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Acute myocardial necrosis caused by aconitine poisoning:A case report 被引量:1
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作者 Yu-Ping Liao Li-Han Shen +2 位作者 Li-Hua Cai Jie Chen Han-Quan Shao 《World Journal of Clinical Cases》 SCIE 2022年第33期12416-12421,共6页
BACKGROUND Herbal medicine has a long history of use in the prevention and treatment of disease and is becoming increasingly popular globally.However,there are also widespread concerns about its safety.Among them,the ... BACKGROUND Herbal medicine has a long history of use in the prevention and treatment of disease and is becoming increasingly popular globally.However,there are also widespread concerns about its safety.Among them,the cardiotoxicity of aconitine has been described.CASE SUMMARY We report a case of a 61-year-old male with aconitine poisoning presenting with malignant arrhythmia and severe cardiogenic shock,which was successfully managed with aggressive advanced life support and heart transplantation.CONCLUSION This is the first case wherein in vivo cardiac pathology was obtained,confirming that aconitine caused acute myocardial necrosis. 展开更多
关键词 ACONITINE ECMO myocardial necrosis Ventricular arrhythmia Herbal medicine Case report
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Nigella sativa protects against isoproterenol-induced myocardial infarction by alleviating oxidative stress,biochemical alterations and histological damage 被引量:5
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作者 Md.Quamrul Hassan Mohd.Akhtar +2 位作者 Sayeed Ahmed Aftab Ahmad Abul Kalam Najmi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2017年第4期294-299,共6页
Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EEN... Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EENS)and N.sativa oil alone and along with enalapril for 28 days.MI was induced by subcutaneous administration of isoproterenol(85 mg/kg) in two consecutive doses.Levels of cardiac biomarkers and antioxidant enzymes such as creatine kinase–N-acetyl-L-cysteine, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were evaluated along with gross histopathological examination.Results: Isoproterenol(85 mg/kg) induced MI by causing the significant(P < 0.01)reduction in the activity of cardiac biomarkers(creatine kinase–N-acetyl-L-cysteine,lactate dehydrogenase, aspartate aminotransferase) and antioxidant markers(superoxide dismutase, catalase, glutathione) along with significant(P < 0.01) increase in the level of malondialdehyde.Furthermore, histopathological evaluation also confirmed the isoproterenol-induced MI.Pretreatment with EENS(800 mg/kg) and combination of EENS(800 mg/kg) with enalapril(1 mg/kg) significantly(P < 0.01) prevented the development of these alteration and restored activity of cardiac biomarkers as well as antioxidant markers almost near to normal levels.Histopathological evaluation of cardiac tissue further confirmed the restoration of biochemical activity.Conclusions: Experimental findings thus indicate that EENS(800 mg/kg) demonstrated cardioprotective effect against isoproterenol-induced MI by restoring cardiac biomarkers and antioxidant status. 展开更多
关键词 Antioxidant ISOPROTERENOL myocardial necrosis Nigella sativa Oxidative stress
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Dynamic Observation of Heart Ultrastructure on Hypertensive Diabetic Rat
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作者 Yao Ronfer,et al.(ACTA ACADEMIAE MEDICINAN NANJING 1994,14(1): 30-34) 《The Journal of Biomedical Research》 CAS 1994年第1期21-21,共1页
An experimental model of hypertensive diabetes in SD rats was established. Eight animalsin each group were respectively killed at the end of the sixth, eithg and tenth month of the experimentalperiod. The heart change... An experimental model of hypertensive diabetes in SD rats was established. Eight animalsin each group were respectively killed at the end of the sixth, eithg and tenth month of the experimentalperiod. The heart changes were dynamically observed under light microscope and transmissive electronmicroscope. The arteriolar walls were thickened with lumina narrowed. Degeneration, necrosis andfibrosis (substitutional and interstitial) of the myocardium were found also.Adiscussion is given on morphological pathgenesis of dilatod cardiomyopathy. 展开更多
关键词 hypertensive diabetes cardiomyopathy ultrastructure myocardial necrosis tibrosis RAT
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A Study on the Diagnostic Standard of Sinus Rhythm
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作者 Yao Ronfer,et al. 《The Journal of Biomedical Research》 CAS 1995年第1期28-28,共1页
An experimental model of hypertensive diabetes in SD rats was established. Eight animalsin each group were respectively killed at the end of the sixth, eithg and tenth month of the experimentalperiod. The heart change... An experimental model of hypertensive diabetes in SD rats was established. Eight animalsin each group were respectively killed at the end of the sixth, eithg and tenth month of the experimentalperiod. The heart changes were dynamically observed under light microscope and transmissive electronmicroscope. The arteriolar walls were thickened with lumina narrowed. Degeneration, necrosis andfibrosis (substitutional and interstitial) of the myocardium were found also.Adiscussion is given on morphological pathgenesis of dilatod cardiomyopathy. 展开更多
关键词 hypertensive diabetes cardiomyopathy ultrastructure myocardial necrosis tibrosis RAT
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