawback of the multiple controllers is their constant conguration of the mapping of the switch-controller,quickly allowing unequal distribution of load between controllers.To overcome this drawback,Software-Dened Vehicular Networking(SDVN)has evolved as a congurable and scalable network,that has quickly achieved attraction in wireless communications from research groups,businesses,and industries administration.In this paper,we have proposed a load balancing algorithm based on latency for multiple SDN controllers.It acknowledges the evolving characteristics of real-time latency vs.controller loads.By choosing the required latency and resolving multiple overloads simultaneously,our proposed algorithm solves the loadbalancing problems with multiple overloaded controllers in the SDN control plane.In addition to the migration,our algorithm has improved 25%latency as compared to the existing algorithms.

Hydrocarbon accumulation principles in troughs within faulted depressions and their significance in exploration

Previously,troughs in continental faulted depressions were usually considered as a zone of hydrocarbon generation and expulsion rather than a zone for hydrocarbon accumulation.If they were confirmed to be the source kitchen,the possibility that they could constitute potential plays would be overlooked in the subsequent exploration program.Based on the hydrocarbon exploration practice of the Jizhong Depression and the Erlian Basin in the past several years,this paper discusses a new understanding that reservoir distribution is controlled by multiple factors and lithological accumulations are more likely to form in trough areas.It further documents the three main factors controlling the formation of large lithological hydrocarbon accumulations in trough areas.The paper also discusses the new concept that structural and lithological accumulations not only co-exist but also complement each other.We propose that fan-delta fronts on inverted steep slopes in troughs,delta fronts and sublacustrine fans on gentle slopes,channel sands along toes of fault scarps are favorable locations for discovery of new oil accumulations.The application of this concept has led to the discovery of several hundreds of million tonnes of oil in place in trough areas in the Jizhong Depression and the Erlian Basin.

Unified control and detection framework and its applications: a review, some new results, and future perspectives

Initiated three decades ago,integrated design of controllers and fault detectors has continuously attracted research attention.The recent development of the unified control and detection framework with an observer-based residual generator in its core gives a more general form of the previous works.Its applications to residual centred modelling of uncertain control systems,fault detection in feedback control systems with uncertainties,fault-tolerant control(FTC)as well as control performance degradation monitoring,detection and recovery are introduced.In conclusion,some future perspectives are proposed.

Reconfigurable Flight Control Design for Combat Flying Wing with Multiple Control Surfaces

With control using redundant multiple control surface arrangement and large-deflection drag rudders,a combat flying wing has a higher probability for control surface failures.Therefore,its flight control system must be able to reconfigure after such failures.Considering three types of typical control surface failures（lock-in-place（LIP）,loss-of-effectiveness（LOE） and float）,flight control reconfiguration characteristic and capability of such aircraft types are analyzed.Because of the control surface redundancy,the aircraft using the dynamic inversion flight control law already has a control allocation block.In this paper,its flight control configuration during the above failures is achieved by modifying this block.It is shown that such a reconfigurable flight control design is valid,through numerical simulations of flight attitude control task.Results indicate that,in the circumstances of control surface failures with limited degree and the degradation of the flying quality level,a combat flying wing adopting this flight control reconfiguration approach based on control allocation could guarantee its flight safety and perform some flight combat missions.

Creation of radially polarized optical fields with multiple controllable parameters using a vectorial optical field generator

A vectorial optical field generator(VOF-Gen) based on two reflective phase-only liquid crystal spatial light modulators enables the creation of an arbitrary optical complex field. In this work, the capabilities of the VOF-Gen in terms of manipulating the spatial distributions of phase, amplitude, and polarization are experimentally demonstrated by generating a radially polarized optical field consisted of five annular rings, the focusing properties of which are also numerically studied with vectorial diffraction theory. By carefully adjusting the relative amplitude and phase between the adjacent rings, an optical needle field with purely longitudinal polarization can be produced in the focal region of a high numerical aperture lens. The versatile method presented in this work can be easily extended to the generation of a vectorial optical field with any desired complex distributions.

A distributed synchronous reservation multiple access control protocol for mobile Ad hoc networks

This study proposes a new multiple access con-trol protocol named distributed synchronous reservation mul-tiple access control protocol,in which the hidden and exposed terminal problems are solved,and the quality of service(QoS)requirements for real-time traffic are guaranteed.The protocol is founded on time division multiplex address and a different type of traffic is assigned to different priority,according to which a node should compete for and reserve the free slots in a different method.Moreover,there is a reservation acknowledgement process before data transmit in each reserved slot,so that the intruded terminal problem is solved.The throughput and average packets drop probability of this protocol are analyzed and simulated in a fully connected network,the results of which indicate that this protocol is efficient enough to support the real-time traffic,and it is more suitable to MANETs.

