Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell he...Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell heteroge neity,tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so on.However,how to circumvent this resista nee to improve antican cer efficacy remains to be determined.To circumvent chemotherapeutic resista nee,many reversal agents have been developed,but most of them fail in clinical trials due to severe adverse effects.Recently,several natural products have been reported to augme nt sen sitivity or overcome resista nee of an ticancer chemotherapeutic drugs,including elemene,curcumin,Shenqi Fuzheng Injection(参芪扶正注射液),PHY906,etc.Thus,understand!ng the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and preve nt or overcome their resista nee in the treatment of can cer patie nts.展开更多
基金Supported by the National Natural Science Foundation of China(No.81672932,81730108,81874380 and 81973635)Zhejiang Provincial Natural Scienee Foundation of China for Distinguished Young Scholars(No.LR18H160001)+3 种基金Zhejia ng Provi nee Scie nee and Tech no logy Project of TCM(No.2019ZZ016)Zhejiang Provinee Medical Science and Tech no logy Project(No.2017RC007)Tale nt Project of Zhejia ng Associati on for Scie nee and Tech no logy(No.2017YCGC002)Key Project of Hangzhou Ministry of Science and Technology(No.20162013A07)。
文摘Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell heteroge neity,tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so on.However,how to circumvent this resista nee to improve antican cer efficacy remains to be determined.To circumvent chemotherapeutic resista nee,many reversal agents have been developed,but most of them fail in clinical trials due to severe adverse effects.Recently,several natural products have been reported to augme nt sen sitivity or overcome resista nee of an ticancer chemotherapeutic drugs,including elemene,curcumin,Shenqi Fuzheng Injection(参芪扶正注射液),PHY906,etc.Thus,understand!ng the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and preve nt or overcome their resista nee in the treatment of can cer patie nts.
