Bacterial graphical user interface oriented by particle swarm optimization strategy for optimization of multiple type DFACTS for power quality enhancement in distribution system

This study proposes a graphical user interface(GUI) based on an enhanced bacterial foraging optimization(EBFO) to find the optimal locations and sizing parameters of multi-type DFACTS in large-scale distribution systems.The proposed GUI based toolbox,allows the user to choose between single and multiple DFACTS allocations,followed by the type and number of them to be allocated.The EBFO is then applied to obtain optimal locations and ratings of the single and multiple DFACTS.This is found to be faster and provides more accurate results compared to the usual PSO and BFO.Results obtained with MATLAB/Simulink simulations are compared with PSO,BFO and enhanced BFO.It reveals that enhanced BFO shows quick convergence to reach the desired solution there by yielding superior solution quality.Simulation results concluded that the EBFO based multiple DFACTS allocation using DSSSC,APC and DSTATCOM is preferable to reduce power losses,improve load balancing and enhance voltage deviation index to 70%,38% and 132% respectively and also it can improve loading factor without additional power loss.

C634Y mutation in RET-induced multiple endocrine neoplasia type 2A:A case report

BACKGROUND Multiple endocrine neoplasia type 2(MEN2)is a rare,autosomal dominant endocrine disease.Currently,the RET proto-oncogene is the only gene implicated in MEN2A pathogenesis.Once an RET carrier is detected,family members should be screened to enable early detection of medullary thyroid carcinoma,pheochromocytoma,and hyperparatitity.Among these,medullary thyroid carcinoma is the main factor responsible for patient mortality.Accordingly,delineating strategies to inform clinical follow-up and treatment plans based on genes is paramount for clinical practitioners.CASE SUMMARY Herein,we present RET proto-oncogene mutations,clinical characteristics,and treatment strategies in a family with MEN2A.A family study was conducted on patients diagnosed with MEN2A.DNA was extracted from the peripheral blood of family members,and first-generation exon sequencing of the RET protooncogene was conducted.The C634Y mutation was identified in three family members spanning three generations.Two patients were sequentially diagnosed with pheochromocytomas and bilateral medullary thyroid carcinomas.A 9-yearold child harboring the gene mutation was diagnosed with medullary thyroid carcinoma.Surgical resection of the tumors was performed.All family members were advised to undergo complete genetic testing related to the C634Y mutation,and the corresponding treatments administered based on test results and associated clinical guidelines.CONCLUSION Advancements in MEN2A research are important for familial management,assessment of medullary thyroid cancer invasive risk,and deciding surgical timing.

Improving early diagnosis of multiple endocrine neoplasia type 1 by assessing the gastrointestinal symptoms,hypercalcemia,and elevated serum gastrin

Despite advancements in the field,early diagnosis of multiple endocrine neoplasia type 1(MEN1)remains unachievable.This letter to the editor highlighted the importance of carefully assessing gastrointestinal symptoms,hypercalcemia,and elevated serum gastrin levels,as suggested by Yuan et al in their paper.They focused on a patient with recurrent abdominal pain and diarrhea whose diagnostic path led to establishing a MEN1 diagnosis within a year.This emphasized the need for clinicians to consider MEN1 in patients with similar presentations,particularly when gastrointestinal symptoms persist or recur after discontinuation of proton pump inhibitors,especially knowing that early recognition and intervention are crucial for improving patient outcomes.

