The title compound （R）-N′-[2-（4-methoxy-6-chloro）-pyrimidyl]-N-[3-methyl-2-（4- chlorophenyl）butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic ...The title compound （R）-N′-[2-（4-methoxy-6-chloro）-pyrimidyl]-N-[3-methyl-2-（4- chlorophenyl）butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic data： C17H18C12N4O3, Mr = 397.25, monoclinic, space group P21/c, a = 12.331（2）, b = 14.025（3）, c = 23.085（5） A, β = 99.607（4）°, Z = 8, V = 3936.2（13） A3, Dc = 1.341 g/cm^3, F（000） = 1648, R = 0.0718, wR = 0.1585 and/t（MoKα） = 0.353 mm^-1. The preliminary biological tests showed that the title compound has definite insecticidal and fungicidal activities.展开更多
A novel fluorescent probe,6-（N,N-dimethylamino）-2-naphthoylacryl acid（ACADAN） was designed and synthesized as a fluorescent sensor for Cu^2＋ in aqueous media.Significant amplification of fluorescence signals with...A novel fluorescent probe,6-（N,N-dimethylamino）-2-naphthoylacryl acid（ACADAN） was designed and synthesized as a fluorescent sensor for Cu^2＋ in aqueous media.Significant amplification of fluorescence signals without causing any discernible change of maximum fluorescence emission wavelength（λ max） was observed upon the addition of Cu^2＋.Importantly,ACADAN is capable of recognizing Cu^2＋ selectively in aqueous media in the presence of various biologically relevant metal ions and the prevalent toxic metal ions in the environment with high sensitivity（detection limit was 0.1 μmol/L）.展开更多
The polargraphic behavior of Bi(Ⅲ)-NOTP complex has been investigated inaqueous solution. It was found that under the conditions of pH 3.0 and of 0.02 mol/L NH_4Cl, theBi(Ⅲ)-NOTP system gives a sensitive second orde...The polargraphic behavior of Bi(Ⅲ)-NOTP complex has been investigated inaqueous solution. It was found that under the conditions of pH 3.0 and of 0.02 mol/L NH_4Cl, theBi(Ⅲ)-NOTP system gives a sensitive second order derivative wave at -0.340 V(vs SCE), which isproved to be an adsorptive complex wave. The composition of the complex is Bi(Ⅲ):NOTP. Furthermore,the peak current is linear to the concentration of Bi(Ⅲ) in the range from 3.0x10^(-8) to5.0x10^(-6) mol/L. Artificial and practical samples have been detected with high sensitivity andreceptivity.展开更多
Dietary omega-3 (n - 3) polyunsaturated fatty acids (PUFA) are recommended by public health organizations to reduce the risk of cardiovascular disease, and several epidemiological studies have suggested there is an in...Dietary omega-3 (n - 3) polyunsaturated fatty acids (PUFA) are recommended by public health organizations to reduce the risk of cardiovascular disease, and several epidemiological studies have suggested there is an inverse association between n - 3 intake and human cancers. However, n - 3 are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from a mixture of n - 3 (with 5.36 g α-linolenic acid and 1.45 g eicosapentaenoic acid and docosahexaenoic acid per 2000 kcal per day), we measured total in vivo lipid peroxidation in healthy postmenopausal women (n = 15). Our results indicated that the diet with 3% of energy from n - 3 significantly increased the urinary concentrations of total polar lipophilic aldehydes and related compounds produced via lipid peroxidation (p α, β-unsaturated hydroxy aldehydes 4-hydroxy-2-trans - hexenal (p trans -decenal (p < 0.05) compared to the diet with less than 1% of energy from n - 3. This is also the first study to document the presence of 4-hydroxy-2-trans -decenal in the urine of individuals consuming n - 3. These results demonstrate that an increase in 3% of energy from dietary n – 3 increases in vivo lipid peroxidation.展开更多
利用实验室筛选得到的高立体选择性脂肪酶产生菌株溜曲霉(Aspergillus tamarii WYC3)不对称水解拆分N-BOC-DL-α-氨基丁酸甲酯得到N-BOC-L-α-氨基丁酸,对其反应条件进行研究,确定其最优反应条件为:0.1 mol/L p H 7.2的磷酸钾缓冲液,反...利用实验室筛选得到的高立体选择性脂肪酶产生菌株溜曲霉(Aspergillus tamarii WYC3)不对称水解拆分N-BOC-DL-α-氨基丁酸甲酯得到N-BOC-L-α-氨基丁酸,对其反应条件进行研究,确定其最优反应条件为:0.1 mol/L p H 7.2的磷酸钾缓冲液,反应温度30℃,底物浓度52.24 mmol/L,0.1 g菌粉,V(底物)∶V(丙酮)=1∶8,200 r/min恒温水浴反应6 h,可获得产物N-BOC-L-α-氨基丁酸,此时e.e._(s)值达到99.95%,对映体选择率E值为20.11,产率为36.21%。展开更多
