Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the world.The treatment of OSCC is mainly radioth...Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the world.The treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is high.This paper reviews the range of effects of natural medicinal plant active ingredients(NMPAIs)on OSCC cancer,including the types of NMPAIs,anti-cancer mechanisms,involved signaling pathways,and clinical trials.The NMPAIs include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile oils.These active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer effects.The mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/Keap1.Clinically,NMPAIs can inhibit the growth of OSCC,and the combined drug is more effective.Natural medicinal plants are promising candidates for the treatment of OSCC.展开更多
基金Supported by National and Provincial First-Class Undergraduate Major Construction Point for 2020-Stomatology Major of Guizhou Province[No.QJH(2021)28]the Zunyi Innovative Talent Team of Oral Diseases Immunity and Medical Biomaterials Research[No.ZSRC(2022)1]+3 种基金the Science and Technology Project of Zunyi[No.ZSKH-HZ(2020)60]the Special Project of Zunyi Medical University for Academic New Talents[QKHPT(2018)5772-067]the Training Program Project of Zunyi Medical University for 2022 National and Provincial College Students Innovation and Entrepreneurship(No.S202210661227)the Training Program Project of Zunyi Medical University for Tutor Tendering Type College Students Innovation and Entrepreneurship(No.ZYDC2022042)。
文摘Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the world.The treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is high.This paper reviews the range of effects of natural medicinal plant active ingredients(NMPAIs)on OSCC cancer,including the types of NMPAIs,anti-cancer mechanisms,involved signaling pathways,and clinical trials.The NMPAIs include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile oils.These active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer effects.The mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/Keap1.Clinically,NMPAIs can inhibit the growth of OSCC,and the combined drug is more effective.Natural medicinal plants are promising candidates for the treatment of OSCC.
