The NAN-190 analogue 2-(2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethoxy)ethyl)isoindoline-1,3-dione(1, C23H27N3O4, Mr = 409.48) was synthesized via a three-step reaction and characterized by 1H NMR, 13 C NMR, ESIMS and...The NAN-190 analogue 2-(2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethoxy)ethyl)isoindoline-1,3-dione(1, C23H27N3O4, Mr = 409.48) was synthesized via a three-step reaction and characterized by 1H NMR, 13 C NMR, ESIMS and single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group Pna21 with a = 7.6445(15), b = 38.851(8), c = 7.1316(14) A, V = 2118.0(7) A3, Z = 4, Dc = 1.2840 mg/mm3, μ = 0.089 mm-1, F(000) = 872.4, R = 0.0545 and w R = 0.1681. The single-crystal X-ray structural analysis reveals that the piperazine ring in compound 1 presents a stable and minimum energy chair conformation. In addition, the preliminary cytotoxic assay shows that the title compound exhibits strong and selective inhibitory activity against DU145 cells(IC50 = 5.88 ± 1.02 μM).展开更多
To characterize the Fe(III)-reducing bacteria,enrichment cultures were initiated by inoculating deep-sea sediment from the South China Sea(SCS)into the media with hydrous ferric oxide(HFO)as the sole electron acceptor...To characterize the Fe(III)-reducing bacteria,enrichment cultures were initiated by inoculating deep-sea sediment from the South China Sea(SCS)into the media with hydrous ferric oxide(HFO)as the sole electron acceptor.As indicated by Meta 16S rDNA Amplicon Sequencing,the microorganisms related to Fe(III)-reduction in the enrichment cultures were mainly Shewanella and Enterobacter.A new facultative Fe(III)-reducing bacterium was obtained and identified as Enterobacter sp.Nan-1 based on its 16S rRNA gene sequence and physiological characterizations.Enterobacter sp.Nan-1 was not only a mesophilic bacterium capable of reducing HFO with a wide range of salinity(4,34,40,50 and 60 g L−1)efficiently,but also a piezotolerant bacterium that can proceed Fe(III)-reduction sustainedly at hydrostatic pressures between 0.1 and 50 MPa using glucose and pyruvate as carbon source.Furthermore,the geochemical characteristics of deep-sea sediment indicated that the microbial metabolism and iron reduction both remain active in the well-developed Fe(III)-reducing zone where the strain Nan-1 was obtained.To our knowledge,Enterobacter sp.Nan-1 could serve as a new applicative Fe(III)-reducing bacterium for future investigation on the iron biogeochemical cycle and diagenetic process of organic matter in the deep-sea environment.展开更多
Field investigations and laboratory integrated research as indicated that ophiolite mélange in the Nan-Uttaradit zone, northern Thailand, consists of fragments of tectonites such as metamorphic peridotite (extrem...Field investigations and laboratory integrated research as indicated that ophiolite mélange in the Nan-Uttaradit zone, northern Thailand, consists of fragments of tectonites such as metamorphic peridotite (extremely silicified serpentinite), cumulates (pyroxenolite, gabbro, and gabbro-diorite), ocean-ridge basalt, oceanic-island ba-salt and radiolarian silicalite, and it was formed during D3-P. The rock series, rock types and petrogeochemical characteristics of metamorphic tholeiites in the Nan area of the Nan-Uttaradit zone are similar to those of ocean-ridge basalts (C1) in China's Ailaoshan zone. As for the Hawaiites in the Nan area of the Nan-Uttaradit zone, their major elements, REEs and trace elements are similar to those of oceanic-island basalts in China's Jinshanjiang zone (P11). In the Uttaradit area of this zone the metamorphic alkaline basalts show transitional petrogeochemical characteristics between ocean-ridge basalts and oceanic-island basalts, which were still formed in oceanic-island environments. The above-described basalts are all oceanic volcanic rocks and they are the most important part of the Paleo-Tethys oceanic crust in the Nan-Uttaradit zone.展开更多
