The first total synthesis of five linear diterpenes: eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4) and epoxyeleganolone (5), was achieved from (E,E)-farnesol (6) via 4 to 6 steps. The key st...The first total synthesis of five linear diterpenes: eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4) and epoxyeleganolone (5), was achieved from (E,E)-farnesol (6) via 4 to 6 steps. The key step was the alkylation reaction of silyl cyanide with allylic iodide.展开更多
Subject Code:B02With the support of the National Natural Science Foundation of China,the research team led by Prof.Qin Yong(秦勇)at Sichuan University accomplished a collective synthesis of 33 monoterpenoid indole alk...Subject Code:B02With the support of the National Natural Science Foundation of China,the research team led by Prof.Qin Yong(秦勇)at Sichuan University accomplished a collective synthesis of 33 monoterpenoid indole alkaloids that belong to four families,by developing new photoredox-initiated radical cascade reactions.展开更多
An efficient route to the natural products bupleurynol and its analog（RB-2）,isolated from Bupleuri Radix,was established based on versatile intermediate（15）.In this synthetic route,Sonogashira and CadiotChodkiewic...An efficient route to the natural products bupleurynol and its analog（RB-2）,isolated from Bupleuri Radix,was established based on versatile intermediate（15）.In this synthetic route,Sonogashira and CadiotChodkiewicz coupling as well as Julia-Kocienski olefination are utilized as key steps.The highly efficient synthetic route provides opportunities to explore the biological behavior of bupleurynol and RB-2.展开更多
文摘The first total synthesis of five linear diterpenes: eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4) and epoxyeleganolone (5), was achieved from (E,E)-farnesol (6) via 4 to 6 steps. The key step was the alkylation reaction of silyl cyanide with allylic iodide.
文摘Subject Code:B02With the support of the National Natural Science Foundation of China,the research team led by Prof.Qin Yong(秦勇)at Sichuan University accomplished a collective synthesis of 33 monoterpenoid indole alkaloids that belong to four families,by developing new photoredox-initiated radical cascade reactions.
基金financially supported by National Natural Science Foundation of China(Nos.21402111,81473415)Basic research program of Shanxi Province(No.2015021039)+1 种基金Shanxi Scholarship Council of China(No.2015-020)science and technology innovation project of Shanxi Province(No.2016115)
文摘An efficient route to the natural products bupleurynol and its analog（RB-2）,isolated from Bupleuri Radix,was established based on versatile intermediate（15）.In this synthetic route,Sonogashira and CadiotChodkiewicz coupling as well as Julia-Kocienski olefination are utilized as key steps.The highly efficient synthetic route provides opportunities to explore the biological behavior of bupleurynol and RB-2.