In order to improve the toughness of the cured aromatic tetrafunctional epoxy resins, a dlmer rarboxylic acid named dlmer fatty acid （DFA） was used to modify an aromatic tetrafunctional epoxy, N, N, N＇, N＇-tetragl...In order to improve the toughness of the cured aromatic tetrafunctional epoxy resins, a dlmer rarboxylic acid named dlmer fatty acid （DFA） was used to modify an aromatic tetrafunctional epoxy, N, N, N＇, N＇-tetraglycidyl-2,2-bis [ 4-（ 4-aminophcuoxy ） phenyl ] propane （TGBAPP）. The curing behaviors of DFA- TGBAPP/MNA （ methyl nadic anhydride） systems were studied by differential scanning calorimetry （DSC） method. And the thermal properties of the cured epoxy resin were investigated with the thermo-gravimetric analysis （TGA） and dynamic mechanical analysis （DMA）. Besides, the toughness was characterized with the impact strength tested by charpy impact testing. The results indicated that the modification would improve the curing reactions, and the curing temperatures were decreased with the increasing content of DFA. The thermal properties were not influenced obviously, and the toughness could be improved when the epoxy resin was modified with DFA.展开更多
（S）-2-aminobutyric acid being initial raw material,（S）-2-hydroxybutyric acid methyl ester was synthesized by means of a three step reaction of hydroxylation, salification and esterification. The product had a yiel...（S）-2-aminobutyric acid being initial raw material,（S）-2-hydroxybutyric acid methyl ester was synthesized by means of a three step reaction of hydroxylation, salification and esterification. The product had a yield rate of 60.4%, purity of 99% and ee value higher than 99% by characterization of GC, HPLC and 1H NMR. This synthesis technique has advantages of high purity and ee value, low cost, short reaction time and mild reaction conditions so that it is suitable for production on industrial scale.展开更多
Biogenic amines are known to have various biological functions such as not only neurotransmitter and cell proliferation but also food poisoning. Bacterially-decomposed amines such as histamine, agmatine, putrescine, c...Biogenic amines are known to have various biological functions such as not only neurotransmitter and cell proliferation but also food poisoning. Bacterially-decomposed amines such as histamine, agmatine, putrescine, cadaverine, spermidine and spermine cause allergic symptoms. We developed simple method for measurement of polyamine as indicator of food decomposition with a fluorometer by using 4-(1-Pyrene)butyric acid N-hydroxysuccinimide ester (PSE). PSE reacts with primary and secondary amino moieties of polyamines and produces the intramolecular excimer fluorescence. Excimer fluorescence with broad peak at around 470 nm was clearly detected in linear type biogenic amines such as putrescine, cadaverine, spermidine and spermine at 10 mM. However neither histamine nor trimethylamine altered the fluorescence. Decomposed sardine and mackerel by improper storage showed stronger intensity than fresh ones. Comparing with OPA-method, PSE method was useful for screening biogenic amines present in food, esp. fish since the analysis was simple after one-step purification procedure. An inexpensive system which can rapidly detect biogenic amines from food is necessary in a medium and small-sized food business. The technique using excimer has potential to realize the high through-put screening system for evaluation of food freshness and is expected to bring the public interests such as food security and safety of consumer.展开更多
基金This work was sponsored by the National Key Technologies R & D Programs (No. 2004BA308A22-8)
文摘The title compound （R）-N′-[2-（4-methoxy-6-chloro）-pyrimidyl]-N-[3-methyl-2-（4- chlorophenyl）butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic data： C17H18C12N4O3, Mr = 397.25, monoclinic, space group P21/c, a = 12.331（2）, b = 14.025（3）, c = 23.085（5） A, β = 99.607（4）°, Z = 8, V = 3936.2（13） A3, Dc = 1.341 g/cm^3, F（000） = 1648, R = 0.0718, wR = 0.1585 and/t（MoKα） = 0.353 mm^-1. The preliminary biological tests showed that the title compound has definite insecticidal and fungicidal activities.
基金Supported by the National Natural Science Foundation of China(Nos.30672560,81172982)the Accented Project for Natural Scientific Research of Universities in Guangdong Province,China(No.05Z012)
文摘A novel fluorescent probe,6-（N,N-dimethylamino）-2-naphthoylacryl acid（ACADAN） was designed and synthesized as a fluorescent sensor for Cu^2＋ in aqueous media.Significant amplification of fluorescence signals without causing any discernible change of maximum fluorescence emission wavelength（λ max） was observed upon the addition of Cu^2＋.Importantly,ACADAN is capable of recognizing Cu^2＋ selectively in aqueous media in the presence of various biologically relevant metal ions and the prevalent toxic metal ions in the environment with high sensitivity（detection limit was 0.1 μmol/L）.