Late Permian-Early Triassic(P2-T1) volcanic rocks distributed on the eastern side of ocean-ridge and oceanic-island basalts in the Nan-Uttaradit zone were analyzed from aspects of petrographic characteristics,rock ass...Late Permian-Early Triassic(P2-T1) volcanic rocks distributed on the eastern side of ocean-ridge and oceanic-island basalts in the Nan-Uttaradit zone were analyzed from aspects of petrographic characteristics,rock assemblage,REE,trace elements,geotectonic setting,etc.,indicating that those volcanic rocks possess the characteristic features of island-arc volcanic rocks.The volcanic rock assemblage is basalt-basaltic andesite-andesite.The volcanic rocks are sub-alkaline,dominated by calc-alkaline series,with tholeiite series coming next.The chemical composition of the volcanic rocks is characterized by low TiO2 and K2O and high Al2O3 and Na2O.Their REE patterns are of the flat,weak LREE-enrichment right-inclined type.The trace elements are characterized by the enrichment of large cation elements such as K,Rb and Ba,common enrichment of U and Th,and depletion of Nb,Ta,Zr and Hf.The petrochemical plot falls within the field of volcanic rocks,in consistency with the plot of island-arc volcanic rocks in the Jinsha River zone of China.This island-arc volcanic zone,together with the ocean-ridge/oceanic island type volcanic rocks in the Nan-Uttaradit zone,constitutes the ocean-ridge volcanic rock-island-arc magmatic rock zones which are distributed in pairs,indicating that the oceanic crust of the Nan-Uttaradit zone once was of eastward subduction.This work is of great significance in exploring the evolution of paleo-Tethys in the Nan-Uttaradit zone.展开更多
The Nan-Uttaradit suture is marked by a narrow N-S trending and discontinuous ophiolite belt in northern Thailand. This suture zone is a mélange composed of gabbro, tholeiitic meta- basalt, andesite and radiolari...The Nan-Uttaradit suture is marked by a narrow N-S trending and discontinuous ophiolite belt in northern Thailand. This suture zone is a mélange composed of gabbro, tholeiitic meta- basalt, andesite and radiolarian chert. Samples of gabbro and meta-basalt in the Nan-Uttaradit suture yield zircon U-Pb ages of 311±10 and 316±3 Ma, respectively, interpreted as the crystallization ages of the rocks, suggesting the Nan-Uttaradit Ocean existed in the Late Carboniferous. Our results indicate that the Nan-Uttaradit Ocean co-existed with the Ailaoshan-Jinshajiang Ocean to the north and was probably an along-strike extension of the latter.展开更多
基金supported by the Technological Innovation Project of Colleges and Universities in Guangdong Province(No.cx2d1127)the China Postdoctoral Science Foundation(Nos.2013M542165 and 2013M531837)+1 种基金the Guangzhou Postdoctoral Scientific Research Foundation(Nos.Q130 and Q074)the Natural Science Foundation of Guangdong Province(No.S2013040014088)
文摘The NAN-190 analogue 2-(2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethoxy)ethyl)isoindoline-1,3-dione(1, C23H27N3O4, Mr = 409.48) was synthesized via a three-step reaction and characterized by 1H NMR, 13 C NMR, ESIMS and single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group Pna21 with a = 7.6445(15), b = 38.851(8), c = 7.1316(14) A, V = 2118.0(7) A3, Z = 4, Dc = 1.2840 mg/mm3, μ = 0.089 mm-1, F(000) = 872.4, R = 0.0545 and w R = 0.1681. The single-crystal X-ray structural analysis reveals that the piperazine ring in compound 1 presents a stable and minimum energy chair conformation. In addition, the preliminary cytotoxic assay shows that the title compound exhibits strong and selective inhibitory activity against DU145 cells(IC50 = 5.88 ± 1.02 μM).
基金the financial support by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB06020000)the Zhejiang Geological Prospecting Bureau Science Projects(No.201713)the Geological Fund of Zhejiang Province(No.20150012).
