Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, ...Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, methods for producing magnetic vortex nanorings/nanodiscs are presented. Finally, theranostic applications of magnetic vortex nanorings/nanodiscs are addressed.展开更多
Synthetic antiferromagnetic (SAF) particles with perpendicular anisotropy display a number of desirable characteristics for applications in biological and other fluid environments. We present an efficient and effectiv...Synthetic antiferromagnetic (SAF) particles with perpendicular anisotropy display a number of desirable characteristics for applications in biological and other fluid environments. We present an efficient and effective method for the patterning of ultrathin Ruderman-Kittel-Kasuya-Yoshida coupled, perpendicularly magnetised SAFs using a combination of nanosphere lithography and ion milling. A Ge sacrificial layer is utilised, which provides a clean and simple lift-off process, as well as maintaining the key magnetic properties that are beneficial to target applications. We demonstrate that the method is capable of producing a particularly high yield of well-defined, thin film based nanoparticles.展开更多
A tunable perfect absorber composed of hexagonal-arranged aluminum nano-disk array embedded in the vanadium dioxide(VO_2) film is proposed. The aim is to achieve the tunability of resonance absorption peak in the visi...A tunable perfect absorber composed of hexagonal-arranged aluminum nano-disk array embedded in the vanadium dioxide(VO_2) film is proposed. The aim is to achieve the tunability of resonance absorption peak in the visible and near-infrared regimes. Numerical results reveal that the absorption peak achieves a large tunability of 76.6% while VO_2 undergoes a structural transition from insulator phase to metallic phase. By optimizing the structural parameters, an average absorption of 95% is achieved from 1242 to 1815 nm at the metallic phase state. In addition, the near unity absorption can be fulfilled in a wide range of incident angle(0°–60°) and under all polarization conditions. The method and results presented here would be beneficial for the design of active optoelectronic devices.展开更多
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally thr...Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.展开更多
分别采用氮气吹干法和旋转蒸发法制备由磷脂和膜支架蛋白组成的电荷型纳米盘,用凝胶过滤色谱对其尺寸分级,分析了其性能,考察了其与肝微粒体细胞色素P450的结合能力。结果表明,纳米盘外观澄清透明,微观呈圆盘状,平均直径10nm,在p H 7.4...分别采用氮气吹干法和旋转蒸发法制备由磷脂和膜支架蛋白组成的电荷型纳米盘,用凝胶过滤色谱对其尺寸分级,分析了其性能,考察了其与肝微粒体细胞色素P450的结合能力。结果表明,纳米盘外观澄清透明,微观呈圆盘状,平均直径10nm,在p H 7.4下Zeta电位为-19.86 m V;肝微粒体破碎液与纳米盘能很好结合,CO差示光谱在450 nm出现明显吸收峰,细胞色素P450含量为0.10 nmol/mg,比活比未经纳米盘处理时提高13.0倍,较传统方法提升1.5倍,且操作时间由数日缩短至数小时。电荷型纳米盘在结合膜蛋白细胞色素P450的同时,活性保持良好,在膜蛋白研究领域极具应用潜力。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.21376192 and 81571809)the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20126101110017)MOE Ac RF Tier 2-MOE2011-T2-1-043 and A-Star SERC 1321202068
文摘Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, methods for producing magnetic vortex nanorings/nanodiscs are presented. Finally, theranostic applications of magnetic vortex nanorings/nanodiscs are addressed.
基金This work was supported by the European Research Council (No. 779822).
文摘Synthetic antiferromagnetic (SAF) particles with perpendicular anisotropy display a number of desirable characteristics for applications in biological and other fluid environments. We present an efficient and effective method for the patterning of ultrathin Ruderman-Kittel-Kasuya-Yoshida coupled, perpendicularly magnetised SAFs using a combination of nanosphere lithography and ion milling. A Ge sacrificial layer is utilised, which provides a clean and simple lift-off process, as well as maintaining the key magnetic properties that are beneficial to target applications. We demonstrate that the method is capable of producing a particularly high yield of well-defined, thin film based nanoparticles.
基金Supported by the National Natural Science Foundation of China under Grant No 41675154the Six Major Talent Peak Expert of Jiangsu Province under Grant Nos 2015-XXRJ-014 and R2016L01+1 种基金the Jiangsu 333 High-Level Talent Cultivation Program under Grant No BRA2016425the Research Innovation Program for College Graduates of Jiangsu Province under Grant No KYCX18_1022
文摘A tunable perfect absorber composed of hexagonal-arranged aluminum nano-disk array embedded in the vanadium dioxide(VO_2) film is proposed. The aim is to achieve the tunability of resonance absorption peak in the visible and near-infrared regimes. Numerical results reveal that the absorption peak achieves a large tunability of 76.6% while VO_2 undergoes a structural transition from insulator phase to metallic phase. By optimizing the structural parameters, an average absorption of 95% is achieved from 1242 to 1815 nm at the metallic phase state. In addition, the near unity absorption can be fulfilled in a wide range of incident angle(0°–60°) and under all polarization conditions. The method and results presented here would be beneficial for the design of active optoelectronic devices.
基金National Natural Science Foundation of China(61006050)National High Technology Research and Development Program of China(2011AA050507)+1 种基金Natural Science Foundation of Beijing(2151004)Fundamental Research Funds for the Central Universities in China(13ZD05)
文摘Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.
文摘分别采用氮气吹干法和旋转蒸发法制备由磷脂和膜支架蛋白组成的电荷型纳米盘,用凝胶过滤色谱对其尺寸分级,分析了其性能,考察了其与肝微粒体细胞色素P450的结合能力。结果表明,纳米盘外观澄清透明,微观呈圆盘状,平均直径10nm,在p H 7.4下Zeta电位为-19.86 m V;肝微粒体破碎液与纳米盘能很好结合,CO差示光谱在450 nm出现明显吸收峰,细胞色素P450含量为0.10 nmol/mg,比活比未经纳米盘处理时提高13.0倍,较传统方法提升1.5倍,且操作时间由数日缩短至数小时。电荷型纳米盘在结合膜蛋白细胞色素P450的同时,活性保持良好,在膜蛋白研究领域极具应用潜力。
