Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,d...Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed.展开更多
Exercise-induced fatigue is a common phenomenon caused by prolonged strenuous exercise and physical labor as a feeling of exhaustion and reduction of muscle performance,which seriously affects people’s health,work ef...Exercise-induced fatigue is a common phenomenon caused by prolonged strenuous exercise and physical labor as a feeling of exhaustion and reduction of muscle performance,which seriously affects people’s health,work efficiency and quality of life.Meanwhile,numerous studies have shown that natural flavonoids can be an excellent source for preventing and treating exercise-induced fatigue due to their extraordinary antioxidant and antiinflammatory properties.However,the review of flavonoids in alleviating exercise-induced fatigue is still limited.Therefore,this review systematically summarizes recent studies on natural bioactive flavonoids that can alleviate exercise-induced fatigue and improve physical performance,including their plant sources,structure types and features,pharmacological effects and underlying mechanisms against exercise-induced fatigue.Also,the clinical trials have also been reviewed.Flavonols,isoflavones,anthocyanins,and their corresponding glycosides are the major bioactive flavonoids in alleviating exercise-induced fatigue.The current data and the further molecular docking evidently support the potential anti-fatigue effects of these flavonoids mainly involving the inhibition of oxidative stress and inflammatory response,as well as the regulation of energy metabolism.Activation of the Keap1/Nrf2/ARE and AMPK/PGC1-αpathways are responsible for the improvement of flavonoids against exercise-induced fatigue.Hence,this review is expected to contribute to the further research and development of anti-fatigue flavonoids in the functional food and nutraceutical industry.展开更多
基金supported by CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-1-010)National Key Research and Development Program(Grant No.2018YFC0311005)National Science and Technology Major Projects(Grant No.2018ZX09711001-012).
文摘Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed.
基金supported by the National Natural Science Foundation of China(No.81703809)the China Postdoctoral Science Foundation(No.2021MD703800)the Science Foundation for Youths of Science&Technology Department of Sichuan Province(No.2022NSFSC1449).
文摘Exercise-induced fatigue is a common phenomenon caused by prolonged strenuous exercise and physical labor as a feeling of exhaustion and reduction of muscle performance,which seriously affects people’s health,work efficiency and quality of life.Meanwhile,numerous studies have shown that natural flavonoids can be an excellent source for preventing and treating exercise-induced fatigue due to their extraordinary antioxidant and antiinflammatory properties.However,the review of flavonoids in alleviating exercise-induced fatigue is still limited.Therefore,this review systematically summarizes recent studies on natural bioactive flavonoids that can alleviate exercise-induced fatigue and improve physical performance,including their plant sources,structure types and features,pharmacological effects and underlying mechanisms against exercise-induced fatigue.Also,the clinical trials have also been reviewed.Flavonols,isoflavones,anthocyanins,and their corresponding glycosides are the major bioactive flavonoids in alleviating exercise-induced fatigue.The current data and the further molecular docking evidently support the potential anti-fatigue effects of these flavonoids mainly involving the inhibition of oxidative stress and inflammatory response,as well as the regulation of energy metabolism.Activation of the Keap1/Nrf2/ARE and AMPK/PGC1-αpathways are responsible for the improvement of flavonoids against exercise-induced fatigue.Hence,this review is expected to contribute to the further research and development of anti-fatigue flavonoids in the functional food and nutraceutical industry.