3D image reconstruction with controllable spatial filtering based on correlation of multiple periodic functions in computational integral imaging

We propose a novel method of slice image reconstruction with controllable spatial filtering by using the correlation of periodic delta-function arrays （PDFAs） with elemental images in computational integral imaging. The multiple PDFAs, whose spatial periods correspond to object＇s depths with the elemental image array （EIA）, can generate a set of spatially filtered EIAs for multiple object depths compared with the conventional method for the depth of a single object. We analyze a controllable spatial filtering effect by the proposed method. To show the feasibility of the proposed method, we carry out preliminary experiments for multiple objects and present the results.

Review:Advances in the control of mechatronic suspension systems

The suspension system is a key element in motor vehicles. Advancements in electronics and microprocessor technology have led to the realization of mechatronic suspensions. Since its introduction in some production motorcars in the 1980 s, it has remained an area which sees active research and development, and this will likely continue for many years to come. With the aim of identifying current trends and future focus areas, this paper presents a review on the state-of-the-art of mechatronic suspensions. First, some commonly used classifications of mechatronic suspensions are presented. This is followed by a discussion on some of the actuating mechanisms used to provide control action. A survey is then reported on the many types of control approaches, including look-ahead preview, predictive, fuzzy logic, proportional–integral–derivative(PID), optimal, robust, adaptive, robust adaptive,and switching control. In conclusion, hydraulic actuators are most commonly used, but they impose high power requirements, limiting practical realizations of active suspensions. Electromagnetic actuators are seen to hold the promise of lower power requirements, and rigorous research and development should be conducted to make them commercially usable. Current focus on control methods that are robust to suspension parameter variations also seems to produce limited performance improvements, and future control approaches should be adaptive to the changeable driving conditions.

A New Hybrid Control Scheme for an Integrated Helicopter and Engine System

A new hybrid control scheme is presented with a robust multiple model fusion control（RMMFC） law for a UH-60 helicopter and an active disturbance rejection control（ADRC） controller for its engines.This scheme is a control design method with every subsystem designed separately but fully considering the couplings between them.With three subspaces with respect to forward flight velocity,a RMMFC is proposed to devise a four-loop reference signal tracing control for the helicopter,which escapes the closed-loop system from unstable state due to the extreme complexity of this integrated nonlinear system.The engines are controlled by the proposed ADRC decoupling controller,which fully takes advantage of a good compensation ability for unmodeled dynamics and extra disturbances,so as to compensate torque disturbance in power turbine speed loop.By simulating a forward acceleration flight task,the RMMFC for the helicopter is validated.It is apparent that the integrated helicopter and engine system（IHES） has much better dynamic performance under the new control scheme.Especially in the switching process,the large transient is significantly weakened,and smooth transition among candidate controllers is achieved.Over the entire simulation task,the droop of power turbine speed with the proposed ADRC controller is significantly slighter than with the conventional PID controller,and the response time of the former is much faster than the latter.By simulating a rapid climb and descent flight task,the results also show the feasibility for the application of the proposed multiple model fusion control.Although there is aggressive power demand in this maneuver,the droop of power turbine speed with an ADRC controller is smaller than using a PID controller.The control performance for helicopter and engine is enhanced by adopting this hybrid control scheme,and simulation results in other envelope state give proofs of robustness for this new scheme.

Fuzzy adaptive tracking control within the full envelope for an unmanned aerial vehicle

Motivated by the autopilot of an unmanned aerial vehicle（UAV） with a wide flight envelope span experiencing large parametric variations in the presence of uncertainties, a fuzzy adaptive tracking controller（FATC） is proposed. The controller consists of a fuzzy baseline controller and an adaptive increment, and the main highlight is that the fuzzy baseline controller and adaptation laws are both based on the fuzzy multiple Lyapunov function approach, which helps to reduce the conservatism for the large envelope and guarantees satisfactory tracking performances with strong robustness simultaneously within the whole envelope. The constraint condition of the fuzzy baseline controller is provided in the form of linear matrix inequality（LMI）, and it specifies the satisfactory tracking performances in the absence of uncertainties. The adaptive increment ensures the uniformly ultimately bounded（UUB） predication errors to recover satisfactory responses in the presence of uncertainties. Simulation results show that the proposed controller helps to achieve high-accuracy tracking of airspeed and altitude desirable commands with strong robustness to uncertainties throughout the entire flight envelope.

ISSAMAC: a High Speed MAC Protocol for B3G Systems

Based on a discussion of the requirements for the multiple acess control protocol of beyond thlrd-generation mobile systems, we in this paper articulate the needs of the new multiple acess control protocol with support of high-speed transmission and guaranteed quality of service, for voice, video and audio. In light of these, we present the design of a new multiple acess control protocol, called intelligent slot-subcarriered assignment multiple acess control protocol, to support multiple service categories and to yield high spectral efficiency. Our simulation results verify that intelligent slot-subcarriered assignment multiple acess control protocol can not only provide low delays for the real-time traffic by using bandwidth reservation and effectual scheduling, but also make full use of the limited bandwidth by using a dynamic sub-carrier assignment algorithm.