Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CA...Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs indifferent nationalities of China. Five SNPs were chosen to perform case-control study andhaplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. OneSNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmission-disequilibrium test (STDT) in 68 type 2 diabetes pedigrees (377 people). Results A totalof 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. TheSNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different fromthose reported in Mexican American. There was no significantly statistical difference in theallele frequency of the 5 SNPs between case and control, and the haplotype frequencies inthe two groups were not significantly different. No positive results was found in TDT andSTDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in differentnationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility onesof type 2 diabetes mellitus in Han people of Northern China.展开更多
Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 ...Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (Sl03F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.展开更多
I. Symposium on National Human Rights Institutions and Research Topics Academic research in the Chinese mainland on national human rights institutions started in February 2003. From October 16-17, 2004, the China Uni...I. Symposium on National Human Rights Institutions and Research Topics Academic research in the Chinese mainland on national human rights institutions started in February 2003. From October 16-17, 2004, the China University of Political Science and Law organized an international sympo- sium in Qingdao, Shandong Province, on research about national human rights protection institutions, inviting experts from Australia, South Africa and Canada to brief the symposium on related information concerning the Asia-Pacific region and South Africa as well as to provide information about Canada's National Human Rights Commission. Chinese participants also discussed the possibility of establishing a national human rights organization in China.展开更多
Flora Cryptogamica Sinica is a phytotaxonomic corpus specializing in recording endemic cryptogamic species of unvascular plants in China. It was compiled and published by its Editorial Committee affiliated to the CAS ...Flora Cryptogamica Sinica is a phytotaxonomic corpus specializing in recording endemic cryptogamic species of unvascular plants in China. It was compiled and published by its Editorial Committee affiliated to the CAS headquarters. Divided by specific contents, it consists of five parts, namely, Marine Flora Algae of China, Fresh water Flora Algae of China, Fungal Flora of China,展开更多
Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces ...Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan's regulation of Ghrelin-Ghrelin receptors.展开更多
The National Mineral Resources Planning(2016-2020)issued by the Ministry of Land and Resources specifies national planning of 9copper mining area across the country.1.Baijiazuizi Copper Nickel Mine The Baijiazuizi cop...The National Mineral Resources Planning(2016-2020)issued by the Ministry of Land and Resources specifies national planning of 9copper mining area across the country.1.Baijiazuizi Copper Nickel Mine The Baijiazuizi copper nickel mining area is a super-large copper nickel deposit in Jinchang City with total proven reserves of 3.展开更多
I. Introduction 1. The children of today will run the families of the 21st century. Their survival, protection and development decide, for the most part, the quality of a people and lay the foundation of human progres...I. Introduction 1. The children of today will run the families of the 21st century. Their survival, protection and development decide, for the most part, the quality of a people and lay the foundation of human progress as a whole. The 1990 World Summit for Children endorsed the "World Declaration on the Survival, Protection and Development of Children" and the "Plan of Action for Implementing the World Declaration on the Survival, Protection and Development of Children in the 1990s," (hereinafter referred to as "Declaration" and "Plan of Action" for short), In March 1991, Premier Li Peng signed the two documents on behalf of the Chinese Government, making a solemn commitment to this major undertaking. 2. The wholesome development of children has a bearing upon the future of China. The Communist Party of China and the Chinese Government have always paid close attention to the survival,展开更多
基金the National Natural Science Foundation (Grant No. 30170441,39896200)863 High Tech Project (Grant No. 2001AA221161)+2 种基金 National 973 Project (Grant No.G1998051016) Beijing Natural Science Fund (Grant No. 7002026)the National High EducationSci
文摘Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs indifferent nationalities of China. Five SNPs were chosen to perform case-control study andhaplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. OneSNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmission-disequilibrium test (STDT) in 68 type 2 diabetes pedigrees (377 people). Results A totalof 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. TheSNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different fromthose reported in Mexican American. There was no significantly statistical difference in theallele frequency of the 5 SNPs between case and control, and the haplotype frequencies inthe two groups were not significantly different. No positive results was found in TDT andSTDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in differentnationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility onesof type 2 diabetes mellitus in Han people of Northern China.
基金supported by the National Natural Science Foundation of China(No.81273144)Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education(KZ201510025024)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201304)
文摘Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (Sl03F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.
文摘I. Symposium on National Human Rights Institutions and Research Topics Academic research in the Chinese mainland on national human rights institutions started in February 2003. From October 16-17, 2004, the China University of Political Science and Law organized an international sympo- sium in Qingdao, Shandong Province, on research about national human rights protection institutions, inviting experts from Australia, South Africa and Canada to brief the symposium on related information concerning the Asia-Pacific region and South Africa as well as to provide information about Canada's National Human Rights Commission. Chinese participants also discussed the possibility of establishing a national human rights organization in China.
文摘Flora Cryptogamica Sinica is a phytotaxonomic corpus specializing in recording endemic cryptogamic species of unvascular plants in China. It was compiled and published by its Editorial Committee affiliated to the CAS headquarters. Divided by specific contents, it consists of five parts, namely, Marine Flora Algae of China, Fresh water Flora Algae of China, Fungal Flora of China,
基金supported by the National Natural Science Youth Foundation in China,No.81001501the Natural Science Foundation of Beijing in China,No.7112071Beijing University of Chinese Medicine Key Project–Nautical Chinese Medicine in China,No.522/100604054
文摘Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan's regulation of Ghrelin-Ghrelin receptors.
文摘The National Mineral Resources Planning(2016-2020)issued by the Ministry of Land and Resources specifies national planning of 9copper mining area across the country.1.Baijiazuizi Copper Nickel Mine The Baijiazuizi copper nickel mining area is a super-large copper nickel deposit in Jinchang City with total proven reserves of 3.
文摘I. Introduction 1. The children of today will run the families of the 21st century. Their survival, protection and development decide, for the most part, the quality of a people and lay the foundation of human progress as a whole. The 1990 World Summit for Children endorsed the "World Declaration on the Survival, Protection and Development of Children" and the "Plan of Action for Implementing the World Declaration on the Survival, Protection and Development of Children in the 1990s," (hereinafter referred to as "Declaration" and "Plan of Action" for short), In March 1991, Premier Li Peng signed the two documents on behalf of the Chinese Government, making a solemn commitment to this major undertaking. 2. The wholesome development of children has a bearing upon the future of China. The Communist Party of China and the Chinese Government have always paid close attention to the survival,