Surface-enhanced Raman scattering(SERS)spectroscopy has been considered as a promising way to realize real-time, in-situ and ultrasensitive analysis of chemoand biochemical molecules in different applications even in ...Surface-enhanced Raman scattering(SERS)spectroscopy has been considered as a promising way to realize real-time, in-situ and ultrasensitive analysis of chemoand biochemical molecules in different applications even in intracellular or aqueous environments. In this work, polymersupported novel Ag nano-necklaces(AgNLs) as flexible SERS substrates were fabricated for ultrasensitive chemical and biological detection. With the stringing of dense 'hot spot' in three-dimension, AgNLs located on polydimethylsiloxane(PDMS) work like the removable and reusable 'tip'on the surface of analytes with different morphologies and conditions. The novel substrate shows ultra-high enhancement factor(as high as 109) with excellent reproducibility and long-term stability(7 months) in an aqueous environment.With further functionalizing with p-mercaptobenzoic acid, AgNLs/PDMS elastomer also reveals sensitive and consistent pH detection ability over the wide range of pH4.0–9.0, indicating their wide applications in biological and environmental fields. This work provides a feasible strategy for designing ultrasensitive, reproducible and flexible SERS substrate for practical detection.展开更多
基金financially supported by the National Natural Science Foundation of China(51503210)the Hundred Talents Program of the Chinese Academy of Sciences(CAS)the State Key Laboratory of Multiphase Complex Systems Open Foundation(MPCS-2013-C-01)
文摘Surface-enhanced Raman scattering(SERS)spectroscopy has been considered as a promising way to realize real-time, in-situ and ultrasensitive analysis of chemoand biochemical molecules in different applications even in intracellular or aqueous environments. In this work, polymersupported novel Ag nano-necklaces(AgNLs) as flexible SERS substrates were fabricated for ultrasensitive chemical and biological detection. With the stringing of dense 'hot spot' in three-dimension, AgNLs located on polydimethylsiloxane(PDMS) work like the removable and reusable 'tip'on the surface of analytes with different morphologies and conditions. The novel substrate shows ultra-high enhancement factor(as high as 109) with excellent reproducibility and long-term stability(7 months) in an aqueous environment.With further functionalizing with p-mercaptobenzoic acid, AgNLs/PDMS elastomer also reveals sensitive and consistent pH detection ability over the wide range of pH4.0–9.0, indicating their wide applications in biological and environmental fields. This work provides a feasible strategy for designing ultrasensitive, reproducible and flexible SERS substrate for practical detection.
