Morphology evolution of ZnO by controlling solvent and electrochemical sensing of hexagonal nanotablets toward amines

Organic amines are important solvent and raw material in laboratory and industry,as well as releasing from cigarette smoke.It is significant to detect low-concentration amines for environment and public health.Here we reported that as-synthesized zinc oxide is an effective electrode material of electrochemical sensor for the detection of amines.The characterization results reveal that the ZnO morphologies experienced a change from hexagonal bowl-like microparticles,cones,prisms to nanoparticles by adjusting the reaction time,temperature,solvents and additives.Interestingly,ZnO material possessing hexagonal shapes and different sizes exhibits distinct electrochemical response in various amines solution,suggesting that there is a better dependent relationship between different morphological ZnO and amines detection.Particularly,regular hexagonal ZnO nanotablets exhibit a detectable electrochemical response and selectivity to ammonia,implying it can be serve as electrode material for highly effective detection of organic amines.

2D MXene纳米片在肿瘤诊断和治疗中的研究进展

2D MXene纳米片有高效的光热转化效率和良好的生物安全性等特点,这些优势使其成为近年来肿瘤诊断治疗相关研究的热门材料。本综述介绍了2D MXene纳米片的结构、理化特征,重点介绍了其在光热治疗、药物递送、生物传感及成像等肿瘤诊断和治疗方面的研究进展,讨论了2D MXene纳米材料在生物医学应用中面临的挑战。

功能化载药黑磷纳米片的制备表征及抗骨肉瘤活性评价

目的:制备可稳定分散的载药纳米黑磷,并将其用于光热/化疗协同的纳米制剂。方法:采用液相剥离法,以N-甲基吡咯烷酮(NMP)为剥离剂,聚乙二醇二胺(H_(2)N-PEG-NH_(2))、壳聚糖(CS)及A型明胶(Gel)为修饰剂,筛选并载带化疗药物盐酸阿霉素(DOX)制备出分散性良好的载药黑磷纳米片。通过透射电镜、傅立叶变换红外光谱仪及流式细胞仪等仪器,进行形貌结构表征及体外细胞学评价。结果:剥离方法筛选试验表明BPNSs最佳制备工艺为:水浴超声300 W,10 h,探头超声180 W,6 h,温度<30℃,表现出外观形貌均一;修饰剂筛选试验表明H_(2)N-PEG-NH_(2)/BPNSs质量比为10:1,BPNSs/DOX质量比为1:1,表现出良好的稳定性及负载率;体外释放试验表明,DOX在弱酸性条件下结合近红外光照(NIR)释放迅速,展现出光控释药特性;体外细胞学试验表明PEG-BPNSs-DOX具有良好的抗骨肉瘤活性。结论:PEG-BPNSs-DOX可稳定分散,制备简单,具有NIR光控释药特性及良好的光热性能,有利于光热/化疗协同治疗骨肉瘤,在纳米递送系统中具有广阔应用前景。