Real-Time 4-Mode MDM Transmission Using Commercial 400G OTN Transceivers and All-Fiber Mode Multiplexers

Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key components.In this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing processing.The measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four modes.Based on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)transceivers.The experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system.

Demonstration of a manufacturable SOT-MRAM multiplexer array towards industrial applications

We have successfully demonstrated a 1 Kb spin-orbit torque(SOT)magnetic random-access memory(MRAM)multiplexer(MUX)array with remarkable performance.The 1 Kb MUX array exhibits an in-die function yield of over 99.6%.Additionally,it provides a sufficient readout window,with a TMR/RP_sigma%value of 21.4.Moreover,the SOT magnetic tunnel junctions(MTJs)in the array show write error rates as low as 10^(-6)without any ballooning effects or back-hopping behaviors,ensuring the write stability and reliability.This array achieves write operations in 20 ns and 1.2 V for an industrial-level temperature range from-40 to 125℃.Overall,the demonstrated array shows competitive specifications compared to the state-of-the-art works.Our work paves the way for the industrial-scale production of SOT-MRAM,moving this technology beyond R&D and towards widespread adoption.

Multi-functional optical fiber sensor system based on a dense wavelength division multiplexer

We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.

A 32-channel 100 GHz wavelength division multiplexer by interleaving two silicon arrayed waveguide gratings

A 32-channel wavelength division multiplexer with 100 GHz spacing is designed and fabricated by interleaving two silicon arrayed waveguide gratings(AWGs).It has a parallel structure consisting of two silicon 16-channel AWGs with200 GHz spacing and a Mach-Zehnder interferometer(MZI)with 200 GHz free spectral range.The 16 channels of one silicon AWG are interleaved with those of the other AWG in spectrum,but with an identical spacing of 200 GHz.For the composed wavelength division multiplexer,the experiment results reveal 32 wavelength channels in C-band,a wavelength spacing of 100 GHz,and a channel crosstalk lower than-15 dB.

DELAY JITTER OF A PERIODIC CELL STREAM THROUGH AN ATM MULTIPLEXER IN A BURSTY TRAFFIC ENVIRONMENT

The periodic cell stream is a very important member among the input traffic sources in ATM networks. In this paper, a finite-buffered ATM multiplexer with traffic sources composed of a periodic cell stream, multiple i.i.d Bernoulli cell streams and bursty two-state Markov Modulated Bernoulli Process (MMBP) cell streams is exactly analyzed. The probability mass function of queuing delay, the autocorrelation and power spectrum of delay jitter for this periodic cell stream are derived. The analysis is used to expose the behavior of delay jitter for a periodic cell stream through an ATM multiplexer in a bursty traffic environment. The simulation results indicate that the analytical results are accurate.

ANALYSIS OF AN ATM MULTIPLEXER UNDER SELF-SIMILAR TRAFFIC

Recent empirical studies of the real traffic measurement show that the traditional traffic models cannot capture the character of long-range dependence of the traffic. And many computer simulations said that this character has large influences on the network performance. So fractal or self-similar models are more suitable to describe the modern traffic. But there is still little known about the performance of the multiplexer under self-similar traffic. In this paper, a quasi-self-similar traffic model (QSSP) is proposed. Using this model, the upper bond of the cell loss rate and multiplexing gain of the multiplexer are gotten when there are N i.i.d. QSSP inputs. If the sources have different parameters, an efficient numerical algorithm to get, this bond is proposed. Simulations indicate that our analysis is correct and accurate.

Silicon-Based Mode Converter and Demultiplexer for Wavelength Division Multiplexing Transmission by Using Multimode Interference Couplers

We present a mode converter and demultiplexer structure for wavelength division multiplexing (WDM) transmission by employing multimode interference (MMI) on Silicon-on-Insulator (SOI) platform. The mode converter and demultiplexer have a compact size of less than 2.7 μm × 43.7 μm. Moreover, the crosstalk between neighboring wavelength channel within C band (1530 nm to 1570 nm) can be reduced by utilizing the tapered phase shifter cascaded with MMI. The simulated results indicate that this structure has a low insertion loss of less than 1 dB, a low crosstalk of better than ?15 dB and a relatively high fabrication tolerance of ~10 nm. Such structure may find many potential applications in silicon photonic integrated devices.

