An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of HClO4-SiO2 as a heterogen...An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of HClO4-SiO2 as a heterogeneous catalyst. The reactions were carried out under reflux and solvent-free conditions. The present methodology offers several advantages such as excellent yields, simple procedure, easy work-up and ecofriendly reaction condition. The catalyst is easily prepared, stable, reusable and efficient under the reaction conditions.展开更多
An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of wet-cyanuric chloride （w...An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of wet-cyanuric chloride （wet-TCT） as a catalyst. The reactions were carried out under solvent-free media. The present methodology offers several advantages such as excellent yields, simple procedure and eco-friendly reaction condition.展开更多
A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholbori...A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.展开更多
The symmetric oxidative coupling reactions of 2-naphthol derivatives with both ferric hydrogensulfate in water and silica ferric hydrogensulfate in solvent free conditions were carried out. The advantages of this gree...The symmetric oxidative coupling reactions of 2-naphthol derivatives with both ferric hydrogensulfate in water and silica ferric hydrogensulfate in solvent free conditions were carried out. The advantages of this green procedure are inexpensive catalyst or cocatalyst, reusability of catalyst, organic solvent-free procedures and simple workup.展开更多
Inclusion reaction of reaction 1, 1'-bi-2-naphthol and (S)-proline was examined uuder the solid state and the solid-liquid conditions. The results indicated that a solid mixture of racemic 1, 1'-bi-2-naphthol ...Inclusion reaction of reaction 1, 1'-bi-2-naphthol and (S)-proline was examined uuder the solid state and the solid-liquid conditions. The results indicated that a solid mixture of racemic 1, 1'-bi-2-naphthol and (S)-proline in a 1 : 1 molar ratio was kept at 50-80 for 3-4 h, followed by treatment with benzene to give an insoluble solid and a benzene solution, from which (S)- (- )- and (R)-(+)-1, 1'-bi-2-naphthols of a modest level or optical purity were obtained. Arter 'kinetic' crystallization, both essentially enantiopure iso- mers were provided in 15%-35 % overall yields ,respectively.展开更多
An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of...An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of tetrachlorosilane (TCS). A binary reagent from (TCS)/ZnCl2 was used upon applying benzonitrile.展开更多
Ultrasonic and microwave-assisted practical methods have been developed for the O-alkylation of aryl (β-naphthols) and Heteroaryl (hydroxy pyridines) in aqueous surfactant media in good to excellent yields. The devel...Ultrasonic and microwave-assisted practical methods have been developed for the O-alkylation of aryl (β-naphthols) and Heteroaryl (hydroxy pyridines) in aqueous surfactant media in good to excellent yields. The developed methods are simple, efficient, economical and environmentally safe. Our novel methods describe a set of green methods to Wil-liamson synthesis.展开更多
文摘An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of HClO4-SiO2 as a heterogeneous catalyst. The reactions were carried out under reflux and solvent-free conditions. The present methodology offers several advantages such as excellent yields, simple procedure, easy work-up and ecofriendly reaction condition. The catalyst is easily prepared, stable, reusable and efficient under the reaction conditions.
文摘An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, 2-naphthol and urea or amides, in the presence of wet-cyanuric chloride （wet-TCT） as a catalyst. The reactions were carried out under solvent-free media. The present methodology offers several advantages such as excellent yields, simple procedure and eco-friendly reaction condition.
文摘A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.
文摘The symmetric oxidative coupling reactions of 2-naphthol derivatives with both ferric hydrogensulfate in water and silica ferric hydrogensulfate in solvent free conditions were carried out. The advantages of this green procedure are inexpensive catalyst or cocatalyst, reusability of catalyst, organic solvent-free procedures and simple workup.
基金Supported by the National Natural Science Foundation of China (29972033) the Key Science Research Foundation of Hubei Provin
文摘Inclusion reaction of reaction 1, 1'-bi-2-naphthol and (S)-proline was examined uuder the solid state and the solid-liquid conditions. The results indicated that a solid mixture of racemic 1, 1'-bi-2-naphthol and (S)-proline in a 1 : 1 molar ratio was kept at 50-80 for 3-4 h, followed by treatment with benzene to give an insoluble solid and a benzene solution, from which (S)- (- )- and (R)-(+)-1, 1'-bi-2-naphthols of a modest level or optical purity were obtained. Arter 'kinetic' crystallization, both essentially enantiopure iso- mers were provided in 15%-35 % overall yields ,respectively.
文摘An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of tetrachlorosilane (TCS). A binary reagent from (TCS)/ZnCl2 was used upon applying benzonitrile.
文摘Ultrasonic and microwave-assisted practical methods have been developed for the O-alkylation of aryl (β-naphthols) and Heteroaryl (hydroxy pyridines) in aqueous surfactant media in good to excellent yields. The developed methods are simple, efficient, economical and environmentally safe. Our novel methods describe a set of green methods to Wil-liamson synthesis.