Early detection of multiple endocrine neoplasia type 1: A case report

BACKGROUND Multiple endocrine neoplasias(MENs)are a group of hereditary diseases invol-ving multiple endocrine glands,and their prevalence is low.MEN type 1(MEN1)has diverse clinical manifestations,mainly involving the parathyroid glands,gastrointestinal tract,pancreas and pituitary gland,making it easy to miss the clinical diagnosis.CASE SUMMARY We present the case of a patient in whom MEN1 was detected early.A middle-aged male with recurrent abdominal pain and diarrhea was admitted to the hos-pital.Blood tests at admission revealed hypercalcemia and hypophosphatemia,and emission computed tomography of the parathyroid glands revealed a hy-perfunctioning parathyroid lesion.Gastroscopy findings suggested a duodenal bulge and ulceration.Ultrasound endoscopy revealed a hypoechoic lesion in the duodenal bulb.Further blood tests revealed elevated levels of serum gastrin.Surgery was performed,and pathological analysis of the surgical specimens revealed a parathyroid adenoma after parathyroidectomy and a neuroendocrine tumor after duodenal bulbectomy.The time from onset to the definitive diagnosis of MEN1 was only approximately 1 year.CONCLUSION For patients who present with gastrointestinal symptoms accompanied by hyper-calcemia and hypophosphatemia,clinicians need to be alert to the possibility of MEN1.

Molecular diagnostic approaches in detecting rearranged during transfection oncogene mutations in multiple endocrine neoplasia type 2

Different types of neuroendocrine cancer,including medullary thyroid cancer(MTC)and thyroid C-cell hyperplasia,are part of multiple endocrine neoplasia type 2(MEN2).A proto-oncogene mutation of the rearranged during transfection(RET)gene changes the way that receptor tyrosine kinases work.Multiple endocrine neoplasia,a pathological condition,involves these kinases.When the RET protooncogene changes,it can cause endocrine adenomas and hyperplasia to happen at the same time or one after the other.Pheochromocytoma,medullary thyroid carcinoma,and hyperparathyroidism,alone or in combination,are present in MEN2A patients.Some patients may also have skin lichen amyloidosis or Hirschsprung's disease.Patients with MEN2A often present with MTC.MTC is aggressive and has the worst prognosis,as most patients exhibit lymph node metastasis.MTC is one of the important causes of death in patients with MEN2A.RET mutation analysis aids in identifying MEN2A symptoms and monitoring levels of calcium,thyroid hormones,calcitonin,normetanephrine,fractionated metanephrines,and parathyroid hormone.The earlier diagnosis of MTC significantly improves survival and prompts better management of MEN2A.In this editorial,we will discuss the significance of molecular diagnostic approaches in detecting RET oncogene mutations in MEN2A.

The Proportional Hazards Model for Multiple Type Recurrent Gap Times

Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consider a proportional hazards model for multiple type recurrent gap times data to assess the effect of covaxiates on the censored event processes of interest.An estimating equation approach is used to obtain the estimators of regression coefficients and baseline cumulative hazard functions.We examine asymptotic properties of the proposed estimators.Finite sample properties of these estimators are demonstrated by simulations.

Management of multiple type II endoleaks detected by duplex ultrasound after endovascular abdominal aneurysm repair

We reported a case of multiple type II endoleaks detected by duplex ultrasound after endovascular abdominal aneurysm repair. The patient was undergoing warfarin therapy. Duplex ultrasound was applied as the sole surveillance method during follow-up and provided the concerned information for reintervention. The endoleaks were successfully repaired by coil embolization of the collaterals from the internal lilac artery feeding the fourth lumbar artery.

MULTIPLE POSITIVE SOLUTIONS FOR QUASILINEAR ELLIPTIC PROBLEMS INVOLVING CONCAVE-CONVEX NONLINEARITIES AND MULTIPLE HARDY-TYPE TERMS

In this paper, we deal with the existence and multiplicity of positive solutions for the quasilinear elliptic problem -△pu-∑i=1^kμi｜u｜^p-2/｜x-ai｜p^u=｜u｜^p^＊-2u＋λ｜u｜^q-2u,x∈Ω,where Ω belong to R^N（N ≥ 3） is a smooth bounded domain such that the different points ai∈Ω,i= 1,2,...,k,0≤μi〈μ^-=（N-p/p）^p,λ〉0,1≤q〈p,and p^＊=p^N/N-p.The results depend crucially cn the parameters λ,q and μi for i=1,2,...,k.

Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients

AIM： To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. METHODS： Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 （MEN 1） and Zollinger-Ellison syndrome （ZES） underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors （NETs） between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test （SASI test） with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy （SRS） and other imaging methods such as computed tomography （CT） or magnetic resonance imaging （MRI）. The modus of surgery for gastrinoma has been changed over time, searching for the optimal surgery： pancreaticoduodenectomy （PD） was first performed guided by localization with the SAST test, then local resection of duodenal gastrinomas with dissection of regional lymph nodes （LR）, and recently pancreas-preserving total duodenectomy （PPTD） has been performed for multiple duodenal gastrinomas. RESULTS： Among various types of preoperative localizing methods for gastrinoma, the SASI test was the most useful method. Imaging methods such as SRS or CT made it essentially impossible to differentiate functioning gastrinoma among various kinds of NETs. However, recent imaging methods including SRS or CT were useful for detecting both distant metastases and ectopic NETs; therefore they are indispensable for staging of NETs. Biochemical cure of gastrinoma was achieved in 14 of 16 patients （87.5%）; that is, 100% in 3 patients who underwent PD, 100% in 6 patients who underwent LR （although in 2 patients （33.3%） second LR was performed for recurrence of duodenal gastri- noma）, and 71.4% in 7 patients who underwent PPTD. Pancreatic NETs more than 1 cm in diameter were resected either by distal pancreatectomy or enucleations, and no hepatic metastases have developed postoperatively. Pathological study of the resected specimens revealed co-existence of pancreatic gastrinoma with duodenal gastrinoma in 2 of 16 patients （13%）, and G cell hyperplasia and/or microgastrinoma in the duodenal Brunner＇s gland was revealed in all of 7 duodenal specimens after PPTD. CONCLUSION： Aggressive resection surgery based on accurate localization with the SASI test was useful for biochemical cure of gastrinoma in patients with MEN 1.Imamura Metal. Curative resection of gastrinoma in MEN-1

Comprehensive treatment of rare multiple endocrine neoplasia type 1:A case report

BACKGROUND Multiple endocrine neoplasia type 1(MEN1)is a rare hereditary disorder caused by mutations of the MEN1 gene.It is characterized by hyperparathyroidism and involves the pancreas,anterior pituitary,duodenum,and adrenal gland.Here,we report a 40-year-old male patient with MEN1 who first manifested as thymic carcinoid,then primary hyperparathyroidism and prolactinoma,and a decade later pancreatic neuroendocrine tumor.CASE SUMMARY The patient underwent a thymectomy because of the thymic carcinoid 10 years prior and a prolactinoma resection 2 years prior.His sister suffered from prolactinoma.His parents displayed a typical triad of amenorrhea,galactorrhea,and infertility.Computed tomography revealed a strong signal in the upper portion of the left lobes and posterior portion of the right lobes of the thyroid and irregular soft tissue densities of the pancreatic body.Positron emission tomography/computed tomography imaging further showed strong 18Fflurodeoxyglucose uptake in the tail of the pancreatic body and segment IV of the liver.The patient underwent pancreatic body tail resection,pancreatic head mass enucleation,and ultrasound-guided radio-frequency ablation for liver cancer.Pathology results reported neuroendocrine tumor grade 2.Whole exome sequencing revealed a verified pathogenic mutation c.378G>A(p.Trp126*)in the MEN1 gene.The diagnosis of MEN1 was confirmed.At the 1.5-year follow-up,the patient appeared healthy without any sign of reoccurrence.CONCLUSION The present case may add some insight into the diagnosis and treatment of patients with MEN1.

