A mouse muscle type nAChR model((α1)_(2)βδg)was built based on the cryoelectron microscopic structure of intact Torpedo marmorata nAChR and the high resolution crystal structure of nAChR-α1 subunit.The conformatio...A mouse muscle type nAChR model((α1)_(2)βδg)was built based on the cryoelectron microscopic structure of intact Torpedo marmorata nAChR and the high resolution crystal structure of nAChR-α1 subunit.The conformation of the pentameric nAChR model was investigated by molecular dynamic simulation.The function of water molecule in the hydrophilic interior was clarified.The reason for Tyr127 showing two alternative conformations was discussed in detail.展开更多
基金the support from Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry.
文摘A mouse muscle type nAChR model((α1)_(2)βδg)was built based on the cryoelectron microscopic structure of intact Torpedo marmorata nAChR and the high resolution crystal structure of nAChR-α1 subunit.The conformation of the pentameric nAChR model was investigated by molecular dynamic simulation.The function of water molecule in the hydrophilic interior was clarified.The reason for Tyr127 showing two alternative conformations was discussed in detail.
