Hierarchical layered structures,whether in a compact form like nacre or a porous manner like bone,are well known for their combined features of high stiffness,strength,and lightweight,inspiring many man-made materials...Hierarchical layered structures,whether in a compact form like nacre or a porous manner like bone,are well known for their combined features of high stiffness,strength,and lightweight,inspiring many man-made materials and structures for high performance applications.The use of nacre/bone like hierarchical structures in polymer nanocomposites can achieve excellent mechanical and functional properties with high filler volume fractions after carefully aligning functional nanofillers,although the fabrication and processing remain a great challenge.In this work,a bio-inspired lightweight nano-cellular epoxy/graphene-Fe_(3)O_(4) nanocomposite with high nanofiller loading of 75 wt.%was successfully fabricated by combining features from both nacre and bone structures,via a simple compression molding process together with an eco-friendly supercritical CO_(2) foaming process to achieve robust mechanical strength and excellent electromagnetic interference(EMI)shielding effectiveness(SE)simultaneously.Highly aligned graphene-Fe_(3)O_(4) nanoplatelets with well controlled nanoscale porous structures(52.6 nm)enabled both low density(1.26 g/cm^(3))and high specific EMI SE>5200 dB/cm^(2)/g,as well as preserved tensile strength of 67 MPa.This study provides a sustainable route to fabricate nature mimicked structures with high performance and high flexibility for a wide range of applications,from portable electronics to healthcare devices.展开更多
肿瘤是目前引起人类死亡的棘手疾病之一,虽然通过各种现代化治疗手段使肿瘤患者的预后得到了一定程度的改善,但多药耐药依然是导致肿瘤治疗效果不佳的主要难题。纳米材料是近年来的研究热点之一,具有EPR(enhanced permeability and rete...肿瘤是目前引起人类死亡的棘手疾病之一,虽然通过各种现代化治疗手段使肿瘤患者的预后得到了一定程度的改善,但多药耐药依然是导致肿瘤治疗效果不佳的主要难题。纳米材料是近年来的研究热点之一,具有EPR(enhanced permeability and retention)效应、可控修饰、靶向性等众多优点,在突破肿瘤耐药方面得到了愈来愈多的关注。纳米载药体系在肿瘤治疗中发挥着极其重要的作用,可以成为逆转肿瘤耐药的新方式。从肿瘤多药耐药机制、纳米技术在肿瘤耐药中的应用等方面进行综述。指出今后可在以下方面展开深入研究:1)结合肿瘤耐药机制研究,合理控制药物浓度,克服耐药;2)深入探索纳米载药体系的生物安全问题,优化纳米载药系统,使其避免或降低可能出现的毒副反应,为逆转肿瘤耐药提供更全面的理论依据;3)结合免疫学、光动力学、声动力学等多种方法,提高纳米载药体系逆转肿瘤耐药的效率。展开更多
This paper reports on progress made in the first 3 years of.ATR's 'CAM-Brain'Project, which aims to use 'evolutionary e.gi...,i.gi' techniques to build/grow/evolve a RAM-and-cellular-automata based...This paper reports on progress made in the first 3 years of.ATR's 'CAM-Brain'Project, which aims to use 'evolutionary e.gi...,i.gi' techniques to build/grow/evolve a RAM-and-cellular-automata based artificial brain consisting of thousands of interconnected neural network modules inside special hardware such as MITs Cellular Automata Machine 'CAM-8,i, or NTT's Content Addressable Memory System 'CAM-System'. The states of a billion (later a trillion) 3D cellular automata cells, and edlions of cellular automata rules which govern their state changes, can be stored relatively cheaply in giga(tera)bytes of RAM. After 3 years work, the CA rules are almost ready. MITt,,'CAM-8' (essentially a serial device) can update 200,000,000 CA cells a second. It is possible that NTT's 'CAM-System' (essentially a massively parallel device) may be able to update a trillion CA cells a second. Hence all the ingredients will soon be ready to create a revolutionary new technology which will allow thousands of evolved neural network modules to be assembled into artificial brains. This in turn will probably create not only a new research field, but hopefully a whole new industry,namely 'brain building'. Building artificial brains with a billion neurons is the aim of ATR's 8 year i,CAM-B,ai.,' research project, ending in 2001.展开更多
Nowadays Quantum Cellular Automata (QCA) as the leading technology in design of microelectronic systems has been raised. With respect to high velocity and density in low power and also simple concepts, this technology...Nowadays Quantum Cellular Automata (QCA) as the leading technology in design of microelectronic systems has been raised. With respect to high velocity and density in low power and also simple concepts, this technology is a viable alternative to CMOS technology. In collector design, the primary component of each processor is very important. Due to the small elements in this technology, failure rate in manufacturing process technology is very high. In the other hand, the simulation shows that the intersection point of two wires is one of the critical points in QCA circuits. This means that defects in the manufacturing process around these points can cause malfunction in the circuit performance. In this paper, a collector in cross sections of wire in his new method used higher reliability against defects during manufacturing has been developed. QCA Designer software is used to simulate the case study system.展开更多