Multiple endocrine neoplasia type 1 combined with thyroid neoplasm:A case report and review of literatures

BACKGROUND Multiple endocrine neoplasia type 1(MEN1)is a rare hereditary tumor syndrome inherited in an autosomal dominant manner and presents mostly as parathyroid,endocrine pancreas(such as gastrinoma)and anterior pituitary tumors.At present,papillary thyroid carcinoma(PTC)and nodular goiter are not regarded as components of MEN1.CASE SUMMARY A 35-year-old woman presented with MEN1 accompanied by coinstantaneous PTC and nodular goiter.The pathological diagnosis was PTC with cervical lymph node metastasis,nodular goiter,parathyroid cyst and adenomatoid hyperplasia.Genetic testing was performed and a MEN1 gene mutation was detected.The patient underwent unilateral lobectomy of the thyroid gland and surgical removal of the parathyroid tumors.At 18 mo of follow-up,ultrasonic examination of the neck showed no abnormality.Serum calcium and parathyroid hormone levels were normal.No new MEN1-associated tumors were detected.CONCLUSION The role of inactivating mutations of MEN1 gene in tumorigenesis of PTC and/or nodular goiter remains to be determined by more case reports and further research.

The Optimal Matching Parameter of Half Discrete Hilbert Type Multiple Integral Inequalities with Non-Homogeneous Kernels and Applications

By using the weight function method,the matching parameters of the half discrete Hilbert type multiple integral inequality with a non-homogeneous kernel K(n,||x||ρ,m)=G(nλ1||x||ρmλ,2)are discussed,some equivalent conditions of the optimal matching parameter are established,and the expression of the optimal constant factor is obtained.Finally,their applications in operator theory are considered.

Special IgD-λtype multiple myeloma based on bone marrow cell morphology:A case report

We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtype 1 multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.The morphology of bone marrow cells,immunofixation electrophoresis,serum free light chain(sFLC)and other detection indexes of a patient with IgD-λtype MM treated in Handan Central Hospital in December 2020 were analyzed.The patient bone marrow smears showed 62%of abnormal cells-which were distributed in clusters and resembled lymphoma and metastatic cancer cells.The Flowcytometry indicates that the cell is a plasma cell tumor.Immunoglobulin IgG,IgA and IgM were all lower than the normal range.There is a monoclonal light chainλcomponent in immunofixation electrophoresis.The serum free light chainλwas 2700.00 mg/L,light chain k/λis 0.0023,the high of serum calcium,LDH,β2 microglobulin.IgD-λtype MM is a rare type of MM.The age of onset is young,the invasiveness is strong,the prognosis is poor,the clinical manifestation is complex,and it is easy to be misdiagnosed or missed.The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in the diagnosis,treatment and prognosis of the disease.

A NOVEL Ser73Gly VARIATION OF SUCCINATE DEHYDROGENASE,SUBUNIT D AND A Cys634Gly MUTATION IN Ret PROTO-ONCOGENE OBSERVED IN A CHINESE MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A PATIENT

Multiple endocrine neoplasia type 2A （ MEN2A ） is an autosomal dominant cancer syndrome that is characterized by medullary thyroid carcinoma （MTC）, pheochromaocytoma （50% - 60% of cases ）, and hyperplasia of the parathyroid glands （ 20% - 30% of cases ）. MEN-2A comprises a heterogeneous group of neoplastic disorders that most commonly have a single missense substitution of the Ret proto-oncogene （RET） involving exons 10 and 11. Here, we reported a novel case of MEN2A associated with two variations in two distinct genes, Cys634Gly in RET and a rare Ser73Gly substitution in succinate dehydrogenase, subunit D （SDHD）. Because the patient presented with medullary thyroid carcinoma and pheochromocytoma but without parathyroid gland involvement, we speculated that this clinical feature could be correlated with the two substitutions. This is the first report of a MEN2A case involving two different changes one in the RET gene and the other in the SDHD gene.

