Cisplatin resistance still remains a major obstacle to successful treatment of cancer.The development of cellular resistance to platinum-based chemotherapies is often associated with reduced intracellular platinum con...Cisplatin resistance still remains a major obstacle to successful treatment of cancer.The development of cellular resistance to platinum-based chemotherapies is often associated with reduced intracellular platinum concentrations.In some models,this reduction is due to abnormal membrane protein trafficking,resulting in reduced uptake by transporters at the cell surface.Given the central role of platinum drugs in the clinic.展开更多
文摘Cisplatin resistance still remains a major obstacle to successful treatment of cancer.The development of cellular resistance to platinum-based chemotherapies is often associated with reduced intracellular platinum concentrations.In some models,this reduction is due to abnormal membrane protein trafficking,resulting in reduced uptake by transporters at the cell surface.Given the central role of platinum drugs in the clinic.
