There are several different types of drug delivery interfaces available on the market.Using the right interface for aerosol drug delivery to children is essential for effective inhalation therapy.However,clinicians us...There are several different types of drug delivery interfaces available on the market.Using the right interface for aerosol drug delivery to children is essential for effective inhalation therapy.However,clinicians usually focus on selecting the right drug-device combination and often overlook the importance of interface selection that lead to suboptimal drug delivery and therapeutic response in neonates and pediatrics.Therefore,it is necessary to critically assess each interface and understand its advantage and disadvantages in aerosol drug delivery to this patient population.The purpose of this paper is to provide a critical assessment of drug delivery interfaces used for the treatment of children with pulmonary diseases by emphasizing advantages and problems associated with their use during inhalation therapy.展开更多
目的探讨经鼻高流量吸氧在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭治疗中的应用效果。方法选取2017年4月至2018年4月入住的慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭患者40例,依据随机数字表法,分为试验组和对照组,每组20例。试...目的探讨经鼻高流量吸氧在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭治疗中的应用效果。方法选取2017年4月至2018年4月入住的慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭患者40例,依据随机数字表法,分为试验组和对照组,每组20例。试验组给予常规治疗,并接受经鼻高流量吸氧;对照组给予文丘里面罩装置控制性氧疗。比较2组患者血气指标、RR、患者舒适度、护理操作难易程度等情况。结果治疗24 h结束后,比较4 h及24 h 2组指标,试验组末梢血氧饱和度(SpO2)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血pH值、呼吸频率(RR)等指标均优于对照组(P<0.01),患者舒适度高于对照组(P<0.01),护理操作难度低于对照组(P<0.01)。结论经鼻高流量吸氧在改善慢性阻塞性肺疾病急性加重患者治疗效果方面优于控制性氧疗,能有效提升患者舒适度,降低护理人员操作难度,此治疗方法具有推广意义。展开更多
文摘There are several different types of drug delivery interfaces available on the market.Using the right interface for aerosol drug delivery to children is essential for effective inhalation therapy.However,clinicians usually focus on selecting the right drug-device combination and often overlook the importance of interface selection that lead to suboptimal drug delivery and therapeutic response in neonates and pediatrics.Therefore,it is necessary to critically assess each interface and understand its advantage and disadvantages in aerosol drug delivery to this patient population.The purpose of this paper is to provide a critical assessment of drug delivery interfaces used for the treatment of children with pulmonary diseases by emphasizing advantages and problems associated with their use during inhalation therapy.
文摘目的探讨经鼻高流量吸氧在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭治疗中的应用效果。方法选取2017年4月至2018年4月入住的慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭患者40例,依据随机数字表法,分为试验组和对照组,每组20例。试验组给予常规治疗,并接受经鼻高流量吸氧;对照组给予文丘里面罩装置控制性氧疗。比较2组患者血气指标、RR、患者舒适度、护理操作难易程度等情况。结果治疗24 h结束后,比较4 h及24 h 2组指标,试验组末梢血氧饱和度(SpO2)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血pH值、呼吸频率(RR)等指标均优于对照组(P<0.01),患者舒适度高于对照组(P<0.01),护理操作难度低于对照组(P<0.01)。结论经鼻高流量吸氧在改善慢性阻塞性肺疾病急性加重患者治疗效果方面优于控制性氧疗,能有效提升患者舒适度,降低护理人员操作难度,此治疗方法具有推广意义。