A New Approach to Implement Synchronous Demultiplexers in High-Speed ISDN Switching Network

This paper proves that a synchronous demultiplexer has the same logic function as a synchronous multiplexer. A new approach is proposed to implement synchronous demultiplexers in high-speed ISDN switching networks. A synchronous demultiplexer is designed utilizing the same structure as a synchronous shuffle multiplexer. Both the theoretical analysis and experimental results show that for the same capacity, the new method is more tolerant of signal delay variation, so a very high-speed synchronous demultiplexer can be designed with the larger capacity required in large capacity synchronous switching networks.

Polymeric 32-channel arrayed waveguide grating multiplexer using fluorinated poly (ether ether ketone)

In wavelength division multiplexing (WDM) systems, an arrayed waveguide grating (AWG) multiplexer is a key component. A polymeric AWG multiplexer has recently attracted much attention due to its low cost processing and a potential of integration with other devices. Fluorinated poly (ether ether ketone) (FPEEK) is excellent material for fabrication of optical waveguides due to its low absorption loss at 1.55-μm wavelength and high thermal stability. A 32-channel AWG multiplexer has been designed based on the grating diffraction theory and fabricated using newly synthesized FPEEK. During the fabrication process of the Polymer/Si AWG device, spin coating, vaporizing, photolithographic patterning and reactive ion etching (RIE) are used. The AWG multiplexer measurement system is based on a tunable semiconductor laser, infrared camera and a Peltier-type heater. The device exhibits a wavelength channel spacing of 0.8 nm and a center wavelength of 1548 nm in the room temperature.

Design of readout electronics based on peak-holding circuit and multiplexer for a fast neutron spectrometer

Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace applications of the model require electronics in small size.Purpose To design a dedicated electronic system to readout and process the 384-channel signals from scintillating fiber array,and to use the designed system to fabricate a neutron detector for aerospace applications.Methods With the method of nuclear recoil,fast neutron is detected by tracking recoil proton of n–p scatter in scintillating plastic fibers.Using the peak-holding circuits and multiplexers,the system size and power consumption were reduced.Results The detector fabricated with the designed system,had 34 cm×34 cm×27 cm mechanical size,20.4 kg weight,and 30.05W power consumption.Comparing to traditional waveform sampling electronics,the designed electronics was highly integrated and had a small size.The readout electronics also gave a better energy resolution of 39%in neutron detection,while the energy resolution was 43%in previous version.Conclusion In this study,a highly integrated readout electronic system was designed and verified.The detector using the system gave good performance.The designed electronics had potential development in fast neutron detection and other high energy physics detection system.

A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic improvement.Currently available genome-editing tools have a limited number of targets,restricting their application in genetic research.In this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software package.By combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was observed.This plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms

Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.

Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators.Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects.Current semi-implantable devices are mainly based on single-parameter detection.Miniaturized semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode sensitivity.This study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)concentrations.The electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing.The MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above ions.In vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex environments.This work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

Turbo Message Passing Based Burst Interference Cancellation for Data Detection in Massive MIMO-OFDM Systems

This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.

Coarse-fine joint target parameter estimation method based on AN-RSC in OFDM passive radar

In this paper,we study the accuracy of delay-Doppler parameter estimation of targets in a passive radar using orthogonal frequency division multiplexing(OFDM)signal.A coarse-fine joint estimation method is proposed to achieve better estimation accuracy of target parameters without excessive computational burden.Firstly,the modulation symbol domain(MSD)method is used to roughly estimate the delay and Doppler of targets.Then,to obtain high-precision Doppler estimation,the atomic norm(AN)based on the multiple measurement vectors(MMV)model(MMV-AN)is used to manifest the signal sparsity in the continuous Doppler domain.At the same time,a reference signal compensation(RSC)method is presented to obtain highprecision delay estimation.Simulation results based on the OFDM signal show that the coarse-fine joint estimation method based on AN-RSC can obtain a more accurate estimation of target parameters compared with other algorithms.In addition,the proposed method also possesses computational advantages compared with the joint parameter estimation.

