Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the tre...Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the treatment of cancer-related pain.However,a series of opioid-associated adverse effects including opioid-induced respiratory depression were reported in clinical practice.Here,we reported a unique patient diagnosed with lung cancer,who underwent respiratory depression resulting from oral administration of ten milligram of morphine and was successfully resuscitated by naloxone.A literature review is then performed to analyze this rare condition.展开更多
目的探讨盐酸纳美芬对老年患者腹部手术麻醉后呼吸抑制的影响。方法将156例2015年1月至2016年12月在我院接受腹部手术的老年患者纳入课题研究,分为实验组和对照组两组(n=78),分组方法为随机数字表法。手术结束后实验组患者静脉推注0.25...目的探讨盐酸纳美芬对老年患者腹部手术麻醉后呼吸抑制的影响。方法将156例2015年1月至2016年12月在我院接受腹部手术的老年患者纳入课题研究,分为实验组和对照组两组(n=78),分组方法为随机数字表法。手术结束后实验组患者静脉推注0.25μg/kg盐酸纳美芬;对照组患者静脉推注1μg/kg的盐酸纳洛酮。结果两组患者拔管后5min Ramsay评分和拔管后30 min VAS评分比较,差异无统计学意义,P>0.05;两组患者的不同时间点收缩压、舒张压、平均动脉压以及心率等各项指标的变化均无统计学意义,P>0.05;实验组和对照组患者的拔管时间分别(5.61±0.42)min和(5.73±0.56)min,差异无统计学意义,t=1.514,P>0.05;实验组患者给予拮抗药10 min后呼吸恢复率为96.15%,显著高于对照组的87.18%,P<0.05;两组患者不良反应发生率差异无统计学意义,P>0.05。结论盐酸纳美芬能够有效拮抗老年患者腹部手术麻醉后呼吸抑制。展开更多
文摘Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the treatment of cancer-related pain.However,a series of opioid-associated adverse effects including opioid-induced respiratory depression were reported in clinical practice.Here,we reported a unique patient diagnosed with lung cancer,who underwent respiratory depression resulting from oral administration of ten milligram of morphine and was successfully resuscitated by naloxone.A literature review is then performed to analyze this rare condition.
文摘目的探讨盐酸纳美芬对老年患者腹部手术麻醉后呼吸抑制的影响。方法将156例2015年1月至2016年12月在我院接受腹部手术的老年患者纳入课题研究,分为实验组和对照组两组(n=78),分组方法为随机数字表法。手术结束后实验组患者静脉推注0.25μg/kg盐酸纳美芬;对照组患者静脉推注1μg/kg的盐酸纳洛酮。结果两组患者拔管后5min Ramsay评分和拔管后30 min VAS评分比较,差异无统计学意义,P>0.05;两组患者的不同时间点收缩压、舒张压、平均动脉压以及心率等各项指标的变化均无统计学意义,P>0.05;实验组和对照组患者的拔管时间分别(5.61±0.42)min和(5.73±0.56)min,差异无统计学意义,t=1.514,P>0.05;实验组患者给予拮抗药10 min后呼吸恢复率为96.15%,显著高于对照组的87.18%,P<0.05;两组患者不良反应发生率差异无统计学意义,P>0.05。结论盐酸纳美芬能够有效拮抗老年患者腹部手术麻醉后呼吸抑制。
