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Reactivity of Human Preformed Natural Antibodies with Various Porcine Pancreatic Cells
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作者 张伟杰 熊沛 刘绍春 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2001年第1期59-61,共3页
The reactivity of human preformed natural antibodies (PNAbs) with various porcine pancreatic cells and its isotypes was investigated. Eighteen serum samples from patients with insulin dependent diabetes mellitus (IDD... The reactivity of human preformed natural antibodies (PNAbs) with various porcine pancreatic cells and its isotypes was investigated. Eighteen serum samples from patients with insulin dependent diabetes mellitus (IDDM) and 20 serum samples from healthy human subjects were collected. The frozen sections of the pig pancreas were incubated with these sera, and subsequently incubated with FITC conjugated goat antihuman IgG and IgM monoclonal antibodies. The reactivity of human PNAbs with various porcine pancreatic cells was determined by indirect immunofluorescence staining technique. The results showed that 55.6 % of IDDM patients and 55.0 % of healthy human individuals contained PNAbs against porcine endocrine cells. However, the percentage of strongly reacting sera in the patient group was significantly increased as compared with that in the control group. All used sera from IDDM patients and 95 % of sera from healthy controls could react to one or more of the various pancreatic cell types, including: endocrine cells, exocrine cells, vascular endothelial cells, ductal epithelial cells and macrophages. The isotypes of PNAbs contained both IgG and IgM. In view of strongly positive reactivity of PNAbs with various porcine pancreatic cells, pretransplantly cross matching test and graft pretreatment may be necessary for survival of islet transplants. 展开更多
关键词 PIG preformed natural antibody insulin dependent diabetes mellitus REACTIVITY
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Tyrosinase,a new innate humoral immune parameter in large yellow croaker(Pseudosciaena crocea R) 被引量:1
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作者 王淑红 王艺磊 +3 位作者 张子平 谢芳靖 林鹏 邰振刚 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2009年第3期527-535,共9页
We evaluated the immune response to infection with a pathogen in large yellow croaker(Pseudosciaena crocea Richardson).The fish were given an intraperitoneal(i.p.) injection of Vibrio parahaemolyticus or sterile sea w... We evaluated the immune response to infection with a pathogen in large yellow croaker(Pseudosciaena crocea Richardson).The fish were given an intraperitoneal(i.p.) injection of Vibrio parahaemolyticus or sterile sea water(control).We collected blood sera from the fish 0.17,1,2,4,8,12,or 16 d after injection(dpi).We measured tyrosinase activity and the concentrations of lysozyme,NOS,and antibodies.Serum tyrosinase activity was significantly higher at 0.17 and 4 dpi than in the control group,and peaked at 8 dpi.Lysozyme activity was significantly higher at 2 and 12 dpi than in the control group,but lower at 16 dpi.There is no statistical difference in the level of nitric oxides synthase(NOS) activity or antibodies between the control and injection groups.This is the first report of the tyrosinase activity in the serum of large yellow croaker.Our results indicate that tyrosinase plays an important role in the immediate immune defense against V.parahaemolyticus in large yellow croaker.Tyrosinase is a candidate parameter for investigation of fish innate immune defense. 展开更多
关键词 pseudosciaena crocea TYROSINASE LYSOZYME nitric oxide synthase (NOS) natural antibodies
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Regulatory functions of innate-like B cells 被引量:12
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作者 Xiaoming Zhang 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2013年第2期113-121,共9页
Innate-like B cells (ILBs) are heterogeneous populations of unconventional B cells with innate sensing and responding properties. ILBs in mice are composed of B1 cells, marginal zone (MZ) B cells and other related... Innate-like B cells (ILBs) are heterogeneous populations of unconventional B cells with innate sensing and responding properties. ILBs in mice are composed of B1 cells, marginal zone (MZ) B cells and other related B cells. ILBs maintain natural IgM levels at steady state, and after innate activation, they can rapidly acquire immune regulatory activities through the secretion of natural IgM and IL-IO. Thus, ILBs constitute an important source of IL-lO-producing regulatory B cells (Bregs), which have been shown to play critical roles in autoimmunity, inflammation and infection. The present review highlights the latest advances in the field of ILBs and focuses on their regulatory functions. Understanding the regulatory activities of ILBs and their underlying mechanisms could open new avenues in manipulating their functions in inflammatory, infectious and other relevant diseases. 展开更多
关键词 immune regulation innate-like B cells interleukin 10 natural antibody regulatory B cells
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Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities
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作者 LU Lu YU Fei +2 位作者 DU Lan-ying XU Wei JIANG Shi-bo 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第12期2374-2379,共6页
Objective To review the mechanisms by which HIV evades different components of the host immune system.Data sources This review is based on data obtained from published articles from 1991 to 2012.To perform the PubMed ... Objective To review the mechanisms by which HIV evades different components of the host immune system.Data sources This review is based on data obtained from published articles from 1991 to 2012.To perform the PubMed literature search,the following key words were input:HIV and immune evasion.Study selection Articles containing information related to HIV immune evasion were selected.Results Although HIV is able to induce vigorous antiviral immune responses,viral replication cannot be fully controlled,and neither pre-existing infected cells nor latent HIV infection can be completely eradicated.Like many other enveloped viruses,HIV can escape recognition by the innate and adaptive immune systems.Recent findings have demonstrated that HIV can also successfully evade host restriction factors,the components of intrinsic immune system,such as APOBEC3G (apolipoprotein B mRNA-editing enzyme,catalytic polypeptide-like 3G),TRIM5α (tripartite motif 5-α),tetherin,and SAMHD1 (SAM-domain HD-domain containing protein).Conclusions HIV immune evasion plays an important role in HIV pathcgenesis.Fully understanding the tactics deployed by HIV to evade various components of the host immune systems will allow for the development of novel strategies aimed toward the prevention and cure of HIV/AIDS. 展开更多
关键词 human immunodeficiency virus immune evasion natural killer antibody cytotoxic T Iymphoeytes
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