Development of a multiplex polymerase chain reaction assay for detection of hepatitis C virus,hepatitis B virus,and human immunodeficiency virus 1

BACKGROUND Hepatitis C virus(HCV),hepatitis B virus(HBV),and human immunodeficiency virus 1(HIV-1)are the most epidemic blood-borne viruses,posing threats to human health and causing economic losses to nations for combating the infection transmission.The diagnostic methodologies that depend on the detection of viral nucleic acids are much more expensive,but they are more accurate than sero-logical testing.AIM To develop a rapid,cost-effective,and accurate diagnostic multiplex polymerase chain reaction(PCR)assay for simultaneous detection of HCV,HBV,and HIV-1.METHODS The design of the proposed PCR assay targets the amplification of a short conserved region featured with a distinguishable melting profile and electro-phoretic molecular weight inside each viral genome.Therefore,this diagnostic method will be appropriate for application in both conventional(combined with electrophoresis)and real-time PCR facilities.Confirmatory in silico investigations were conducted to prove the capability of the approached PCR assay to detect variants of each virus.Then,Egyptian isolates of each virus were subjected to the wet lab examination using the given diagnostic assay.RESULTS The in silico investigations confirmed that the PCR primers can match many viral variants in a multiplex PCR assay.The wet lab experiment proved the efficiency of the assay in distinguishing each viral type through high-resolution melting analysis.Compared to related published assays,the proposed assay in the current study is more sensitive and competitive with many expensive PCR assays.CONCLUSION This study provides a simple,cost-effective,and sensitive diagnostic PCR assay facilitating the detection of the most epidemic blood-borne viruses;this makes the proposed assay promising to be substitutive for the mistakable and cheap serological-based assays.

Study on Distribution of Four Pseudomonas Species in Living Environment Using Multiplex PCR

Purpose: The genus Pseudomonas is a ubiquitous microorganism frequently detected from immunocompromised patients. The inherent resistance to numerous antimicrobial agents contributes to the opportunistic character of this pathogen exhaustive monitoring of this pathogen is considered of critical importance to public health organizations. The reliable identification method able to distinguish genetic close Pseudomonas species is needed, because these organisms are difficult to differentiate by phenotypic or biochemical methods. The purpose of the present study was to design species-specific primers in order to identify and detect four Pseudomonas species which are frequently detected from the human oral cavities, and to investigate the distribution of these organisms in the living environment using a multiplex PCR. Methods: Polymerase chain reaction (PCR) primers were designed based on partial sequences of the rpoD gene of four Pseudomonas species. Swab samples were collected from fifty washstands, and the distribution of Pseudomonas species was investigated using a conventional PCR at genus level and a multiplex PCR at species level. Results: Multiplex PCR method developed in this study was able to distinguish four Pseudomonas species clearly. The genus Pseudomonas was detected from all samples (100%), whereas P. putida, P, aeruginosa, P. stutzeri and P. fluorescens were detected at 44%, 8%, 4% and 2% in fifty swab samples, respectively. Conclusion: Our developed one-step multiplex PCR method is accurate, specific, cost-effective, time-saving, and works without requiring DNA extraction. It was indicated that washstands were the uninhabitable environment for P. putida, P, aeruginosa, P. stutzeri and P. fluorescens.

Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with HIV

Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex? HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex? HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

Vertical integration of self-rolled-up microtube and silicon waveguides: a two-channel optical add–drop multiplexer

A novel design of a two-channel optical add–drop multiplexer based on a self-rolled-up microtube(SRM) is presented. This design consists of an SRM that has a parabolic lobe-like pattern along the tube's axial direction,as well as straight silicon waveguides and a 180° waveguide bend. The vertical configuration of the SRM and waveguides is analyzed by the coupled mode theory for achieving the optimum gap. In the critical coupling regime, when the device serves as an optical demultiplexer, the minimum insertion loss is 1.94 dB,and the maximum channel crosstalk is-6.036 dB. Also, as an optical multiplexer, the maximum crosstalk becomes-11.9 dB.

Tone Modulation in a Passive OTDM Multiplexer for Clock Recovery from a 160 Gbit/s OTDM Signal

Tone modulation in a passive OTDM multiplexer for clock recovery from a 160-Gbit/s OTDM signal by using a base-rate receiver is demonstrated. We performed synchronous demultiplexing in back-to-back arrangement and optical sampling after 320-km transmission.