基金the National Natural Science Foundation of China(Grant No.51773170)the Shaanxi Coal Joint Fund(Grant 2019JLM-24)+3 种基金funded by the International Science&Technology Cooperation Plan of Shaanxi Province(2021KW-52)Fund of Natural Science Foundation of Shaanxi Provincial(2021JQ-111)Fund of Basic and Applied Fundamental Research of Guangdong Provincial(2020A1515110861)sponsored by Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(No.CX202051)。
文摘Hierarchical layered structures,whether in a compact form like nacre or a porous manner like bone,are well known for their combined features of high stiffness,strength,and lightweight,inspiring many man-made materials and structures for high performance applications.The use of nacre/bone like hierarchical structures in polymer nanocomposites can achieve excellent mechanical and functional properties with high filler volume fractions after carefully aligning functional nanofillers,although the fabrication and processing remain a great challenge.In this work,a bio-inspired lightweight nano-cellular epoxy/graphene-Fe_(3)O_(4) nanocomposite with high nanofiller loading of 75 wt.%was successfully fabricated by combining features from both nacre and bone structures,via a simple compression molding process together with an eco-friendly supercritical CO_(2) foaming process to achieve robust mechanical strength and excellent electromagnetic interference(EMI)shielding effectiveness(SE)simultaneously.Highly aligned graphene-Fe_(3)O_(4) nanoplatelets with well controlled nanoscale porous structures(52.6 nm)enabled both low density(1.26 g/cm^(3))and high specific EMI SE>5200 dB/cm^(2)/g,as well as preserved tensile strength of 67 MPa.This study provides a sustainable route to fabricate nature mimicked structures with high performance and high flexibility for a wide range of applications,from portable electronics to healthcare devices.
文摘肿瘤是目前引起人类死亡的棘手疾病之一,虽然通过各种现代化治疗手段使肿瘤患者的预后得到了一定程度的改善,但多药耐药依然是导致肿瘤治疗效果不佳的主要难题。纳米材料是近年来的研究热点之一,具有EPR(enhanced permeability and retention)效应、可控修饰、靶向性等众多优点,在突破肿瘤耐药方面得到了愈来愈多的关注。纳米载药体系在肿瘤治疗中发挥着极其重要的作用,可以成为逆转肿瘤耐药的新方式。从肿瘤多药耐药机制、纳米技术在肿瘤耐药中的应用等方面进行综述。指出今后可在以下方面展开深入研究:1)结合肿瘤耐药机制研究,合理控制药物浓度,克服耐药;2)深入探索纳米载药体系的生物安全问题,优化纳米载药系统,使其避免或降低可能出现的毒副反应,为逆转肿瘤耐药提供更全面的理论依据;3)结合免疫学、光动力学、声动力学等多种方法,提高纳米载药体系逆转肿瘤耐药的效率。
基金The financial supports provided, in whole or in part, by the National Natural Science Foundation of China （81071257, 81201192, 81 lO1147, 11272083 ）, Postdoctal Program of China （2011M501297, 2012T50715 ） , and the Fundamental Research Funds for Central Uni- versities （ ZYGX2010X019, ZYGX201OJ101, ZYGX2011 J099） , are greatly appreciated.
文摘This paper reports on progress made in the first 3 years of.ATR's 'CAM-Brain'Project, which aims to use 'evolutionary e.gi...,i.gi' techniques to build/grow/evolve a RAM-and-cellular-automata based artificial brain consisting of thousands of interconnected neural network modules inside special hardware such as MITs Cellular Automata Machine 'CAM-8,i, or NTT's Content Addressable Memory System 'CAM-System'. The states of a billion (later a trillion) 3D cellular automata cells, and edlions of cellular automata rules which govern their state changes, can be stored relatively cheaply in giga(tera)bytes of RAM. After 3 years work, the CA rules are almost ready. MITt,,'CAM-8' (essentially a serial device) can update 200,000,000 CA cells a second. It is possible that NTT's 'CAM-System' (essentially a massively parallel device) may be able to update a trillion CA cells a second. Hence all the ingredients will soon be ready to create a revolutionary new technology which will allow thousands of evolved neural network modules to be assembled into artificial brains. This in turn will probably create not only a new research field, but hopefully a whole new industry,namely 'brain building'. Building artificial brains with a billion neurons is the aim of ATR's 8 year i,CAM-B,ai.,' research project, ending in 2001.
文摘Nowadays Quantum Cellular Automata (QCA) as the leading technology in design of microelectronic systems has been raised. With respect to high velocity and density in low power and also simple concepts, this technology is a viable alternative to CMOS technology. In collector design, the primary component of each processor is very important. Due to the small elements in this technology, failure rate in manufacturing process technology is very high. In the other hand, the simulation shows that the intersection point of two wires is one of the critical points in QCA circuits. This means that defects in the manufacturing process around these points can cause malfunction in the circuit performance. In this paper, a collector in cross sections of wire in his new method used higher reliability against defects during manufacturing has been developed. QCA Designer software is used to simulate the case study system.