基金This project is financially supported by the National Natural Science Foundation of China (No.29575207) KJCXGC-01 of Northwest Normal University
文摘The polargraphic behavior of Bi(Ⅲ)-NOTP complex has been investigated inaqueous solution. It was found that under the conditions of pH 3.0 and of 0.02 mol/L NH_4Cl, theBi(Ⅲ)-NOTP system gives a sensitive second order derivative wave at -0.340 V(vs SCE), which isproved to be an adsorptive complex wave. The composition of the complex is Bi(Ⅲ):NOTP. Furthermore,the peak current is linear to the concentration of Bi(Ⅲ) in the range from 3.0x10^(-8) to5.0x10^(-6) mol/L. Artificial and practical samples have been detected with high sensitivity andreceptivity.
文摘Dietary omega-3 (n - 3) polyunsaturated fatty acids (PUFA) are recommended by public health organizations to reduce the risk of cardiovascular disease, and several epidemiological studies have suggested there is an inverse association between n - 3 intake and human cancers. However, n - 3 are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from a mixture of n - 3 (with 5.36 g α-linolenic acid and 1.45 g eicosapentaenoic acid and docosahexaenoic acid per 2000 kcal per day), we measured total in vivo lipid peroxidation in healthy postmenopausal women (n = 15). Our results indicated that the diet with 3% of energy from n - 3 significantly increased the urinary concentrations of total polar lipophilic aldehydes and related compounds produced via lipid peroxidation (p α, β-unsaturated hydroxy aldehydes 4-hydroxy-2-trans - hexenal (p trans -decenal (p < 0.05) compared to the diet with less than 1% of energy from n - 3. This is also the first study to document the presence of 4-hydroxy-2-trans -decenal in the urine of individuals consuming n - 3. These results demonstrate that an increase in 3% of energy from dietary n – 3 increases in vivo lipid peroxidation.
基金Shanghai Leading Academic Discipline Project,China(No.s30107)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning,Chinathe Project of Shanghai Science and Technology Committee,China(No.12520500300)
文摘In order to improve the toughness of the cured aromatic tetrafunctional epoxy resins, a dlmer rarboxylic acid named dlmer fatty acid （DFA） was used to modify an aromatic tetrafunctional epoxy, N, N, N＇, N＇-tetraglycidyl-2,2-bis [ 4-（ 4-aminophcuoxy ） phenyl ] propane （TGBAPP）. The curing behaviors of DFA- TGBAPP/MNA （ methyl nadic anhydride） systems were studied by differential scanning calorimetry （DSC） method. And the thermal properties of the cured epoxy resin were investigated with the thermo-gravimetric analysis （TGA） and dynamic mechanical analysis （DMA）. Besides, the toughness was characterized with the impact strength tested by charpy impact testing. The results indicated that the modification would improve the curing reactions, and the curing temperatures were decreased with the increasing content of DFA. The thermal properties were not influenced obviously, and the toughness could be improved when the epoxy resin was modified with DFA.
文摘（S）-2-aminobutyric acid being initial raw material,（S）-2-hydroxybutyric acid methyl ester was synthesized by means of a three step reaction of hydroxylation, salification and esterification. The product had a yield rate of 60.4%, purity of 99% and ee value higher than 99% by characterization of GC, HPLC and 1H NMR. This synthesis technique has advantages of high purity and ee value, low cost, short reaction time and mild reaction conditions so that it is suitable for production on industrial scale.
文摘Biogenic amines are known to have various biological functions such as not only neurotransmitter and cell proliferation but also food poisoning. Bacterially-decomposed amines such as histamine, agmatine, putrescine, cadaverine, spermidine and spermine cause allergic symptoms. We developed simple method for measurement of polyamine as indicator of food decomposition with a fluorometer by using 4-(1-Pyrene)butyric acid N-hydroxysuccinimide ester (PSE). PSE reacts with primary and secondary amino moieties of polyamines and produces the intramolecular excimer fluorescence. Excimer fluorescence with broad peak at around 470 nm was clearly detected in linear type biogenic amines such as putrescine, cadaverine, spermidine and spermine at 10 mM. However neither histamine nor trimethylamine altered the fluorescence. Decomposed sardine and mackerel by improper storage showed stronger intensity than fresh ones. Comparing with OPA-method, PSE method was useful for screening biogenic amines present in food, esp. fish since the analysis was simple after one-step purification procedure. An inexpensive system which can rapidly detect biogenic amines from food is necessary in a medium and small-sized food business. The technique using excimer has potential to realize the high through-put screening system for evaluation of food freshness and is expected to bring the public interests such as food security and safety of consumer.