文摘To characterize the Fe(III)-reducing bacteria,enrichment cultures were initiated by inoculating deep-sea sediment from the South China Sea(SCS)into the media with hydrous ferric oxide(HFO)as the sole electron acceptor.As indicated by Meta 16S rDNA Amplicon Sequencing,the microorganisms related to Fe(III)-reduction in the enrichment cultures were mainly Shewanella and Enterobacter.A new facultative Fe(III)-reducing bacterium was obtained and identified as Enterobacter sp.Nan-1 based on its 16S rRNA gene sequence and physiological characterizations.Enterobacter sp.Nan-1 was not only a mesophilic bacterium capable of reducing HFO with a wide range of salinity(4,34,40,50 and 60 g L−1)efficiently,but also a piezotolerant bacterium that can proceed Fe(III)-reduction sustainedly at hydrostatic pressures between 0.1 and 50 MPa using glucose and pyruvate as carbon source.Furthermore,the geochemical characteristics of deep-sea sediment indicated that the microbial metabolism and iron reduction both remain active in the well-developed Fe(III)-reducing zone where the strain Nan-1 was obtained.To our knowledge,Enterobacter sp.Nan-1 could serve as a new applicative Fe(III)-reducing bacterium for future investigation on the iron biogeochemical cycle and diagenetic process of organic matter in the deep-sea environment.
基金by the National Natural Science Foundation of China(Grant Nos. 40372105 and 40772143)
文摘Field investigations and laboratory integrated research as indicated that ophiolite mélange in the Nan-Uttaradit zone, northern Thailand, consists of fragments of tectonites such as metamorphic peridotite (extremely silicified serpentinite), cumulates (pyroxenolite, gabbro, and gabbro-diorite), ocean-ridge basalt, oceanic-island ba-salt and radiolarian silicalite, and it was formed during D3-P. The rock series, rock types and petrogeochemical characteristics of metamorphic tholeiites in the Nan area of the Nan-Uttaradit zone are similar to those of ocean-ridge basalts (C1) in China's Ailaoshan zone. As for the Hawaiites in the Nan area of the Nan-Uttaradit zone, their major elements, REEs and trace elements are similar to those of oceanic-island basalts in China's Jinshanjiang zone (P11). In the Uttaradit area of this zone the metamorphic alkaline basalts show transitional petrogeochemical characteristics between ocean-ridge basalts and oceanic-island basalts, which were still formed in oceanic-island environments. The above-described basalts are all oceanic volcanic rocks and they are the most important part of the Paleo-Tethys oceanic crust in the Nan-Uttaradit zone.
基金the National Natural Science Foundation of China (Grant Nos. 40372105 and 40772143)
文摘Late Permian-Early Triassic(P2-T1) volcanic rocks distributed on the eastern side of ocean-ridge and oceanic-island basalts in the Nan-Uttaradit zone were analyzed from aspects of petrographic characteristics,rock assemblage,REE,trace elements,geotectonic setting,etc.,indicating that those volcanic rocks possess the characteristic features of island-arc volcanic rocks.The volcanic rock assemblage is basalt-basaltic andesite-andesite.The volcanic rocks are sub-alkaline,dominated by calc-alkaline series,with tholeiite series coming next.The chemical composition of the volcanic rocks is characterized by low TiO2 and K2O and high Al2O3 and Na2O.Their REE patterns are of the flat,weak LREE-enrichment right-inclined type.The trace elements are characterized by the enrichment of large cation elements such as K,Rb and Ba,common enrichment of U and Th,and depletion of Nb,Ta,Zr and Hf.The petrochemical plot falls within the field of volcanic rocks,in consistency with the plot of island-arc volcanic rocks in the Jinsha River zone of China.This island-arc volcanic zone,together with the ocean-ridge/oceanic island type volcanic rocks in the Nan-Uttaradit zone,constitutes the ocean-ridge volcanic rock-island-arc magmatic rock zones which are distributed in pairs,indicating that the oceanic crust of the Nan-Uttaradit zone once was of eastward subduction.This work is of great significance in exploring the evolution of paleo-Tethys in the Nan-Uttaradit zone.
基金supported by the National Natural Science Foundation of China(Nos.41172202,41190073,41302178)the China Geological Survey(No.1212011121256)the State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences in Wuhan(No.MSFGPMR201402)
文摘The Nan-Uttaradit suture is marked by a narrow N-S trending and discontinuous ophiolite belt in northern Thailand. This suture zone is a mélange composed of gabbro, tholeiitic meta- basalt, andesite and radiolarian chert. Samples of gabbro and meta-basalt in the Nan-Uttaradit suture yield zircon U-Pb ages of 311±10 and 316±3 Ma, respectively, interpreted as the crystallization ages of the rocks, suggesting the Nan-Uttaradit Ocean existed in the Late Carboniferous. Our results indicate that the Nan-Uttaradit Ocean co-existed with the Ailaoshan-Jinshajiang Ocean to the north and was probably an along-strike extension of the latter.