Aim To investigate the relationship between pH environment of meptazinolhydrochloride (MEP) and its nasal absorption. Methods In situ nasal peifusion was performed to studythe effect of pH environment on the nasal abs...Aim To investigate the relationship between pH environment of meptazinolhydrochloride (MEP) and its nasal absorption. Methods In situ nasal peifusion was performed to studythe effect of pH environment on the nasal absorption. Its effect on the transport from nose tobrain was further researched by in vivo experiment. Results In in situ perfusion experiment, thenasal absorption of MEP in basic environment was significantly higher than that in acid condition,but the difference was not observed in in vivo experiment. Conclusion The pH environment ofmeptazinol hydrocloride in formulation cannot be regarded as an important factor influencing nasalabsorption and transport from nose to brain.展开更多
Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15...Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15 dogs at a dosage of 5 mg/kg for each through three routes of administration, ie, the intravenous, intramuscular and iutranasal. The serum levels of gentamyciu from 0 to 180 minutes after receiving the drug were determined with thin-layer scanning chromatographic method. It was found that if the bioavailability of the intravenous route was considered as 100%, the bioavailability of the intranasal route was 80.5%,and that of the intramuscular route was 42％. After giving drops of the drug into nasal cavity in above-mentioned dosage,the serum drug level reached a peak in 10 to 30 min ranging in 3.7 to 6.6 μg/ml. The half-life period of the drug given through this route was about three hours, indicating that the na sal mucosa is apt to be penetrated by gentamycin and allows the drug to be abso展开更多
文摘Aim To investigate the relationship between pH environment of meptazinolhydrochloride (MEP) and its nasal absorption. Methods In situ nasal peifusion was performed to studythe effect of pH environment on the nasal absorption. Its effect on the transport from nose tobrain was further researched by in vivo experiment. Results In in situ perfusion experiment, thenasal absorption of MEP in basic environment was significantly higher than that in acid condition,but the difference was not observed in in vivo experiment. Conclusion The pH environment ofmeptazinol hydrocloride in formulation cannot be regarded as an important factor influencing nasalabsorption and transport from nose to brain.
文摘Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15 dogs at a dosage of 5 mg/kg for each through three routes of administration, ie, the intravenous, intramuscular and iutranasal. The serum levels of gentamyciu from 0 to 180 minutes after receiving the drug were determined with thin-layer scanning chromatographic method. It was found that if the bioavailability of the intravenous route was considered as 100%, the bioavailability of the intranasal route was 80.5%,and that of the intramuscular route was 42％. After giving drops of the drug into nasal cavity in above-mentioned dosage,the serum drug level reached a peak in 10 to 30 min ranging in 3.7 to 6.6 μg/ml. The half-life period of the drug given through this route was about three hours, indicating that the na sal mucosa is apt to be penetrated by gentamycin and allows the drug to be abso