Scheduling Multiple Orders per Job with Multiple Constraints on Identical Parallel Machines

With a comprehensive consideration of multiple product types, past-sequence-dependent （ p-s-d ） setup times, and deterioration effects constraints in processes of wafer fabrication systems, a novel scheduling model of multiple orders per job（MOJ） on identical parallel machines was developed and an immune genetic algorithm（IGA） was applied to solving the scheduling problem. A scheduling problem domain was described. A non-linear mathematical programming model was also set up with an objective function of minimizing total weighted earliness-tardlness penalties of the system. On the basis of the mathematical model, IGA was put forward. Based on the genetic algorithm （GA）, the proposed algorithm （IGA） can generate feasible solutions and ensure the diversity of antibodies. In the process of immunization programming, to guarantee the algorithm＇s convergence performance, the modified rule of apparent tardiness cost with setups （ATCS） was presented. Finally, simulation experiments were designed, and the results indicated that the algorithm had good adaptability when the values of the constraints＇ characteristic parameters were changed and it verified the validity of the algorithm.

Rate decline analysis of multiple fractured horizontal well in shale reservoir with triple continuum

Multiple fractured horizontal well(MFHW) is widely applied in the development of shale gas. To investigate the gas flow characteristics in shale, based on a new dual mechanism triple continuum model, an analytical solution for MFHW surrounded by stimulated reservoir volume(SRV) was presented. Pressure and pressure derivative curves were used to identify the characteristics of flow regimes in shale. Blasingame type curves were established to evaluate the effects of sensitive parameters on rate decline curves, which indicates that the whole flow regimes could be divided into transient flow, feeding flow, and pseudo steady state flow. In feeding flow regime, the production of gas well is gradually fed by adsorbed gases in sub matrix, and free gases in matrix. The proportion of different gas sources to well production is determined by such parameters as storability ratios of triple continuum, transmissibility coefficients controlled by dual flow mechanism and fracture conductivity.

Robust adaptive estimator based on a novel objective function—Using the L1-norm and L0-norm

To fully take advantage of LMS,LMAT,and SELMS,a novel adaptive estimator using the L1-norm and L0-norm of the estimated error is proposed in this paper.Then based on minimizing the mean-square deviation at the current time,the optimal step-size,parameters𝛿and𝜃of the proposed adaptive estimator are obtained.Besides,the stability and computational complexity of the mean estimation error is analyzed theoretically.Experimental results(both simulation and real mechanical system datasets)show that the proposed adaptive estimator is more robust to input signals and a variety of measurement noises(Gaussian and non-Gaussian noises).In addition,it is superior to LMS,LMAT,SELMS,the convex combination of LMS and LMAT algorithm,the convex combination of LMS and SELMS algorithm,and the convex combination of SELMS and LMAT algorithm.The theoretical analysis is consistent with the Monte-Carlo results.Both of them show that the adaptive estimator has an excellent performance in the estimation of unknown linear systems under various measurement noises.

Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features

Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome （ZES）. ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal reflux disease and occasional diarrhea. Genetically, nonhereditary （sporadic） gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 （MEN1） syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors （NETs） includes 18 patients （23.4%） with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients （4.5%） suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished from tumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas.

An improved estimation of distribution algorithm for multi-compartment electric vehicle routing problem

The multi-compartment electric vehicle routing problem(EVRP)with soft time window and multiple charging types(MCEVRP-STW&MCT)is studied,in which electric multi-compartment vehicles that are environmentally friendly but need to be recharged in course of transport process,are employed.A mathematical model for this optimization problem is established with the objective of minimizing the function composed of vehicle cost,distribution cost,time window penalty cost and charging service cost.To solve the problem,an estimation of the distribution algorithm based on Lévy flight(EDA-LF)is proposed to perform a local search at each iteration to prevent the algorithm from falling into local optimum.Experimental results demonstrate that the EDA-LF algorithm can find better solutions and has stronger robustness than the basic EDA algorithm.In addition,when comparing with existing algorithms,the result shows that the EDA-LF can often get better solutions in a relatively short time when solving medium and large-scale instances.Further experiments show that using electric multi-compartment vehicles to deliver incompatible products can produce better results than using traditional fuel vehicles.

Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered.