Can environmental sustainability be decoupled from economic growth? Empirical evidence from Eastern Europe using the common correlated effect mean group test

The European Union(EU) and Organisation for Economic Co-operation and Development(OECD) aim to develop long-term policies for their respective member countries. Having observed increasing dangers to the environment posed by rising economic growth, they are seeking pathways to enable policy action on economic growth and environmental sustainability. Given the facts in theoretical and empirical studies, this study assessed the validity of the decoupling hypothesis by investigating asymmetricity in the relationship between environmental sustainability and economic growth in nine Eastern European countries from 1998 to 2017 using the cross-section augmented Dickey-Fuller(CADF) unit root, panel corrected standard error(PCSE), common correlated effect mean group(CCEMG), and Dumitrescu Hurlin causality approaches. Both population growth and drinking water are used as controlled variables. The outcomes establish strong cointegration among all the variables of interest. According to the results of CCEMG test, economic growth exerts short-term environmental degradation but has long-term environmental benefits in Eastern Europe;and population growth and drinking water exert a positive effect on environmental sustainability in both the short-and long-run. The results of Dumitrescu Hurlin causality test indicate that environmental sustainability is unidirectionally affected by economic growth. Based on these outcomes, we suggest the following policies:(1) the EU and OECD should implement member-targeted policies on economic growth and fossil-fuel use towards regulating industrial pollution, water use, and population control;and(2) the EU and OECD member countries should invest in environmental technologies through green research and development(R&D) to transform their dirty industrial processes and ensure productive energy use.

Growth performance and physiological parameters of the second generation selected and control groups of Pinctada martensii

In May of 2007,the second generation selected （SS） and control （SC） groups of pearl oyster Pinctada martensii were established by selecting 10% breeders with the largest and mean shell length,respectively,from the first generation selected group.Growth performance of the SS and SC groups were compared on the basis of measurement data at Days 8,18,60,95,195 and 365.On Day 365,100 individuals （60.0–75.0 mm at shell length） were sampled from each group and then subjected to the experiment where physiological parameters such as filtrate rate,oxygen consumption and ammonia excretion were measured at 15,20,25 and 30°C.The results show that the SS group had significantly larger mean shell length and shell height than the SC group at Days 8,18,60,95,195 and 365 （P 0.05）.The genetic gains at different ages varied from 6.0% to 17.0% for shell length and 5.7% to 14.6% for shell height,respectively.At 15,20,25 and 30 ° C,the SS groups had significantly larger filtrate rate than the SC group （P 0.05）.At 15 and 25 °C,the differences in oxygen consumption rate between the SS and SC groups were not significant （P 0.05）.At 20 and 30 °C,however,the oxygen consumption rate of the SS group was significantly larger than the SC group （P 0.05）.At 15,20,25 and 30 °C,there were no significant differences in ammonia excretion rate between the SS and SC groups （P 0.05）.The present results indicate that there existed considerable genetic variability in the base population and a further selection could be likely fruitful.Mass selection for faster growth might produce animals that had higher intake of metabolizable energy by virtue of faster filtrating behavior.

Analysis on Polymorphisms of GHR Gene in Improved Hybrid Yellow Cattle Groups from Liupan Mountain Area in Ningxia

[Objective] The paper aimed to analyze the polymorphism of the growth hormone receptor （GHR） in improved hybrid yellow cattle group from Liupan Mountain area in Ningxia Autonomous Region,so as to provide technological basis for hybrid improvement. [Method] Polymerase chain reaction-restriction fragment length polymorphisms （PCR-RFLP） technology was carried out to examine polymorphisms of GHR gene of 70 individuals. [Result] The target fragment of 338 bp was amplified. The PCR product digested by restriction enzyme Alu I showed polymorphisms. The frequencies of the two genotypes （AA,BB） were 75.71% （53 individuals） and 24.29% （17 individuals）,respectively. [Conclusion] Two genotypes of GHR gene were detected in improved hybrid yellow cattle groups from Liupan Mountain area in Ningxia.

Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling

AIM: To investigate the molecular mechanisms underlying the reversal effect of emodin on platinum resistance in hepatocellular carcinoma. METHODS: After the addition of 10 μmol/L emodin to HepG2/oxaliplatin (OXA) cells, the inhibition rate (IR), 50% inhibitory concentration (IC 50 ) and reversal index (IC 50 in experimental group/IC 50 in control group) were calculated. For HepG2, HepG2/OXA, HepG2/OXA/T, each cell line was divided into a control group, OXA group, OXA + fibroblast growth factor 7 (FGF7) group and OXA + emodin group, and the final concentrations of FGF7, emodin and OXA in each group were 5 ng/mL, 10 μg/mL and 10 μmol/L, respectively. Single-cell gel electrophoresis was conducted to detect DNA damage, and the fibroblast growth factor receptor 2 (FGFR2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) and excision repair cross-complementing gene 1 (ERCC1) protein expression levels in each group were examined by Western blotting. RESULTS: Compared with the IC50 of 120.78 μmol/L in HepG2/OXA cells, the IC 50 decreased to 39.65 μmol/L after treatment with 10 μmol/L emodin; thus, the reversal index was 3.05. Compared with the control group, the tail length and Olive tail length in the OXA group, OXA + FGF7 group and OXA + emodin group were significantly increased, and the differences were statistically significant (P < 0.01). The tail length and Olive tail length were lower in the OXA + FGF7 group than in the OXA group, and this difference was also statistically significant. Compared with the OXA + FGF7 group, the tail extent, the Olive tail moment and the percentage of tail DNA were significantly increased in the OXA + emodin group, and these differences were statistically significant (P < 0.01). In comparison with its parental cell line HepG2, the HepG2/OXA cells demonstrated significantly increased FGFR2, p-ERK1/2 and ERCC1 expression levels, whereas the expression of all three molecules was significantly inhibited in HepG2/ OXA/T cells, in which FGFR2 was silenced by FGFR2 shRNA. In the examined HepG2 cells, the FGFR2, p-ERK1/2 and ERCC1 expression levels demonstrated increasing trends in the OXA group and OXA + FGF7 group. Compared with the OXA group and OXA + FGF7 group, the FGFR2, p-ERK1/2, and ERCC1 expression levels were significantly lower in the OXA + emodin group, and these differences were statistically significant. In the HepG2/OXA/T cell line that was transfected with FGFR2 shRNA, the FGFR2, p-ERK1/2 and ERCC1 expression levels were significantly inhibited, but there were no significant differences in these expression levels among the OXA, OXA + FGF7 and OXA + emodin groups. CONCLUSION: Emodin markedly reversed OXA resistance by enhancing OXA DNA damage in HepG2/OXA cells, and the molecular mechanism was related to the inhibitory effect on ERCC1 expression being mediated by the FGFR2/ERK1/2 signaling pathway.

Temporal and spatial distribution of phytoplankton functional groups and role of environment factors in a deep subtropical reservoir

Phytoplankton and environment factors were investigated in 2015 and phytoplankton functional groups were used to understand their temporal and spatial distribution and their driving factors in Wanfeng Reservoir. Seventeen functional groups(B, D, E, F, G, J, Lo, MP, P, S1, T, W1, W2, X1, X2, Xph, Y) were identified based on 34 species. The dominant groups were: J/B/P/D in dry season, X1/J/Xph/G/T in normal season and J in flood season. Phytoplankton abundance ranged from 5.33×10~4 cells/L to 3.65×10~7 cells/L, with the highest value occurring in flood season and lowest in dry season. The vertical profi le of dominant groups showed little differentiation except for P, which dominated surface layers over 20 m as a result of mixing water masses and higher transparency during dry season. However, the surface waters presented higher values of phytoplankton abundance than other layers, possibly because of greater irradiance. The significant explaining variables and their ability to describe the spatial distribution of the phytoplankton community in RDA diff ered seasonally as follows: dry season, NH4-N, NO_3-N, NO_2-N, TN:TP ratio and transparency(SD); normal season, temperature(WT), water depth, TN, NH4-N and NO_3-N; flood season, WT, water depth, NO_3-N and NO_2-N. Furthermore, nitrogen, water temperature, SD and water depth were significant variables explaining the variance of phytoplankton communities when datasets included all samples. The results indicated that water physical conditions and hydrology were important in phytoplankton community dynamics, and nitrogen was more important than phosphorus in modifying phytoplankton communities. Seasonal differences in the relationship between the environment and phytoplankton community should be considered in water quality management.

Anastomosis Groups and Pathogenicity of Rhizoctonia solani from Potato in Inner Mongolia

A total of 148 samples of potato black scurf were collected from 15 potato producing counties in Inner Mongolia Autonomous Region of China, and the strains were identified to be Rhizoctonia solani. The collected R. solani strains were grouped into three types, fast growth, slow growth and medium growth, based on the mycelial growth rate. Most of the fungi isolated were of fast and medium growth types. To examine the anastomosis groups of isolated R. solani strains, the isolated strains were co-cultured with anastomosis standard strains on sterile slide glass, and the occurrence of mycelial fusion was observed under microscope. The examination results indicated that 45 strains(73.77%), four strains(6.56%), and three strains(4.92%) belonged to AG-3, AG-1-IB and AG-2 anastomosis groups, respectively, while nine strains(14.75%) did not belong to any anastomosis groups above. These results suggested that the dominant strains causing potato black scurf in Inner Mongolia Autonomous Region were mainly R. solani AG-3. To test the pathogenicity of different anastomosis groups of R. solani, the potato tubers were planted with soil infected by isolated fungi. The results showed that all the tested fungi were able to cause typical symptoms of potato black scurf on tubers and stalk, but their pathogenicity levels varied. Moreover, it was found that the mycelial growth rate was positively correlated with their pathogenicity.

Group planting of cherry (Prunus avium L.) fosters growth and tree quality is superior to conventional row planting in Germany

Wild cherry trees produce high-quality timber and provide multiple ecosystem services. However, planting and tending cherry stands in conventional rows are too costly. Therefore, low density group planting was trialled as an alternative to row planting. The mortality, growth, and quality of planted cherry trees were compared between the group and row planting. The influence of neighbourhood competition and light availability on growth and quality was studied. The group and row planting of cherry trees were established at a wind-thrown site in southwestern Germany in the year 2000. In group planting, five cherry seedlings and seven lime seedlings （Tilia cordata Mill.） were planted with a 1 x 1 m spacing. In total, 60 groups were planted per hectare with a 13 × 13 m spacing. In contrast, 3300 seedlings （2475 cherries and 825 limes） were planted per hectare in row planting with a 3 × 1 m spacing. Ten groups and plots （10 × 10 m） were randomly established in group and row planting stand, respectively. The survival rate, stability （height to diameter ratio）, diameter, and height growth were significantly higher in group planting. In the group plantings,40.5% of cherry trees had straight stems and 13.5% had a monopodial crown compared with 15% with straight stems and 2% with a monopodial crown in row planting. The proportion of dominant cherry trees in canopy was 49% in groups compared with 22% in rows. The length of branch free bole was significantly higher in cherries planted in groups than those grown in rows. Intra- and interspecific competition reduced the growth and stability of cherry trees in row planting, but not in group planting. Light availability did not cause any significant effects on growth and quality between group and row planting. This first study on cherry group planting indicates that the survival rate, growth, and tree quality were higher in groups than in rows at this early development stage. The competition by naturally born seedlings was an important reason for the difference in performance between group and row planting. This study will encourage forest practitioners to establish more cherry group planting trials on multiple sites to test the effectiveness of this alternative technique as a tool of regeneration and restoration silviculture.

Close Coupled Showerhead Reactors for the Growth of Group Ⅲ Nitrides

The group Ⅲ nitrides are an important class of materials with aplications in UV and visible optoelectronics,high temperature electronics,cold cathodes and solar blind detectors.In recent years,with the realisation of nitride based LEDs,the use of GaN IED has the potential to compete with 1raditional filament and discharge lamps,for the provision of white lighting,and there has been an explosion of interest in the MOCVD growth of GaN based materials with an increasing focus on large area multiwafer reactors and wafer uniforrmity.This paper will review the design philosophy and characteristics of close-coupled showerhead reactors,relating these to the requirements of group Ⅲ-nitride growth,and will present a selection of data resulting from the operation of such equipment.These results suggest that the close coupled showerhead style of reactor is very suitable for the growth of GaN based structures in both research and production environments.

Oerlikon Group Growth momentum continued in all businesses–guidance raised for full-year

"We are pleased to announce another quarter of profitable growth,"said Dr.Roland Fischer,CEO of Oerlikon Group."Our positive performance confirms that our strategy addresses attractive markets,our initiatives and activities are delivering positive results,and we are able to take advantage of the growth momentum and opportunities in our end markets.Consequently,we are in a position to increase our full-year expectations for the second time this year."

Effectiveness of Post-Traumatic Growth Intervention to Promote Positive Post-Traumatic Traits in Chinese Breast Cancer Patients:A Randomized Controlled Trial

Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomized control trial of a psychological group intervention based on PTG model.Methods:The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264.A total of 92 patients with breast cancer were recruited.The participants were randomly assigned to the experimental group(n=46)and the control group(n=46).A six-session psychological group intervention based on PTG model was implemented in the experimental group,and a six-session health education was implemented in the control group.The outcomes weremeasured at baseline(pre-intervention),3 weeks,6 weeks after the intervention.The primary outcome was posttraumatic growth assessed by the Chinese version of the Post-Traumatic Growth Inventory(PTGI);Secondary outcomes included psychological resilience,family resilience,rumination,and self-disclosure.Results:A total of 87 patients with breast cancer completed this study,including 44 patients in the experimental group and 43 patients in the control group.There was no significant difference in baseline data of breast cancer patients between the two groups except for the treatment regimen(p>0.05).The two groups were compared after the intervention;the interaction effects between the total scores of posttraumatic growth,family resilience,and self-disclosure and the time term were statistically significant(p<0.05),indicating that the trend of change in total scores of post-traumatic growth,family resilience,and self-disclosure differed between the experimental and control groups over time,and the scores improved in the experimental group were significantly higher than those in the control group.The comparison of psychological resilience and total score of rumination at each time point was statistically significant(p<0.05),indicating that group intervention based on the PTG model could improve the psychological recovery ability and rumination level of the experimental group.Conclusion:The psychological group intervention based on the PTG model significantly improved post-traumatic growth,family resilience,and self-disclosure in patients with breast cancer.However,the impact on psychological resilience and rumination was relatively small.Long-term intervention is needed to further test the effect of the PTG model on psychological resilience and rumination.

短程焦点解决团体疗法对脑瘫患儿父母创伤后成长体验病耻感及照顾能力的影响

目的探讨短程焦点解决团体疗法对脑瘫患儿父母创伤后成长体验、病耻感及照顾能力的影响。方法将脑瘫患儿的81名父母按照随机数字表法分为研究组(40名)和对照组(41名)。对照组患儿父母给予常规心理护理,研究组患儿父母在对照组基础上给予短程焦点解决团体疗法,观察3周。比较干预前后两组患儿父母焦虑自评量表(SAS)、抑郁自评量表(SDS)、创伤后成长量表(PTGI)、连带病耻感量表(ASS)、家属照顾者照顾能力量表(FCTI)评分及护理满意度。结果干预后两组患儿父母SAS评分、SDS评分、ASS各维度评分、FCTI各维度评分均较干预前降低,研究组患儿父母低于对照组(P<0.01)。干预后两组患儿父母PTGI各维度评分均较干预前升高,研究组患儿父母高于对照组(P<0.01)。研究组患儿父母护理总满意度高于对照组(P<0.05)。结论短程焦点解决团体疗法能缓解脑瘫患儿的父母焦虑、抑郁情绪,减轻其病耻感,促进其创伤后成长,提升其照顾能力,有利于提高护理满意度。

积极心理干预对中学生创伤后成长的影响

对经历过重大校园危机事件的中学生开展积极心理干预团体辅导干预的实验研究,结果表明,实施积极心理干预能够提高中学生创伤后成长水平,传统心理干预中蕴含着积极趋向与积极价值,可以在一定程度上提高中学生创伤后成长水平。为提高中学生的心理健康水平,学校要重视学生心理健康教育,坚持积极心理干预与传统心理干预相结合,并推广以班级为单位的积极心理干预团体辅导活动。

我国中等收入群体的成长机制及其区域差异

二十大报告指出:“中国式现代化是全体人民共同富裕的现代化。”扩大中等收入群体是实现全体人民共同富裕的重要途径。本文首先在理论上从需求侧和供给侧两端建构了推动中等收入群体成长的机制框架,接着使用CGSS2010—2021年调查数据,对不同地区中等收入群体的成长过程与成长机制进行了系统分析。研究发现,在不同地区,中等收入群体的整体成长以及中等收入群体内部结构变化都不一样;经济发展未必一定推动中等收入群体的成长,收入再分配政策与经济结构升级也发挥着重要作用。本文强调,要想有效扩大中等收入群体,必须加强有关具体政策效果的实证分析。

基于人才培养的职教集团高质量发展途径探索——以湖北省国防科技工业职业教育集团建设为例

职业教育集团化办学经过30多年的发展,行业或区域特征日益明显,推动了我国职业教育发展,使产教融合、校企合作的概念更加具体化,但与此同时,机制建设、文化认同、利益链构建等方面的困难也影响着职教集团的有效运行。职教集团需要以推动行业企业高质量发展为主题,以产教融合为主线,构建运行机制,搭建产教融合平台,打造行业文化、企业文化、校园文化“三化融合”的文化共同体,多方联动,深化校企合作,不断完善行业人才培养体系。

Analysis on Characters and Growth Factors of academicians of Agriculture Faculty of Chinese Academy of Engineering

The research analyzed birthplace, work site and Work unit, discipline, agri- cultural product variety, current age, and selected age, as well as internal and exter- nal factors for growth, which providers references for exploring development of high- level agricultural S＆T talents and formulation of relevant policies.

三种轨迹分析方法的比较研究

目的介绍几种常见的轨迹分析方法,并对其使用效果和适用条件进行比较。方法在模拟实验中对不同轨迹分析方法在各种情境下的效果以及适用条件进行比较研究,并在实例分析中进行验证。结果增长混合模型(growth mixture modeling,GMM)在单轨迹分析中表现最好,基于群体的轨迹模型(group-based trajectory modeling,GBTM)总体表现较好且可以拓展对多轨迹进行研究,聚类分析表现尚可且能分析多轨迹,但对随访数据质量要求较高。结论三种方法各有其优点,可根据分析数据的具体情况选择合适的方法。

财政资金支持与低收入群体持续增收

促进欠发达地区农民持续增收是实现乡村全面振兴的经济基础。本文基于2006—2019年县级面板数据,以脱贫县农民为研究对象,使用合成控制法评估财政资金支持力度下降后欠发达地区低收入群体的收入增长情况及地区异质性。研究发现:与合成县相比,约35.48%的县的农民收入增长幅度上升,约45.16%的县下降,约19.36%的县基本无差异。财政收入端和支出端的共同挤压使得地方政府财政支出压力增大,进一步对地方政府整体财政支出产生约束,进而对不同自我发展能力的地区产生异质性影响。进一步分析表明,产业结构优化与基础设施建设提升了欠发达地区的自我发展能力,为低收入群体持续增收提供了原动力。

燕辽裂陷槽基底陆壳生长事件——来自长城系碎屑锆石U-Pb年龄和Lu—Hf同位素的启示

华北克拉通大陆地壳生长已有大量研究,但对于被巨厚沉积盖层覆盖的燕辽裂陷槽基底地壳生长的问题前人讨论较少。笔者等以燕辽裂陷槽基底之上的长城系沉积岩为研究对象,统计了燕辽裂陷槽内长城系地层中碎屑锆石年龄频谱和Lu—Hf同位素数据,探讨长城系地层沉积年龄、碎屑锆石沉积源区和地壳生长事件等科学问题。同位素年龄将燕辽裂陷槽长城系沉积年龄约束为1680 Ma,代表着燕辽裂陷槽的开启时间。燕辽裂陷槽长城系碎屑锆石年龄频谱主要显示为2.7~2.5 Ga和2.2~1.9 Ga两个阶段,Hf同位素ε_(Hf)(t)表现为高的正值区间0.1~34.6。通过对比长城系碎屑锆石与华北克拉通结晶基底的U-Pb定年、Lu—Hf同位素ε_(Hf)(t)和T_(DM2)模式年龄数据,推测燕辽裂陷槽长城系沉积物源为燕辽裂陷槽下伏基底。结合碎屑锆石U-Pb定年、ε_(Hf)(t)值和T_(DM2)模式年龄数据,我们认为燕辽裂陷槽下伏基底中元古代前地壳生长有3个峰值,分别为2.7~2.5 Ga,2.2~1.9 Ga和1.7~1.6 Ga。

前置胎盘合并胎盘植入组织中HMGB1蛋白、EphA5蛋白、VEGF表达水平及临床意义

目的探讨前置胎盘合并胎盘植入组织中高迁移率族蛋白B1(HMGB1)蛋白、促红细胞生成素产生肝细胞受体A5(EphA5)蛋白、血管内皮生长因子(VEGF)表达水平及临床意义。方法回顾性选取2021年1月至2023年12月衡水市第二人民医院收治的前置胎盘合并胎盘植入患者60例作为病例组,并选取同期健康产妇60名作为对照组,比较两组临床资料(年龄、体重指数、孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置)及胎盘组织中HMGB1蛋白、EphA5蛋白、VEGF表达水平,并对前置胎盘合并胎盘植入的危险因素进行多因素Logistic回归分析,同时采用受试者工作特征(ROC)曲线分析HMGB1蛋白、EphA5蛋白、VEGF对前置胎盘合并胎盘植入的预测价值。结果病例组患者年龄、体重指数与对照组比较,差异均无统计学意义(P>0.05);病例组患者孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置与对照组比较,差异均有统计学意义(P<0.05)。病例组患者胎盘组织HMGB1蛋白、VEGF水平分别为1.35±0.34、0.90±0.24,均高于对照组(1.12±0.36、0.60±0.19),胎盘组织EphA5蛋白水平为0.75±0.26,低于对照组(2.05±0.66),差异均有统计学意义(P<0.05)。经二元Logistic回归分析显示,孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置、HMGB1蛋白、EphA5蛋白、VEGF均是前置胎盘合并胎盘植入的独立影响因素(P<0.05)。ROC曲线分析显示,胎盘组织HMGB1蛋白、EphA5蛋白、VEGF、三者联合预测前置胎盘合并胎盘植入的曲线下面积(AUC)分别为0.817、0.814、0.764、0.956,且三者联合的敏感度为78.30%,特异度为100.00%。结论前置胎盘合并胎盘植入组织中可见HMGB1蛋白、VEGF表达升高,EphA5蛋白表达降低,前置胎盘合并胎盘植入影响因素较多,而胎盘组织HMGB1蛋白、EphA5蛋白、VEGF是前置胎盘合并胎盘植入的危险因素,3种指标联合对前置胎盘合并胎盘植入具有较高的预测价值。

基于横断面调查的支气管哮喘中医证候客观化因素分析

目的:筛选支气管哮喘(简称哮喘)中医证候相关临床因素及生物学标志物,为中医证候客观化研究提供参考。方法:采用横断面临床调查方法,选取河南中医药大学第一附属医院呼吸科门诊及住院收治的哮喘患者390例作为研究对象,收集临床特征并检测相关血清生物标志物。SPSS 23.0建立数据库,采用单因素分析、Logistic回归分析、Spearman相关分析方法,3种方法中2种具有统计学意义的被筛选为相关因素。结果:共招募390例患者,分析资料相对完整的293例数据。外寒内饮证与年龄、哮喘控制测试(ACT)评分相关,痰浊阻肺证与性别、吸烟史、血清高迁移率族蛋白B1(HMGB1)、血清嗜酸粒细胞趋化蛋白(Eotaxin)相关,风痰阻肺证与年龄、ACT评分相关,肺气虚证与ACT评分、血清HMGB1、血清γ干扰素(IFN-γ)、血清骨膜蛋白(Periostin)相关,脾气虚证与ACT评分相关,肾气虚证与血清IFN-γ相关,肾阳虚证与血清转化生长因子-β_(2)(TGF-β_(2))、血清肿瘤坏死因子α(TNF-α)相关,肺脾气虚证与ACT评分相关,肺肾气虚证与年龄、ACT评分、病程相关,肺肾阳虚证与民族、ACT评分、血清白细胞介素-4(IL-4)具有相关性(P<0.05)。结论:血清HMGB1、Eotaxin、IFN-γ、Periostin、TGF-β_(2)、TNF-α、IL-4可能是哮喘中医证候潜在的生物标志物。性别、年龄、民族、吸烟史、病程、ACT评分与哮喘证候存在一定相关性,但研究结论有待于进一步全国多中心研究进行验证。