Recently,photodynamic therapy(PDT)has been extensively applied in clinical and coadjuvant treatment of various kinds of tumors.However,the photosensitizer(PS)of PDT still lack of high production of singlet oxygen(^(1)...Recently,photodynamic therapy(PDT)has been extensively applied in clinical and coadjuvant treatment of various kinds of tumors.However,the photosensitizer(PS)of PDT still lack of high production of singlet oxygen(^(1)O_(2)),low cytotoxicity and high biocompatibility.Herein,we propose a facile method for establishing a new core-shell structured Sn nanocluster@carbon dots(CDs)PS.Firstly,Sn^(4+)@S-CDs complex is synthesized using the sulfur-doped CDs(S-CDs)and SnCl4 as raw materials,and subsequently the new PS(Sn nanocluster@CDs)is obtained after vaporization of Sn4+@S-CDs solution.Remarkably,the obtained Sn nanocluster@CDs show an enhanced fluorescence as well as a higher ^(1)O_(2) quantum yield(QY)than S-CDs.The high ^(1)O_(2) QY(58.3%)irradiated by the LED light(400-700 nm,40 mW/cm^(2)),induce the reduction of 4 T1 cancer cells viability by 25%.More intriguingly,no visible damage happens to healthy cells,with little impact on liver tissue due to renal excretion,both in vitro and in vivo experiments demonstrate that Sn nanocluster@CDs may become a promising PS,owning a high potential for application in PDT.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51772001)the support from the Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University),Ministry of Education,Chinathe Key Laboratory of Environment-Friendly Polymer Materials of Anhui Province,Anhui University。
文摘Recently,photodynamic therapy(PDT)has been extensively applied in clinical and coadjuvant treatment of various kinds of tumors.However,the photosensitizer(PS)of PDT still lack of high production of singlet oxygen(^(1)O_(2)),low cytotoxicity and high biocompatibility.Herein,we propose a facile method for establishing a new core-shell structured Sn nanocluster@carbon dots(CDs)PS.Firstly,Sn^(4+)@S-CDs complex is synthesized using the sulfur-doped CDs(S-CDs)and SnCl4 as raw materials,and subsequently the new PS(Sn nanocluster@CDs)is obtained after vaporization of Sn4+@S-CDs solution.Remarkably,the obtained Sn nanocluster@CDs show an enhanced fluorescence as well as a higher ^(1)O_(2) quantum yield(QY)than S-CDs.The high ^(1)O_(2) QY(58.3%)irradiated by the LED light(400-700 nm,40 mW/cm^(2)),induce the reduction of 4 T1 cancer cells viability by 25%.More intriguingly,no visible damage happens to healthy cells,with little impact on liver tissue due to renal excretion,both in vitro and in vivo experiments demonstrate that Sn nanocluster@CDs may become a promising PS,owning a high potential for application in PDT.
